Works by Higgins, Guy

Results: 34

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 26, p. 8989, doi. 10.1523/JNEUROSCI.23-26-08989.2003

By:

Richards, J. Grayson;
Higgins, Guy A.;
Ouagazzal, Abdel-Mouttalib;
Ozmen, Laurence;
Kew, James N. C.;
Bohrmann, Bernd;
Malherbe, Pari;
Brockhaus, Manfred;
Loetscher, Hansruedi;
Czech, Christian;
Huber, Gerda;
Bluethmann, Horst;
Jacobsen, Helmut;
Kemp, John A.

Publication type:

Article

The hydroxycarboxylic acid receptor HCA2 is required for the protective effect of ketogenic diet in epilepsy.

Published in:

Pharmacology Research & Perspectives, 2024, v. 12, n. 6, p. 1, doi. 10.1002/prp2.70026

By:

Richardson, Jill C.;
Higgins, Guy A.;
Upton, Neil;
Massey, Peter;
Cunningham, Mark;
Wilson, Steve;
Holenz, Joerg;
Taylor, Colleen;
Lavrov, Arseniy;
Lin, Hong;
Matsuoka, Yasuji;
Brown, Andrew J.

Publication type:

Article

Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.

Published in:

Pharmacology Research & Perspectives, 2015, v. 3, n. 1, p. n/a, doi. 10.1002/prp2.84

By:

Higgins, Guy A.;
Desnoyer, Jill;
Van Niekerk, Annalise;
Silenieks, Leo B.;
Lau, Winnie;
Thevarkunnel, Sandy;
Izhakova, Julia;
DeLannoy, Ines A.M.;
Fletcher, Paul J.;
DeLay, Josepha;
Dobson, Howard

Publication type:

Article

Differential effects of ondansetron and α-flupenthixol on responding for conditioned reward.

Published in:

Psychopharmacology, 1997, v. 134, n. 1, p. 64, doi. 10.1007/s002130050426

By:

Fletcher, P. J.;
Higgins, Guy A.

Publication type:

Article

Improving decision making in crisis.

Published in:

Journal of Business Continuity & Emergency Planning, 2013, v. 7, n. 1, p. 65, doi. 10.69554/ayck9571

By:

Higgins, Guy;
Freedman, Jennifer

Publication type:

Article

Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.640241

By:

Higgins, Guy A.;
Carroll, Nicole K.;
Brown, Matt;
MacMillan, Cam;
Silenieks, Leo B.;
Thevarkunnel, Sandy;
Izhakova, Julia;
Magomedova, Lilia;
DeLannoy, Ines;
Sellers, Edward M.

Publication type:

Article

Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00427

By:

Higgins, Guy A.;
Silenieks, Leo B.;
MacMillan, Cam;
Thevarkunnel, Sandy;
Parachikova, Anna I.;
Mombereau, Cedric;
Lindgren, Hanna;
Bastlund, Jesper F.

Publication type:

Article

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control.

Published in:

Neuropsychopharmacology, 2012, v. 37, n. 5, p. 1177, doi. 10.1038/npp.2011.303

By:

Higgins, Guy A;
Silenieks, Leo B;
Roßmann, Anne;
Rizos, Zoe;
Noble, Kevin;
Soko, Ashlie D;
Fletcher, Paul J

Publication type:

Article

Effects of 5-HT, 5-HT and 5-HT receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate.

Published in:

Psychopharmacology, 2017, v. 234, n. 5, p. 889, doi. 10.1007/s00213-017-4529-5

By:

Fletcher, Paul;
Zeeb, Fiona D.;
Browne, Caleb J.;
Higgins, Guy;
Soko, Ashlie

Publication type:

Article

Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT receptor agonists.

Published in:

Psychopharmacology, 2016, v. 233, n. 14, p. 2841, doi. 10.1007/s00213-016-4329-3

By:

Higgins, Guy;
Silenieks, Leo;
Altherr, Everett;
MacMillan, Cam;
Fletcher, Paul;
Pratt, Wayne

Publication type:

Article

Impulsive action in the 5-choice serial reaction time test in 5-HT receptor null mutant mice.

Published in:

Psychopharmacology, 2013, v. 226, n. 3, p. 561, doi. 10.1007/s00213-012-2929-0

By:

Fletcher, Paul;
Soko, Ashlie;
Higgins, Guy

Publication type:

Article

Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists.

Published in:

2017

By:

Higgins, Guy A.;
Zeeb, Fiona D.;
Fletcher, Paul J.

Publication type:

journal article

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.

Published in:

2013

By:

Hyde, Lynn A.;
Qi Zhang;
Del Vecchio, Robert A.;
Leach, Prescott T.;
Cohen-Williams, Mary E.;
Lei Chen;
Wong, Gwendolyn T.;
McHugh, Nansie A.;
Chen, Joseph;
Higgins, Guy A.;
Asberom, Theodros;
Wei Li;
Pissarnitski, Dmitri;
Levitan, Diane;
Nomeir, Amin A.;
Clader, John W.;
Zhang, Lili;
Parker, Eric M.

Publication type:

Journal Article

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.

Published in:

International Journal of Alzheimer's Disease, 2013, p. 1, doi. 10.1155/2013/823528

By:

Hyde, Lynn A.;
Qi Zhang;
Del Vecchio, Robert A.;
Leach, Prescott T.;
Cohen-Williams, Mary E.;
Lei Chen;
Wong, Gwendolyn T.;
McHugh, Nansie A.;
Chen, Joseph;
Higgins, Guy A.;
Asberom, Theodros;
Wei Li;
Pissarnitski, Dmitri;
Levitan, Diane;
Nomeir, Amin A.;
Clader, John W.;
Zhang, Lili;
Parker, Eric M.

Publication type:

Article

Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew).

Published in:

Frontiers in Pharmacology, 2016, v. 7, p. 1, doi. 10.3389/fphar.2016.00263

By:

Rudd, John A.;
Ngan, Man P.;
Zengbing Lu;
Higgins, Guy A.;
Giuliano, Claudio;
Lovati, Emanuela;
Pietra, Claudio

Publication type:

Article

Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.

Published in:

2019

By:

Fletcher, Paul J.;
Li, Zhaoxia;
Silenieks, Leo B.;
MacMillan, Cam;
DeLannoy, Ines;
Higgins, Guy A.

Publication type:

journal article

Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment.

Published in:

Journal of Psychopharmacology, 1994, v. 8, n. 3, p. 148, doi. 10.1177/026988119400800302

By:

Varty, Geoffrey B.;
Higgins, Guy A.

Publication type:

Article

Inhibition of DOI-induced wet dog shakes in the guinea-pig by 5-HT2 receptor antagonists.

Published in:

Journal of Psychopharmacology, 1991, v. 5, n. 3, p. 196, doi. 10.1177/026988119100500303

By:

Skingle, Malcolm;
Cole, Nicola;
Higgins, Guy;
Feniuk, Wasyl

Publication type:

Article

The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues.

Published in:

Neuropsychopharmacology, 2008, v. 33, n. 7, p. 1402, doi. 10.1038/sj.npp.1301509

By:

Fletcher, Paul J.;
Rizos, Zoë;
Sinyard, Judy;
Tampakeras, Maria;
Higgins, Guy A

Publication type:

Article

Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Venral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration.

Published in:

Neuropsychopharmacology, 2004, v. 29, n. 2, p. 308, doi. 10.1038/sj.npp.1300319

By:

Fletcher, Paul J.;
Chintoh, Araba F.;
Sinyard, Judy;
Higgins, Guy A.

Publication type:

Article

Phencyclidine Exacerbates Attentional Deficits in a Neurodevelopmental Rat Model of Schizophrenia.

Published in:

Neuropsychopharmacology, 2003, v. 28, n. 10, p. 1799, doi. 10.1038/sj.npp.1300208

By:

Le Pen, Gwenaëlle;
Grottick, Andrew J.;
Higgins, Guy A.;
Moreau, Jean-Luc

Publication type:

Article

Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands.

Published in:

Neuropsychopharmacology, 2003, v. 28, n. 5, p. 880, doi. 10.1038/sj.npp.1300102

By:

Grottick, Andrew J.;
Haman, Marie;
Wyler, Rene;
Higgins, Guy A.

Publication type:

Article

Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

Published in:

Neuropsychopharmacology, 2002, v. 27, n. 4, p. 576

By:

Fletcher, Paul J.;
Grottick, Andrew J.;
Higgins, Guy A.

Publication type:

Article

Evaluation of translational Alzheimer's disease biomarkers in the aged dog: The effects of age and bace inhibition on CSF amyloid

Published in:

2011

By:

Araujo, Joseph A.;
Higgins, Guy;
de Rivera, Christina;
Milgram, Norton

Publication type:

Abstract

Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property.

Published in:

Psychopharmacology, 2010, v. 207, n. 4, p. 513, doi. 10.1007/s00213-009-1682-5

By:

Higgins, Guy;
Breysse, Nathalie;
Undzys, Elijus;
Derksen, D. Richard;
Jeffrey, Melanie;
Scott, Brian W.;
Tao Xin;
Roucard, Corinne;
Bressand, Karine;
Depaulis, Antoine;
Burnham, W. M.

Publication type:

Article

Opposing effects of 5-HT2A and 5-HT2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test.

Published in:

Psychopharmacology, 2007, v. 195, n. 2, p. 223, doi. 10.1007/s00213-007-0891-z

By:

Fletcher, Paul J.;
Tampakeras, Maria;
Sinyard, Judy;
Higgins, Guy A.

Publication type:

Article

The effects of the 5-HT2C receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists.

Published in:

Psychopharmacology, 2006, v. 187, n. 4, p. 515, doi. 10.1007/s00213-006-0453-9

By:

Fletcher, Paul J.;
Sinyard, Judy;
Higgins, Guy A.

Publication type:

Article

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.

Published in:

Psychopharmacology, 2005, v. 179, n. 1, p. 207, doi. 10.1007/s00213-005-2143-4

By:

Varty, Geoffrey B.;
Grilli, Mariagrazia;
Forlani, Angelo;
Fredduzzi, Silva;
Grzelak, Michael E.;
Guthrie, Donald H.;
Hodgson, Robert A.;
Lu, Sherry X.;
Nicolussi, Elisa;
Pond, Annamarie J.;
Parker, Eric M.;
Hunter, John C.;
Higgins, Guy A.;
Reggiani, Angelo;
Bertorelli, Rosalia

Publication type:

Article

Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat.

Published in:

Psychopharmacology, 2005, v. 179, n. 1, p. 85, doi. 10.1007/s00213-005-2203-9

By:

Higgins, Guy A.;
Ballard, Theresa M.;
Enderlin, Michel;
Haman, Marie;
Kemp, John A.

Publication type:

Article

Glutamate receptor subtypes: promising new pharmacotherapeutic targets.

Published in:

2005

By:

Higgins, Guy A.;
Miczek, Klaus A.

Publication type:

Editorial

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition.

Published in:

Psychopharmacology, 2004, v. 175, n. 1, p. 99, doi. 10.1007/s00213-004-1785-y

By:

Spooren, Will;
Mombereau, Cedric;
Maco, Martine;
Gill, Rammy;
Kemp, John A.;
Ozmen, Laurence;
Nakanishi, Shigetada;
Higgins, Guy A.

Publication type:

Article

The 5-HT[sub 2A] receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism.

Published in:

Psychopharmacology, 2003, v. 170, n. 3, p. 309, doi. 10.1007/s00213-003-1549-0

By:

Higgins, Guy A.;
Enderlin, Michel;
Haman, Marie;
Fletcher, Paul J.

Publication type:

Article

Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants.

Published in:

Psychopharmacology, 2002, v. 164, n. 1, p. 33, doi. 10.1007/s00213-002-1174-3

By:

Grottick, Andrew J.;
Higgins, Guy A.

Publication type:

Article

From Rodents to Recovery.

Published in:

CNS Drugs, 1998, v. 9, n. 1, p. 59, doi. 10.2165/00023210-199809010-00006

By:

Higgins, Guy A.

Publication type:

Article

Works by Higgins, Guy

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation.

The hydroxycarboxylic acid receptor HCA2 is required for the protective effect of ketogenic diet in epilepsy.

Characterization of the 5-HT<sub>2C</sub> receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.

Differential effects of ondansetron and α-flupenthixol on responding for conditioned reward.

Improving decision making in crisis.

Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property.

Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research.

The 5-HT<sub>2C</sub> Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control.

Effects of 5-HT, 5-HT and 5-HT receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate.

Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT receptor agonists.

Impulsive action in the 5-choice serial reaction time test in 5-HT receptor null mutant mice.

Role of impulsivity and reward in the anti-obesity actions of 5-HT<sub>2C</sub> receptor agonists.

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.

Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew).

Preclinical evidence for combining the 5-HT<sub>2C</sub> receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.

Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment.

Inhibition of DOI-induced wet dog shakes in the guinea-pig by 5-HT2 receptor antagonists.

The 5-HT<sub>2C</sub> Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues.

Injection of the 5-HT<sub>2C</sub> Receptor Agonist Ro60-0175 into the Venral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration.

Phencyclidine Exacerbates Attentional Deficits in a Neurodevelopmental Rat Model of Schizophrenia.

Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands.

Differential Effects of the 5-HT<sub>2A</sub> Receptor Antagonist M100,907 and the 5-HT<sub>2C</sub> Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

Evaluation of translational Alzheimer's disease biomarkers in the aged dog: The effects of age and bace inhibition on CSF amyloid

Comparative study of five antiepileptic drugs on a translational cognitive measure in the rat: relationship to antiepileptic property.

Opposing effects of 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test.

The effects of the 5-HT<sub>2C</sub> receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists.

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.

Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat.

Glutamate receptor subtypes: promising new pharmacotherapeutic targets.

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition.

The 5-HT[sub 2A] receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism.

Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants.

From Rodents to Recovery.