Works matching AU Hilbi, Hubert

Results: 68

Phosphoinositides and the Fate of Legionella in Phagocytes.

Published in:

Frontiers in Immunology, 2020, p. 1, doi. 10.3389/fimmu.2020.00025

By:

Swart, A. Leoni;
Hilbi, Hubert

Publication type:

Article

Rapid Icm/Dot T4SS Inactivation Prevents Resuscitation of Heat‐Induced VBNCLegionella pneumophila by Amoebae.

Published in:

Environmental Microbiology, 2025, v. 27, n. 1, p. 1, doi. 10.1111/1462-2920.70035

By:

Schmid, Camille;
Hilbi, Hubert

Publication type:

Article

Migration of Acanthamoeba through Legionella biofilms is regulated by the bacterial Lqs‐LvbR network, effector proteins and the flagellum.

Published in:

Environmental Microbiology, 2022, v. 24, n. 8, p. 3672, doi. 10.1111/1462-2920.16008

By:

Hochstrasser, Ramon;
Michaelis, Sarah;
Brülisauer, Sabrina;
Sura, Thomas;
Fan, Mingzhen;
Maaß, Sandra;
Becher, Dörte;
Hilbi, Hubert

Publication type:

Article

The pleiotropic Legionella transcription factor LvbR links the Lqs and c‐di‐GMP regulatory networks to control biofilm architecture and virulence.

Published in:

Environmental Microbiology, 2019, v. 21, n. 3, p. 1035, doi. 10.1111/1462-2920.14523

By:

Hochstrasser, Ramon;
Kessler, Aline;
Sahr, Tobias;
Simon, Sylvia;
Schell, Ursula;
Gomez‐Valero, Laura;
Buchrieser, Carmen;
Hilbi, Hubert

Publication type:

Article

Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway.

Published in:

PLoS Pathogens, 2015, v. 11, n. 12, p. 1, doi. 10.1371/journal.ppat.1005307

By:

Simon, Sylvia;
Schell, Ursula;
Heuer, Natalie;
Hager, Dominik;
Albers, Michael F.;
Matthias, Jan;
Fahrnbauer, Felix;
Trauner, Dirk;
Eichinger, Ludwig;
Hedberg, Christian;
Hilbi, Hubert

Publication type:

Article

Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection.

Published in:

PLoS Pathogens, 2013, v. 9, n. 9, p. 1, doi. 10.1371/journal.ppat.1003598

By:

Rothmeier, Eva;
Pfaffinger, Gudrun;
Hoffmann, Christine;
Harrison, Christopher F.;
Grabmayr, Heinrich;
Repnik, Urska;
Hannemann, Mandy;
Wölke, Stefan;
Bausch, Andreas;
Griffiths, Gareth;
Müller-Taubenberger, Annette;
Itzen, Aymelt;
Hilbi, Hubert

Publication type:

Article

Legionella pneumophila Exploits PI(4)P to Anchor Secreted Effector Proteins to the Replicative Vacuole.

Published in:

PLoS Pathogens, 2006, v. 2, n. 5, p. e46, doi. 10.1371/journal.ppat.0020046

By:

Weber, Stefan S.;
Ragaz, Curdin;
Reus, Katrin;
Nyfeler, Yves;
Hilbi, Hubert

Publication type:

Article

Pathogen vacuole membrane contact sites – close encounters of the fifth kind.

Published in:

MicroLife, 2023, v. 4, p. 1, doi. 10.1093/femsml/uqad018

By:

Vormittag, Simone;
Ende, Rachel J;
Derré, Isabelle;
Hilbi, Hubert

Publication type:

Article

Formation of a pathogen vacuole according to L egionella pneumophila: how to kill one bird with many stones.

Published in:

Cellular Microbiology, 2015, v. 17, n. 7, p. 935, doi. 10.1111/cmi.12450

By:

Finsel, Ivo;
Hilbi, Hubert

Publication type:

Article

Icm/ Dot-dependent inhibition of phagocyte migration by L egionella is antagonized by a translocated Ran GTPase activator.

Published in:

Cellular Microbiology, 2014, v. 16, n. 7, p. 977, doi. 10.1111/cmi.12258

By:

Simon, Sylvia;
Wagner, Maria A.;
Rothmeier, Eva;
Müller‐Taubenberger, Annette;
Hilbi, Hubert

Publication type:

Article

Functional analysis of novel Rab GTPases identified in the proteome of purified L egionella-containing vacuoles from macrophages.

Published in:

Cellular Microbiology, 2014, v. 16, n. 7, p. 1034, doi. 10.1111/cmi.12256

By:

Hoffmann, Christine;
Finsel, Ivo;
Otto, Andreas;
Pfaffinger, Gudrun;
Rothmeier, Eva;
Hecker, Michael;
Becher, Dörte;
Hilbi, Hubert

Publication type:

Article

The natural alternative: protozoa as cellular models for L egionella infection.

Published in:

Cellular Microbiology, 2014, v. 16, n. 1, p. 15, doi. 10.1111/cmi.12235

By:

Hoffmann, Christine;
Harrison, Christopher F.;
Hilbi, Hubert

Publication type:

Article

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.

Published in:

Cellular Microbiology, 2009, v. 11, n. 3, p. 442, doi. 10.1111/j.1462-5822.2008.01266.x

By:

Weber, Stefan S.;
Ragaz, Curdin;
Hilbi, Hubert

Publication type:

Article

The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole.

Published in:

Cellular Microbiology, 2008, v. 10, n. 12, p. 2416, doi. 10.1111/j.1462-5822.2008.01219.x

By:

Ragaz, Curdin;
Pietsch, Holger;
Urwyler, Simon;
Tiaden, Andr;
Weber, Stefan S.;
Hilbi, Hubert

Publication type:

Article

The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA.

Published in:

Cellular Microbiology, 2007, v. 9, n. 12, p. 2903, doi. 10.1111/j.1462-5822.2007.01005.x

By:

Tiaden, André;
Spirig, Thomas;
Weber, Stefan S.;
Brüggemann, Holger;
Bosshard, Rachel;
Buchrieser, Carmen;
Hilbi, Hubert

Publication type:

Article

Cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after phagosomal escape of Shigella.

Published in:

Cellular Microbiology, 2007, v. 9, n. 1, p. 265, doi. 10.1111/j.1462-5822.2006.00787.x

By:

Schroeder, Gunnar N.;
Hilbi, Hubert

Publication type:

Article

Modulation of phosphoinositide metabolism by pathogenic bacteria.

Published in:

Cellular Microbiology, 2006, v. 8, n. 11, p. 1697, doi. 10.1111/j.1462-5822.2006.00793.x

By:

Hilbi, Hubert

Publication type:

Article

The large GTPase atlastin controls ER remodeling around a pathogen vacuole.

Published in:

Communicative & Integrative Biology, 2018, v. 11, n. 2, p. 1, doi. 10.1080/19420889.2018.1440880

By:

Steiner, Bernhard;
Weber, Stephen;
Kaech, Andres;
Ziegler, Urs;
Hilbi, Hubert

Publication type:

Article

Endosomal and secretory markers of the Legionella-containing vacuole.

Published in:

Communicative & Integrative Biology, 2009, v. 2, n. 2, p. 107, doi. 10.4161/cib.7713

By:

Urwyler, Simon;
Brombacher, Eva;
Hilbi, Hubert

Publication type:

Article

Establishment and Validation of Whole-Cell Based Fluorescence Assays to Identify Anti-Mycobacterial Compounds Using the Acanthamoeba castellanii - Mycobacterium marinum Host-Pathogen System.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0087834

By:

Kicka, Sébastien;
Trofimov, Valentin;
Harrison, Christopher;
Ouertatani-Sakouhi, Hajer;
McKinney, John;
Scapozza, Leonardo;
Hilbi, Hubert;
Cosson, Pierre;
Soldati, Thierry

Publication type:

Article

Exploring Anti-Bacterial Compounds against Intracellular Legionella.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0074813

By:

Harrison, Christopher F.;
Kicka, Sébastien;
Trofimov, Valentin;
Berschl, Kathrin;
Ouertatani-Sakouhi, Hajer;
Ackermann, Nikolaus;
Hedberg, Christian;
Cosson, Pierre;
Soldati, Thierry;
Hilbi, Hubert

Publication type:

Article

Autoinducers Act as Biological Timers in Vibrio harveyi.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0048310

By:

Anetzberger, Claudia;
Reiger, Matthias;
Fekete, Agnes;
Schell, Ursula;
Stambrau, Nina;
Plener, Laure;
Kopka, Joachim;
Schmitt-Kopplin, Phillippe;
Hilbi, Hubert;
Jung, Kirsten

Publication type:

Article

Purification and proteomics of pathogen-modified vacuoles and membranes.

Published in:

Frontiers in Cellular & Infection Microbiology, 2015, p. 55, doi. 10.3389/fcimb.2015.00048

By:

Herweg, Jo-Ana;
Hansmeier, Nicole;
Otto, Andreas;
Geffken, Anna C.;
Subbarayal, Prema;
Prusty, Bhupesh K.;
Becher, Dörte;
Hensel, Michael;
Schaible, Ulrich E.;
Rudel, Thomas;
Hilbi, Hubert;
Belisle, John T.;
Torrents, Eduard

Publication type:

Article

Metabolism of the vacuolar pathogen Legionella and implications for virulence.

Published in:

Frontiers in Cellular & Infection Microbiology, 2014, p. 1, doi. 10.3389/fcimb.2014.00125

By:

Manske, Christian;
Hilbi, Hubert

Publication type:

Article

Metabolism of the vacuolar pathogen Legionella and implications for virulence.

Published in:

Frontiers in Cellular & Infection Microbiology, 2014, p. 1, doi. 10.3389/fcimb.2014.00125

By:

Manske, Christian;
Hilbi, Hubert

Publication type:

Article

The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit.

Published in:

Environmental Microbiology, 2013, v. 15, n. 2, p. 646, doi. 10.1111/j.1462-2920.2012.02889.x

By:

Kessler, Aline;
Schell, Ursula;
Sahr, Tobias;
Tiaden, André;
Harrison, Christopher;
Buchrieser, Carmen;
Hilbi, Hubert

Publication type:

Article

The autoinducer synthase LqsA and putative sensor kinase LqsS regulate phagocyte interactions, extracellular filaments and a genomic island of Legionella pneumophila.

Published in:

Environmental Microbiology, 2010, v. 12, n. 5, p. 1243, doi. 10.1111/j.1462-2920.2010.02167.x

By:

Tiaden, André;
Spirig, Thomas;
Sahr, Tobias;
Wälti, Martin A.;
Boucke, Karin;
Buchrieser, Carmen;
Hilbi, Hubert

Publication type:

Article

Environmental predators as models for bacterial pathogenesis.

Published in:

Environmental Microbiology, 2007, v. 9, n. 3, p. 563, doi. 10.1111/j.1462-2920.2007.01238.x

By:

Hilbi, Hubert;
Weber, Stefan S.;
Ragaz, Curdin;
Nyfeler, Yves;
Urwyler, Simon

Publication type:

Article

Phosphorylation signalling through the L egionella quorum sensing histidine kinases LqsS and LqsT converges on the response regulator LqsR.

Published in:

Molecular Microbiology, 2014, v. 92, n. 5, p. 1039, doi. 10.1111/mmi.12612

By:

Schell, Ursula;
Kessler, Aline;
Hilbi, Hubert

Publication type:

Article

Update on Legionnaires’ disease: pathogenesis, epidemiology, detection and control.

Published in:

Molecular Microbiology, 2010, v. 76, n. 1, p. 1, doi. 10.1111/j.1365-2958.2010.07086.x

By:

Hilbi, Hubert;
Jarraud, Sophie;
Hartland, Elizabeth;
Buchrieser, Carmen

Publication type:

Article

Pathogen trafficking pathways and host phosphoinositide metabolism.

Published in:

Molecular Microbiology, 2009, v. 71, n. 6, p. 1341, doi. 10.1111/j.1365-2958.2009.06608.x

By:

Weber, Stefan S.;
Ragaz, Curdin;
Hilbi, Hubert

Publication type:

Article

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum.

Published in:

Molecular Microbiology, 2004, v. 51, n. 1, p. 63, doi. 10.1046/j.1365-2958.2003.03826.x

By:

Otto, Grant P.;
Wu, Mary Y.;
Clarke, Margaret;
Lu, Hao;
Anderson, O. Roger;
Hilbi, Hubert;
Shuman, Howard A.;
Kessin, Richard K.

Publication type:

Article

Quorum sensing controls persistence, resuscitation, and virulence of Legionella subpopulations in biofilms.

Published in:

ISME Journal: Multidisciplinary Journal of Microbial Ecology, 2021, v. 15, n. 1, p. 196, doi. 10.1038/s41396-020-00774-0

By:

Personnic, Nicolas;
Striednig, Bianca;
Hilbi, Hubert

Publication type:

Article

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.

Published in:

PLoS Pathogens, 2019, v. 15, n. 2, p. 1, doi. 10.1371/journal.ppat.1007551

By:

Buckley, Catherine M.;
Heath, Victoria L.;
Guého, Aurélie;
Bosmani, Cristina;
Knobloch, Paulina;
Sikakana, Phumzile;
Personnic, Nicolas;
Dove, Stephen K.;
Michell, Robert H.;
Meier, Roger;
Hilbi, Hubert;
Soldati, Thierry;
Insall, Robert H.;
King, Jason S.

Publication type:

Article

Transcriptional Responses of Dictyostelium discoideum Exposed to Different Classes of Bacteria.

Published in:

Frontiers in Microbiology, 2020, p. 1, doi. 10.3389/fmicb.2020.00410

By:

Lamrabet, Otmane;
Melotti, Astrid;
Burdet, Frédéric;
Hanna, Nabil;
Perrin, Jackie;
Nitschke, Jahn;
Pagni, Marco;
Hilbi, Hubert;
Soldati, Thierry;
Cosson, Pierre

Publication type:

Article

Identification of Anti- Mycobacterium and Anti- Legionella Compounds With Potential Distinctive Structural Scaffolds From an HD-PBL Using Phenotypic Screens in Amoebae Host Models.

Published in:

Frontiers in Microbiology, 2020, p. 1, doi. 10.3389/fmicb.2020.00266

By:

Hanna, Nabil;
Kicka, Sébastien;
Chiriano, Gianpaolo;
Harrison, Christopher;
Sakouhi, Hajer Ouertatani;
Trofimov, Valentin;
Kranjc, Agata;
Nitschke, Jahn;
Pagni, Marco;
Cosson, Pierre;
Hilbi, Hubert;
Scapozza, Leonardo;
Soldati, Thierry

Publication type:

Article

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0181121

By:

Ouertatani-Sakouhi, Hajer;
Kicka, Sébastien;
Chiriano, Gianpaolo;
Harrison, Christopher F.;
Hilbi, Hubert;
Scapozza, Leonardo;
Soldati, Thierry;
Cosson, Pierre

Publication type:

Article

Legionella‐ and host‐driven lipid flux at LCV‐ER membrane contact sites promotes vacuole remodeling.

Published in:

EMBO Reports, 2023, v. 24, n. 3, p. 1, doi. 10.15252/embr.202256007

By:

Vormittag, Simone;
Hüsler, Dario;
Haneburger, Ina;
Kroniger, Tobias;
Anand, Aby;
Prantl, Manuel;
Barisch, Caroline;
Maaß, Sandra;
Becher, Dörte;
Letourneur, François;
Hilbi, Hubert

Publication type:

Article

Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery.

Published in:

EMBO Reports, 2021, v. 22, n. 9, p. 1, doi. 10.15252/embr.202152972

By:

Striednig, Bianca;
Lanner, Ulrike;
Niggli, Selina;
Katic, Ana;
Vormittag, Simone;
Brülisauer, Sabrina;
Hochstrasser, Ramon;
Kaech, Andres;
Welin, Amanda;
Flieger, Antje;
Ziegler, Urs;
Schmidt, Alexander;
Hilbi, Hubert;
Personnic, Nicolas

Publication type:

Article

ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila.

Published in:

EMBO Reports, 2017, v. 18, n. 10, p. 1817, doi. 10.15252/embr.201743903

By:

Steiner, Bernhard;
Swart, Anna Leoni;
Welin, Amanda;
Weber, Stephen;
Personnic, Nicolas;
Kaech, Andres;
Freyre, Christophe;
Ziegler, Urs;
Klemm, Robin W;
Hilbi, Hubert

Publication type:

Article

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.

Published in:

EMBO Reports, 2013, v. 14, n. 2, p. 199, doi. 10.1038/embor.2012.211

By:

Mihai Gazdag, Emerich;
Streller, Alexandra;
Haneburger, Ina;
Hilbi, Hubert;
Vetter, Ingrid R;
Goody, Roger S;
Itzen, Aymelt

Publication type:

Article

Tapping lipid droplets: A rich fat diet of intracellular bacterial pathogens.

Published in:

Molecular Microbiology, 2023, v. 120, n. 2, p. 194, doi. 10.1111/mmi.15120

By:

Hüsler, Dario;
Stauffer, Pia;
Hilbi, Hubert

Publication type:

Article

The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization.

Published in:

Molecular Microbiology, 2020, v. 113, n. 6, p. 1070, doi. 10.1111/mmi.14477

By:

Hochstrasser, Ramon;
Hutter, Cedric A. J.;
Arnold, Fabian M.;
Bärlocher, Kevin;
Seeger, Markus A.;
Hilbi, Hubert

Publication type:

Article

Pathway analysis using 13C-glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila.

Published in:

Molecular Microbiology, 2016, v. 100, n. 2, p. 229, doi. 10.1111/mmi.13313

By:

Häuslein, Ina;
Manske, Christian;
Goebel, Werner;
Eisenreich, Wolfgang;
Hilbi, Hubert

Publication type:

Article

The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signalling and gene expression of Legionella pneumophila.

Published in:

Molecular Microbiology, 2016, v. 99, n. 4, p. 778, doi. 10.1111/mmi.13265

By:

Schell, Ursula;
Simon, Sylvia;
Sahr, Tobias;
Hager, Dominik;
Albers, Michael F.;
Kessler, Aline;
Fahrnbauer, Felix;
Trauner, Dirk;
Hedberg, Christian;
Buchrieser, Carmen;
Hilbi, Hubert

Publication type:

Article

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.

Published in:

Small GTPases, 2019, v. 10, n. 5, p. 336, doi. 10.1080/21541248.2017.1331721

By:

Hilbi, Hubert;
Kortholt, Arjan

Publication type:

Article

Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.

Published in:

Small GTPases, 2014, v. 5, n. 3, p. 1, doi. 10.4161/21541248.2014.972859

By:

Hilbi, Hubert;
Rothmeier, Eva;
Hoffmann, Christine;
Harrison, Christopher F

Publication type:

Article

Inter-kingdom signaling by the Legionella autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBP.

Published in:

PLoS Pathogens, 2025, v. 21, n. 4, p. 1, doi. 10.1371/journal.ppat.1013026

By:

Solger, Franziska;
Rauch, Jonas;
Vormittag, Simone;
Fan, Mingzhen;
Raykov, Lyudmil;
Charki, Paul;
Katic, Ana;
Letourneur, François;
Soldati, Thierry;
Seibel, Jürgen;
Hilbi, Hubert

Publication type:

Article

Secretive Bacterial Pathogens and the Secretory Pathway.

Published in:

Traffic, 2012, v. 13, n. 9, p. 1187, doi. 10.1111/j.1600-0854.2012.01344.x

By:

Hilbi, Hubert;
Haas, Albert

Publication type:

Article

Proteome Analysis of Legionella Vacuoles Purified by Magnetic Immunoseparation Reveals Secretory and Endosomal GTPases.

Published in:

Traffic, 2009, v. 10, n. 1, p. 76, doi. 10.1111/j.1600-0854.2008.00851.x

By:

Urwyler, Simon;
Nyfeler, Yves;
Ragaz, Curdin;
Lee, Hookeun;
Mueller, Lukas N.;
Aebersold, Ruedi;
Hilbi, Hubert

Publication type:

Article