Works by Heiser, Laura

Results: 37

Bayesian Inference of Signaling Network Topology in a Cancer Cell Line.

Published in:

Bioinformatics, 2012, v. 28, n. 21, p. 2804, doi. 10.1093/bioinformatics/bts514

By:

Hill, Steven M.;
Lu, Yiling;
Molina, Jennifer;
Heiser, Laura M.;
Spellman, Paul T.;
Speed, Terence P.;
Gray, Joe W.;
Mills, Gordon B.;
Mukherjee, Sach

Publication type:

Article

A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03218-x

By:

Ternes, Luke;
Dane, Mark;
Gross, Sean;
Labrie, Marilyne;
Mills, Gordon;
Gray, Joe;
Heiser, Laura;
Chang, Young Hwan

Publication type:

Article

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31138-1

By:

Erdem, Cemal;
Mutsuddy, Arnab;
Bensman, Ethan M.;
Dodd, William B.;
Saint-Antoine, Michael M.;
Bouhaddou, Mehdi;
Blake, Robert C.;
Gross, Sean M.;
Heiser, Laura M.;
Feltus, F. Alex;
Birtwistle, Marc R.

Publication type:

Article

Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133219

By:

Korkola, James E.;
Collisson, Eric A.;
Heiser, Laura;
Oates, Chris;
Bayani, Nora;
Itani, Sleiman;
Esch, Amanda;
Thompson, Wallace;
Griffith, Obi L.;
Wang, Nicholas J.;
Kuo, Wen-Lin;
Cooper, Brian;
Billig, Jessica;
Ziyad, Safiyyah;
Hung, Jenny L.;
Jakkula, Lakshmi;
Feiler, Heidi;
Lu, Yiling;
Mills, Gordon B.;
Spellman, Paul T.

Publication type:

Article

ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051786

By:

Ordinario, Ellen;
Han, Hye-Jung;
Furuta, Saori;
Heiser, Laura M.;
Jakkula, Lakshmi R.;
Rodier, Francis;
Spellman, Paul T.;
Campisi, Judith;
Gray, Joe W.;
Bissell, Mina J.;
Kohwi, Yoshinori;
Kohwi-Shigematsu, Terumi

Publication type:

Article

Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival.

Published in:

Journal of Neuroscience, 2024, v. 44, n. 16, p. 1, doi. 10.1523/JNEUROSCI.1600-23.2024

By:

Tuttle, Adam M.;
Miller, Lauren N.;
Royer, Lindsey J.;
Hua Wen;
Kelly, Jimmy J.;
Calistri, Nicholas L.;
Heiser, Laura M.;
Nechiporuk, Alex V.

Publication type:

Article

A Network-Based Model of Oncogenic Collaboration for Prediction of Drug Sensitivity.

Published in:

Frontiers in Genetics, 2015, p. 1, doi. 10.3389/fgene.2015.00341

By:

Laderas, Ted G.;
Heiser, Laura M.;
Sönmez, Kemal

Publication type:

Article

Live Cell Lineage Tracing of Dormant Cancer Cells.

Published in:

Advanced Healthcare Materials, 2023, v. 12, n. 14, p. 1, doi. 10.1002/adhm.202202275

By:

Kim, Hyuna;
Wirasaputra, Anna;
Mohammadi, Farnaz;
Kundu, Aritra Nath;
Esteves, Jennifer A. E.;
Heiser, Laura M.;
Meyer, Aaron S.;
Peyton, Shelly R.

Publication type:

Article

An altered extracellular matrix–integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.

Published in:

Human Molecular Genetics, 2023, v. 32, n. 9, p. 1483, doi. 10.1093/hmg/ddac303

By:

Hernandez, Sarah J;
Lim, Ryan G;
Onur, Tarik;
Dane, Mark A;
Smith, Rebecca;
Wang, Keona;
Jean, Grace En-Hway;
Reyes-Ortiz, Andrea;
Devlin, Kaylyn;
Miramontes, Ricardo;
Wu, Jie;
Casale, Malcolm;
Kilburn, David;
Heiser, Laura M;
Korkola, James E;
Vactor, David Van;
Botas, Juan;
Thompson-Peer, Katherine L;
Thompson, Leslie M

Publication type:

Article

MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39729-2

By:

Erdem, Cemal;
Gross, Sean M.;
Heiser, Laura M.;
Birtwistle, Marc R.

Publication type:

Article

Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39122-z

By:

Gross, Sean M.;
Mohammadi, Farnaz;
Sanchez-Aguila, Crystal;
Zhan, Paulina J.;
Liby, Tiera A.;
Dane, Mark A.;
Meyer, Aaron S.;
Heiser, Laura M.

Publication type:

Article

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder.

Published in:

Scientific Reports, 2016, p. 31750, doi. 10.1038/srep31750

By:

Brown, Anna;
Patel, Siddharth;
Ward, Carl;
Lorenz, Anna;
Ortiz, Mauren;
DuRoss, Allison;
Wieghardt, Fabian;
Esch, Amanda;
Otten, Elsje G.;
Heiser, Laura M.;
Korolchuk, Viktor I.;
Sun, Conroy;
Sarkar, Sovan;
Sahay, Gaurav

Publication type:

Article

Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.

Published in:

2017

By:

Korkola, James E.;
Collisson, Eric A.;
Heiser, Laura M.;
Oates, Chris;
Bayani, Nora;
Itani, Sleiman;
Esch, Amanda;
Thompson, Wallace;
Griffith, Obi L.;
Wang, Nicholas J.;
Kuo, Wen-Lin;
Cooper, Brian;
Billig, Jessica;
Ziyad, Safiyyah;
Hung, Jenny L.;
Jakkula, Lakshmi;
Feiler, Heidi;
Lu, Yiling;
Mills, Gordon B.;
Spellman, Paul T.

Publication type:

Correction Notice

Theoretical and experimental analysis of negative dielectrophoresis‐induced particle trajectories.

Published in:

Electrophoresis, 2022, v. 43, n. 12, p. 1366, doi. 10.1002/elps.202100372

By:

Luna, Ramona;
Heineck, Daniel P.;
Bucher, Elmar;
Heiser, Laura;
Ibsen, Stuart D.

Publication type:

Article

Front Cover: Theoretical and experimental analysis of negative dielectrophoresis‐induced particle trajectories.

Published in:

Electrophoresis, 2022, v. 43, n. 12, p. NA, doi. 10.1002/elps.202270071

By:

Luna, Ramona;
Heineck, Daniel P.;
Bucher, Elmar;
Heiser, Laura;
Ibsen, Stuart D.

Publication type:

Article

Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-78798-x

By:

Smith, Rebecca;
Liu, Moqing;
Liby, Tiera;
Bayani, Nora;
Bucher, Elmar;
Chiotti, Kami;
Derrick, Daniel;
Chauchereau, Anne;
Heiser, Laura;
Alumkal, Joshi;
Feiler, Heidi;
Carroll, Peter;
Korkola, James E.

Publication type:

Article

Characterizing advanced breast cancer heterogeneity and treatment resistance through serial biopsies and comprehensive analytics.

Published in:

NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00165-4

By:

Li, Allen;
Keck, Jamie M.;
Parmar, Swapnil;
Patterson, Janice;
Labrie, Marilyne;
Creason, Allison L.;
Johnson, Brett E.;
Downey, Molly;
Thomas, George;
Beadling, Carol;
Heiser, Laura M.;
Kolodzie, Annette;
Guimaraes, Alexander R.;
Corless, Christopher L.;
Gray, Joe W.;
Mills, Gordon B.;
Bergan, Raymond C.;
Mitri, Zahi I.

Publication type:

Article

Morphodynamical cell state description via live-cell imaging trajectory embedding.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04837-8

By:

Copperman, Jeremy;
Gross, Sean M.;
Chang, Young Hwan;
Heiser, Laura M.;
Zuckerman, Daniel M.

Publication type:

Article

A lineage tree-based hidden Markov model quantifies cellular heterogeneity and plasticity.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-04208-9

By:

Mohammadi, Farnaz;
Visagan, Shakthi;
Gross, Sean M.;
Karginov, Luka;
Lagarde, J. C.;
Heiser, Laura M.;
Meyer, Aaron S.

Publication type:

Article

TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-024-82218-9

By:

Calistri, Nicholas L.;
Liby, Tiera A.;
Hu, Zhi;
Zhang, Hongmei;
Dane, Mark A.;
Gross, Sean M.;
Heiser, Laura M.

Publication type:

Article

Common Cervicovaginal Microbial Supernatants Alter Cervical Epithelial Function: Mechanisms by Which Lactobacillus crispatus Contributes to Cervical Health.

Published in:

Frontiers in Microbiology, 2018, p. N.PAG, doi. 10.3389/fmicb.2018.02181

By:

Anton, Lauren;
Sierra, Luz-Jeannette;
DeVine, Ann;
Barila, Guillermo;
Heiser, Laura;
Brown, Amy G.;
Elovitz, Michal A.

Publication type:

Article

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01967-6

By:

Farrell, Amy S.;
Joly, Meghan Morrison;
Allen-Petersen, Brittany L.;
Worth, Patrick J.;
Lanciault, Christian;
Sauer, David;
Link, Jason;
Pelz, Carl;
Heiser, Laura M.;
Morton, Jennifer P.;
Muthalagu, Nathiya;
Hoffman, Megan T.;
Manning, Sara L.;
Pratt, Erica D.;
Kendsersky, Nicholas D.;
Egbukichi, Nkolika;
Amery, Taylor S.;
Thoma, Mary C.;
Jenny, Zina P.;
Rhim, Andrew D.

Publication type:

Article

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

Published in:

Breast Cancer Research, 2014, v. 16, n. 5, p. 1, doi. 10.1186/s13058-014-0430-x

By:

Xiaoyong Fu;
Creighton, Chad J.;
Biswal, Nrusingh C.;
Kumar, Vijetha;
Shea, Martin;
Herrera, Sabrina;
Contreras, Alejandro;
Gutierrez, Carolina;
Tao Wang;
Nanda, Sarmistha;
Giuliano, Mario;
Morrison, Gladys;
Nardone, Agostina;
Karlin, Kristen L.;
Westbrook, Thomas F.;
Heiser, Laura M.;
Anur, Pavana;
Spellman, Paul;
Guichard, Sylvie M.;
Smith, Paul D.

Publication type:

Article

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

Published in:

2014

By:

Fu, Xiaoyong;
Creighton, Chad J;
Biswal, Nrusingh C;
Kumar, Vijetha;
Shea, Martin;
Herrera, Sabrina;
Contreras, Alejandro;
Gutierrez, Carolina;
Wang, Tao;
Nanda, Sarmistha;
Giuliano, Mario;
Morrison, Gladys;
Nardone, Agostina;
Karlin, Kristen L;
Westbrook, Thomas F;
Heiser, Laura M;
Anur, Pavana;
Spellman, Paul;
Guichard, Sylvie M;
Smith, Paul D

Publication type:

journal article

Metrics other than potency reveal systematic variation in responses to cancer drugs.

Published in:

Nature Chemical Biology, 2013, v. 9, n. 11, p. 708, doi. 10.1038/nchembio.1337

By:

Fallahi-Sichani, Mohammad;
Honarnejad, Saman;
Heiser, Laura M;
Gray, Joe W;
Sorger, Peter K

Publication type:

Article

Modeling precision treatment of breast cancer.

Published in:

Genome Biology, 2013, v. 14, n. 10, p. R110, doi. 10.1186/gb-2013-14-10-r110

By:

Daemen, Anneleen;
Griffith, Obi L;
Heiser, Laura M;
Wang, Nicholas J;
Enache, Oana M;
Sanborn, Zachary;
Pepin, Francois;
Durinck, Steffen;
Korkola, James E;
Griffith, Malachi;
Joe S Hur;
Nam Huh;
Jongsuk Chung;
Cope, Leslie;
Fackler, Mary Jo;
Umbricht, Christopher;
Sukumar, Saraswati;
Seth, Pankaj;
Sukhatme, Vikas P;
Jakkula, Lakshmi R

Publication type:

Article

Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.

Published in:

2017

By:

Hu, Zhi;
Mao, Jian-Hua;
Curtis, Christina;
Huang, Ge;
Gu, Shenda;
Heiser, Laura;
Lenburg, Marc E;
Korkola, James E;
Bayani, Nora;
Samarajiwa, Shamith;
Seoane, Jose A;
Dane, Mark A;
Esch, Amanda;
Feiler, Heidi S;
Wang, Nicholas J;
Hardwicke, Mary Ann;
Laquerre, Sylvie;
Jackson, Jeff;
Wood, Kenneth W;
Weber, Barbara

Publication type:

journal article

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.

Published in:

2016

By:

Zhi Hu;
Jian-Hua Mao;
Curtis, Christina;
Ge Huang;
Shenda Gu;
Heiser, Laura;
Lenburg, Marc E.;
Korkola, James E.;
Bayani, Nora;
Samarajiwa, Shamith;
Seoane, Jose A.;
Dane, Mark A.;
Esch, Amanda;
Feiler, Heidi S.;
Wang, Nicholas J.;
Hardwicke, Mary Ann;
Laquerre, Sylvie;
Jackson, Jeff;
Wood, Kenneth W.;
Weber, Barbara

Publication type:

journal article

Systematic replication enables normalization of high-throughput imaging assays.

Published in:

Bioinformatics, 2022, v. 38, n. 21, p. 4934, doi. 10.1093/bioinformatics/btac606

By:

Hunt, Gregory J;
Dane, Mark A;
Korkola, James E;
Heiser, Laura M;
Gagnon-Bartsch, Johann A

Publication type:

Article

Automatic Transformation and Integration to Improve Visualization and Discovery of Latent Effects in Imaging Data.

Published in:

Journal of Computational & Graphical Statistics, 2020, v. 29, n. 4, p. 929, doi. 10.1080/10618600.2020.1741379

By:

Hunt, Gregory J.;
Dane, Mark A.;
Korkola, James E.;
Heiser, Laura M.;
Gagnon-Bartsch, Johann A.

Publication type:

Article

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes.

Published in:

Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0429-x

By:

Rahman, Mumtahena;
MacNeil, Shelley M.;
Jenkins, David F.;
Shrestha, Gajendra;
Wyatt, Sydney R.;
McQuerry, Jasmine A.;
Piccolo, Stephen R.;
Heiser, Laura M.;
Gray, Joe W.;
Johnson, W. Evan;
Bild, Andrea H.

Publication type:

Article

A robust prognostic signature for hormone-positive node-negative breast cancer.

Published in:

Genome Medicine, 2013, v. 5, n. 10, p. 19, doi. 10.1186/gm496

By:

Griffith, Obi L.;
Pepin, François;
Enache, Oana M.;
Heiser, Laura M.;
Collisson, Eric A.;
Spellman, Paul T.;
Gray, Joe W.

Publication type:

Article

Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA.

Published in:

2021

By:

Garay, Joseph P.;
Smith, Rebecca;
Devlin, Kaylyn;
Hollern, Daniel P.;
Liby, Tiera;
Liu, Moqing;
Boddapati, Shanta;
Watson, Spencer S.;
Esch, Amanda;
Zheng, Ting;
Thompson, Wallace;
Babcock, Darcie;
Kwon, Sunjong;
Chin, Koei;
Heiser, Laura;
Gray, Joe W.;
Korkola, James E.

Publication type:

journal article

Annot: a Django-based sample, reagent, and experiment metadata tracking system.

Published in:

BMC Bioinformatics, 2019, v. 20, n. 1, p. 1, doi. 10.1186/s12859-019-3147-0

By:

Bucher, Elmar;
Claunch, Cheryl J.;
Hee, Derrick;
Smith, Rebecca L.;
Devlin, Kaylyn;
Thompson, Wallace;
Korkola, James E.;
Heiser, Laura M.

Publication type:

Article

The tracking of lipopolysaccharide through the feto‐maternal compartment and the involvement of maternal TLR4 in inflammation‐induced fetal brain injury.

Published in:

American Journal of Reproductive Immunology, 2019, v. 82, n. 6, p. N.PAG, doi. 10.1111/aji.13189

By:

Brown, Amy G.;
Maubert, Monique E.;
Anton, Lauren;
Heiser, Laura M.;
Elovitz, Michal A.

Publication type:

Article

A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs.

Published in:

Nature Biotechnology, 2022, v. 40, n. 12, p. 1823, doi. 10.1038/s41587-022-01379-y

By:

Tatarova, Zuzana;
Blumberg, Dylan C.;
Korkola, James E.;
Heiser, Laura M.;
Muschler, John L.;
Schedin, Pepper J.;
Ahn, Sebastian W.;
Mills, Gordon B.;
Coussens, Lisa M.;
Jonas, Oliver;
Gray, Joe W.

Publication type:

Article

A community effort to assess and improve drug sensitivity prediction algorithms.

Published in:

Nature Biotechnology, 2014, v. 32, n. 12, p. 1202, doi. 10.1038/nbt.2877

By:

Costello, James C;
Collins, James J;
Gallahan, Dan;
Singer, Dinah;
Kaski, Samuel;
Stolovitzky, Gustavo;
Heiser, Laura M;
Georgii, Elisabeth;
Gönen, Mehmet;
Ammad-ud-din, Muhammad;
Khan, Suleiman A;
Menden, Michael P;
Saez-Rodriguez, Julio;
Wang, Nicholas J;
Gray, Joe W;
Bansal, Mukesh;
Hintsanen, Petteri;
Mpindi, John-Patrick;
Kallioniemi, Olli;
Aittokallio, Tero

Publication type:

Article