Works by Hellman, Lars

Results: 94

KRAB Zinc Finger Proteins: An Analysis of the Molecular Mechanisms Governing Their Increase in Numbers and Complexity During Evolution.

Published in:

Molecular Biology & Evolution, 2002, v. 19, n. 12, p. 2118, doi. 10.1093/oxfordjournals.molbev.a004037

By:

Looman, Camilla;
Åbrink, Magnus;
Mark, Charlotta;
Hellman, Lars

Publication type:

Article

House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model.

Published in:

Journal of Immunology Research, 2023, p. 1, doi. 10.1155/2023/9393497

By:

Ramos-Ramírez, Patricia;
Liu, Jielu;
Mogren, Sofia;
Gregory, Joshua;
Noreby, Malin;
Petrén, Anne;
Lei, Ying;
Olsson, Henric;
van Hage, Marianne;
Kervinen, Jukka;
Hellman, Lars;
Andersson, Cecilia;
Nilsson, Gunnar;
Adner, Mikael

Publication type:

Article

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1211295

By:

Aybay, Erdem;
Jinhye Ryu;
Zhirong Fu;
Akula, Srinivas;
Enriquez, Erika Mendez;
Hallgren, Jenny;
Wernersson, Sara;
Olsson, Anna-Karin;
Hellman, Lars

Publication type:

Article

Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Published in:

Pigment Cell & Melanoma Research, 2020, v. 33, n. 4, p. 579, doi. 10.1111/pcmr.12859

By:

Grujic, Mirjana;
Hellman, Lars;
Gustafson, Ann‐Marie;
Akula, Srinivas;
Melo, Fabio Rabelo;
Pejler, Gunnar

Publication type:

Article

Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation.

Published in:

Inflammation, 2024, v. 47, n. 5, p. 1820, doi. 10.1007/s10753-024-02011-8

By:

Grujic, Mirjana;
Alim, Md Abdul;
Hellman, Lars;
Peterson, Magnus;
Pejler, Gunnar

Publication type:

Article

Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology.

Published in:

Cells (2073-4409), 2024, v. 13, n. 1, p. 98, doi. 10.3390/cells13010098

By:

Akula, Srinivas;
Tripathi, Shiva Raj;
Franke, Kristin;
Wernersson, Sara;
Babina, Magda;
Hellman, Lars

Publication type:

Article

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells.

Published in:

Cells (2073-4409), 2020, v. 9, n. 9, p. 2118, doi. 10.3390/cells9092118

By:

Akula, Srinivas;
Paivandy, Aida;
Fu, Zhirong;
Thorpe, Michael;
Pejler, Gunnar;
Hellman, Lars

Publication type:

Article

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity.

Published in:

Cells (2073-4409), 2020, v. 9, n. 1, p. 1, doi. 10.3390/cells9010211

By:

Akula, Srinivas;
Paivandy, Aida;
Zhirong Fu;
Thorpe, Michael;
Pejler, Gunnar;
Hellman, Lars

Publication type:

Article

MZF6D, a Novel KRAB Zinc-Finger Gene Expressed Exclusively in Meiotic Male Germ Cells.

Published in:

DNA & Cell Biology, 2003, v. 22, n. 8, p. 489, doi. 10.1089/10445490360708892

By:

Looman, Camilla;
Mark, Charlotta;
Abrink, Magnus;
Hellman, Lars

Publication type:

Article

Molecular Cloning and Preliminary Functional Analysis of Two Novel Human KRAB Zinc Finger Proteins, HKr18 and HKr19.

Published in:

DNA & Cell Biology, 2001, v. 20, n. 5, p. 275, doi. 10.1089/104454901750232472

By:

Mark, Charlotta;
Looman, Camilla;
Åbrink, Magnus;
Hellman, Lars

Publication type:

Article

Comparative Analysis of KRAB Zinc Finger Proteins in Rodents and Man: Evidence for Several Evolutionarily Distinct Subfamilies of KRAB Zinc Finger Genes.

Published in:

DNA & Cell Biology, 1999, v. 18, n. 5, p. 381, doi. 10.1089/104454999315277

By:

Mark, Charlotta;
Abrink, Magnus;
Hellman, Lars

Publication type:

Article

Demethylation of ERV3, an Endogenous Retrovirus Regulating the Krüppel-Related Zinc Finger Gene H-plk, in Several Human Cell Lines Arrested During Early Monocyte Development.

Published in:

DNA & Cell Biology, 1998, v. 17, n. 1, p. 27, doi. 10.1089/dna.1998.17.27

By:

ÅBRINK, MAGNUS;
LARSSON, ERIK;
HELLMAN, LARS

Publication type:

Article

Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates.

Published in:

FEBS Journal, 2011, v. 278, n. 15, p. 2635, doi. 10.1111/j.1742-4658.2011.08189.x

By:

Korkmaz, Brice;
Jégot, Gwenhael;
Lau, Laurie C.;
Thorpe, Michael;
Pitois, Elodie;
Juliano, Luiz;
Walls, Andrew F.;
Hellman, Lars;
Gauthier, Francis

Publication type:

Article

Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2′ of substrates.

Published in:

FEBS Journal, 2010, v. 277, n. 10, p. 2255, doi. 10.1111/j.1742-4658.2010.07642.x

By:

Andersson, Mattias K.;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins.

Published in:

Biological Chemistry, 2021, v. 402, n. 7, p. 861, doi. 10.1515/hsz-2020-0386

By:

Fu, Zhirong;
Akula, Srinivas;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution.

Published in:

Biological Chemistry, 2014, v. 395, n. 1, p. 15, doi. 10.1515/hsz-2013-0211

By:

Hellman, Lars;
Thorpe, Michael

Publication type:

Article

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.

Published in:

Biological Chemistry, 2012, v. 393, n. 12, p. 1555, doi. 10.1515/hsz-2012-0189

By:

Waern, Ida;
Karlsson, Iulia;
Thorpe, Michael;
Schlenner, Susan M.;
Feyerabend, Thorsten B.;
Rodewald, Hans-Reimer;
Åbrink, Magnus;
Hellman, Lars;
Pejler, Gunnar;
Wernersson, Sara

Publication type:

Article

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02387

By:

Fu, Zhirong;
Thorpe, Michael;
Akula, Srinivas;
Chahal, Gurdeep;
Hellman, Lars T.

Publication type:

Article

Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01749

By:

Hellman, Lars Torkel;
Akula, Srinivas;
Thorpe, Michael;
Zhirong Fu

Publication type:

Article

Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase.

Published in:

International Immunology, 2012, v. 24, n. 12, p. 771, doi. 10.1093/intimm/dxs081

By:

Thorpe, Michael;
Yu, Jing;
Boinapally, Vamsi;
Ahooghalandari, Parvin;
Kervinen, Jukka;
Garavilla, Lawrence de;
Hellman, Lars

Publication type:

Article

Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution.

Published in:

PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0154886

By:

Fu, Zhirong;
Thorpe, Michael;
Akula, Srinivas;
Hellman, Lars

Publication type:

Article

Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus).

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 3, p. 1669, doi. 10.3390/ijms25031669

By:

Valentini, Paolo;
Akula, Srinivas;
Alvarado-Vazquez, Abigail;
Hallgren, Jenny;
Fu, Zhirong;
Racicot, Brett;
Braasch, Ingo;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 1, p. 356, doi. 10.3390/ijms25010356

By:

Thorpe, Michael;
Akula, Srinivas;
Fu, Zhirong;
Hellman, Lars

Publication type:

Article

Identification of the Major Protein Components of Human and Cow Saliva.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 23, p. 16838, doi. 10.3390/ijms242316838

By:

Akula, Srinivas;
Welinder, Charlotte;
Fu, Zhirong;
Olsson, Anna-Karin;
Hellman, Lars

Publication type:

Article

Phenotypic and Functional Heterogeneity of Monocytes and Macrophages.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14525, doi. 10.3390/ijms241914525

By:

Hellman, Lars

Publication type:

Article

Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 13976, doi. 10.3390/ijms232213976

By:

Akula, Srinivas;
Riihimäki, Miia;
Waern, Ida;
Åbrink, Magnus;
Raine, Amanda;
Hellman, Lars;
Wernersson, Sara

Publication type:

Article

Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines—THP-1 and Mono Mac 6—Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 10, p. 5818, doi. 10.3390/ijms23105818

By:

Akula, Srinivas;
Lara, Sandra;
Olsson, Anna-Karin;
Hellman, Lars

Publication type:

Article

The Human Monocyte—A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 7, p. 3890, doi. 10.3390/ijms23073890

By:

Lara, Sandra;
Akula, Srinivas;
Fu, Zhirong;
Olsson, Anna-Karin;
Kleinau, Sandra;
Hellman, Lars

Publication type:

Article

Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1185, doi. 10.3390/ijms23031185

By:

Paivandy, Aida;
Akula, Srinivas;
Lara, Sandra;
Fu, Zhirong;
Olsson, Anna-Karin;
Kleinau, Sandra;
Pejler, Gunnar;
Hellman, Lars

Publication type:

Article

Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 23, p. 12627, doi. 10.3390/ijms222312627

By:

Fu, Zhirong;
Akula, Srinivas;
Olsson, Anna-Karin;
Kervinen, Jukka;
Hellman, Lars

Publication type:

Article

The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 20, p. 10975, doi. 10.3390/ijms222010975

By:

Akula, Srinivas;
Fu, Zhirong;
Wernersson, Sara;
Hellman, Lars

Publication type:

Article

Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1658, doi. 10.3390/ijms22041658

By:

Weiss, Stefanie A. I.;
Rehm, Salome R. T.;
Perera, Natascha C.;
Biniossek, Martin L.;
Schilling, Oliver;
Jenne, Dieter E.;
Hellman, Lars

Publication type:

Article

Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8546, doi. 10.3390/ijms21228546

By:

Berglund, Petter;
Akula, Srinivas;
Fu, Zhirong;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 2, p. 1, doi. 10.3390/ijms21020651

By:

Zhirong Fu;
Akula, Srinivas;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 1, p. 319, doi. 10.3390/ijms21010319

By:

Fu, Zhirong;
Akula, Srinivas;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 24, p. 6340, doi. 10.3390/ijms20246340

By:

Zhongwei, Yuan;
Akula, Srinivas;
Fu, Zhirong;
de Garavilla, Lawrence;
Kervinen, Jukka;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 5147, doi. 10.3390/ijms20205147

By:

Fu, Zhirong;
Akula, Srinivas;
Thorpe, Michael;
Hellman, Lars

Publication type:

Article

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.

Published in:

Virulence, 2018, v. 9, n. 1, p. 879, doi. 10.1080/21505594.2018.1451284

By:

Liu, Jingyi;
Ma'ayeh, Showgy;
Peirasmaki, Dimitra;
Lundström-Stadelmann, Britta;
Hellman, Lars;
Svärd, Staffan G.

Publication type:

Article

Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities.

Published in:

PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0195077

By:

Thorpe, Michael;
Fu, Zhirong;
Chahal, Gurdeep;
Akula, Srinivas;
Kervinen, Jukka;
de Garavilla, Lawrence;
Hellman, Lars

Publication type:

Article

Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cells.

Published in:

British Journal of Haematology, 1989, v. 73, n. 3, p. 348, doi. 10.1111/j.1365-2141.1989.tb07751.x

By:

Hellman, Lars;
Smedsröd, Bård;
Sandberg, Helena;
Pettersson, Ulf

Publication type:

Article

Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)—A Marcus Wallenberg Symposium.

Published in:

Allergy, 2020, v. 75, n. 3, p. 707, doi. 10.1111/all.14065

By:

Hallgren, Jenny;
Hellman, Lars;
Maurer, Marcus;
Nilsson, Gunnar P.;
Wernersson, Sara;
Åbrink, Magnus;
Pejler, Gunnar

Publication type:

Article

Therapeutic vaccines against IgE-mediated allergies.

Published in:

Expert Review of Vaccines, 2008, v. 7, n. 2, p. 193, doi. 10.1586/14760584.7.2.193

By:

Hellman, Lars

Publication type:

Article

Correction to: Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden.

Published in:

2022

By:

Femel, Julia;
van Hooren, Luuk;
Herre, Melanie;
Cedervall, Jessica;
Saupe, Falk;
Huijbers, Elisabeth J. M.;
Verboogen, Danielle R. J.;
Reichel, Matthias;
Thijssen, Victor L.;
Griffioen, Arjan W.;
Hellman, Lars;
Dimberg, Anna;
Olsson, Anna-Karin

Publication type:

Correction Notice

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden.

Published in:

Cancer Immunology, Immunotherapy, 2022, v. 71, n. 8, p. 2029, doi. 10.1007/s00262-021-03139-4

By:

Femel, Julia;
van Hooren, Luuk;
Herre, Melanie;
Cedervall, Jessica;
Saupe, Falk;
Huijbers, Elisabeth J. M.;
Verboogen, Danielle R. J.;
Reichel, Matthias;
Thijssen, Victor L.;
Griffioen, Arjan W.;
Hellman, Lars;
Dimberg, Anna;
Olsson, Anna-Karin

Publication type:

Article

The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase.

Published in:

International Immunology, 2010, v. 22, n. 6, p. 421, doi. 10.1093/intimm/dxq021

By:

Gallwitz, Maike;
Enoksson, Mattias;
Thorpe, Michael;
Xueliang Ge;
Hellman, Lars

Publication type:

Article

The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.

Published in:

International Immunology, 2009, v. 21, n. 1, p. 95, doi. 10.1093/intimm/dxn128

By:

Mattias K. Andersson;
Mattias Enoksson;
Maike Gallwitz;
Lars Hellman

Publication type:

Article

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0207826

By:

Thorpe, Michael;
Fu, Zhirong;
Albat, Emanuelle;
Akula, Srinivas;
de Garavilla, Lawrence;
Kervinen, Jukka;
Hellman, Lars

Publication type:

Article

Expression of lactoferrin in the kidney: Implications for innate immunity and iron metabolism.

Published in:

Kidney International, 2000, v. 57, n. 5, p. 2004, doi. 10.1046/j.1523-1755.2000.00050.x

By:

Åbrink, Magnus;
Larsson, Eric;
Gobl, Anders;
Hellman, Lars

Publication type:

Article

Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43368-4

By:

Riihimäki, Miia;
Fegraeus, Kim;
Nordlund, Jessica;
Waern, Ida;
Wernersson, Sara;
Akula, Srinivas;
Hellman, Lars;
Raine, Amanda

Publication type:

Article

Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.582044

By:

Teufelberger, Andrea R.;
Van Nevel, Sharon;
Hulpiau, Paco;
Nordengrün, Maria;
Savvides, Savvas N.;
De Graeve, Sarah;
Akula, Srinivas;
Holtappels, Gabriele;
De Ruyck, Natalie;
Declercq, Wim;
Vandenabeele, Peter;
Hellman, Lars;
Bröker, Barbara M.;
Krysko, Dmitri V.;
Bachert, Claus;
Krysko, Olga

Publication type:

Article