Works by Hennighausen, Lothar

Results: 102

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.

Published in:

Life Science Alliance, 2025, v. 8, n. 7, p. 1, doi. 10.26508/lsa.202503222

By:

Hye Kyung Lee;
Jichun Chen;
Philips, Rachael L.;
Sung-Gwon Lee;
Xingmin Feng;
Zhijie Wu;
Chengyu Liu;
Schultz, Aaron B.;
Dalzell, Molly;
Meggendorfer, Manja;
Haferlach, Claudia;
Birnbaum, Foster;
Sexton, Joel A.;
Keating, Amy E.;
O'Shea, John J.;
Young, Neal S.;
Villarino, Alejandro V.;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression.

Published in:

Hepatology Research, 2017, v. 47, n. 8, p. 813, doi. 10.1111/hepr.12816

By:

Hosui, Atsushi;
Tatsumi, Tomohide;
Hikita, Hayato;
Saito, Yoshinobu;
Hiramatsu, Naoki;
Tsujii, Masahiko;
Hennighausen, Lothar;
Takehara, Tetsuo

Publication type:

Article

The Microarray Explorer tool for data mining of cDNA microarrays: application for the mammary gland.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 22, p. 4452, doi. 10.1093/nar/28.22.4452

By:

Lemkin, Peter F.;
Thornwall, Gregory C.;
Walton, Katherine D.;
Hennighausen, Lothar

Publication type:

Article

Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40712-0

By:

Lee, Hye Kyung;
Willi, Michaela;
Liu, Chengyu;
Hennighausen, Lothar

Publication type:

Article

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and...

Published in:

Journal of Cell Biology, 2001, v. 155, n. 4, p. 531, doi. 10.1083/jcb.200107065

By:

Miyoshi, Keiko;
Shillingford, Jonathan M.;
Smith, Gilbert H.;
Grimm, Sandra L.;
Wagner, Kay-Uwe;
Oka, Takami;
Rosen, Jeffrey M.;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83110-6

By:

Lee, Hye Kyung;
Knabl, Ludwig;
Pipperger, Lisa;
Volland, Andre;
Furth, Priscilla A.;
Kang, Keunsoo;
Smith, Harold E.;
Bellmann, Romuald;
Bernhard, Christina;
Kaiser, Norbert;
Gänzer, Hannes;
Ströhle, Mathias;
Walser, Andreas;
von Laer, Dorothee;
Hennighausen, Lothar

Publication type:

Article

Prior Vaccination Exceeds Prior Infection in Eliciting Innate and Humoral Immune Responses in Omicron Infected Outpatients.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.916686

By:

Lee, Hye Kyung;
Knabl, Ludwig;
Walter, Mary;
Knabl Sr, Ludwig;
Dai, Yuhai;
Füßl, Magdalena;
Caf, Yasemin;
Jeller, Claudia;
Knabl, Philipp;
Obermoser, Martina;
Baurecht, Christof;
Kaiser, Norbert;
Zabernigg, August;
Wurdinger, Gernot M.;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.

Published in:

Carcinogenesis, 2015, v. 36, n. 1, p. 122, doi. 10.1093/carcin/bgu237

By:

Dabydeen, Sarah A.;
Kang, Keunsoo;
Díaz-Cruz, Edgar S.;
Alamri, Ahmad;
Axelrod, Margaret L.;
Bouker, Kerrie B.;
Al-Kharboosh, Rawan;
Clarke, Robert;
Hennighausen, Lothar;
Furth, Priscilla A.

Publication type:

Article

Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet.

Published in:

European Journal of Nutrition, 2017, v. 56, n. 2, p. 569, doi. 10.1007/s00394-015-1101-0

By:

Baik, Myunggi;
Lee, Mi;
Kang, Hyeok;
Park, Seung;
Piao, Min;
Nguyen, Trang;
Hennighausen, Lothar

Publication type:

Article

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.

Published in:

EMBO Molecular Medicine, 2010, v. 2, n. 3, p. 98, doi. 10.1002/emmm.201000062

By:

Hoelbl, Andrea;
Schuster, Christian;
Kovacic, Boris;
Zhu, Bingmei;
Wickre, Mark;
Hoelzl, Maria A.;
Fajmann, Sabine;
Grebien, Florian;
Warsch, Wolfgang;
Stengl, Gabriele;
Hennighausen, Lothar;
Poli, Valeria;
Beug, Hartmut;
Moriggl, Richard;
Sexl, Veronika

Publication type:

Article

The versatile regulation of cellular events by Jak-Stat signaling: from transcriptional control to microtubule dynamics and energy metabolism.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2012, v. 10, n. 1, p. 193, doi. 10.1515/hmbci-2012-0010

By:

Groner, Bernd;
Hennighausen, Lothar

Publication type:

Article

Genomic and bioinformatics tools to understand the biology of signal transducers and activators of transcription.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2012, v. 10, n. 1, p. 207, doi. 10.1515/hmbci-2012-0012

By:

Kang, Keunsoo;
Hennighausen, Lothar

Publication type:

Article

Cytokine receptors and their Stat-mediated mechanisms of action.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2012, v. 10, n. 1, p. 191, doi. 10.1515/hmbci-2012-0017

By:

Groner, Bernd;
Hennighausen, Lothar

Publication type:

Article

Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor.

Published in:

FASEB Journal, 2009, v. 23, n. 9, p. 3140, doi. 10.1096/fj.08-128215

By:

Klover, Peter;
Chen, Weiping;
Bing-Mei Zhu;
Hennighausen, Lothar

Publication type:

Article

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules.

Published in:

BMC Genomics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2164-14-4

By:

Kang, Keunsoo;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

Understanding mammary gland development through the imbalanced expression of growth regulators.

Published in:

Developmental Dynamics, 1996, v. 206, n. 2, p. 159, doi. 10.1002/(SICI)1097-0177(199606)206:2<159::AID-AJA5>3.0.CO;2-H

By:

Robinson, Gertraud W.;
Smith, Gilbert H.;
Gallahan, Daniel;
Zimmer, Andreas;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06855-6

By:

Jankowski, Jakub;
Lee, Hye Kyung;
Liu, Chengyu;
Wilflingseder, Julia;
Hennighausen, Lothar

Publication type:

Article

Information networks in the mammary gland.

Published in:

Nature Reviews Molecular Cell Biology, 2005, v. 6, n. 9, p. 715, doi. 10.1038/nrm1714

By:

Hennighausen, Lothar;
Robinson, Gertraud W.

Publication type:

Article

Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated ß-catenin.

Published in:

Oncogene, 2003, v. 22, n. 29, p. 4594, doi. 10.1038/sj.onc.1206596

By:

Renou, Jean-Pierre;
Bierie, Brian;
Miyoshi, Keiko;
Cui, Yongzhi;
Djiane, Jean;
Reichenstein, Moshe;
Shani, Moshe;
Hennighausen, Lothar

Publication type:

Article

Activation of b-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

Published in:

Oncogene, 2003, v. 22, n. 25, p. 3875, doi. 10.1038/sj.onc.1206426

By:

Bierie, Brian;
Nozawa, Masahiro;
Renou, Jean-Pierre;
Shillingford, Jonathan M;
Morgan, Fanta;
Oka, Takami;
Taketo, Makoto M;
Cardiff, Robert D;
Miyoshi, Keiko;
Wagner, Kay-Uwe;
Robinson, Gertraud W;
Hennighausen, Lothar

Publication type:

Article

Activation of different Wnt/β-catenin signaling components in mammary epitelium induces transdifferentiation and the formation of pilar tumors.

Published in:

Oncogene, 2002, v. 21, n. 36, p. 5548, doi. 10.1038/sj.onc.1205686

By:

Miyoshi, Keiko;
Rosner, Andrea;
Nozawa, Masahiro;
Byrd, Christopher;
Morgan, Fanta;
Landesman-Bollag, Esther;
Xin Xu;
Seldin, David C.;
Schmidt, Emmett V.;
Taketo, Makato M.;
Robinson, Gertraud W.;
Cardiff, Robert D.;
Hennighausen, Lothar

Publication type:

Article

Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene.

Published in:

Oncogene, 2001, v. 20, n. 48, p. 7115, doi. 10.1038/sj.onc.1204888

By:

Robinson, Gertraud W;
Wagner, Kay-Uwe;
Hennighausen, Lothar

Publication type:

Article

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting‡.

Published in:

Oncogene, 2000, v. 19, n. 8, p. 968, doi. 10.1038/sj.onc.1203277

By:

Cardiff, Robert D;
Anver, Miriam R;
Gusterson, Barry A;
Hennighausen, Lothar;
Jensen, Roy A;
Merino, Maria J;
Rehm, Sabine;
Russo, Jose;
Tavassoli, Fattaneh A;
Wakefield, Lalage M;
Ward, Jerrold M;
Green, Jeffrey E

Publication type:

Article

Transforming growth factor alpha and mouse models of human breast cancer.

Published in:

Oncogene, 2000, v. 19, n. 8, p. 1085, doi. 10.1038/sj.onc.1203278

By:

Humphreys, Robin C;
Hennighausen, Lothar

Publication type:

Article

The interactive web-based histology atlas system.

Published in:

Oncogene, 2000, v. 19, n. 8, p. 989, doi. 10.1038/sj.onc.1203279

By:

Evans, Jai A;
Wagner, Ulrike;
Santos, Christopher M;
Hennighausen, Lothar

Publication type:

Article

Mouse models for breast cancer.

Published in:

Oncogene, 2000, v. 19, n. 8, p. 966, doi. 10.1038/sj.onc.1203346

By:

Hennighausen, Lothar

Publication type:

Article

Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants.

Published in:

Oncogene, 1998, v. 17, n. 21, p. 2761, doi. 10.1038/sj.onc.1202529

By:

Wagner, Kay-Uwe;
Dierisseau, Patricia;
B Rucker, Edmund;
Robinson, Gertraud W;
Hennighausen, Lothar

Publication type:

Article

Mammary gland involution studies with cDNA microarrays.

Published in:

1999

By:

Gangi, Lisa;
Owens, Garrison;
Humphreys, Robin;
Hennighausen, Lothar;
Liu, Edison

Publication type:

Abstract

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

Published in:

Nature Genetics, 1999, v. 22, n. 1, p. 37, doi. 10.1038/8743

By:

Xu, Xiaoling;
Wagner, Kay-Uwe;
Larson, Denise;
Weaver, Zoë;
Li, Cuiling;
Ried, Thomas;
Hennighausen, Lothar;
Wynshaw-Boris, Anthony;
Deng, Chu-Xia

Publication type:

Article

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.

Published in:

PLoS Genetics, 2020, v. 16, n. 5, p. 1, doi. 10.1371/journal.pgen.1008796

By:

Lau-Corona, Dana;
Bae, Woo Kyun;
Hennighausen, Lothar;
Waxman, David J.

Publication type:

Article

Severe position effects imposed on a 1 kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions.

Published in:

Molecular Reproduction & Development, 1996, v. 44, n. 2, p. 179, doi. 10.1002/(SICI)1098-2795(199606)44:2<179::AID-MRD6>3.0.CO;2-K

By:

McKnight, Robert A.;
Spencer, Mark;
Wall, Robert J.;
Hennighausen, Lothar

Publication type:

Article

Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasisThis article is a US Government work and, as such, is in the public domain in the United States of America.

Published in:

Developmental Dynamics, 2007, v. 236, n. 3, p. 654, doi. 10.1002/dvdy.21058

By:

Gertraud W. Robinson;
Margit Pacher‐Zavisin;
Bing Mei Zhu;
Akihiko Yoshimura;
Lothar Hennighausen

Publication type:

Article

Spotlight on amino acid changing mutations in the JAK-STAT pathway: from disease-specific mutation to general mutation databases.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-90788-5

By:

Hoffmann, Markus;
Hennighausen, Lothar

Publication type:

Article

Targeting fidelity of adenine and cytosine base editors in mouse embryos.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07322-7

By:

Lee, Hye Kyung;
Willi, Michaela;
Miller, Shannon M.;
Kim, Sojung;
Liu, Chengyu;
Liu, David R.;
Hennighausen, Lothar

Publication type:

Article

Deficiency of Stat1 in CD11c<sup>+</sup> Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet.

Published in:

2021

By:

Antony, Antu;
Lian, Zeqin;
Perrard, Xiaoyuan Dai;
Perrard, Jerry;
Liu, Hua;
Cox, Aaron R.;
Saha, Pradip;
Hennighausen, Lothar;
Hartig, Sean M.;
Ballantyne, Christie M.;
Wu, Huaizhu

Publication type:

journal article

Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 16, p. 2108, doi. 10.1128/MCB.00089-16

By:

Kyung Hyun Yoo;
Sumin Oh;
Keunsoo Kang;
Chaochen Wang;
Robinson, Gertraud W.;
Kai Ge;
Hennighausen, Lothar

Publication type:

Article

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 11, p. 1673, doi. 10.1128/MCB.00999-15

By:

Sakamoto, Kazuhito;
Wehde, Barbara L.;
Kyung Hyun Yoo;
Taemook Kim;
Rajbhandari, Nirakar;
Ha Youn Shin;
Triplett, Aleata A.;
Rädler, Patrick D.;
Schuler, Fabian;
Villunger, Andreas;
Keunsoo Kang;
Hennighausen, Lothar;
Wagner, Kay-Uwe

Publication type:

Article

The prospects for domesticating milk protein genes.

Published in:

Journal of Cellular Biochemistry, 1992, v. 49, n. 4, p. 325, doi. 10.1002/jcb.240490402

By:

Hennighausen, Lothar

Publication type:

Article

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

Published in:

PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0181948

By:

Fu, Shu-Ping;
Hong, Hao;
Lu, Sheng-Feng;
Hu, Chen-Jun;
Xu, Hou-Xi;
Li, Qian;
Yu, Mei-Ling;
Ou, Chen;
Meng, Jian-Zhong;
Wang, Tian-Lin;
Hennighausen, Lothar;
Zhu, Bing-Mei

Publication type:

Article

GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

Published in:

Biological Chemistry, 2005, v. 386, n. 9, p. 845, doi. 10.1515/BC.2005.099

By:

Hart, Stefan;
Fischer, Oliver M.;
Prenzel, Norbert;
Zwick-Wallasch, Esther;
Schneider, Matthias;
Hennighausen, Lothar;
Ullrich, Axel

Publication type:

Article

Studying Development of Disease Through Temporally Controlled Gene Expression in the Salivary Gland<sup>a</sup>.

Published in:

Annals of the New York Academy of Sciences, 1998, v. 842, n. 1, p. 181, doi. 10.1111/j.1749-6632.1998.tb09646.x

By:

FURTH, PRISCILLA A.;
LI, MINGLIN;
HENNIGHAUSEN, LOTHAR

Publication type:

Article

The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers.

Published in:

Molecular Carcinogenesis, 2015, v. 54, n. 10, p. 1172, doi. 10.1002/mc.22188

By:

Bae, Woo Kyun;
Yoo, Kyung Hyun;
Lee, Ji Shin;
Kim, Young;
Chung, Ik‐Joo;
Park, Min Ho;
Yoon, Jung Han;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development.

Published in:

Genesis: The Journal of Genetics & Development, 2012, v. 50, n. 9, p. 665, doi. 10.1002/dvg.22023

By:

Feuermann, Yonatan;
Robinson, Gertraud W.;
Zhu, Bing-Mei;
Kang, Keunsoo;
Raviv, Noa;
Yamaji, Daisuke;
Hennighausen, Lothar

Publication type:

Article

The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility.

Published in:

Genesis: The Journal of Genetics & Development, 2002, v. 32, n. 3, p. 231, doi. 10.1002/gene.10037

By:

Le Provost, Fabienne;
Riedlinger, Gregory;
Hee Yim, Sun;
Benedict, Jamie;
Gonzalez, Frank J.;
Flaws, Jodi;
Hennighausen, Lothar

Publication type:

Article

High-affinity binding site for a specific nuclear protein in the human IgM gene.

Published in:

Nature, 1985, p. 289, doi. 10.1038/314289a0

By:

Hennighausen, Lothar;
Siebenlist, Ulrich;
Danner, David;
Leder, Philip;
Rawlins, Dan;
Rosenfeld, Philip;
Kelly Jr, Thomas

Publication type:

Article

A central role for STAT5 in the transcriptional programing of T helper cell metabolism.

Published in:

Science Immunology, 2022, v. 7, n. 77, p. 1, doi. 10.1126/sciimmunol.abl9467

By:

Villarino, Alejandro V.;
Laurence, Arian DJ;
Davis, Fred P.;
Nivelo, Luis;
Brooks, Stephen R.;
Sun, Hong-Wei;
Jiang, Kan;
Afzali, Behdad;
Frasca, Daniela;
Hennighausen, Lothar;
Kanno, Yuka;
O'Shea, John J.

Publication type:

Article

Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06752-0

By:

Lee, Hye Kyung;
Knabl, Ludwig;
Knabl Sr., Ludwig;
Wieser, Manuel;
Mur, Anna;
Zabernigg, August;
Schumacher, Jana;
Kapferer, Sebastian;
Kaiser, Norbert;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

Cre-mediated gene deletion in the mammary gland.

Published in:

Nucleic Acids Research, 1997, v. 25, n. Supplement, p. 4323, doi. 10.1093/nar/25.21.4323

By:

Wagner, Kay-Uwe;
Wall, Robert J.;
St-Onge, Luc;
Gruss, Peter;
Wynshaw-Boris, Anthony;
Garrett, Lisa;
Li, Minglin;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.

Published in:

RNA Biology, 2013, v. 10, n. 12, p. 1807, doi. 10.4161/rna.27239

By:

Yonatan Feuermann;
Keunsoo Kang;
Oksana Gavrilova;
Haetscher, Nadine;
Seung Jin Jang;
Kyung Hyun Yoo;
Changtao Jiang;
Gonzalez, Frank J.;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.

Published in:

British Journal of Haematology, 2011, v. 153, n. 5, p. 589, doi. 10.1111/j.1365-2141.2011.08663.x

By:

Takeda, Yusuke;
Nakaseko, Chiaki;
Tanaka, Hiroaki;
Takeuchi, Masahiro;
Yui, Makiko;
Saraya, Atsunori;
Miyagi, Satoru;
Wang, Changshan;
Tanaka, Satomi;
Ohwada, Chikako;
Sakaida, Emiko;
Yamaguchi, Naoto;
Yokote, Koutaro;
Hennighausen, Lothar;
Iwama, Atsushi

Publication type:

Article