Works matching AU Hessel, Edith M.

Results: 23

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases.

Published in:

Annals of the New York Academy of Sciences, 2013, v. 1280, n. 1, p. 35, doi. 10.1111/nyas.12039

By:

Sriskantharajah, Srividya;
Hamblin, Nicole;
Worsley, Sally;
Calver, Andrew R.;
Hessel, Edith M.;
Amour, Augustin

Publication type:

Article

Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2021, v. 65, n. 5, p. 544, doi. 10.1165/rcmb.2020-0337OC

By:

Wronski, Sabine;
Beinke, Soren;
Obernolte, Helena;
Belyaev, Nikolai N.;
Saunders, Ken A.;
Lennon, Mark G.;
Schaudien, Dirk;
Braubach, Peter;
Jonigk, Danny;
Warnecke, Gregor;
Zardo, Patrick;
Fieguth, Hans-Gerd;
Wilkens, Ludwig;
Braun, Armin;
Hessel, Edith M.;
Sewald, Katherina

Publication type:

Article

Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 17, p. 5122, doi. 10.1093/nar/gkg700

By:

Marshall, Jason D.;
Hessel, Edith M.;
Gregorio, Josh;
Abbate, Christina;
Yee, Priscilla;
Chu, Mabel;
Nest, Gary Van;
Coffman, Robert L.;
Fearon, Karen L.

Publication type:

Article

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

Published in:

2016

By:

Juss, Jatinder K.;
House, David;
Amour, Augustin;
Begg, Malcolm;
Herre, Jurgen;
Storisteanu, Daniel M. L.;
Hoenderdos, Kim;
Bradley, Glyn;
Lennon, Mark;
Summers, Charlotte;
Hessel, Edith M.;
Condliffe, Alison;
Chilvers, Edwin R.

Publication type:

journal article

Superior Activity of the Type C Class of ISSandAcross Multiple Species.

Published in:

DNA & Cell Biology, 2005, v. 24, n. 2, p. 63, doi. 10.1089/dna.2005.24.63

By:

Marshall, Jason D.;
Fearon, Karen L.;
Higgins, Debbie;
Hessel, Edith M.;
Kanzler, Holger;
Abbate, Christi;
Yee, Priscilla;
Gregorio, Josh;
Cruz, Tracy Dela;
Lizcano, Jennifer O.;
Zolotorev, Alya;
McClure, Hazel M.;
Brasky, Kathleen M.;
Murthy, Krishna K.;
Coffman, Robert L.;
VanNest, Gary

Publication type:

Article

PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.

Published in:

BMC Immunology, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12865-021-00461-5

By:

Uddin, Sorif;
Amour, Augustin;
Lewis, David J.;
Edwards, Chris D.;
Williamson, Matthew G.;
Hall, Simon;
Lione, Lisa A.;
Hessel, Edith M.

Publication type:

Article

CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans.

Published in:

2009

By:

Campbell, John D.;
Yan Cho;
Foster, Martyn L.;
Kanzler, Holger;
Kachura, Melissa A.;
Lum, Jeremy A.;
Ratcliffe, Marianne J.;
Sathe, Atul;
Leishman, Andrew J.;
Bahl, Ash;
McHale, Mark;
Coffman, Robert L.;
Hessel, Edith M.;
Cho, Yan

Publication type:

journal article

Functions of T cells in asthma: more than just T(H)2 cells.

Published in:

2010

By:

Lloyd, Clare M.;
Hessel, Edith M.

Publication type:

journal article

An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2017, v. 44, n. 9, p. 932, doi. 10.1111/1440-1681.12784

By:

Khan, Abid;
Southworth, Thomas;
Worsley, Sally;
Sriskantharajah, Srividya;
Amour, Augustin;
Hessel, Edith M;
Singh, Dave

Publication type:

Article

Immunostimulatory Sequences Regulate Interferon-inducible Genes but not Allergic Airway Responses.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2006, v. 174, n. 1, p. 15, doi. 10.1164/rccm.200601-057OC

By:

Gauvreau, Gail M.;
Hessel, Edith M.;
Boulet, Louis-Philippe;
Coffman, Robert L.;
O'Byrne, Paul M.

Publication type:

Article

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-55504-0

By:

Lima, Braulio Henrique Freire;
Marques, Pedro Elias;
Gomides, Lindisley Ferreira;
Mattos, Matheus Silvério;
Kraemer, Lucas;
Queiroz-Junior, Celso M.;
Lennon, Mark;
Hirsch, Emilio;
Russo, Remo Castro;
Menezes, Gustavo Batista;
Hessel, Edith M.;
Amour, Augustin;
Teixeira, Mauro Martins

Publication type:

Article

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.

Published in:

Clinical Pharmacokinetics, 2022, v. 61, n. 2, p. 281, doi. 10.1007/s40262-021-01066-2

By:

Miller, Neil A.;
Graves, Rebecca H.;
Edwards, Chris D.;
Amour, Augustin;
Taylor, Ed;
Robb, Olivia;
O'Brien, Brett;
Patel, Aarti;
Harrell, Andrew W.;
Hessel, Edith M.

Publication type:

Article

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

Published in:

EMBO Molecular Medicine, 2016, v. 8, n. 9, p. 1099, doi. 10.15252/emmm.201606413

By:

Davidson, Sophia;
McCabe, Teresa M;
Crotta, Stefania;
Gad, Hans Henrik;
Hessel, Edith M;
Beinke, Soren;
Hartmann, Rune;
Wack, Andreas

Publication type:

Article

Airway host-microbiome interactions in chronic obstructive pulmonary disease.

Published in:

2019

By:

Wang, Zhang;
Maschera, Barbara;
Lea, Simon;
Kolsum, Umme;
Michalovich, David;
Van Horn, Stephanie;
Traini, Christopher;
Brown, James R;
Hessel, Edith M;
Singh, Dave

Publication type:

journal article

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages.

Published in:

Journal of Cell Biology, 2017, v. 216, n. 4, p. 1123, doi. 10.1083/jcb.201608094

By:

Lopes, Filipa B.;
Bálint, Štefan;
Valvo, Salvatore;
Felce, James H.;
Hessel, Edith M.;
Dustin, Michael L.;
Davis, Daniel M.

Publication type:

Article

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05674-8

By:

Stark, Anne-Katrien;
Chandra, Anita;
Chakraborty, Krishnendu;
Alam, Rafeah;
Carbonaro, Valentina;
Clark, Jonathan;
Sriskantharajah, Srividya;
Bradley, Glyn;
Richter, Alex G.;
Banham-Hall, Edward;
Clatworthy, Menna R.;
Nejentsev, Sergey;
Hamblin, J. Nicole;
Hessel, Edith M.;
Condliffe, Alison M.;
Okkenhaug, Klaus

Publication type:

Article

An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial.

Published in:

International Journal of COPD, 2021, v. 16, p. 1607, doi. 10.2147/COPD.S309129

By:

Cahn, Anthony;
Hamblin, J Nicole;
Robertson, Jon;
Begg, Malcolm;
Jarvis, Emily;
Wilson, Robert;
Dear, Gordon;
Leemereise, Claudia;
Cui, Yi;
Mizuma, Maki;
Montembault, Mickael;
Holsbeke, Cedric Van;
Vos, Wim;
Backer, Wilfried De;
Backer, Jan De;
Hessel, Edith M

Publication type:

Article

Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.

Published in:

International Journal of COPD, 2021, v. 16, p. 1637, doi. 10.2147/COPD.S309320

By:

Fahy, William A;
Homayoun-Valiani, Farshid;
Cahn, Anthony;
Robertson, Jon;
Templeton, Alison;
Meeraus, Wilhelmine H;
Wilson, Robert;
Lowings, Mike;
Marotti, Miriam;
West, Sarah L;
Tabberer, Maggie;
Hessel, Edith M

Publication type:

Article

Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort.

Published in:

International Journal of COPD, 2021, v. 16, p. 225, doi. 10.2147/COPD.S279315

By:

Meeraus, Wilhelmine H;
Mullerova, Hana;
Baou, Céline El;
Fahey, Marion;
Hessel, Edith M;
Fahy, William A

Publication type:

Article

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages.

Published in:

International Journal of COPD, 2018, v. 13, p. 771, doi. 10.2147/COPD.S97071

By:

Lea, Simon R;
Reynolds, Sophie L;
Kaur, Manminder;
Simpson, Karen D;
Hall, Simon R;
Hessel, Edith M;
Singh, Dave

Publication type:

Article

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK.

Published in:

International Journal of COPD, 2017, v. 12, p. 1507, doi. 10.2147/COPD.S135338

By:

Maddi, Satyanarayana;
Kolsum, Umme;
Jackson, Sarah;
Barraclough, Richard;
Maschera, Barbara;
Simpson, Karen D.;
Pascal, Thierry G.;
Durviaux, Serge;
Hessel, Edith M.;
Singh, Dave

Publication type:

Article

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

Published in:

Nature Medicine, 2007, v. 13, n. 5, p. 552, doi. 10.1038/nm1589

By:

Kanzler, Holger;
Barrat, Franck J.;
Hessel, Edith M.;
Coffman, Robert L.

Publication type:

Article

First‐in‐Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well‐Tolerated.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 2, p. 335, doi. 10.1002/cpt.938

By:

Jackson, Sam;
Candia, Albert F.;
Delaney, Stephen;
Floettmann, Simone;
Wong, Clifford;
Campbell, John D.;
Kell, Sariah;
Lum, Jeremy;
Hessel, Edith M.;
Traquina, Paula;
McHale, Mark;
Robinson, Ian;
Bell, John;
Fuhr, Rainard;
Keeling, David;
Coffman, Robert L.

Publication type:

Article