Works by Hill, Adam P.

Results: 31

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia.

Published in:

Stem Cell Research & Therapy, 2023, v. 14, n. 1, p. 1, doi. 10.1186/s13287-023-03405-5

By:

Thorpe, Jordan;
Perry, Matthew D.;
Contreras, Osvaldo;
Hurley, Emily;
Parker, George;
Harvey, Richard P.;
Hill, Adam P.;
Vandenberg, Jamie I.

Publication type:

Article

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events.

Published in:

Cardiovascular Research, 2021, v. 117, n. 10, p. 2216, doi. 10.1093/cvr/cvaa280

By:

Ballouz, Sara;
Mangala, Melissa M;
Perry, Matthew D;
Heitmann, Stewart;
Gillis, Jesse A;
Hill, Adam P;
Vandenberg, Jamie I

Publication type:

Article

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization.

Published in:

Cardiovascular Research, 2020, v. 116, n. 8, p. 1434, doi. 10.1093/cvr/cvz247

By:

Perry, Matthew D;
Ng, Chai-Ann;
Mangala, Melissa M;
Ng, Timothy Y M;
Hines, Adam D;
Liang, Whitney;
Xu, Michelle J O;
Hill, Adam P;
Vandenberg, Jamie I

Publication type:

Article

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics.

Published in:

Bulletin of Mathematical Biology, 2024, v. 86, n. 1, p. 1, doi. 10.1007/s11538-023-01224-6

By:

Shuttleworth, Joseph G.;
Lei, Chon Lok;
Whittaker, Dominic G.;
Windley, Monique J.;
Hill, Adam P.;
Preston, Simon P.;
Mirams, Gary R.

Publication type:

Article

Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 11, p. 2631, doi. 10.1111/bph.15757

By:

TeBay, Clifford;
McArthur, Jeffrey R.;
Mangala, Melissa;
Kerr, Nicholas;
Heitmann, Stewart;
Perry, Matthew D.;
Windley, Monique J.;
Vandenberg, Jamie I.;
Hill, Adam P.

Publication type:

Article

Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype.

Published in:

Journal of Cardiovascular Electrophysiology, 2009, v. 20, n. 8, p. 923, doi. 10.1111/j.1540-8167.2009.01468.x

By:

ZHAO, JING TING;
HILL, ADAM P.;
VARGHESE, ANTHONY;
COOPER, ANTONY A.;
SWAN, HEIKKI;
LAITINEN‐FORSBLOM, PÄIVI J.;
REES, MARK I.;
SKINNER, JONATHAN R.;
CAMPBELL, TERENCE J.;
VANDENBERG, JAMIE I.

Publication type:

Article

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs.

Published in:

Frontiers in Physiology, 2016, p. 1, doi. 10.3389/fphys.2016.00154

By:

Hodkinson, Emily C.;
Neijts, Melanie;
Sadrieh, Arash;
Imtiaz, Mohammad S.;
Baumert, Mathias;
Subbiah, Rajesh N.;
Hayward, Christopher S.;
Boomsma, Dorret;
Willemsen, Gonneke;
Vandenberg, Jamie I.;
Hill, Adam P.;
De Geus, Eco

Publication type:

Article

PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.

Published in:

BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1820-x

By:

Chaudhuri, Rima;
Sadrieh, Arash;
Hoffman, Nolan J.;
Parker, Benjamin L.;
Humphrey, Sean J.;
Stöckli, Jacqueline;
Hill, Adam P.;
James, David E.;
Yee Hwa Yang, Jean

Publication type:

Article

PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.

Published in:

BMC Genomics, 2015, v. 16, n. 1, p. 617, doi. 10.1186/s12864-015-1820-x

By:

Chaudhuri, Rima;
Sadrieh, Arash;
Hoffman, Nolan J.;
Parker, Benjamin L.;
Humphrey, Sean J.;
Stöckli, Jacqueline;
Hill, Adam P.;
James, David E.;
Hwa Yang, Jean Yee

Publication type:

Article

Arrhythmogenic effects of ultra-long and bistable cardiac action potentials.

Published in:

PLoS Computational Biology, 2021, v. 17, n. 2, p. 1, doi. 10.1371/journal.pcbi.1008683

By:

Heitmann, Stewart;
Shpak, Anton;
Vandenberg, Jamie I.;
Hill, Adam P.

Publication type:

Article

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

Published in:

Journal of Physiology, 2018, v. 596, n. 10, p. 1813, doi. 10.1113/JP275733

By:

Beattie, Kylie A.;
Hill, Adam P.;
Bardenet, Rémi;
Cui, Yi;
Vandenberg, Jamie I.;
Gavaghan, David J.;
Boer, Teun P.;
Mirams, Gary R.

Publication type:

Article

Boosting the reserves: additive regulation of cardiac repolarisation.

Published in:

Journal of Physiology, 2017, v. 595, n. 7, p. 2269, doi. 10.1113/JP273940

By:

Hill, Adam P.

Publication type:

Article

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Published in:

Journal of Physiology, 2016, v. 594, n. 23, p. 6893, doi. 10.1113/JP272015

By:

Hill, Adam P.;
Perry, Matthew D.;
Abi‐Gerges, Najah;
Couderc, Jean‐Philippe;
Fermini, Bernard;
Hancox, Jules C.;
Knollmann, Bjorn C.;
Mirams, Gary R.;
Skinner, Jon;
Zareba, Wojciech;
Vandenberg, Jamie I.

Publication type:

Article

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.

Published in:

Journal of Physiology, 2016, v. 594, n. 14, p. 4031, doi. 10.1113/JP271805

By:

Perry, Matthew D.;
Ng, Chai Ann;
Phan, Kevin;
David, Erikka;
Steer, Kieran;
Hunter, Mark J.;
Mann, Stefan A.;
Imtiaz, Mohammad;
Hill, Adam P.;
Ke, Ying;
Vandenberg, Jamie I.

Publication type:

Article

An 'alternans' way to quantify arrhythmogenic substrates.

Published in:

Journal of Physiology, 2016, v. 594, n. 9, p. 2375, doi. 10.1113/JP271838

By:

Vandenberg, Jamie I.;
Hill, Adam P.

Publication type:

Article

Getting to the heart of hERG K+ channel gating.

Published in:

Journal of Physiology, 2015, v. 593, n. 12, p. 2575, doi. 10.1113/JP270095

By:

Perry, Matthew D.;
Ng, Chai‐Ann;
Mann, Stefan A.;
Sadrieh, Arash;
Imtiaz, Mohammad;
Hill, Adam P.;
Vandenberg, Jamie I.

Publication type:

Article

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram.

Published in:

Journal of Physiology, 2013, v. 591, n. 17, p. 4207, doi. 10.1113/jphysiol.2013.251710

By:

Sadrieh, Arash;
Mann, Stefan A.;
Subbiah, Rajesh N.;
Domanski, Luke;
Taylor, John A.;
Vandenberg, Jamie I.;
Hill, Adam P.

Publication type:

Article

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.

Published in:

Nature Communications, 2016, v. 7, n. 6, p. 11984, doi. 10.1038/ncomms11984

By:

Bavi, Navid;
Cortes, D. Marien;
Cox, Charles D.;
Rohde, Paul R.;
Liu, Weihong;
Deitmer, Joachim W.;
Bavi, Omid;
Strop, Pavel;
Hill, Adam P.;
Rees, Douglas;
Corry, Ben;
Perozo, Eduardo;
Martinac, Boris

Publication type:

Article

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

Published in:

Nature Communications, 2014, v. 5, n. 9, p. 5069, doi. 10.1038/ncomms6069

By:

Sadrieh, Arash;
Domanski, Luke;
Pitt-Francis, Joe;
Mann, Stefan A;
Hodkinson, Emily C;
Ng, Chai-Ann;
Perry, Matthew D;
Taylor, John A;
Gavaghan, David;
Subbiah, Rajesh N;
Vandenberg, Jamie I;
Hill, Adam P

Publication type:

Article

Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials.

Published in:

PLoS Computational Biology, 2012, v. 8, n. 4, p. 1, doi. 10.1371/journal.pcbi.1002456

By:

Yu, Yuguo;
Hill, Adam P.;
McCormick, David A.

Publication type:

Article

The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review.

Published in:

Annals of Noninvasive Electrocardiology, 2023, v. 28, n. 1, p. 1, doi. 10.1111/anec.13015

By:

Tardo, Daniel T.;
Peck, Matthew;
Subbiah, Rajesh N.;
Vandenberg, Jamie I.;
Hill, Adam. P.

Publication type:

Article

Mapping the sequence of conformational changes underlying selectivity filter gating in the Kv11.1 potassium channel.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 1, p. 35, doi. 10.1038/nsmb.1966

By:

Wang, David T;
Hill, Adam P;
Mann, Stefan A;
Tan, Peter S;
Vandenberg, Jamie I

Publication type:

Article

Trafficking defects in PAS domain mutant Kv 11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

Published in:

Biochemical Journal, 2013, v. 454, n. 1, p. 69, doi. 10.1042/BJ20130328

By:

Ying KE;
Chai Ann NG;
HUNTER, Mark J.;
MANN, Stefan A.;
HEIDE, Juliane;
HILL, Adam P.;
VANDENBERG, Jamie I.

Publication type:

Article

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology.

Published in:

Biology Methods & Protocols, 2021, v. 6, n. 1, p. 1, doi. 10.1093/biomethods/bpab003

By:

Ng, Chai-Ann;
Farr, Jessica;
Young, Paul;
Windley, Monique J;
Perry, Matthew D;
Hill, Adam P;
Vandenberg, Jamie I

Publication type:

Article

Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL‐1 atrial myocytes.

Published in:

Journal of Physiology, 2024, v. 602, n. 18, p. 4363, doi. 10.1113/JP284474

By:

Guo, Yang;
Cheng, Delfine;
Yu, Ze‐Yan;
Schiatti, Teresa;
Chan, Andrea Y.;
Hill, Adam P.;
Peyronnet, Rémi;
Feneley, Michael P.;
Cox, Charles D.;
Martinac, Boris

Publication type:

Article

A constricted opening in Kir channels does not impede potassium conduction.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16842-0

By:

Black, Katrina A.;
He, Sitong;
Jin, Ruitao;
Miller, David M.;
Bolla, Jani R.;
Clarke, Oliver B.;
Johnson, Paul;
Windley, Monique;
Burns, Christopher J.;
Hill, Adam P.;
Laver, Derek;
Robinson, Carol V.;
Smith, Brian J.;
Gulbis, Jacqueline M.

Publication type:

Article

C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077032

By:

Ng, Chai Ann;
Ke, Ying;
Perry, Matthew D.;
Tan, Peter S.;
Hill, Adam P.;
Vandenberg, Jamie I.

Publication type:

Article

The S4-S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation Gating.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031640

By:

Chai, Ann Ng;
Perry, Matthew D.;
Tan, Peter S.;
Hill, Adam P.;
Kuchel, Philip W.;
Vandenberg, Jamie I.

Publication type:

Article

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities.

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.01035

By:

Munawar, Saba;
Windley, Monique J.;
Tse, Edwin G.;
Todd, Matthew H.;
Hill, Adam P.;
Vandenberg, Jamie I.;
Jabeen, Ishrat

Publication type:

Article

Complementarity and integration of animal and in vitro non-animal pre-clinical model systems– an Australian perspective.

Published in:

Mammalian Genome, 2025, v. 36, n. 2, p. 482, doi. 10.1007/s00335-025-10132-0

By:

Arkell, Ruth M.;
Wolvetang, Ernst J.;
Gulati, Twishi;
Hennessy, James E.;
Hill, Adam P.;
Jardé, Thierry;
Kueh, Andrew J.;
Thomas, Paul Q.;
Winteringham, Louise N.;
Dobbie, Michael S.

Publication type:

Article

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00934

By:

Lee, William;
Windley, Monique J.;
Vandenberg, Jamie I.;
Hill, Adam P.

Publication type:

Article

Works by Hill, Adam P.

Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia.

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events.

Pharmacological activation of I<sub>Kr</sub> in models of long QT Type 2 risks overcorrection of repolarization.

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics.

Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.

Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype.

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs.

PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.

PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.

Arrhythmogenic effects of ultra-long and bistable cardiac action potentials.

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

Boosting the reserves: additive regulation of cardiac repolarisation.

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.

An 'alternans' way to quantify arrhythmogenic substrates.

Getting to the heart of hERG K<sup>+</sup> channel gating.

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram.

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials.

The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review.

Mapping the sequence of conformational changes underlying selectivity filter gating in the K<sub>v</sub>11.1 potassium channel.

Trafficking defects in PAS domain mutant K<sub>v</sub> 11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology.

Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL‐1 atrial myocytes.

A constricted opening in Kir channels does not impede potassium conduction.

C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels.

The S4-S5 Linker Acts as a Signal Integrator for hERG K<sup>+</sup> Channel Activation and Deactivation Gating.

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities.

Complementarity and integration of animal and in vitro non-animal pre-clinical model systems– an Australian perspective.

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.