Works by Heinzle, Elmar

Results: 93

The yeast Kluyveromyces marxianus and its biotechnological potential.

Published in:

Applied Microbiology & Biotechnology, 2008, v. 79, n. 3, p. 339, doi. 10.1007/s00253-008-1458-6

By:

Fonseca, Gustavo;
Heinzle, Elmar;
Wittmann, Christoph;
Gombert, Andreas

Publication type:

Article

In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor.

Published in:

Journal of Tissue Engineering & Regenerative Medicine, 2011, v. 5, n. 8, p. e207, doi. 10.1002/term.418

By:

Mueller, Daniel;
Tascher, Georg;
Müller-Vieira, Ursula;
Knobeloch, Daniel;
Nuessler, Andreas K.;
Zeilinger, Katrin;
Heinzle, Elmar;
Noor, Fozia

Publication type:

Article

Species identification of Oetzi's clothing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based on peptide pattern similarities of hair digests.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2008, v. 22, n. 18, p. 2751, doi. 10.1002/rcm.3679

By:

Hollemeyer, Klaus;
Altmeyer, Wolfgang;
Heinzle, Elmar;
Pitra, Christian

Publication type:

Article

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2007, v. 21, n. 3, p. 336, doi. 10.1002/rcm.2840

By:

Hollemeyer, Klaus;
Velagapudi, Vidya R.;
Wittmann, Christoph;
Heinzle, Elmar

Publication type:

Article

Qualitative and quantitative analysis of low molecular weight compounds by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrices.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2004, v. 18, n. 2, p. 141, doi. 10.1002/rcm.1293

By:

Masoud Zabet-Moghaddam;
Elmar Heinzle;
Andreas Tholey

Publication type:

Article

Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2003, v. 17, n. 24, p. 2721, doi. 10.1002/rcm.1251

By:

Tae Hoon Yang;
Christoph Wittmann;
Elmar Heinzle

Publication type:

Article

Application of automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the measurement of enzyme activities.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2001, v. 15, n. 15, p. 1327, doi. 10.1002/rcm.376

By:

Kang, Min-Jung;
Tholey, Andreas;
Heinzle, Elmar

Publication type:

Article

Rapid detection of multiple chlorinated bis(bibenzyls) in bryophyte crude extracts using laser desorption/ionization time-of-flight mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2001, v. 15, n. 2, p. 124, doi. 10.1002/1097-0231(20010130)15:2<124::AID-RCM203>3.0.CO;2-5

By:

Speicher, Andreas;
Hollemeyer, Klaus;
Heinzle, Elmar

Publication type:

Article

Quantitation of low molecular mass substrates and products of enzyme catalyzed reactions using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2000, v. 14, n. 21, p. 1972, doi. 10.1002/1097-0231(20001115)14:21<1972::AID-RCM119>3.0.CO;2-5

By:

Kang, Min-Jung;
Tholey, Andreas;
Heinzle, Elmar

Publication type:

Article

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine.

Published in:

Microbial Cell Factories, 2012, v. 11, n. 1, p. 138, doi. 10.1186/1475-2859-11-138

By:

Peifer, Susanne;
Barduhn, Tobias;
Zimmet, Sarah;
Volmer, Dietrich A.;
Heinzle, Elmar;
Schneider, Konstantin

Publication type:

Article

Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening.

Published in:

Microbial Cell Factories, 2009, v. 8, p. 1, doi. 10.1186/1475-2859-8-12

By:

Schneider, Konstantin;
Krömer, Jens Olaf;
Wittmann, Christoph;
Alves-Rodrigues, Isabel;
Meyerhans, Andreas;
Diez, Juana;
Heinzle, Elmar

Publication type:

Article

Hepatocytes of Wistar and Sprague Dawley rats differ significantly in their central metabolism.

Published in:

Journal of Cellular Biochemistry, 2018, v. 119, n. 1, p. 909, doi. 10.1002/jcb.26255

By:

Garg, Richa;
Heinzle, Elmar;
Noor, Fozia

Publication type:

Article

Proteomic Characterization of Primary Mouse Hepatocytes in Collagen Monolayer and Sandwich Culture.

Published in:

Journal of Cellular Biochemistry, 2018, v. 119, n. 1, p. 447, doi. 10.1002/jcb.26202

By:

Orsini, Malina;
Sperber, Saskia;
Noor, Fozia;
Hoffmann, Esther;
Weber, Susanne N.;
Hall, Rabea A.;
Lammert, Frank;
Heinzle, Elmar

Publication type:

Article

Engineering the supply chain for protein production/secretion in yeasts and mammalian cells.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2015, v. 42, n. 3, p. 453, doi. 10.1007/s10295-014-1569-2

By:

Klein, Tobias;
Niklas, Jens;
Heinzle, Elmar

Publication type:

Article

Microplates with Integrated Oxygen Sensors for Kinetic Cell Respiration Measurement and Cytotoxicity Testing in Primary and Secondary Cell Lines.

Published in:

Assay & Drug Development Technologies, 2005, v. 3, n. 3, p. 299

By:

Rahul Ravi Deshpande;
Yvonne Koch-Kirsch;
Ruth Maas;
Gernot T. John;
Christian Krause;
Elmar Heinzle

Publication type:

Article

Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale.

Published in:

Biotechnology & Bioengineering, 2004, v. 87, n. 1, p. 1, doi. 10.1002/bit.20103

By:

Wittmann, Christoph;
Kim, Hyung Min;
Heinzle, Elmar

Publication type:

Article

Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.

Published in:

Biotechnology & Bioengineering, 2003, v. 82, n. 2, p. 143, doi. 10.1002/bit.10553

By:

Michael A. Hans;
Elmar Heinzle;
Christoph Wittmann

Publication type:

Article

Integrated optical sensing of dissolved oxygen in microtiter plates: A novel tool for microbial cultivation.

Published in:

Biotechnology & Bioengineering, 2003, v. 81, n. 7, p. 829, doi. 10.1002/bit.10534

By:

John, Gernot T.;
Klimant, Ingo;
Wittmann, Christoph;
Heinzle, Elmar

Publication type:

Article

Correcting mass isotopomer distributions for naturally occurring isotopes.

Published in:

Biotechnology & Bioengineering, 2002, v. 80, n. 4, p. 477, doi. 10.1002/bit.10393

By:

Van Winden, Wouter A.;
Wittmann, Christoph;
Heinzle, Elmar;
Heijnen, Joseph J.

Publication type:

Article

Metabolic-flux analysis of continuously cultured hybridoma cells using 13CO2 mass spectrometry in combination with 13C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing.

Published in:

Biotechnology & Bioengineering, 2001, v. 74, n. 6, p. 528, doi. 10.1002/bit.1145

By:

Bonarius, Hendrik P. J.;
Özemre, Ahmet;
Timmerarends, Bram;
Skrabal, Peter;
Tramper, Johannes;
Schmid, Georg;
Heinzle, Elmar

Publication type:

Article

MALDI-TOF MS for quantification of substrates and products in cultivations of Corynebacterium glutamicum.

Published in:

Biotechnology & Bioengineering, 2001, v. 72, n. 6, p. 642, doi. 10.1002/1097-0290(20010320)72:6<642::AID-BIT1030>3.0.CO;2-7

By:

Wittmann, Christoph;
Heinzle, Elmar

Publication type:

Article

Quantitative screening method for hydrolases in microplates using pH indicators: Determination of kinetic parameters by dynamic pH monitoring.

Published in:

Biotechnology & Bioengineering, 2001, v. 72, n. 6, p. 620, doi. 10.1002/1097-0290(20010320)72:6<620::AID-BIT1027>3.0.CO;2-W

By:

John, Gernot Thomas;
Heinzle, Elmar

Publication type:

Article

Modeling and simulation of competition between two microorganisms for a single inhibitory substrate in a biofilm reactor.

Published in:

Biotechnology & Bioengineering, 1999, v. 66, n. 4, p. 258, doi. 10.1002/(SICI)1097-0290(1999)66:4<258::AID-BIT7>3.0.CO;2-Z

By:

Soda, Satoshi;
Heinzle, Elmar;
Fujita, Masanori

Publication type:

Article

Mass spectrometry for metabolic flux analysis.

Published in:

Biotechnology & Bioengineering, 1999, v. 62, n. 6, p. 739, doi. 10.1002/(SICI)1097-0290(19990320)62:6<739::AID-BIT13>3.0.CO;2-E

By:

Wittmann, Christoph;
Heinzle, Elmar

Publication type:

Article

On-line estimation of viable cells in a hybridoma culture at various DO levels using ATP balancing and redox potential measurement.

Published in:

Biotechnology & Bioengineering, 1996, v. 49, n. 3, p. 277, doi. 10.1002/(SICI)1097-0290(19960205)49:3<277::AID-BIT5>3.0.CO;2-H

By:

Eyer, Kurt;
Heinzle, Elmar

Publication type:

Article

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.

Published in:

Journal of Applied Toxicology, 2011, v. 31, n. 3, p. 191, doi. 10.1002/jat.1663

By:

Mandenius, Carl-Fredrik;
Steel, Daniella;
Noor, Fozia;
Meyer, Thomas;
Heinzle, Elmar;
Asp, Julia;
Arain, Sarina;
Kraushaar, Udo;
Bremer, Susanne;
Class, Reiner;
Sartipy, Peter

Publication type:

Article

N-acetylation and phosphorylation of Sec complex subunits in the ER membrane.

Published in:

BMC Cell Biology, 2012, v. 13, n. 1, p. 34, doi. 10.1186/1471-2121-13-34

By:

Soromani, Christina;
Zeng, Naiyan;
Hollemeyer, Klaus;
Heinzle, Elmar;
Klein, Marie-Christine;
Tretter, Thomas;
Seaman, Matthew N.J.;
R”misch, Karin

Publication type:

Article

Multistep Synthesis of UDP-Glucose Using Tailored, Permeabilized Cells of E. coli.

Published in:

Applied Biochemistry & Biotechnology, 2015, v. 175, n. 8, p. 3729, doi. 10.1007/s12010-015-1540-3

By:

Weyler, Christian;
Heinzle, Elmar

Publication type:

Article

Identification of oxidized methionine residues in peptides containing two methionine residues by derivatization and matrix-assisted laser desorption/ionization mass spectrometry.

Published in:

Proteomics, 2002, v. 2, n. 11, p. 1524, doi. 10.1002/1615-9861(200211)2:11<1524::AID-PROT1524>3.0.CO;2-7

By:

Hollemeyer, Klaus;
Heinzle, Elmar;
Tholey, Andreas

Publication type:

Article

Repeatability of peptide identifications in shotgun proteome analysis employing off‐line two‐dimensional chromatographic separations and ion‐trap MS.

Published in:

Journal of Separation Science, 2009, v. 32, n. 8, p. 1156, doi. 10.1002/jssc.200800615

By:

Delmotte, Nathanaël;
Lasaosa, Maria;
Tholey, Andreas;
Heinzle, Elmar;
van Dorsselaer, Alain;
Huber, Christian G.

Publication type:

Article

Bewertung biotechnologischer Prozesse in frühen Phasen der Entwicklung hinsichtlich Risiken bezüglich Ökologie, Sicherheit und Gesundheit.

Published in:

Chemie Ingenieur Technik (CIT), 2006, v. 78, n. 3, p. 301, doi. 10.1002/cite.200500191

By:

Heinzle, Elmar;
Biwer, A.;
Eissen, M.;
Abdul Kholiq, M.

Publication type:

Article

Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase.

Published in:

Biotechnology Letters, 2016, v. 38, n. 3, p. 477, doi. 10.1007/s10529-015-1995-x

By:

Weyler, Christian;
Bureik, Matthias;
Heinzle, Elmar

Publication type:

Article

Online monitoring of oxygen in spinner flasks.

Published in:

Biotechnology Letters, 2009, v. 31, n. 5, p. 665, doi. 10.1007/s10529-009-9919-2

By:

Deshpande, Rahul Ravi;
Heinzle, Elmar

Publication type:

Article

Quantification of S-adenosyl Methionine in Microbial Cell Extracts.

Published in:

Biotechnology Letters, 2006, v. 28, n. 2, p. 69, doi. 10.1007/s10529-005-4947-z

By:

Krömer, Jens;
Heinzle, Elmar;
Wittmann, Christoph

Publication type:

Article

Screening of sugar converting enzymes using quantitative MALDI-ToF mass spectrometry.

Published in:

Biotechnology Letters, 2004, v. 26, n. 13, p. 1025, doi. 10.1023/B:BILE.0000032965.18721.62

By:

Bungert, Ditte;
Bastian, Sabine;
Heckmann-Pohl, Dorothée M.;
Giffhorn, Friedrich;
Heinzle, Elmar;
Tholey, Andreas

Publication type:

Article

On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen sensors.

Published in:

Biotechnology Letters, 2004, v. 26, n. 9, p. 763, doi. 10.1023/B:BILE.0000024101.57683.6d

By:

Deshpande, Rahul Ravi;
Heinzle, Elmar

Publication type:

Article

Review: Minibioreactors.

Published in:

2004

By:

Kumar, Sathish;
Wittmann, Christoph;
Heinzle, Elmar

Publication type:

Other

Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks.

Published in:

Biotechnology Letters, 2003, v. 25, n. 5, p. 377, doi. 10.1023/A:1022402212537

By:

Wittmann, Christoph;
Kim, Hyung Min;
John, Gernot;
Heinzle, Elmar

Publication type:

Article

Optical device for parallel online measurement of dissolved oxygen and pH in shake flask cultures.

Published in:

Bioprocess & Biosystems Engineering, 2010, v. 33, n. 5, p. 541, doi. 10.1007/s00449-009-0367-0

By:

Schneider, Konstantin;
Schütz, Verena;
John, Gernot Thomas;
Heinzle, Elmar

Publication type:

Article

Estimation of metabolic fluxes, expression levels and metabolite dynamics of a secondary metabolic pathway in potato using label pulse-feeding experiments combined with kinetic network modelling and simulation.

Published in:

Plant Journal, 2007, v. 50, n. 1, p. 176, doi. 10.1111/j.1365-313X.2007.03037.x

By:

Heinzle, Elmar;
Matsuda, Fumio;
Miyagawa, Hisashi;
Wakasa, Kyo;
Nishioka, Takaaki

Publication type:

Article

Multienzyme Whole-Cell In Situ Biocatalysis for the Production of Flaviolin in Permeabilized Cells of Escherichia coli.

Published in:

ChemCatChem, 2012, v. 4, n. 6, p. 786, doi. 10.1002/cctc.201100351

By:

Krauser, Steffen;
Kiefer, Patrick;
Heinzle, Elmar

Publication type:

Article

Toward Preclinical Predictive Drug Testing for Metabolism and Hepatotoxicity by Using In Vitro Models Derived from Human Embryonic Stem Cells and Human Cell Lines--A Report on the Vitrocellomics EU-project.

Published in:

Alternatives to Laboratory Animals, 2011, v. 39, n. 2, p. 147, doi. 10.1177/026119291103900210

By:

Mandenius, Carl-Fredrik;
Andersson, Tommy B.;
Alves, Paula M.;
Batzl-Hartmann, Christine;
Björquist,, Petter;
Carrondo, Manuel J. T.;
Chesne, Christophe;
Coecke, Sandra;
Edsbagge, Josefina;
Fredriksson, J. Magnus;
Gerlach, Jörg C.;
Heinzle, Elmar;
Ingelman-Sundberg, Magnus;
Johansson, Inger;
Küppers-Munther, Barbara;
Müller-Vieira,, Ursula;
Noor, Fozia;
Zeilinger, Katrin

Publication type:

Article

Metabolic switches from quiescence to growth in synchronized Saccharomyces cerevisiae.

Published in:

Metabolomics, 2019, v. 15, n. 9, p. N.PAG, doi. 10.1007/s11306-019-1584-4

By:

Zhang, Jinrui;
Martinez-Gomez, Karla;
Heinzle, Elmar;
Wahl, Sebastian Aljoscha

Publication type:

Article

Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation.

Published in:

BMC Systems Biology, 2014, v. 8, n. 1, p. 1, doi. 10.1186/1752-0509-8-50

By:

Nicolae, Averina;
Wahrheit, Judith;
Bahnemann, Janina;
An-Ping Zeng;
Heinzle, Elmar

Publication type:

Article

Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification.

Published in:

BMC Systems Biology, 2008, v. 2, p. 1, doi. 10.1186/1752-0509-2-29

By:

Tae Hoon Yang;
Frick, Oliver;
Heinzle, Elmar

Publication type:

Article

Network design and analysis for multi-enzyme biocatalysis.

Published in:

BMC Bioinformatics, 2017, v. 18, p. 1, doi. 10.1186/s12859-017-1773-y

By:

Blaß, Lisa Katharina;
Weyler, Christian;
Heinzle, Elmar

Publication type:

Article

Acetate-containing substrate mixtures improve recombinant protein secretion in Schizosaccharomyces pombe.

Published in:

Engineering in Life Sciences, 2015, v. 15, n. 4, p. 437, doi. 10.1002/elsc.201400192

By:

Klein, Tobias;
Heinzle, Elmar;
Schneider, Konstantin

Publication type:

Article

High-throughput respiration screening of single mitochondrial substrates using permeabilized CHO cells highlights control of mitochondria metabolism.

Published in:

Engineering in Life Sciences, 2015, v. 15, n. 2, p. 184, doi. 10.1002/elsc.201400175

By:

Wahrheit, Judith;
Nonnenmacher, Yannic;
Sperber, Saskia;
Heinzle, Elmar

Publication type:

Article

Batch-to-batch variability of two human designer cell lines - AGE1. HN and AGE1. HN. AAT - carried out by different laboratories under defined culture conditions using a mathematical model.

Published in:

Engineering in Life Sciences, 2013, v. 13, n. 6, p. 580, doi. 10.1002/elsc.201200111

By:

Freund, Susann;
Rath, Alexander;
Barradas, Oscar Platas;
Skerhutt, Eva;
Scholz, Sebastian;
Niklas, Jens;
Sandig, Volker;
Rose, Thomas;
Heinzle, Elmar;
Noll, Thomas;
Pörtner, Ralf;
Zeng, An Ping;
Reichl, Udo

Publication type:

Article

In search of an effective cell disruption method to isolate intact mitochondria from Chinese hamster ovary cells.

Published in:

Engineering in Life Sciences, 2014, v. 14, n. 2, p. 161, doi. 10.1002/elsc.201200182

By:

Bahnemann, Janina;
Kayo, Sabrina;
Wahrheit, Judith;
Heinzle, Elmar;
Pörtner, Ralf;
Zeng, An‐Ping

Publication type:

Article