Works by Helmchen, Fritjof

Results: 77

Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.93804

By:

Masala, Nicola;
Mittag, Manuel;
Giovannetti, Eleonora Ambrad;
O'Neil, Darik A.;
Distler, Fabian J.;
Rupprecht, Peter;
Helmchen, Fritjof;
Yuste, Rafael;
Fuhrmann, Martin;
Beck, Heinz;
Wenzel, Michael;
Kelly, Tony

Publication type:

Article

History information emerges in the cortex during learning.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.83702

By:

Marmor, Odeya;
Pollak, Yael;
Doron, Chen;
Helmchen, Fritjof;
Gilad, Ariel

Publication type:

Article

HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53072-0

By:

Leblond, Anne-Laure;
Helmchen, Birgit;
Ankavay, Maliki;
Lenggenhager, Daniela;
Jetzer, Jasna;
Helmchen, Fritjof;
Yurtsever, Hueseyin;
Parrotta, Rossella;
Healy, Marc E.;
Pöschel, Amiskwia;
Markkanen, Enni;
Semmo, Nasser;
Ferrié, Martin;
Cocquerel, Laurence;
Seeger, Harald;
Hopfer, Helmut;
Müllhaupt, Beat;
Gouttenoire, Jérôme;
Moradpour, Darius;
Gaspert, Ariana

Publication type:

Article

HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53072-0

By:

Leblond, Anne-Laure;
Helmchen, Birgit;
Ankavay, Maliki;
Lenggenhager, Daniela;
Jetzer, Jasna;
Helmchen, Fritjof;
Yurtsever, Hueseyin;
Parrotta, Rossella;
Healy, Marc E.;
Pöschel, Amiskwia;
Markkanen, Enni;
Semmo, Nasser;
Ferrié, Martin;
Cocquerel, Laurence;
Seeger, Harald;
Hopfer, Helmut;
Müllhaupt, Beat;
Gouttenoire, Jérôme;
Moradpour, Darius;
Gaspert, Ariana

Publication type:

Article

Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50658-6

By:

Damilou, Angeliki;
Cai, Linbi;
Argunşah, Ali Özgür;
Han, Shuting;
Kanatouris, George;
Karatsoli, Maria;
Hanley, Olivia;
Gesuita, Lorenzo;
Kollmorgen, Sepp;
Helmchen, Fritjof;
Karayannis, Theofanis

Publication type:

Article

Months-long tracking of neuronal ensembles spanning multiple brain areas with Ultra-Flexible Tentacle Electrodes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49226-9

By:

Yasar, Tansel Baran;
Gombkoto, Peter;
Vyssotski, Alexei L.;
Vavladeli, Angeliki D.;
Lewis, Christopher M.;
Wu, Bifeng;
Meienberg, Linus;
Lundegardh, Valter;
Helmchen, Fritjof;
von der Behrens, Wolfger;
Yanik, Mehmet Fatih

Publication type:

Article

Functional Architecture and Encoding of Tactile Sensorimotor Behavior in Rat Posterior Parietal Cortex.

Published in:

Journal of Neuroscience, 2019, v. 39, n. 37, p. 7332, doi. 10.1523/JNEUROSCI.0693-19.2019

By:

Mohan, Hemanth;
Haan, Roelde;
Broersen, Robin;
Pieneman, Anton W.;
Helmchen, Fritjof;
Staiger, Jochen F.;
Mansvelder, Huibert D.;
de Kock, Christiaan P. J.

Publication type:

Article

Functional Imaging of Dentate Granule Cells in the Adult Mouse Hippocampus.

Published in:

Journal of Neuroscience, 2016, v. 38, n. 28, p. 7407, doi. 10.1523/JNEUROSCI.3065-15.2016

By:

Pilz, Gregor-Alexander;
Carta, Stefano;
Stauble, Andreas;
Ayaz, Asll;
Jessberger, Sebastian;
Helmchen, Fritjof

Publication type:

Article

Specific Early and Late Oddball-Evoked Responses in Excitatory and Inhibitory Neurons of Mouse Auditory Cortex.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 36, p. 12560, doi. 10.1523/JNEUROSCI.2240-15.2015

By:

I-Wen Chen;
Helmchen, Fritjof;
Lütcke, Henry

Publication type:

Article

Spatial Organization of Neuronal Population Responses in Layer 2/3 of Rat Barrel Cortex.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 48, p. 13316, doi. 10.1523/JNEUROSCI.2210-07.2007

By:

Kerr, Jason N. D.;
De Kock, Christiaan P. J.;
Greenberg, David S.;
Bruno, Randy M.;
Sakmann, Bert;
Helmchen, Fritjof

Publication type:

Article

Dendritic Spikes in Apical Dendrites of Neocortical Layer 2/3 Pyramidal Neurons.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 34, p. 8999, doi. 10.1523/JNEUROSCI.1717-07.2007

By:

Larkum, Matthew Evan;
Waters, Jack;
Sakmann, Bert;
Helmchen, Fritjof

Publication type:

Article

Background Synaptic Activity Is Sparse in Neocortex.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 32, p. 8267, doi. 10.1523/JNEUROSCI.2152-06.2006

By:

Waters, Jack;
Helmchen, Fritjof

Publication type:

Article

Boosting of Action Potential Backpropagation by Neocortical Network Activity In Vivo.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 49, p. 11127, doi. 10.1523/JNEUROSCI.2933-04.2004

By:

Waters, Jack;
Helmchen, Fritjof

Publication type:

Article

Novel Approaches to Monitor and Manipulate Single Neurons In Vivo.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 42, p. 9223, doi. 10.1523/JNEUROSCI.3344-04.2004

By:

Brecht, Michael;
Fee, Michale S.;
Garaschuk, Olga;
Helmchen, Fritjof;
Osten, Pavel;
Margrie, Troy W.;
Svoboda, Karel

Publication type:

Article

Supralinear Ca2+ Influx into Dendritic Tuffs of Layer 2/3 Neocortical Pyramidal Neurons In Vitro and In Vivo.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 24, p. 8558, doi. 10.1523/JNEUROSCI.23-24-08558.2003

By:

Waters, Jack;
Larkum, Matthew;
Sakmann, Bert;
Helmchen, Fritjof

Publication type:

Article

EXPLORE: a novel deep learning-based analysis method for exploration behaviour in object recognition tests.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-31094-w

By:

Ibañez, Victor;
Bohlen, Laurens;
Manuella, Francesca;
Mansuy, Isabelle;
Helmchen, Fritjof;
Wahl, Anna-Sophia

Publication type:

Article

Spike Rate Inference from Mouse Spinal Cord Calcium Imaging Data.

Published in:

Journal of Neuroscience, 2025, v. 45, n. 18, p. 1, doi. 10.1523/JNEUROSCI.1187-24.2025

By:

Rupprecht, Peter;
Wei Fan;
Sullivan, Steve J.;
Helmchen, Fritjof;
Sdrulla, Andrei D.

Publication type:

Article

Estimating anisotropy directly via neural timeseries.

Published in:

Journal of Computational Neuroscience, 2022, v. 50, n. 2, p. 241, doi. 10.1007/s10827-021-00810-8

By:

Fagerholm, Erik D.;
Foulkes, W. M. C.;
Gallero-Salas, Yasir;
Helmchen, Fritjof;
Moran, Rosalyn J.;
Friston, Karl J.;
Leech, Robert

Publication type:

Article

Whole-mouse clearing and imaging at the cellular level with vDISCO.

Published in:

Nature Protocols, 2023, v. 18, n. 4, p. 1197, doi. 10.1038/s41596-022-00788-2

By:

Cai, Ruiyao;
Kolabas, Zeynep Ilgin;
Pan, Chenchen;
Mai, Hongcheng;
Zhao, Shan;
Kaltenecker, Doris;
Voigt, Fabian F.;
Molbay, Muge;
Ohn, Tzu-lun;
Vincke, Cécile;
Todorov, Mihail I.;
Helmchen, Fritjof;
Van Ginderachter, Jo A.;
Ertürk, Ali

Publication type:

Article

Isotropic imaging across spatial scales with axially swept light-sheet microscopy.

Published in:

Nature Protocols, 2022, v. 17, n. 9, p. 2025, doi. 10.1038/s41596-022-00706-6

By:

Dean, Kevin M.;
Chakraborty, Tonmoy;
Daetwyler, Stephan;
Lin, Jinlong;
Garrelts, Gerard;
M'Saad, Ons;
Mekbib, Hannahmariam T.;
Voigt, Fabian F.;
Schaettin, Martina;
Stoeckli, Esther T.;
Helmchen, Fritjof;
Bewersdorf, Joerg;
Fiolka, Reto

Publication type:

Article

Fiber-optic implant for simultaneous fluorescence-based calcium recordings and BOLD fMRI in mice.

Published in:

Nature Protocols, 2018, v. 13, n. 5, p. 840, doi. 10.1038/nprot.2018.003

By:

Schlegel, Felix;
Sych, Yaroslav;
Schroeter, Aileen;
Stobart, Jillian;
Weber, Bruno;
Helmchen, Fritjof;
Rudin, Markus

Publication type:

Article

An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.

Published in:

PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0179460

By:

Bethge, Philipp;
Egolf, Ladan;
Chen, Jerry L.;
Carta, Stefano;
Lorenzo, Dayra A.;
Voigt, Fabian F.;
Helmchen, Fritjof;
Goniotaki, Despoina;
Aguzzi, Adriano;
Madisen, Linda;
Zeng, Hongkui;
Schneider, Bernard;
Ohkura, Masamichi;
Nakai, Junichi

Publication type:

Article

Distinct Functional Properties of Primary and Posteromedial Visual Area of Mouse Neocortex.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 28, p. 9716, doi. 10.1523/JNEUROSCI.0110-12.2012

By:

Roth, Morgane M.;
Helmchen, Fritjof;
Kampa, Björn M.

Publication type:

Article

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

Published in:

PLoS Pathogens, 2018, v. 14, n. 11, p. 1, doi. 10.1371/journal.ppat.1007424

By:

Keller, Annika;
Nuvolone, Mario;
Abakumova, Irina;
Chincisan, Andra;
Reimann, Regina;
Avar, Merve;
Heinzer, Daniel;
Hornemann, Simone;
Wagner, Josephin;
Kirschenbaum, Daniel;
Voigt, Fabian F.;
Zhu, Caihong;
Regli, Luca;
Helmchen, Fritjof;
Aguzzi, Adriano

Publication type:

Article

Pathway-specific reorganization of projection neurons in somatosensory cortex during learning.

Published in:

Nature Neuroscience, 2015, v. 18, n. 8, p. 1101, doi. 10.1038/nn.4046

By:

Chen, Jerry L;
Margolis, David J;
Stankov, Atanas;
Sumanovski, Lazar T;
Schneider, Bernard L;
Helmchen, Fritjof

Publication type:

Article

Tactile frequency discrimination is enhanced by circumventing neocortical adaptation.

Published in:

Nature Neuroscience, 2014, v. 17, n. 11, p. 1567, doi. 10.1038/nn.3821

By:

Musall, Simon;
von der Behrens, Wolfger;
Mayrhofer, Johannes M;
Weber, Bruno;
Helmchen, Fritjof;
Haiss, Florent

Publication type:

Article

Reorganization of cortical population activity imaged throughout long-term sensory deprivation.

Published in:

Nature Neuroscience, 2012, v. 15, n. 11, p. 1539, doi. 10.1038/nn.3240

By:

Margolis, David J;
Lütcke, Henry;
Schulz, Kristina;
Haiss, Florent;
Weber, Bruno;
Kügler, Sebastian;
Hasan, Mazahir T;
Helmchen, Fritjof

Publication type:

Article

Striatum-projecting prefrontal cortex neurons support working memory maintenance.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42777-3

By:

Wilhelm, Maria;
Sych, Yaroslav;
Fomins, Aleksejs;
Alatorre Warren, José Luis;
Lewis, Christopher;
Serratosa Capdevila, Laia;
Boehringer, Roman;
Amadei, Elizabeth A.;
Grewe, Benjamin;
O'Connor, Eoin C.;
Hall, Benjamin J.;
Helmchen, Fritjof

Publication type:

Article

Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies.

Published in:

EMBO Molecular Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.15252/emmm.202216789

By:

Kirschenbaum, Daniel;
Dadgar‐Kiani, Ehsan;
Catto, Francesca;
Voigt, Fabian F;
Trevisan, Chiara;
Bichsel, Oliver;
Shirani, Hamid;
Nilsson, K Peter R;
Frontzek, Karl J;
Paganetti, Paolo;
Helmchen, Fritjof;
Lee, Jin Hyung;
Aguzzi, Adriano

Publication type:

Article

Post hoc immunostaining of GABAergic neuronal subtypes following in vivo two-photon calcium imaging in mouse neocortex.

Published in:

Pflügers Archiv: European Journal of Physiology, 2012, v. 463, n. 2, p. 339, doi. 10.1007/s00424-011-1048-9

By:

Langer, Dominik;
Helmchen, Fritjof

Publication type:

Article

Calcium indicator loading of neurons using single-cell electroporation.

Published in:

Pflügers Archiv: European Journal of Physiology, 2007, v. 454, n. 4, p. 675, doi. 10.1007/s00424-007-0234-2

By:

Nevian, Thomas;
Helmchen, Fritjof

Publication type:

Article

Online correction of licking-induced brain motion during two-photon imaging with a tunable lens.

Published in:

Journal of Physiology, 2013, v. 591, n. 19, p. 4689, doi. 10.1113/jphysiol.2013.259804

By:

Chen, Jerry L.;
Pfäffli, Oliver A.;
Voigt, Fabian F.;
Margolis, David J.;
Helmchen, Fritjof

Publication type:

Article

Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator.

Published in:

Journal of Physiology, 2012, v. 590, n. 1, p. 99, doi. 10.1113/jphysiol.2011.219014

By:

Minderer, Matthias;
Liu, Wenrui;
Sumanovski, Lazar T.;
Kügler, Sebastian;
Helmchen, Fritjof;
Margolis, David J.

Publication type:

Article

In vivo Ca2+ imaging of dorsal horn neuronal populations in mouse spinal cord.

Published in:

Journal of Physiology, 2010, v. 588, n. 18, p. 3397, doi. 10.1113/jphysiol.2010.191833

By:

Johannssen, Helge C.;
Helmchen, Fritjof

Publication type:

Article

Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells.

Published in:

Nature Communications, 2016, v. 7, n. 11, p. 13480, doi. 10.1038/ncomms13480

By:

Brandalise, Federico;
Carta, Stefano;
Helmchen, Fritjof;
Lisman, John;
Gerber, Urs

Publication type:

Article

Basomedial amygdala activity in mice reflects specific and general aversion uncontrollability.

Published in:

European Journal of Neuroscience, 2022, v. 55, n. 9/10, p. 2435, doi. 10.1111/ejn.15090

By:

Ineichen, Christian;
Greter, Alexandra;
Baer, Mischa;
Sigrist, Hannes;
Sautter, Eva;
Sych, Yaroslav;
Helmchen, Fritjof;
Pryce, Christopher R.

Publication type:

Article

Temporal refinement of sensory‐evoked activity across layers in developing mouse barrel cortex.

Published in:

European Journal of Neuroscience, 2019, v. 50, n. 6, p. 2955, doi. 10.1111/ejn.14413

By:

van der Bourg, Alexander;
Yang, Jenq‐Wei;
Stüttgen, Maik C.;
Reyes‐Puerta, Vicente;
Helmchen, Fritjof;
Luhmann, Heiko J.

Publication type:

Article

Neural Systems Under Change of Scale.

Published in:

Frontiers in Computational Neuroscience, 2021, v. 15, p. N.PAG, doi. 10.3389/fncom.2021.643148

By:

Fagerholm, Erik D.;
Foulkes, W. M. C.;
Gallero-Salas, Yasir;
Helmchen, Fritjof;
Friston, Karl J.;
Leech, Robert;
Moran, Rosalyn J.

Publication type:

Article

Tissue Clearing and Light Sheet Microscopy: Imaging the Unsectioned Adult Zebra Finch Brain at Cellular Resolution.

Published in:

Frontiers in Neuroanatomy, 2019, p. N.PAG, doi. 10.3389/fnana.2019.00013

By:

Rocha, Mariana Diales;
Düring, Daniel Normen;
Bethge, Philipp;
Voigt, Fabian F.;
Hildebrand, Staffan;
Helmchen, Fritjof;
Pfeifer, Alexander;
Hahnloser, Richard Hans Robert;
Gahr, Manfred

Publication type:

Article

iDISCO+ for the Study of Neuroimmune Architecture of the Rat Auditory Brainstem.

Published in:

Frontiers in Neuroanatomy, 2019, p. N.PAG, doi. 10.3389/fnana.2019.00015

By:

Perin, Paola;
Voigt, Fabian F.;
Bethge, Philipp;
Helmchen, Fritjof;
Pizzala, Roberto

Publication type:

Article

Neuronale Netzwerke im Rampenlicht: Mit leuchtenden Proteinen zelluläre Aktivitätsmuster entschlüsseln.

Published in:

Neuroforum, 2013, v. 19, n. 2, p. 47, doi. 10.1515/nf-2013-0203

By:

Helmchen, Fritjof;
Hübener, Mark

Publication type:

Article

Optische Messung neuronaler Netzwerkdynamik in 3D.

Published in:

Neuroforum, 2008, v. 14, n. 2, p. 184, doi. 10.1515/nf-2008-0202

By:

Göbel, Werner;
Helmchen, Fritjof

Publication type:

Article

Model-based analysis of pattern motion processing in mouse primary visual cortex.

Published in:

Frontiers in Neural Circuits, 2015, v. 9, p. 1, doi. 10.3389/fncir.2015.00038

By:

Muir, Dylan R.;
Roth, Morgane M.;
Helmchen, Fritjof;
Kampa, Björn M.

Publication type:

Article

Inference of neuronal network spike dynamics and topology from calcium imaging data.

Published in:

Frontiers in Neural Circuits, 2013, v. 7, p. 1, doi. 10.3389/fncir.2013.00201

By:

Lütcke, Henry;
Gerhard, Felipe;
Zenke, Friedemann;
Gerstner, Wulfram;
Helmchen, Fritjof

Publication type:

Article

Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response.

Published in:

2019

By:

Zarb, Yvette;
Weber-Stadlbauer, Ulrike;
Kirschenbaum, Daniel;
Kindler, Diana Rita;
Richetto, Juliet;
Keller, Daniel;
Rademakers, Rosa;
Dickson, Dennis W;
Pasch, Andreas;
Byzova, Tatiana;
Nahar, Khayrun;
Voigt, Fabian F;
Helmchen, Fritjof;
Boss, Andreas;
Aguzzi, Adriano;
Klohs, Jan;
Keller, Annika

Publication type:

journal article

Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex.

Published in:

Nature Methods, 2012, v. 9, n. 6, p. 597, doi. 10.1038/nmeth.2013

By:

Schulz, Kristina;
Sydekum, Esther;
Krueppel, Roland;
Engelbrecht, Christoph J;
Schlegel, Felix;
Schröter, Aileen;
Rudin, Markus;
Helmchen, Fritjof

Publication type:

Article

High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision.

Published in:

2010

By:

Grewe, Benjamin F;
Langer, Dominik;
Kasper, Hansjörg;
Kampa, Björn M;
Helmchen, Fritjof

Publication type:

Correction Notice

High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision.

Published in:

Nature Methods, 2010, v. 7, n. 5, p. 399, doi. 10.1038/nmeth.1453

By:

Grewe, Benjamin F.;
Langer, Dominik;
Kasper, Hansjörg;
Kampa, Björn M.;
Helmchen, Fritjof

Publication type:

Article

New views into the brain of mice on the move.

Published in:

Nature Methods, 2008, v. 5, n. 11, p. 925, doi. 10.1038/nmeth1108-925

By:

Helmchen, Fritjof;
Petersen, Carl C. H.

Publication type:

Article

Imaging cellular network dynamics in three dimensions using fast 3D laser scanning.

Published in:

Nature Methods, 2007, v. 4, n. 1, p. 73, doi. 10.1038/nmeth989

By:

Göbel, Werner;
Kampa, Björn M.;
Helmchen, Fritjof

Publication type:

Article