Works by Hiroshi Tomoda

Results: 133

Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B0171.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 95, n. 2, p. 451, doi. 10.1007/s00253-012-3973-8

By:

Inokoshi, Junji;
Matsuhama, Maki;
Miyake, Midori;
Ikeda, Haruo;
Tomoda, Hiroshi

Publication type:

Article

Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2016, v. 43, n. 2/3, p. 325, doi. 10.1007/s10295-015-1694-6

By:

Ikeda, Haruo;
Shin-ya, Kazuo;
Nagamitsu, Tohru;
Tomoda, Hiroshi

Publication type:

Article

Simaomicin α, a polycyclic xanthone, induces G1 arrest with suppression of retinoblastoma protein phosphorylation.

Published in:

Cancer Science, 2009, v. 100, n. 2, p. 322, doi. 10.1111/j.1349-7006.2008.01033.x

By:

Koizumi, Yukio;
Tomoda, Hiroshi;
Kumagai, Ayako;
Zhou, Xiao-ping;
Koyota, Souichi;
Sugiyama, Toshihiro

Publication type:

Article

Monapinone Coupling Enzyme Produces Non-Natural Heterodimers.

Published in:

Catalysts (2073-4344), 2021, v. 11, n. 8, p. 1015, doi. 10.3390/catal11081015

By:

Ohte, Satoshi;
Toyoda, Masayuki;
Kobayashi, Keisuke;
Fujii, Isao;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Complete Inhibition of Mouse Macrophage-Derived Foam Cell Formation by Triacsin C1.

Published in:

Journal of Biochemistry, 1999, v. 125, n. 2, p. 319, doi. 10.1093/oxfordjournals.jbchem.a022289

By:

Namatame, Ichiji;
Tomoda, Hiroshi;
Arai, Hiroyuki;
Inoue, Keizo;
Õmura, Satoshi

Publication type:

Article

Catalytic Enantioconvergent Alkylation Reactions That Construct Chiral Quaternary Carbon Centers and Tune C(sp3)‐C(sp2) Bond Rotation.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 20, p. 1, doi. 10.1002/chem.202500140

By:

Sohail, Muhammad;
Kobayashi, Keisuke;
Tomoda, Hiroshi;
Ohshiro, Taichi;
Tanaka, Fujie

Publication type:

Article

Antibiotic production by an endophytic Streptomyces isolated from the medicinal plant Poikilospermum suaveolens.

Published in:

Biodiversitas: Journal of Biological Diversity, 2024, v. 25, n. 5, p. 2221, doi. 10.13057/biodiv/d250540

By:

ALI, ALIMUDDIN;
PASSITTA, MUHARRAM;
RANTE, HERLINA;
WAHYUDIN, ELLY;
NATSIR DJIDE, NANA JUNIARTI;
POLITAN, ROLAND JANSEN;
NUR, ELYZA AIMAN;
SHIGENO, SATORU;
OHTE, SATOSHI;
KOBAYASHI, KEISUKE;
HOSODA, KANJI;
TOMODA, HIROSHI;
OHSHIRO, TAICHI

Publication type:

Article

Correction: New potentiators of amphotericin B activity, shodoamides A to C produced by Pseudophialophora sp. BF-0158.

Published in:

2025

By:

Yagi, Akiho;
Kashima, Masahiro;
Ishijima, Hiroyuki;
Tomoda, Hiroshi;
Uchida, Ryuji

Publication type:

Correction Notice

Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.

Published in:

Journal of Antibiotics, 2025, v. 78, n. 1, p. 26, doi. 10.1038/s41429-024-00785-5

By:

Seki, Reiko;
Nagai, Kenichiro;
Kobayashi, Keisuke;
Shigeno, Satoru;
Shirahata, Tatsuya;
Kobayashi, Yoshinori;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 12, p. 837, doi. 10.1038/s41429-024-00774-8

By:

Nur, Elyza Aiman Azizah;
Kobayashi, Keisuke;
Tejima, Rio;
Katada, Yosuke;
Tomoda, Hiroshi;
Ohshiro, Taichi

Publication type:

Article

Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 7, p. 403, doi. 10.1038/s41429-024-00725-3

By:

Kobayashi, Keisuke;
Tejima, Rio;
Nagai, Kenichiro;
Seki, Reiko;
Hosoya, Tsuyoshi;
Une, Yumi;
Shigeno, Satoru;
Tomoda, Hiroshi;
Ohshiro, Taichi

Publication type:

Article

New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 5, p. 265, doi. 10.1038/s41429-024-00710-w

By:

Shigeno, Satoru;
Kadowaki, Miyu;
Nagai, Kenichiro;
Hosoda, Kanji;
Terahara, Takeshi;
Nishimura, Tomoyasu;
Hasegawa, Naoki;
Tomoda, Hiroshi;
Ohshiro, Taichi

Publication type:

Article

Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 4, p. 214, doi. 10.1038/s41429-023-00700-4

By:

Nagai, Kenichiro;
Kobayashi, Keisuke;
Miyake, Ryosuke;
Sato, Yukino;
Seki, Reiko;
Fukuda, Takashi;
Yagi, Akiho;
Uchida, Ryuji;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8.

Published in:

Journal of Antibiotics, 2023, v. 76, n. 11, p. 650, doi. 10.1038/s41429-023-00648-5

By:

Uemura, Moeka;
Kobayashi, Keisuke;
Sato, Noriko;
Nagai, Kenichiro;
Seki, Reiko;
Kamio, Michiya;
Fukuda, Takashi;
Tsubouchi, Taishi;
Tomoda, Hiroshi;
Ohshiro, Taichi;
Kobayashi, Takeshi;
Terahara, Takeshi

Publication type:

Article

New potentiators of amphotericin B activity, shodoamides A to C produced by Pseudophialophora sp. BF-0158.

Published in:

Journal of Antibiotics, 2023, v. 76, n. 10, p. 579, doi. 10.1038/s41429-023-00642-x

By:

Yagi, Akiho;
Kashima, Masahiro;
Ishijima, Hiroyuki;
Tomoda, Hiroshi;
Uchida, Ryuji

Publication type:

Article

Discovery of prescopranone, a key intermediate in scopranone biosynthesis.

Published in:

Journal of Antibiotics, 2022, v. 75, n. 6, p. 305, doi. 10.1038/s41429-022-00521-x

By:

Demachi, Ayumu;
Ohte, Satoshi;
Uchida, Ryuji;
Shin-ya, Kazuo;
Ohshiro, Taichi;
Tomoda, Hiroshi;
Ikeda, Haruo

Publication type:

Article

Kimidinomycin, a new antibiotic against Mycobacterium avium complex, produced by Streptomyces sp. KKTA-0263.

Published in:

Journal of Antibiotics, 2022, v. 75, n. 2, p. 72, doi. 10.1038/s41429-021-00494-3

By:

Hikima, Ayumi;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Zhang, Huiping;
Tomoda, Hiroshi;
Koyama, Nobuhiro

Publication type:

Article

Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 11, p. 748, doi. 10.1038/s41429-020-0327-0

By:

Ohshiro, Taichi;
Morita, Haruka;
Nur, Elyza Aiman Azizah;
Hosoda, Kanji;
Uchida, Ryuji;
Tomoda, Hiroshi

Publication type:

Article

Special issue dedicated to William Fenical: a pioneer in marine/marine-derived microbial chemistry.

Published in:

2020

By:

Tomoda, Hiroshi;
McAlpine, James B.

Publication type:

Editorial

A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 8, p. 554, doi. 10.1038/s41429-020-0316-3

By:

Ohte, Satoshi;
Shiokawa, Takehiro;
Koyama, Nobuhiro;
Katagiri, Takenobu;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

2-Epi-anthracimycin, a new cytotoxic agent from the marine-derived actinomycete Streptomyces sp. OPMA00631.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 8, p. 548, doi. 10.1038/s41429-020-0309-2

By:

Fukuda, Takashi;
Nagai, Kenichiro;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

Steffimycin E, a new anti-mycobacterial agent against Mycobacterium avium complex, produced by Streptomyces sp. OPMA02852.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 8, p. 581, doi. 10.1038/s41429-020-0290-9

By:

Koyama, Nobuhiro;
Shigeno, Satoru;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

Polyketide glycosides phialotides A to H, new potentiators of amphotericin B activity, produced by Pseudophialophora sp. BF-0158.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 4, p. 211, doi. 10.1038/s41429-019-0276-7

By:

Yagi, Akiho;
Uchida, Ryuji;
Kobayashi, Keisuke;
Tomoda, Hiroshi

Publication type:

Article

Simpotentin, a new potentiator of amphotericin B activity against Candida albicans, produced by Simplicillium minatense FKI-4981.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 3, p. 134, doi. 10.1038/s41429-018-0128-x

By:

Uchida, Ryuji;
Kondo, Ariko;
Yagi, Akiho;
Nonaka, Kenichi;
Masuma, Rokurou;
Kobayashi, Keisuke;
Tomoda, Hiroshi

Publication type:

Article

MS network-based screening for new antibiotics discovery.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 1, p. 54, doi. 10.1038/s41429-018-0109-0

By:

Koyama, Nobuhiro;
Tomoda, Hiroshi

Publication type:

Article

Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 1, p. 8, doi. 10.1038/s41429-018-0101-8

By:

Fukuda, Takashi;
Furukawa, Takun;
Kobayashi, Keisuke;
Nagai, Kenichiro;
Uchida, Ryuji;
Tomoda, Hiroshi

Publication type:

Article

Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 12, p. 1000, doi. 10.1038/s41429-018-0097-0

By:

Ohshiro, Taichi;
Seki, Reiko;
Fukuda, Takashi;
Uchida, Ryuji;
Tomoda, Hiroshi

Publication type:

Article

Anti-Rhizopus activity of tanzawaic acids produced by the hot spring-derived fungus Penicillium sp. BF-0005.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 7, p. 626, doi. 10.1038/s41429-018-0049-8

By:

Tominaga, Takehiro;
Uchida, Ryuji;
Koyama, Nobuhiro;
Tomoda, Hiroshi

Publication type:

Article

Winners of the 2016 JA Medals for excellence.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 12, p. 1085, doi. 10.1038/ja.2017.133

By:

Tomoda, Hiroshi;
Yoshida, Minoru

Publication type:

Article

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 5, p. 590, doi. 10.1038/ja.2016.152

By:

Fukuda, Takashi;
Takahashi, Misaki;
Nagai, Kenichiro;
Harunari, Enjuro;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 5, p. 685, doi. 10.1038/ja.2017.23

By:

Yagi, Akiho;
Uchida, Ryuji;
Hamamoto, Hiroshi;
Sekimizu, Kazuhisa;
Kimura, Ken-ichi;
Tomoda, Hiroshi

Publication type:

Article

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 5, p. 562, doi. 10.1038/ja.2017.28

By:

Fukumoto, Atsushi;
Kim, Yong-Pil;
Matsumoto, Atsuko;
Takahashi, Yoko;
Suzuki, Makoto;
Onodera, Hideyuki;
Tomoda, Hiroshi;
Matsui, Hidehito;
Hanaki, Hideaki;
Iwatsuki, Masato;
Ōmura, Satoshi;
Shiomi, Kazuro

Publication type:

Article

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 1, p. 96, doi. 10.1038/ja.2016.46

By:

Suzuki, Aika;
Fukuda, Takashi;
Kobayashi, Keisuke;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules.

Published in:

Journal of Antibiotics, 2016, v. 69, n. 11, p. 798, doi. 10.1038/ja.2016.35

By:

Inokoshi, Junji;
Nakamura, Yuichiro;
Komada, Saori;
Komatsu, Katsuichiro;
Umeyama, Hideaki;
Tomoda, Hiroshi

Publication type:

Article

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007.

Published in:

Journal of Antibiotics, 2016, v. 69, n. 8, p. 647, doi. 10.1038/ja.2016.27

By:

Uchida, Ryuji;
Nakajyo, Kento;
Kobayashi, Keisuke;
Ohshiro, Taichi;
Terahara, Takeshi;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 10, p. 638, doi. 10.1038/ja.2015.38

By:

Kobayashi, Keisuke;
Fukuda, Takashi;
Terahara, Takeshi;
Harunari, Enjuro;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp. OPMF00224.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 10, p. 620, doi. 10.1038/ja.2015.41

By:

Fukuda, Takashi;
Shinkai, Minori;
Sasaki, Eri;
Nagai, Kenichiro;
Kurihara, Yuko;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 10, p. 615, doi. 10.1038/ja.2015.37

By:

Kobayashi, Keisuke;
Tsukasaki, Nobuaki;
Uchida, Ryuji;
Yamaguchi, Yuichi;
Tomoda, Hiroshi

Publication type:

Article

Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 2, p. 126, doi. 10.1038/ja.2014.100

By:

Kobayashi, Keisuke;
Fukuda, Takashi;
Usui, Takeo;
Kurihara, Yuko;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 1, p. 27, doi. 10.1038/ja.2014.91

By:

Matsuda, Daisuke;
Ohshiro, Taichi;
Ohtawa, Masaki;
Yamazaki, Hiroyuki;
Nagamitsu, Tohru;
Tomoda, Hiroshi

Publication type:

Article

Habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 11, p. 777, doi. 10.1038/ja.2014.62

By:

Uchida, Ryuji;
Yokota, Sayaka;
Matsuda, Daisuke;
Matsumoto, Atsuko;
Iwamoto, Susumu;
Onodera, Hideyuki;
Takahashi, Yoko;
Tomoda, Hiroshi

Publication type:

Article

Structure elucidation of meroterpenoid habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 11, p. 783, doi. 10.1038/ja.2014.71

By:

Uchida, Ryuji;
Yokota, Sayaka;
Tomoda, Hiroshi

Publication type:

Article

Terretonin G, a new sesterterpenoid antibiotic from marine-derived Aspergillus sp. OPMF00272.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 8, p. 593, doi. 10.1038/ja.2014.46

By:

Fukuda, Takashi;
Kurihara, Yuko;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

5-Prenyltryptophol, a new inhibitor of bone morphogenetic protein-induced alkaline phosphatase expression in myoblasts, produced by Streptomyces colinus subsp. albescens HEK608.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 8, p. 589, doi. 10.1038/ja.2014.44

By:

Uchida, Ryuji;
Nakai, Megumi;
Ohte, Satoshi;
Onaka, Hiroyasu;
Katagiri, Takenobu;
Tomoda, Hiroshi

Publication type:

Article

Synthesis and biological activity of Citridone A and its derivatives.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 6, p. 445, doi. 10.1038/ja.2014.14

By:

Fukuda, Takashi;
Shimoyama, Kenta;
Nagamitsu, Tohru;
Tomoda, Hiroshi

Publication type:

Article

Epi-trichosetin, a new undecaprenyl pyrophosphate synthase inhibitor, produced by Fusarium oxysporum FKI-4553.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 9, p. 549, doi. 10.1038/ja.2013.44

By:

Inokoshi, Junji;
Shigeta, Naoki;
Fukuda, Takashi;
Uchida, Ryuji;
Nonaka, Kenichi;
Masuma, Rokurou;
Tomoda, Hiroshi

Publication type:

Article

Tylopilusin C, a new diphenolic compound from the fruiting bodies of Tylopilus eximinus.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 6, p. 355, doi. 10.1038/ja.2013.23

By:

Fukuda, Takashi;
Tomoda, Hiroshi

Publication type:

Article

New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 5, p. 303, doi. 10.1038/ja.2012.122

By:

Koyama, Nobuhiro;
Yotsumoto, Makoto;
Onaka, Hiroyasu;
Tomoda, Hiroshi

Publication type:

Article

New dinapinone derivatives, potent inhibitors of triacylglycerol synthesis in mammalian cells, produced by Talaromyces pinophilus FKI-3864.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 3, p. 179, doi. 10.1038/ja.2012.127

By:

Kawaguchi, Mio;
Uchida, Ryuji;
Ohte, Satoshi;
Miyachi, Natsuki;
Kobayashi, Keisuke;
Sato, Noriko;
Nonaka, Kenichi;
Masuma, Rokuro;
Fukuda, Takashi;
Yasuhara, Tadashi;
Tomoda, Hiroshi

Publication type:

Article

A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 1, p. 23, doi. 10.1038/ja.2012.75

By:

Kawaguchi, Mio;
Fukuda, Takashi;
Uchida, Ryuji;
Nonaka, Kenichi;
Masuma, Rokuro;
Tomoda, Hiroshi

Publication type:

Article