Works by Hewett, Sandra

Results: 26

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.

Published in:

Epilepsia (Series 4), 2011, v. 52, n. 2, p. 273, doi. 10.1111/j.1528-1167.2010.02889.x

By:

Claycomb, Robert J.;
Hewett, Sandra J.;
Hewett, James A.

Publication type:

Article

System xc- Activity and Astrocytes Are Necessary for Interleukin-1β-Mediated Hypoxic Neuronal Injury.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 38, p. 10094, doi. 10.1523/JNEUROSCI.2459-07.2007

By:

Fogal, Birgit;
Li, Jun;
Lobner, Doug;
McCullough, Louise D.;
Hewett, Sandra J.

Publication type:

Article

Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 46, p. 10335, doi. 10.1523/JNEUROSCI.2599-04.2004

By:

Ferrante, Robert J.;
Ryu, Hoon;
Kubilus, James K.;
Lee, Junghee;
Smith, Karen;
D'Mello, Santosh;
Sugars, Katharine L.;
Rubinsztein, David C.;
Lu, Peiyuan;
Langley, Brett;
Browne, Susan;
Beal, M. Flint;
Hewett, Sandra;
Kristal, Bruce S.;
Stavrovskaya, Irina G.;
Ratan, Rajiv R.

Publication type:

Article

The Cystine/Glutamate Antiporter, System xc– Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.821036

By:

He, Yan;
Hewett, Sandra J.

Publication type:

Article

Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κ B-Dependent upregulation of glutathione synthesis.

Published in:

Glia (0894-1491), 2015, v. 63, n. 9, p. 1568, doi. 10.1002/glia.22828

By:

He, Yan;
Jackman, Nicole A.;
Thorn, Trista L.;
Vought, Valarie E.;
Hewett, Sandra J.

Publication type:

Article

Regulation of System xc−Activity and Expression in Astrocytes by Interleukin-1β.

Published in:

Glia (0894-1491), 2010, v. 58, n. 15, p. 1806, doi. 10.1002/glia.21050

By:

Jackman, Nicole A.;
Uliasz, Tracy F.;
Hewett, James A.;
Hewett, Sandra J.

Publication type:

Article

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression.

Published in:

Glia (0894-1491), 2010, v. 58, n. 11, p. 1282, doi. 10.1002/glia.21005

By:

Hamby, Mary E.;
Hewett, James A.;
Hewett, Sandra J.

Publication type:

Article

TGF‐β1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS‐2.

Published in:

Glia (0894-1491), 2006, v. 54, n. 6, p. 566, doi. 10.1002/glia.20411

By:

Mary E. Hamby;
James A. Hewett;
Sandra J. Hewett

Publication type:

Article

Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system xc−.

Published in:

Journal of Neuroscience Research, 2021, v. 99, n. 12, p. 3339, doi. 10.1002/jnr.24971

By:

Sears, Sheila M. S.;
Roberts, Sarah H.;
Hewett, Sandra J.

Publication type:

Article

Sex- and age-dependent contribution of System Xc ̅ to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System Xc ̅ null mice.

Published in:

Frontiers in Behavioral Neuroscience, 2023, p. 1, doi. 10.3389/fnbeh.2023.1238349

By:

Frare, Carla;
Pitt, Shannon K.;
Hewett, Sandra J.

Publication type:

Article

Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study.

Published in:

2017

By:

Wilson, Jack H;
Criss, Amy H;
Spangler, Sean A;
Walukevich, Katherine;
Hewett, Sandra

Publication type:

journal article

Main path and byways: non-vesicular glutamate release by system xc- as an important modifier of glutamatergic neurotransmission.

Published in:

Journal of Neurochemistry, 2015, v. 135, n. 6, p. 1062, doi. 10.1111/jnc.13348

By:

Massie, Ann;
Boillée, Séverine;
Hewett, Sandra;
Knackstedt, Lori;
Lewerenz, Jan

Publication type:

Article

Relationship between NMDA receptor expression and MPP+ toxicity in cultured dopaminergic cells.

Published in:

Journal of Neuroscience Research, 2003, v. 73, n. 6, p. 811, doi. 10.1002/jnr.10732

By:

William H. Church;
Sandra J. Hewett

Publication type:

Article

Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia.

Published in:

Journal of Neuroscience Research, 1999, v. 56, n. 2, p. 189, doi. 10.1002/(SICI)1097-4547(19990415)56:2<189::AID-JNR8>3.0.CO;2-B

By:

Hewett, James A.;
Hewett, Sandra J.;
Winkler, Susan;
Pfeiffer, Steve E.

Publication type:

Article

Analysis of the Neuroprotective Effects of Various NitricOxide Donor Compounds in Murine Mixed Cortical Cell Culture.

Published in:

Journal of Neurochemistry, 1999, v. 72, n. 5, p. 1843, doi. 10.1046/j.1471-4159.1999.0721843.x

By:

Vidwans, Aniruddha S.;
Kim, Sungmee;
Coffin, Deborah O.;
Wink, David A.;
Hewett, Sandra J.

Publication type:

Article

Decreased epileptogenesis in mice lacking the System xc− transporter occurs in association with a reduction in AMPA receptor subunit GluA1.

Published in:

Epilepsia Open, 2019, v. 4, n. 1, p. 133, doi. 10.1002/epi4.12307

By:

Sears, Sheila M. S.;
Hewett, James A.;
Hewett, Sandra J.

Publication type:

Article

Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis.

Published in:

Epilepsia Open, 2018, v. 3, n. 2, p. 255, doi. 10.1002/epi4.12221

By:

Kanzler, Matthew A.;
Van Dyke, Adam M.;
He, Yan;
Hewett, James A.;
Hewett, Sandra J.

Publication type:

Article

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production.

Published in:

Antioxidants, 2018, v. 7, n. 8, p. 100, doi. 10.3390/antiox7080100

By:

Chowdhury, Twinkle;
Allen, Matthew F.;
Thorn, Trista L.;
He, Yan;
Hewett, Sandra J.

Publication type:

Article

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance.

Published in:

Experimental Biology & Medicine, 2021, v. 246, n. 9, p. 1069, doi. 10.1177/1535370221989263

By:

Sears, Sheila MS;
Hewett, Sandra J

Publication type:

Article

Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.

Published in:

Journal of Neurochemistry, 2009, v. 110, n. 6, p. 1766, doi. 10.1111/j.1471-4159.2009.06266.x

By:

Chi-un Choe;
Lewerenz, Jan;
Fischer, Gerry;
Uliasz, Tracy F.;
Espey, Michael Graham;
Hummel, Friedhelm C.;
King, Stephen Bruce;
Schwedhelm, Edzard;
Böger, Rainer H.;
Gerloff, Christian;
Hewett, Sandra J.;
Magnus, Tim;
Donzelli, Sonia

Publication type:

Article

Cytosolic phospholipase A2α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death.

Published in:

Journal of Neurochemistry, 2008, v. 106, n. 4, p. 1828, doi. 10.1111/j.1471-4159.2008.05527.x

By:

Taylor, Ava L.;
Bonventre, Joseph V.;
Uliasz, Tracy F.;
Hewett, James A.;
Hewett, Sandra J.

Publication type:

Article

Interleukin-1β: a bridge between inflammation and excitotoxicity?

Published in:

Journal of Neurochemistry, 2008, v. 106, n. 1, p. 1, doi. 10.1111/j.1471-4159.2008.05315.x

By:

Fogal, Birgit;
Hewett, Sandra J.

Publication type:

Article

Arsenite-Mediated Transcriptional Regulation of Glutathione Synthesis in Mammalian Primary Cortical Astrocytes.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5375, doi. 10.3390/ijms26115375

By:

Leisawitz, Jacob P.;
He, Jiali;
Baggeroer, Caroline;
Hewett, Sandra J.

Publication type:

Article

Nrf2 Regulates Basal Glutathione Production in Astrocytes.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 687, doi. 10.3390/ijms26020687

By:

He, Jiali;
Hewett, Sandra J.

Publication type:

Article

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death.

Published in:

ASN Neuro, 2015, v. 7, n. 6, p. 1, doi. 10.1177/1759091415614301

By:

Thorn, Trista L.;
Yan He;
Jackman, Nicole A.;
Lobner, Doug;
Hewett, James A.;
Hewett, Sandra J.

Publication type:

Article

Editorial: The known, the unknown, and the future of glutamate transporters.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.1005834

By:

Martinez-Lozada, Zila;
Hewett, Sandra J.;
Zafra, Francisco;
Ortega, Arturo

Publication type:

Article

Works by Hewett, Sandra

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.

System x<sub>c</sub><sup>-</sup> Activity and Astrocytes Are Necessary for Interleukin-1β-Mediated Hypoxic Neuronal Injury.

Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease.

The Cystine/Glutamate Antiporter, System x<sub>c</sub><sup>–</sup> Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice.

Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κ B-Dependent upregulation of glutathione synthesis.

Regulation of System x<sub>c</sub><sup>−</sup>Activity and Expression in Astrocytes by Interleukin-1β.

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression.

TGF‐β1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS‐2.

Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system x<sub>c</sub><sup>−</sup>.

Sex- and age-dependent contribution of System X<sub>c</sub> ̅ to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System X<sub>c</sub> ̅ null mice.

Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study.

Main path and byways: non-vesicular glutamate release by system x<sub>c</sub><sup>-</sup> as an important modifier of glutamatergic neurotransmission.

Relationship between NMDA receptor expression and MPP<sup>+</sup> toxicity in cultured dopaminergic cells.

Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia.

Analysis of the Neuroprotective Effects of Various NitricOxide Donor Compounds in Murine Mixed Cortical Cell Culture.

Decreased epileptogenesis in mice lacking the System x<sub>c</sub><sup>−</sup> transporter occurs in association with a reduction in AMPA receptor subunit GluA1.

Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis.

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production.

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance.

Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.

Cytosolic phospholipase A<sub>2</sub>α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death.

Interleukin-1β: a bridge between inflammation and excitotoxicity?

Arsenite-Mediated Transcriptional Regulation of Glutathione Synthesis in Mammalian Primary Cortical Astrocytes.

Nrf2 Regulates Basal Glutathione Production in Astrocytes.

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x<sub>c</sub><sup>-</sup> Mediates Aglycemic Neuronal Cell Death.

Editorial: The known, the unknown, and the future of glutamate transporters.