Works by Higgins, Matthew K.

Results: 28

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.88960

By:

Cook, Alexander D.;
Carrington, Mark;
Higgins, Matthew K.

Publication type:

Article

Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.83681

By:

Jamwal, Abhishek;
Constantin, Cristina F.;
Hirschi, Stephan;
Henrich, Sebastian;
Bildl, Wolfgang;
Fakler, Bernd;
Draper, Simon J.;
Schulte, Uwe;
Higgins, Matthew K.

Publication type:

Article

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01254

By:

Illingworth, Joseph J.;
Alanine, Daniel G.;
Brown, Rebecca;
Marshall, Jennifer M.;
Bartlett, Helen E.;
Silk, Sarah E.;
Labbé, Geneviève M.;
Quinkert, Doris;
Cho, Jee Sun;
Wendler, Jason P.;
Pattinson, David J.;
Barfod, Lea;
Douglas, Alexander D.;
Shea, Michael W.;
Wright, Katherine E.;
de Cassan, Simone C.;
Higgins, Matthew K.;
Draper, Simon J.

Publication type:

Article

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes.

Published in:

Cellular Microbiology, 2013, v. 15, n. 12, p. 1976, doi. 10.1111/cmi.12183

By:

Smith, Joseph D.;
Rowe, J. Alexandra;
Higgins, Matthew K.;
Lavstsen, Thomas

Publication type:

Article

Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39357-w

By:

Moskovitz, Re'em;
Pholcharee, Tossapol;
DonVito, Sophia M.;
Guloglu, Bora;
Lowe, Edward;
Mohring, Franziska;
Moon, Robert W.;
Higgins, Matthew K.

Publication type:

Article

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06340-9

By:

Lennartz, Frank;
Brod, Florian;
Dabbs, Rebecca;
Miura, Kazutoyo;
Mekhaiel, David;
Marini, Arianna;
Jore, Matthijs M.;
Søgaard, Max M.;
Jørgensen, Thomas;
de Jongh, Willem A.;
Sauerwein, Robert W.;
Long, Carole A.;
Biswas, Sumi;
Higgins, Matthew K.

Publication type:

Article

Severe malaria is associated with parasite binding to endothelial protein C receptor.

Published in:

Nature, 2013, v. 498, n. 7455, p. 502, doi. 10.1038/nature12216

By:

Turner, Louise;
Lavstsen, Thomas;
Berger, Sanne S.;
Wang, Christian W.;
Petersen, Jens E. V.;
Avril, Marion;
Brazier, Andrew J.;
Freeth, Jim;
Jespersen, Jakob S.;
Nielsen, Morten A.;
Magistrado, Pamela;
Lusingu, John;
Smith, Joseph D.;
Higgins, Matthew K.;
Theander, Thor G.

Publication type:

Article

Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49550-0

By:

Jamwal, Abhishek;
Colomb, Florent;
McSorley, Henry J.;
Higgins, Matthew K.

Publication type:

Article

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Published in:

PLoS Pathogens, 2019, v. 15, n. 6, p. 1, doi. 10.1371/journal.ppat.1007809

By:

Knuepfer, Ellen;
Wright, Katherine E.;
Kumar Prajapati, Surendra;
Rawlinson, Thomas A.;
Mohring, Franziska;
Koch, Marion;
Lyth, Oliver R.;
Howell, Steven A.;
Villasis, Elizabeth;
Snijders, Ambrosius P.;
Moon, Robert W.;
Draper, Simon J.;
Rosanas-Urgell, Anna;
Higgins, Matthew K.;
Baum, Jake;
Holder, Anthony A.

Publication type:

Article

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.

Published in:

Nature, 2014, v. 515, n. 7527, p. 427, doi. 10.1038/nature13715

By:

Wright, Katherine E.;
Bartlett, Jonathan;
Higgins, Matthew K.;
Hjerrild, Kathryn A.;
Douglas, Alexander D.;
Jin, Jing;
Brown, Rebecca E.;
Illingworth, Joseph J.;
Ashfield, Rebecca;
Draper, Simon J.;
Clemmensen, Stine B.;
de Jongh, Willem A.

Publication type:

Article

Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains.

Published in:

EMBO Journal, 2002, v. 21, n. 9, p. 2087, doi. 10.1093/emboj/21.9.2087

By:

Higgins, Matthew K.;
Weitz, Dietmar;
Warne, Tony;
Schertler, Gebhard F. X.;
Kaupp, U. Benjamin

Publication type:

Article

The structural basis for CD36 binding by the malaria parasite.

Published in:

Nature Communications, 2016, v. 7, n. 9, p. 12837, doi. 10.1038/ncomms12837

By:

Hsieh, Fu-Lien;
Turner, Louise;
Bolla, Jani Reddy;
Robinson, Carol V.;
Lavstsen, Thomas;
Higgins, Matthew K.

Publication type:

Article

Heparan sulphate binding controls in vivo half-life of the HpARI protein family.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.99000

By:

Colomb, Florent;
Jamwal, Abhishek;
Ogunkanbi, Adefunke;
Frangova, Tania;
Savage, Alice R.;
Kelly, Sarah;
Wright, Gavin J.;
Higgins, Matthew K.;
McSorley, Henry J.

Publication type:

Article

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system.

Published in:

Scientific Reports, 2016, p. 30357, doi. 10.1038/srep30357

By:

Hjerrild, Kathryn A.;
Jin, Jing;
Wright, Katherine E.;
Brown, Rebecca E.;
Marshall, Jennifer M.;
Labbé, Geneviève M.;
Silk, Sarah E.;
Cherry, Catherine J.;
Clemmensen, Stine B.;
Jørgensen, Thomas;
Illingworth, Joseph J.;
Alanine, Daniel G. W.;
Milne, Kathryn H.;
Ashfield, Rebecca;
de Jongh, Willem A.;
Douglas, Alexander D.;
Higgins, Matthew K.;
Draper, Simon J.

Publication type:

Article

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15125-y

By:

Macleod, Olivia J. S.;
Bart, Jean-Mathieu;
MacGregor, Paula;
Peacock, Lori;
Savill, Nicholas J.;
Hester, Svenja;
Ravel, Sophie;
Sunter, Jack D.;
Trevor, Camilla;
Rust, Steven;
Vaughan, Tristan J.;
Minter, Ralph;
Mohammed, Shabaz;
Gibson, Wendy;
Taylor, Martin C.;
Higgins, Matthew K.;
Carrington, Mark

Publication type:

Article

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5.

Published in:

EMBO Molecular Medicine, 2024, v. 16, n. 10, p. 2539, doi. 10.1038/s44321-024-00123-0

By:

Harrison, Thomas E;
Alam, Nawsad;
Farrell, Brendan;
Quinkert, Doris;
Lias, Amelia M;
King, Lloyd D W;
Barfod, Lea K;
Draper, Simon J;
Campeotto, Ivan;
Higgins, Matthew K

Publication type:

Article

Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016414

By:

Ghumra, Ashfaq;
Khunrae, Pongsak;
Ataide, Ricardo;
Raza, Ahmed;
Rogerson, Stephen J.;
Higgins, Matthew K.;
Rowe, J. Alexandra

Publication type:

Article

Design of a basigin‐mimicking inhibitor targeting the malaria invasion protein RH5.

Published in:

Proteins, 2020, v. 88, n. 1, p. 187, doi. 10.1002/prot.25786

By:

Warszawski, Shira;
Dekel, Elya;
Campeotto, Ivan;
Marshall, Jennifer M.;
Wright, Katherine E.;
Lyth, Oliver;
Knop, Orli;
Regev‐Rudzki, Neta;
Higgins, Matthew K.;
Draper, Simon J.;
Baum, Jake;
Fleishman, Sarel J.

Publication type:

Article

The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.27311

By:

Fu-Lien Hsieh;
Higgins, Matthew K.

Publication type:

Article

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.13044

By:

Lane-Serff, Harriet;
MacGregor, Paula;
Peacock, Lori;
Macleod, Olivia J. S.;
Kay, Christopher;
Gibson, Wendy;
Higgins, Matthew K.;
Carrington, Mark

Publication type:

Article

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28601-4

By:

Ragotte, Robert J.;
Pulido, David;
Lias, Amelia M.;
Quinkert, Doris;
Alanine, Daniel G. W.;
Jamwal, Abhishek;
Davies, Hannah;
Nacer, Adéla;
Lowe, Edward D.;
Grime, Geoffrey W.;
Illingworth, Joseph J.;
Donat, Robert F.;
Garman, Elspeth F.;
Bowyer, Paul W.;
Higgins, Matthew K.;
Draper, Simon J.

Publication type:

Article

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33379-6

By:

Ko, Kuang-Ting;
Lennartz, Frank;
Mekhaiel, David;
Guloglu, Bora;
Marini, Arianna;
Deuker, Danielle J.;
Long, Carole A.;
Jore, Matthijs M.;
Miura, Kazutoyo;
Biswas, Sumi;
Higgins, Matthew K.

Publication type:

Article

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32728-9

By:

Macleod, Olivia J. S.;
Cook, Alexander D.;
Webb, Helena;
Crow, Mandy;
Burns, Roisin;
Redpath, Maria;
Seisenberger, Stefanie;
Trevor, Camilla E.;
Peacock, Lori;
Schwede, Angela;
Kimblin, Nicola;
Francisco, Amanda F.;
Pepperl, Julia;
Rust, Steve;
Voorheis, Paul;
Gibson, Wendy;
Taylor, Martin C.;
Higgins, Matthew K.;
Carrington, Mark

Publication type:

Article

A Receptor’s Tale: An Eon in the Life of a Trypanosome Receptor.

Published in:

PLoS Pathogens, 2017, v. 13, n. 1, p. 1, doi. 10.1371/journal.ppat.1006055

By:

Higgins, Matthew K.;
Lane-Serff, Harriet;
MacGregor, Paula;
Carrington, Mark

Publication type:

Article

Differential Trafficking and Expression of PIR Proteins in Acute and Chronic Plasmodium Infections.

Published in:

Frontiers in Cellular & Infection Microbiology, 2022, v. 12, p. 1, doi. 10.3389/fcimb.2022.877253

By:

Giorgalli, Maria;
Cunningham, Deirdre A.;
Broncel, Malgorzata;
Sait, Aaron;
Harrison, Thomas E.;
Hosking, Caroline;
Vandomme, Audrey;
Amis, Sarah I.;
Antonello, Ana;
Sullivan, Lauren;
Uwadiae, Faith;
Torella, Laura;
Higgins, Matthew K.;
Langhorne, Jean

Publication type:

Article

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28601-4

By:

Ragotte, Robert J.;
Pulido, David;
Lias, Amelia M.;
Quinkert, Doris;
Alanine, Daniel G. W.;
Jamwal, Abhishek;
Davies, Hannah;
Nacer, Adéla;
Lowe, Edward D.;
Grime, Geoffrey W.;
Illingworth, Joseph J.;
Donat, Robert F.;
Garman, Elspeth F.;
Bowyer, Paul W.;
Higgins, Matthew K.;
Draper, Simon J.

Publication type:

Article

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2019, v. 13, n. 5, p. 1, doi. 10.1371/journal.pntd.0007373

By:

MacGregor, Paula;
Gonzalez-Munoz, Andrea L.;
Jobe, Fatoumatta;
Taylor, Martin C.;
Rust, Steven;
Sandercock, Alan M.;
Macleod, Olivia J. S.;
Van Bocxlaer, Katrien;
Francisco, Amanda F.;
D’Hooge, Francois;
Tiberghien, Arnaud;
Barry, Conor S.;
Howard, Philip;
Higgins, Matthew K.;
Vaughan, Tristan J.;
Minter, Ralph;
Carrington, Mark

Publication type:

Article

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families.

Published in:

Protein Science: A Publication of the Protein Society, 2014, v. 23, n. 4, p. 354, doi. 10.1002/pro.2428

By:

Higgins, Matthew K.;
Carrington, Mark

Publication type:

Article