Works matching AU Hennighausen, Lothar

Results: 102

High-affinity binding site for a specific nuclear protein in the human IgM gene.

Published in:

Nature, 1985, p. 289, doi. 10.1038/314289a0

By:

Hennighausen, Lothar;
Siebenlist, Ulrich;
Danner, David;
Leder, Philip;
Rawlins, Dan;
Rosenfeld, Philip;
Kelly Jr, Thomas

Publication type:

Article

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02167-1

By:

Lee, Hye Kyung;
Jung, Olive;
Hennighausen, Lothar

Publication type:

Article

Mammary gland involution studies with cDNA microarrays.

Published in:

1999

By:

Gangi, Lisa;
Owens, Garrison;
Humphreys, Robin;
Hennighausen, Lothar;
Liu, Edison

Publication type:

Abstract

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

Published in:

Nature Genetics, 1999, v. 22, n. 1, p. 37, doi. 10.1038/8743

By:

Xu, Xiaoling;
Wagner, Kay-Uwe;
Larson, Denise;
Weaver, Zoë;
Li, Cuiling;
Ried, Thomas;
Hennighausen, Lothar;
Wynshaw-Boris, Anthony;
Deng, Chu-Xia

Publication type:

Article

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules.

Published in:

BMC Genomics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2164-14-4

By:

Kang, Keunsoo;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Published in:

Nature Immunology, 2013, v. 14, n. 4, p. 364, doi. 10.1038/ni.2541

By:

Bell, Bryan D;
Kitajima, Masayuki;
Larson, Ryan P;
Stoklasek, Thomas A;
Dang, Kristen;
Sakamoto, Kazuhito;
Wagner, Kay-Uwe;
Reizis, Boris;
Hennighausen, Lothar;
Ziegler, Steven F

Publication type:

Article

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Published in:

Nature Immunology, 2010, v. 11, n. 3, p. 257, doi. 10.1038/ni.1840

By:

Jung-Hyun Park;
Adoro, Stanley;
Guinter, Terry;
Erman, Batu;
Alag, Amala S.;
Catalfamo, Marta;
Kimura, Motoko Y.;
Yongzhi Cui;
Lucas, Philip J.;
Gress, Ronald E.;
Kubo, Masato;
Hennighausen, Lothar;
Feigenbaum, Lionel;
Singer, Alfred

Publication type:

Article

Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

Published in:

Nature Immunology, 2009, v. 10, n. 2, p. 149, doi. 10.1038/ni.1695

By:

Guimond, Martin;
Veenstra, Rachelle G;
Grindler, David J;
Zhang, Hua;
Cui, Yongzhi;
Murphy, Ryan D;
Kim, Su Young;
Na, Risu;
Hennighausen, Lothar;
Kurtulus, Sema;
Erman, Batu;
Matzinger, Polly;
Merchant, Melinda S;
Mackall, Crystal L

Publication type:

Article

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system.

Published in:

Nature Immunology, 2006, v. 7, n. 9, p. 937, doi. 10.1038/ni1376

By:

Stumhofer, Jason S;
Laurence, Arian;
Wilson, Emma H;
Huang, Elaine;
Tato, Cristina M;
Johnson, Leanne M;
Villarino, Alejandro V;
Qiulong Huang;
Yoshimura, Akihiko;
Sehy, David;
Saris, Christiaan J M;
O'Shea, John J;
Hennighausen, Lothar;
Ernst, Matthias;
Hunter, Christopher A

Publication type:

Article

Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06752-0

By:

Lee, Hye Kyung;
Knabl, Ludwig;
Knabl Sr., Ludwig;
Wieser, Manuel;
Mur, Anna;
Zabernigg, August;
Schumacher, Jana;
Kapferer, Sebastian;
Kaiser, Norbert;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.

Published in:

Carcinogenesis, 2015, v. 36, n. 1, p. 122, doi. 10.1093/carcin/bgu237

By:

Dabydeen, Sarah A.;
Kang, Keunsoo;
Díaz-Cruz, Edgar S.;
Alamri, Ahmad;
Axelrod, Margaret L.;
Bouker, Kerrie B.;
Al-Kharboosh, Rawan;
Clarke, Robert;
Hennighausen, Lothar;
Furth, Priscilla A.

Publication type:

Article

The versatile regulation of cellular events by Jak-Stat signaling: from transcriptional control to microtubule dynamics and energy metabolism.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2012, v. 10, n. 1, p. 193, doi. 10.1515/hmbci-2012-0010

By:

Groner, Bernd;
Hennighausen, Lothar

Publication type:

Article

Genomic and bioinformatics tools to understand the biology of signal transducers and activators of transcription.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2012, v. 10, n. 1, p. 207, doi. 10.1515/hmbci-2012-0012

By:

Kang, Keunsoo;
Hennighausen, Lothar

Publication type:

Article

Cytokine receptors and their Stat-mediated mechanisms of action.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2012, v. 10, n. 1, p. 191, doi. 10.1515/hmbci-2012-0017

By:

Groner, Bernd;
Hennighausen, Lothar

Publication type:

Article

MiR-21 Is under Control of STAT5 but Is Dispensable for Mammary Development and Lactation.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085123

By:

Feuermann, Yonatan;
Kang, Keunsoo;
Shamay, Avi;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

Genetic Ablation of Bcl-x Attenuates Invasiveness without Affecting Apoptosis or Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Cancer.

Published in:

PLoS ONE, 2009, v. 4, n. 2, p. 1, doi. 10.1371/journal.pone.0004455

By:

Hager, Jeffrey H.;
Ulanet, Danielle B.;
Hennighausen, Lothar;
Hanahan, Douglas

Publication type:

Article

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity.

Published in:

PLoS ONE, 2008, v. 3, n. 2, p. 1, doi. 10.1371/journal.pone.0001639

By:

Ji-Yeon Lee;
Muenzberg, Heike;
Gavrilova, Oksana;
Reed, Jacquelyn A.;
Berryman, Darlene;
Villanueva, Eneida C.;
Louis, Gwendolyn W.;
Leinninger, Gina M.;
Bertuzzi, Stefano;
Seeley, Randy J.;
Robinson, Gertraud W.;
Myers Jr., Martin G.;
Hennighausen, Lothar

Publication type:

Article

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.

Published in:

FASEB Journal, 2015, v. 29, n. 5, p. 1653, doi. 10.1096/fj.14-261537

By:

Woo Kyun Bae;
Keunsoo Kang;
Ji Hoon Yu;
Kyung Hyun Yoo;
Factor, Valentina M.;
Kosuke Kaji;
Matter, Matthias;
Thorgeirsson, Snorri;
Hennighausen, Lothar

Publication type:

Article

Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor.

Published in:

FASEB Journal, 2009, v. 23, n. 9, p. 3140, doi. 10.1096/fj.08-128215

By:

Klover, Peter;
Chen, Weiping;
Bing-Mei Zhu;
Hennighausen, Lothar

Publication type:

Article

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.

Published in:

PLoS Genetics, 2020, v. 16, n. 5, p. 1, doi. 10.1371/journal.pgen.1008796

By:

Lau-Corona, Dana;
Bae, Woo Kyun;
Hennighausen, Lothar;
Waxman, David J.

Publication type:

Article

GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

Published in:

Biological Chemistry, 2005, v. 386, n. 9, p. 845, doi. 10.1515/BC.2005.099

By:

Hart, Stefan;
Fischer, Oliver M.;
Prenzel, Norbert;
Zwick-Wallasch, Esther;
Schneider, Matthias;
Hennighausen, Lothar;
Ullrich, Axel

Publication type:

Article

Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression.

Published in:

Hepatology Research, 2017, v. 47, n. 8, p. 813, doi. 10.1111/hepr.12816

By:

Hosui, Atsushi;
Tatsumi, Tomohide;
Hikita, Hayato;
Saito, Yoshinobu;
Hiramatsu, Naoki;
Tsujii, Masahiko;
Hennighausen, Lothar;
Takehara, Tetsuo

Publication type:

Article

The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice.

Published in:

2009

By:

Iwasawa, Mitsuyasu;
Miyazaki, Tsuyoshi;
Nagase, Yuichi;
Akiyama, Toru;
Kadono, Vuho;
Nakamura, Masaki;
Oshima, Yasushi;
Yasui, Tetsuro;
Matsumoto, Takumi;
Nakamura, Takashi;
Kato, Shigeaki;
Hennighausen, Lothar;
Nakamura, Kozo;
Tanaka, Sakae;
Kadono, Yuho

Publication type:

journal article

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

Published in:

2008

By:

Liu, Fulu;
Kunter, Ghada;
Krem, Maxwell M;
Eades, William C;
Cain, Jennifer A;
Tomasson, Michael H;
Hennighausen, Lothar;
Link, Daniel C

Publication type:

journal article

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

Published in:

Journal of Clinical Investigation, 2008, v. 118, n. 3, p. 946

By:

Fulu Liu;
Kunter, Ghada;
Krem, Maxwell M.;
Eades, William C.;
Cain, Jennifer A.;
Tomasson, Michael H.;
Hennighausen, Lothar;
Link, Daniel C.

Publication type:

Article

Severe position effects imposed on a 1 kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions.

Published in:

Molecular Reproduction & Development, 1996, v. 44, n. 2, p. 179, doi. 10.1002/(SICI)1098-2795(199606)44:2<179::AID-MRD6>3.0.CO;2-K

By:

McKnight, Robert A.;
Spencer, Mark;
Wall, Robert J.;
Hennighausen, Lothar

Publication type:

Article

Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system.

Published in:

Journal of Cellular Biochemistry, 1995, v. 59, n. 4, p. 463, doi. 10.1002/jcb.240590407

By:

Hennighausen, Lothar;
Wall, Robert J.;
Tillmann, Urich;
Li, Minglin;
Furth, Priscilla A.

Publication type:

Article

The prospects for domesticating milk protein genes.

Published in:

Journal of Cellular Biochemistry, 1992, v. 49, n. 4, p. 325, doi. 10.1002/jcb.240490402

By:

Hennighausen, Lothar

Publication type:

Article

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.

Published in:

Life Science Alliance, 2025, v. 8, n. 7, p. 1, doi. 10.26508/lsa.202503222

By:

Hye Kyung Lee;
Jichun Chen;
Philips, Rachael L.;
Sung-Gwon Lee;
Xingmin Feng;
Zhijie Wu;
Chengyu Liu;
Schultz, Aaron B.;
Dalzell, Molly;
Meggendorfer, Manja;
Haferlach, Claudia;
Birnbaum, Foster;
Sexton, Joel A.;
Keating, Amy E.;
O'Shea, John J.;
Young, Neal S.;
Villarino, Alejandro V.;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06855-6

By:

Jankowski, Jakub;
Lee, Hye Kyung;
Liu, Chengyu;
Wilflingseder, Julia;
Hennighausen, Lothar

Publication type:

Article

STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis.

Published in:

Scientific Reports, 2016, p. 30977, doi. 10.1038/srep30977

By:

Lee, Jongwon;
Seong, Semun;
Kim, Jung Ha;
Kim, Kabsun;
Kim, Inyoung;
Jeong, Byung-chul;
Nam, Kwang-Il;
Kim, Kyung Keun;
Hennighausen, Lothar;
Kim, Nacksung

Publication type:

Article

Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet.

Published in:

European Journal of Nutrition, 2017, v. 56, n. 2, p. 569, doi. 10.1007/s00394-015-1101-0

By:

Baik, Myunggi;
Lee, Mi;
Kang, Hyeok;
Park, Seung;
Piao, Min;
Nguyen, Trang;
Hennighausen, Lothar

Publication type:

Article

Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression.

Published in:

International Journal of Cancer, 2012, v. 131, n. 12, p. 2774, doi. 10.1002/ijc.27580

By:

Hosui, Atsushi;
Klover, Peter;
Tatsumi, Tomohide;
Uemura, Akio;
Nagano, Hiroaki;
Doki, Yuichiro;
Mori, Masaki;
Hiramatsu, Naoki;
Kanto, Tatsuya;
Hennighausen, Lothar;
Hayashi, Norio;
Takehara, Tetsuo

Publication type:

Article

Targeting fidelity of adenine and cytosine base editors in mouse embryos.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07322-7

By:

Lee, Hye Kyung;
Willi, Michaela;
Miller, Shannon M.;
Kim, Sojung;
Liu, Chengyu;
Liu, David R.;
Hennighausen, Lothar

Publication type:

Article

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

Published in:

PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0181948

By:

Fu, Shu-Ping;
Hong, Hao;
Lu, Sheng-Feng;
Hu, Chen-Jun;
Xu, Hou-Xi;
Li, Qian;
Yu, Mei-Ling;
Ou, Chen;
Meng, Jian-Zhong;
Wang, Tian-Lin;
Hennighausen, Lothar;
Zhu, Bing-Mei

Publication type:

Article

The right time and place for molecular scissors.

Published in:

Nature Biotechnology, 1999, v. 17, n. 11, p. 1062, doi. 10.1038/15046

By:

Hennighausen, Lothar;
Furth, Priscilla A.

Publication type:

Article

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice.

Published in:

Nature Biotechnology, 1999, v. 17, n. 2, p. 165, doi. 10.1038/6165

By:

Redfern, Charles H.;
Coward, Peter;
Degtyarev, Michael Y.;
Lee, Elena K.;
Kwa, Andrew T.;
Hennighausen, Lothar;
Bujard, Hermann;
Fishman, Glenn I.;
Conklin, Bruce R.

Publication type:

Article

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy.

Published in:

Experimental & Molecular Medicine EMM, 2020, v. 52, n. 4, p. 682, doi. 10.1038/s12276-020-0425-x

By:

Zeng, Xianke;
Lee, Hye Kyung;
Wang, Chaochen;
Achikeh, Precious;
Liu, Chengyu;
Hennighausen, Lothar

Publication type:

Article

Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 16, p. 2108, doi. 10.1128/MCB.00089-16

By:

Kyung Hyun Yoo;
Sumin Oh;
Keunsoo Kang;
Chaochen Wang;
Robinson, Gertraud W.;
Kai Ge;
Hennighausen, Lothar

Publication type:

Article

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 11, p. 1673, doi. 10.1128/MCB.00999-15

By:

Sakamoto, Kazuhito;
Wehde, Barbara L.;
Kyung Hyun Yoo;
Taemook Kim;
Rajbhandari, Nirakar;
Ha Youn Shin;
Triplett, Aleata A.;
Rädler, Patrick D.;
Schuler, Fabian;
Villunger, Andreas;
Keunsoo Kang;
Hennighausen, Lothar;
Wagner, Kay-Uwe

Publication type:

Article

Mammary-Specific Gene Activation Is Defined by Progressive Recruitment of STAT5 during Pregnancy and the Establishment of H3K4me3 Marks.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 3, p. 464, doi. 10.1128/MCB.00988-13

By:

Keunsoo Kang;
Daisuke Yamaji;
Kyung Hyun Yoo;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing.

Published in:

Journal of Mammary Gland Biology & Neoplasia, 2019, v. 24, n. 1, p. 47, doi. 10.1007/s10911-018-9417-z

By:

Yoo, Kyung Hyun;
Hennighausen, Lothar;
Shin, Ha Youn

Publication type:

Article

STAT5-Driven Enhancers Tightly Control Temporal Expression of Mammary-Specific Genes.

Published in:

Journal of Mammary Gland Biology & Neoplasia, 2019, v. 24, n. 1, p. 61, doi. 10.1007/s10911-018-9418-y

By:

Shin, Ha Youn;
Hennighausen, Lothar;
Yoo, Kyung Hyun

Publication type:

Article

circRNA-sponging: a pipeline for extensive analysis of circRNA expression and their role in miRNA sponging.

Published in:

Bioinformatics Advances, 2023, v. 3, n. 1, p. 1, doi. 10.1093/bioadv/vbad093

By:

Hoffmann, Markus;
Schwartz, Leon;
Ciora, Octavia-Andreea;
Trummer, Nico;
Willruth, Lina-Liv;
Jankowski, Jakub;
Lee, Hye Kyung;
Baumbach, Jan;
Furth, Priscilla A;
Hennighausen, Lothar;
List, Markus

Publication type:

Article

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83110-6

By:

Lee, Hye Kyung;
Knabl, Ludwig;
Pipperger, Lisa;
Volland, Andre;
Furth, Priscilla A.;
Kang, Keunsoo;
Smith, Harold E.;
Bellmann, Romuald;
Bernhard, Christina;
Kaiser, Norbert;
Gänzer, Hannes;
Ströhle, Mathias;
Walser, Andreas;
von Laer, Dorothee;
Hennighausen, Lothar

Publication type:

Article

Activation of b-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

Published in:

Oncogene, 2003, v. 22, n. 25, p. 3875, doi. 10.1038/sj.onc.1206426

By:

Bierie, Brian;
Nozawa, Masahiro;
Renou, Jean-Pierre;
Shillingford, Jonathan M;
Morgan, Fanta;
Oka, Takami;
Taketo, Makoto M;
Cardiff, Robert D;
Miyoshi, Keiko;
Wagner, Kay-Uwe;
Robinson, Gertraud W;
Hennighausen, Lothar

Publication type:

Article

Activation of different Wnt/β-catenin signaling components in mammary epitelium induces transdifferentiation and the formation of pilar tumors.

Published in:

Oncogene, 2002, v. 21, n. 36, p. 5548, doi. 10.1038/sj.onc.1205686

By:

Miyoshi, Keiko;
Rosner, Andrea;
Nozawa, Masahiro;
Byrd, Christopher;
Morgan, Fanta;
Landesman-Bollag, Esther;
Xin Xu;
Seldin, David C.;
Schmidt, Emmett V.;
Taketo, Makato M.;
Robinson, Gertraud W.;
Cardiff, Robert D.;
Hennighausen, Lothar

Publication type:

Article

Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene.

Published in:

Oncogene, 2001, v. 20, n. 48, p. 7115, doi. 10.1038/sj.onc.1204888

By:

Robinson, Gertraud W;
Wagner, Kay-Uwe;
Hennighausen, Lothar

Publication type:

Article

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting‡.

Published in:

Oncogene, 2000, v. 19, n. 8, p. 968, doi. 10.1038/sj.onc.1203277

By:

Cardiff, Robert D;
Anver, Miriam R;
Gusterson, Barry A;
Hennighausen, Lothar;
Jensen, Roy A;
Merino, Maria J;
Rehm, Sabine;
Russo, Jose;
Tavassoli, Fattaneh A;
Wakefield, Lalage M;
Ward, Jerrold M;
Green, Jeffrey E

Publication type:

Article

Transforming growth factor alpha and mouse models of human breast cancer.

Published in:

Oncogene, 2000, v. 19, n. 8, p. 1085, doi. 10.1038/sj.onc.1203278

By:

Humphreys, Robin C;
Hennighausen, Lothar

Publication type:

Article