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Combination of Pseudo‐Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo‐Sesquiterpenoid Alkaloids.
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- Angewandte Chemie, 2021, v. 133, n. 39, p. 21554, doi. 10.1002/ange.202106654
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- Article
Dynamic Catalytic Highly Enantioselective 1,3‐Dipolar Cycloadditions.
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- Angewandte Chemie, 2021, v. 133, n. 36, p. 20165, doi. 10.1002/ange.202108072
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- Article
Pseudo Natural Products—Chemical Evolution of Natural Product Structure.
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- Angewandte Chemie, 2021, v. 133, n. 29, p. 15837, doi. 10.1002/ange.202016575
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- Article
Cell‐Based Identification of New IDO1 Modulator Chemotypes.
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- Angewandte Chemie, 2021, v. 133, n. 18, p. 9957, doi. 10.1002/ange.202016004
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Design, Synthesis, and Biological Evaluation of Chemically and Biologically Diverse Pyrroquinoline Pseudo Natural Products.
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- Angewandte Chemie, 2021, v. 133, n. 9, p. 4698, doi. 10.1002/ange.202013731
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- Article
Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.
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- Angewandte Chemie, 2021, v. 133, n. 4, p. 1841, doi. 10.1002/ange.202009749
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- Article
Phenotyping Reveals Targets of a Pseudo‐Natural‐Product Autophagy Inhibitor.
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- Angewandte Chemie, 2020, v. 132, n. 30, p. 12570, doi. 10.1002/ange.202000364
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- Article
Image‐Based Morphological Profiling Identifies a Lysosomotropic, Iron‐Sequestering Autophagy Inhibitor.
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- Angewandte Chemie, 2020, v. 132, n. 14, p. 5770, doi. 10.1002/ange.201913712
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- Article
Development of a PDEδ‐Targeting PROTACs that Impair Lipid Metabolism.
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- Angewandte Chemie, 2020, v. 132, n. 14, p. 5644, doi. 10.1002/ange.201913904
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- Article
Synthesis of Indomorphan Pseudo‐Natural Product Inhibitors of Glucose Transporters GLUT‐1 and ‐3.
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- Angewandte Chemie, 2019, v. 131, n. 47, p. 17172, doi. 10.1002/ange.201909518
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- Article
Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.
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- Angewandte Chemie, 2019, v. 131, n. 46, p. 16770, doi. 10.1002/ange.201907632
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- Article
Design, Synthesis, and Phenotypic Profiling of Pyrano‐Furo‐Pyridone Pseudo Natural Products.
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- Angewandte Chemie, 2019, v. 131, n. 41, p. 14857, doi. 10.1002/ange.201907853
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- Article
Chemical Genetics Reveals a Role of dCTP Pyrophosphatase 1 in Wnt Signaling.
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- Angewandte Chemie, 2019, v. 131, n. 37, p. 13143, doi. 10.1002/ange.201905977
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- Article
Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
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- Angewandte Chemie, 2019, v. 131, n. 4, p. 1074, doi. 10.1002/ange.201810312
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- Publication type:
- Article
Enantioselective Formal C(sp<sup>3</sup>)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives.
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- Angewandte Chemie, 2019, v. 131, n. 1, p. 313, doi. 10.1002/ange.201811041
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- Article
Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis.
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- Angewandte Chemie, 2018, v. 130, n. 44, p. 14701, doi. 10.1002/ange.201712882
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- Article
C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors.
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- Angewandte Chemie, 2018, v. 130, n. 43, p. 14446, doi. 10.1002/ange.201809680
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- Article
Ligandengesteuerte divergente Synthese von carbo‐ und heterocyclischen Ringsystemen.
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- Angewandte Chemie, 2018, v. 130, n. 19, p. 5308, doi. 10.1002/ange.201710247
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- Publication type:
- Article
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.
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- Angewandte Chemie, 2017, v. 129, n. 42, p. 13201, doi. 10.1002/ange.201707394
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- Publication type:
- Article
Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors.
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- Angewandte Chemie, 2017, v. 129, n. 37, p. 11384, doi. 10.1002/ange.201706005
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- Article
Neue Modalitäten für schwierige Zielstrukturen in der Wirkstoffentwicklung.
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- Angewandte Chemie, 2017, v. 129, n. 35, p. 10428, doi. 10.1002/ange.201611914
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- Publication type:
- Article
Lateral Organization of Host Heterogeneous Raft-like Membranes Altered by the Myristoyl Modification of Tyrosine Kinase c-Src.
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- Angewandte Chemie, 2017, v. 129, n. 35, p. 10647, doi. 10.1002/ange.201706233
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- Publication type:
- Article
Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.
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- Angewandte Chemie, 2017, v. 129, n. 28, p. 8265, doi. 10.1002/ange.201703738
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- Publication type:
- Article
Small-Molecule Inhibition of the UNC119-Cargo Interaction.
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- Angewandte Chemie, 2017, v. 129, n. 22, p. 6277, doi. 10.1002/ange.201701905
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- Publication type:
- Article
A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
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- Angewandte Chemie, 2017, v. 129, n. 9, p. 2463, doi. 10.1002/ange.201610957
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- Publication type:
- Article
General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands.
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- Angewandte Chemie, 2017, v. 129, n. 9, p. 2469, doi. 10.1002/ange.201611981
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- Publication type:
- Article
Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.
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- Angewandte Chemie, 2017, v. 129, n. 8, p. 2177, doi. 10.1002/ange.201611670
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- Publication type:
- Article
Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition.
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- Angewandte Chemie, 2016, v. 128, n. 27, p. 7892, doi. 10.1002/ange.201602084
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- Publication type:
- Article
Organokatalytische Synthese von enantiomerenreinen 2 H- und 3 H-Pyrrolen: Inhibitoren des Hedgehog-Signalwegs.
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- Angewandte Chemie, 2016, v. 128, n. 27, p. 7824, doi. 10.1002/ange.201602932
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- Publication type:
- Article
Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity.
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- Angewandte Chemie, 2016, v. 128, n. 27, p. 7897, doi. 10.1002/ange.201602666
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- Publication type:
- Article
Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
- Published in:
- Angewandte Chemie International Edition, 2019, v. 58, n. 4, p. 1062, doi. 10.1002/anie.201810312
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- Publication type:
- Article
Enantioselective Formal C(sp<sup>3</sup>)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives.
- Published in:
- Angewandte Chemie International Edition, 2019, v. 58, n. 1, p. 307, doi. 10.1002/anie.201811041
- By:
- Publication type:
- Article
Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis.
- Published in:
- Angewandte Chemie International Edition, 2018, v. 57, n. 44, p. 14493, doi. 10.1002/anie.201712882
- By:
- Publication type:
- Article
C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors.
- Published in:
- Angewandte Chemie International Edition, 2018, v. 57, n. 43, p. 14250, doi. 10.1002/anie.201809680
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- Publication type:
- Article
Ligand‐Directed Divergent Synthesis of Carbo‐ and Heterocyclic Ring Systems.
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- Angewandte Chemie International Edition, 2018, v. 57, n. 19, p. 5212, doi. 10.1002/anie.201710247
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- Publication type:
- Article
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 42, p. 13021, doi. 10.1002/anie.201707394
- By:
- Publication type:
- Article
Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 37, p. 11232, doi. 10.1002/anie.201706005
- By:
- Publication type:
- Article
Lateral Organization of Host Heterogeneous Raft-like Membranes Altered by the Myristoyl Modification of Tyrosine Kinase c-Src.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 35, p. 10511, doi. 10.1002/anie.201706233
- By:
- Publication type:
- Article
New Modalities for Challenging Targets in Drug Discovery.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 35, p. 10294, doi. 10.1002/anie.201611914
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- Publication type:
- Article
Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 28, p. 8153, doi. 10.1002/anie.201703738
- By:
- Publication type:
- Article
Small-Molecule Inhibition of the UNC119-Cargo Interaction.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 22, p. 6181, doi. 10.1002/anie.201701905
- By:
- Publication type:
- Article
A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 9, p. 2423, doi. 10.1002/anie.201610957
- By:
- Publication type:
- Article
General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 9, p. 2429, doi. 10.1002/anie.201611981
- By:
- Publication type:
- Article
Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 8, p. 2145, doi. 10.1002/anie.201611670
- By:
- Publication type:
- Article
The Organocatalytic Approach to Enantiopure 2 H- and 3 H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 27, p. 7693, doi. 10.1002/anie.201602932
- By:
- Publication type:
- Article
Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 27, p. 7761, doi. 10.1002/anie.201602084
- By:
- Publication type:
- Article
Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 27, p. 7766, doi. 10.1002/anie.201602666
- By:
- Publication type:
- Article
Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association.
- Published in:
- Angewandte Chemie International Edition, 2015, v. 54, n. 52, p. 15892, doi. 10.1002/anie.201507266
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- Publication type:
- Article
Direct Modulation of Small GTPase Activity and Function.
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- Angewandte Chemie International Edition, 2015, v. 54, n. 46, p. 13516, doi. 10.1002/anie.201504357
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- Publication type:
- Article
Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4.
- Published in:
- Angewandte Chemie International Edition, 2015, v. 54, n. 42, p. 12398, doi. 10.1002/anie.201501515
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- Publication type:
- Article