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β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome-lysosome pathway.
Published in:
2012
By:
- Sukhdeo K;
- Mani M;
- Hideshima T;
- Takada K;
- Pena-Cruz V;
- Mendez G;
- Ito S;
- Anderson KC;
- Carrasco DR;
- Sukhdeo, K;
- Mani, M;
- Hideshima, T;
- Takada, K;
- Pena-Cruz, V;
- Mendez, G;
- Ito, S;
- Anderson, K C;
- Carrasco, D R
Publication type:
Letter
Novel therapeutic avenues in myeloma: changing the treatment paradigm.
Published in:
2007
By:
- Ghobrial J;
- Ghobrial IM;
- Mitsiades C;
- Leleu X;
- Hatjiharissi E;
- Moreau A;
- Roccaro A;
- Schlossman R;
- Hideshima T;
- Anderson KC;
- Richardson P
Publication type:
Journal Article
New treatments for multiple myeloma.
Published in:
2005
By:
- Richardson PG;
- Schlossman R;
- Hideshima T;
- Anderson KC
Publication type:
Journal Article
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition.
Published in:
Oncogene, 2010, v. 29, n. 16, p. 2325, doi. 10.1038/onc.2009.510
By:
- Santo, L.;
- Vallet, S.;
- Hideshima, T.;
- Cirstea, D.;
- Ikeda, H.;
- Pozzi, S.;
- Patel, K.;
- Okawa, Y.;
- Gorgun, G.;
- Perrone, G.;
- Calabrese, E.;
- Yule, M.;
- Squires, M.;
- Ladetto, M.;
- Boccadoro, M.;
- Richardson, P. G.;
- Munshi, N. C.;
- Anderson, K. C.;
- Raje, N.
Publication type:
Article
A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
Published in:
Oncogene, 2008, v. 27, n. 6, p. 721, doi. 10.1038/sj.onc.1210679
By:
- Podar, K.;
- Gouill, S. L.;
- Zhang, J.;
- Opferman, J. T.;
- Zorn, E.;
- Tai, Y.-T.;
- Hideshima, T.;
- Amiot, M.;
- Chauhan, D.;
- Harousseau, J.-L.;
- Anderson, K. C.
Publication type:
Article
A novel Bcl-2/Bcl-X<sub>L</sub>/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Published in:
Oncogene, 2007, v. 26, n. 16, p. 2374, doi. 10.1038/sj.onc.1210028
By:
- Chauhan, D.;
- Velankar, M.;
- Brahmandam, M.;
- Hideshima, T.;
- Podar, K.;
- Richardson, P.;
- Schlossman, R.;
- Ghobrial, I.;
- Raje, N.;
- Munshi, N.;
- Anderson, K. C.
Publication type:
Article
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Published in:
2001
By:
- Gupta, D;
- Treon, S P;
- Shima, Y;
- Hideshima, T;
- Podar, K;
- Tai, Y T;
- Lin, B;
- Lentzsch, S;
- Davies, F E;
- Chauhan, D;
- Schlossman, R L;
- Richardson, P;
- Ralph, P;
- Wu, L;
- Payvandi, F;
- Muller, G;
- Stirling, D I;
- Anderson, K C
Publication type:
journal article
Detection of chromogranin A mRNA in small cell lung carcinoma using a new, highly sensitive in situ hybridization method with a non-radioisotope oligonucleotide probe.
Published in:
1998
By:
- Sumiyoshi, Yoshiaki;
- Shirakusa, Takayuki;
- Yamashita, Yuichi;
- Maekawa, Takafumi;
- Hideshima, Teru;
- Sakai, Toshimi;
- Kawahara, Katsunobu;
- Kikuchi, Masahiro;
- Sumiyoshi, Y;
- Shirakusa, T;
- Yamashita, Y;
- Maekawa, T;
- Hideshima, T;
- Sakai, T;
- Kawahara, K;
- Kikuchi, M
Publication type:
journal article
Expression of HRF20, a regulatory molecule of complement activation, on peripheral blood mononuclear cells.
Published in:
Immunology, 1990, v. 69, n. 3, p. 396
By:
- Hideshima, T.;
- Okada, N.;
- Okada, H.
Publication type:
Article
Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma.
Published in:
Leukemia (08876924), 2015, v. 29, n. 9, p. 1918, doi. 10.1038/leu.2015.83
By:
- Kikuchi, S;
- Suzuki, R;
- Ohguchi, H;
- Yoshida, Y;
- Lu, D;
- Cottini, F;
- Jakubikova, J;
- Bianchi, G;
- Harada, T;
- Gorgun, G;
- Tai, Y-T;
- Richardson, P G;
- Hideshima, T;
- Anderson, K C
Publication type:
Article
Anti-tumor activities of selective HSP90α/β inhibitor, TAS-116, in combination with bortezomib in multiple myeloma.
Published in:
2015
By:
- Suzuki, R;
- Hideshima, T;
- Mimura, N;
- Minami, J;
- Ohguchi, H;
- Kikuchi, S;
- Yoshida, Y;
- Gorgun, G;
- Cirstea, D;
- Cottini, F;
- Jakubikova, J;
- Tai, Y-T;
- Chauhan, D;
- Richardson, P G;
- Munshi, N C;
- Utsugi, T;
- Anderson, K C
Publication type:
Letter
Anti-tumor activities of selective HSP90α/β inhibitor, TAS-116, in combination with bortezomib in multiple myeloma.
Published in:
Leukemia (08876924), 2015, v. 29, n. 2, p. 510, doi. 10.1038/leu.2014.300
By:
- Suzuki, R;
- Hideshima, T;
- Mimura, N;
- Minami, J;
- Ohguchi, H;
- Kikuchi, S;
- Yoshida, Y;
- Gorgun, G;
- Cirstea, D;
- Cottini, F;
- Jakubikova, J;
- Tai, Y-T;
- Chauhan, D;
- Richardson, P G;
- Munshi, N C;
- Utsugi, T;
- Anderson, K C
Publication type:
Article
Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 680, doi. 10.1038/leu.2013.231
By:
- Minami, J;
- Suzuki, R;
- Mazitschek, R;
- Gorgun, G;
- Ghosh, B;
- Cirstea, D;
- Hu, Y;
- Mimura, N;
- Ohguchi, H;
- Cottini, F;
- Jakubikova, J;
- Munshi, N C;
- Haggarty, S J;
- Richardson, P G;
- Hideshima, T;
- Anderson, K C
Publication type:
Article
Induction of differential apoptotic pathways in multiple myeloma cells by class-selective histone deacetylase inhibitors.
Published in:
Leukemia (08876924), 2014, v. 28, n. 2, p. 457, doi. 10.1038/leu.2013.301
By:
- Hideshima, T;
- Mazitschek, R;
- Santo, L;
- Mimura, N;
- Gorgun, G;
- Richardson, P G;
- Raje, N;
- Anderson, K C
Publication type:
Article
Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.
Published in:
Leukemia (08876924), 2013, v. 27, n. 12, p. 2366, doi. 10.1038/leu.2013.194
By:
- Cirstea, D;
- Hideshima, T;
- Santo, L;
- Eda, H;
- Mishima, Y;
- Nemani, N;
- Hu, Y;
- Mimura, N;
- Cottini, F;
- Gorgun, G;
- Ohguchi, H;
- Suzuki, R;
- Loferer, H;
- Munshi, N C;
- Anderson, K C;
- Raje, N
Publication type:
Article
β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome-lysosome pathway.
Published in:
Leukemia (08876924), 2012, v. 26, n. 5, p. 1116, doi. 10.1038/leu.2011.303
By:
- Sukhdeo, K;
- Mani, M;
- Hideshima, T;
- Takada, K;
- Pena-Cruz, V;
- Mendez, G;
- Ito, S;
- Anderson, K C;
- Carrasco, D R
Publication type:
Article
A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function.
Published in:
2011
By:
- Vallet, S.;
- Pozzi, S.;
- Patel, K.;
- Vaghela, N.;
- Fulciniti, M. T.;
- Veiby, P.;
- Hideshima, T.;
- Santo, L.;
- Cirstea, D.;
- Scadden, D. T.;
- Anderson, K. C.;
- Raje, N.
Publication type:
journal article
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Published in:
2011
By:
- Song, W.;
- Tai, Y.-T;
- Tian, Z.;
- Hideshima, T.;
- Chauhan, D.;
- Nanjappa, P.;
- Exley, M. A.;
- Anderson, K. C.;
- Munshi, N. C.
Publication type:
journal article
The use of novel agents in the treatment of relapsed and refractory multiple myeloma.
Published in:
2009
By:
- Laubach, J. P.;
- Mahindra, A.;
- Mitsiades, C. S.;
- Schlossman, R. L.;
- Munshi, N. C.;
- Ghobrial, I. M.;
- Carreau, N.;
- Hideshima, T.;
- Anderson, K. C.;
- Richardson, P. G.
Publication type:
journal article
Ascorbic acid inhibits antitumor activity of bortezomib in vivo.
Published in:
Leukemia (08876924), 2009, v. 23, n. 9, p. 1679, doi. 10.1038/leu.2009.83
By:
- Perrone, G.;
- Hideshima, T.;
- Ikeda, H.;
- Okawa, Y.;
- Calabrese, E.;
- Gorgun, G.;
- Santo, L.;
- Cirstea, D.;
- Raje, N.;
- Chauhan, D.;
- Baccarani, M.;
- Cavo, M.;
- Anderson, K. C.
Publication type:
Article
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma.
Published in:
Leukemia (08876924), 2009, v. 23, n. 5, p. 961, doi. 10.1038/leu.2008.378
By:
- Raje, N.;
- Hideshima, T.;
- Mukherjee, S.;
- Raab, M.;
- Vallet, S.;
- Chhetri, S.;
- Cirstea, D.;
- Pozzi, S.;
- Mitsiades, C.;
- Rooney, M.;
- Kiziltepe, T.;
- Podar, K.;
- Okawa, Y.;
- Ikeda, H.;
- Carrasco, R.;
- Richardson, P. G.;
- Chauhan, D.;
- Munshi, N. C.;
- Sharma, S.;
- Parikh, H.
Publication type:
Article
Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
Published in:
2008
By:
- Breitkreutz, I;
- Raab, M S;
- Vallet, S;
- Hideshima, T;
- Raje, N;
- Mitsiades, C;
- Chauhan, D;
- Okawa, Y;
- Munshi, N C;
- Richardson, P G;
- Anderson, K C
Publication type:
Correction Notice
Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
Published in:
Leukemia (08876924), 2008, v. 22, n. 10, p. 1925, doi. 10.1038/leu.2008.174
By:
- Breitkreutz, I.;
- Raab, M. S.;
- Vallet, S.;
- Hideshima, T.;
- Raje, N.;
- Mitsiades, C.;
- Chauhan, D.;
- Okawa, Y.;
- Munshi, N. C.;
- Richardson, P. G.;
- Anderson, K. C.
Publication type:
Article
Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma.
Published in:
Leukemia (08876924), 2007, v. 21, n. 12, p. 2519, doi. 10.1038/sj.leu.2404912
By:
- Neri, P.;
- Tassone, P.;
- Shammas, M.;
- Yasui, H.;
- Schipani, E.;
- Batchu, R. B.;
- Blotta, S.;
- Prabhala, R.;
- Catley, L.;
- Hamasaki, M.;
- Hideshima, T.;
- Chauhan, D.;
- Jacob, G. S.;
- Picker, D.;
- Venuta, S.;
- Anderson, K. C.;
- Munshi, N. C.
Publication type:
Article
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of β-catenin/TCF pathway.
Published in:
Leukemia (08876924), 2007, v. 21, n. 3, p. 535, doi. 10.1038/sj.leu.2404561
By:
- Yasui, H.;
- Hideshima, T.;
- Ikeda, H.;
- Ocio, E. M.;
- Kiziltepe, T.;
- Vallet, S.;
- Okawa, Y.;
- Neri, P.;
- Sukhdeo, K.;
- Podar, K.;
- Chauhan, D.;
- Richardson, P. G.;
- Raje, N.;
- Carrasco, D. R.;
- Anderson, K. C.
Publication type:
Article
Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.
Published in:
2006
By:
- Navas, T. A.;
- Nguyen, A. N.;
- Hideshima, T.;
- Reddy, M.;
- Ma, J. Y.;
- Haghnazari, E.;
- Henson, M.;
- Stebbins, E. G.;
- Kerr, I.;
- O'Young, G.;
- Kapoun, A. M.;
- Chakravarty, S.;
- Mavunkel, B.;
- Perumattam, J.;
- Luedtke, G.;
- Dugar, S.;
- Medicherla, S.;
- Protter, A. A.;
- Schreiner, G. F.;
- Anderson, K. C.
Publication type:
journal article
Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs.
Published in:
Leukemia (08876924), 2005, v. 19, n. 7, p. 1253, doi. 10.1038/sj.leu.2403776
By:
- Kumar, S.;
- Raje, N.;
- Hideshima, T.;
- Ishitsuka, K.;
- Roccaro, A.;
- Shiraishi, N.;
- Hamasaki, M.;
- Yasui, H.;
- Munshi, N. C.;
- Richardson, P.;
- Figg, W. D.;
- Anderson, K. C.
Publication type:
Article
Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo.
Published in:
Leukemia (08876924), 2003, v. 17, n. 1, p. 41, doi. 10.1038/sj.leu.2402745
By:
- Lentzsch, S;
- LeBlanc, R;
- Podar, K;
- Davies, F;
- Lin, B;
- Hideshima, T;
- Catley, L;
- Stirling, D I;
- Anderson, K C
Publication type:
Article
Video-assisted thoracoscopic esophagectomy for esophageal cancer.
Published in:
1999
By:
- Kawahara, K.;
- Maekawa, T.;
- Okabayashi, K.;
- Hideshima, T.;
- Shiraishi, T.;
- Yoshinaga, Y.;
- Shirakusa, T.
Publication type:
journal article
Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells.
Published in:
British Journal of Haematology, 2006, v. 135, n. 1, p. 52, doi. 10.1111/j.1365-2141.2006.06261.x
By:
- Raje, N.;
- Kumar, S.;
- Hideshima, T.;
- Ishitsuka, K.;
- Yasui, H.;
- Chhetri, S.;
- Vallet, S.;
- Vonescu, E.;
- Shiraishi, N.;
- Kiziltepe, T.;
- Elford, H.L.;
- Munshi, N.C.;
- Anderson, K.C.
Publication type:
Article
2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Published in:
Apoptosis, 2004, v. 9, n. 2, p. 149, doi. 10.1023/B:APPT.0000018797.66067.6c
By:
- Chauhan, D.;
- Li, G.;
- Auclair, D.;
- Hideshima, T.;
- Podar, K.;
- Mitsiades, N.;
- Mitsiades, C.;
- Chen, L. B.;
- Munshi, N.;
- Saxena, S.;
- Anderson, K. C.
Publication type:
Article
A novel proteasome inhibitor NPI-0052 as an anticancer therapy.
Published in:
British Journal of Cancer, 2006, v. 95, n. 8, p. 961, doi. 10.1038/sj.bjc.6603406
By:
- Chauhan, D.;
- Hideshima, T.;
- Anderson, K. C.
Publication type:
Article
Discrimination of double primary lung cancer from intrapulmonary metastasis by p53 gene mutation.
Published in:
British Journal of Cancer, 1999, v. 79, n. 9/10, p. 1549, doi. 10.1038/sj.bjc.6690247
By:
- Matsuzoe, D;
- Hideshima, T;
- Ohshima, K;
- Kawahara, K;
- Shirakusa, T;
- Kimura, A
Publication type:
Article

Found: 33