Works matching AU Heine, Holger

Results: 49

Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59550-3

By:

Fu, Yaoyao;
Kim, Hyojin;
Lee, Dong Sun;
Han, Ah-reum;
Heine, Holger;
Zamyatina, Alla;
Kim, Ho Min

Publication type:

Article

Lipid A Mimetics Based on Unnatural Disaccharide Scaffold as Potent TLR4 Agonists for Prospective Immunotherapeutics and Adjuvants.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 35, p. 1, doi. 10.1002/chem.202200547

By:

Strobl, Sebastian;
Hofbauer, Karin;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00122

By:

Jappe, Uta;
Schwager, Christian;
Schromm, Andra B.;
González Roldán, Nestor;
Stein, Karina;
Heine, Holger;
Duda, Katarzyna A.

Publication type:

Article

Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.

Published in:

European Journal of Immunology, 2005, v. 35, n. 3, p. 911, doi. 10.1002/eji.200425336

By:

Manukyan, Maria;
Triantafilou, Kathy;
Triantafilou, Martha;
Mackie, Alan;
Nilsen, Nadra;
Espevik, Terje;
Wiesmüller, Karl-Heinz;
Ulmer, Artur J.;
Heine, Holger

Publication type:

Article

Toll-like receptor 6-independent signaling by diacylated lipopeptides.

Published in:

European Journal of Immunology, 2005, v. 35, n. 1, p. 282, doi. 10.1002/eji.200424955

By:

Buwitt-Beckmann, Ute;
Heine, Holger;
Wiesmüller, Karl-Heinz;
Jung, Günther;
Brock, Roland;
Akira, Shizuo;
Ulmer, Artur J.

Publication type:

Article

The generalized endotoxic principle.

Published in:

European Journal of Immunology, 2003, v. 33, n. 6, p. 1586, doi. 10.1002/eji.200323649

By:

Seydel, Ulrich;
Hawkins, Lynn;
Schromm, Andra B.;
Heine, Holger;
Scheel, Olaf;
Koch, Michel H. J.;
Brandenburg, Klaus

Publication type:

Article

CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex.

Published in:

European Journal of Immunology, 2003, v. 33, n. 5, p. 1399, doi. 10.1002/eji.200323381

By:

Heine, Holger;
El-Samalouti, Volker T.;
Nötzel, Corinna;
Pfeiffer, Alexandra;
Lentschat, Arnd;
Kusumoto, Shoichi;
Schmitz, Gerd;
Hamann, Lutz;
Ulmer, Artur J.

Publication type:

Article

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts.

Published in:

European Journal of Immunology, 2001, v. 31, n. 11, p. 3153, doi. 10.1002/1521-4141(200111)31:11<3153::AID-IMMU3153>3.0.CO;2-0

By:

Pfeiffer, Alexandra;
Böttcher, Alfred;
Orsó, Evelyn;
Kapinsky, Michael;
Nagy, Peter;
Bodnár, Andrea;
Spreitzer, Ingo;
Liebisch, Gerhard;
Drobnik, Wolfgang;
Gempel, Klaus;
Horn, Markus;
Holmer, Stefan;
Hartung, Thomas;
Multhoff, Gabriele;
Schütz, Gerhard;
Schindler †, Hansgeorg;
Ulmer, Artur J.;
Heine, Holger;
Stelter, Felix;
Schütt, Christine

Publication type:

Article

Nonreducing Sugar Scaffold Enables the Development of Immunomodulatory TLR4‐specific LPS Mimetics with Picomolar Potency.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 39, p. 1, doi. 10.1002/anie.202408421

By:

Strobl, Sebastian;
Zucchetta, Daniele;
Vašíček, Tomáš;
Monti, Alessandro;
Ruda, Alessandro;
Widmalm, Göran;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121.

Published in:

Biological Chemistry, 2012, v. 393, n. 8, p. 749, doi. 10.1515/hsz-2012-0142

By:

Fischer, Kathleen;
Vinogradov, Evgueny;
Lindner, Buko;
Heine, Holger;
Holst, Otto

Publication type:

Article

Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids.

Published in:

Molecules, 2023, v. 28, n. 16, p. 5948, doi. 10.3390/molecules28165948

By:

Borio, Alessio;
Holgado, Aurora;
Passegger, Christina;
Strobl, Herbert;
Beyaert, Rudi;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system.

Published in:

FEBS Journal, 2025, v. 292, n. 6, p. 1316, doi. 10.1111/febs.17123

By:

Kuehnast, Torben;
Kumpitsch, Christina;
Mohammadzadeh, Rokhsareh;
Weichhart, Thomas;
Moissl‐Eichinger, Christine;
Heine, Holger

Publication type:

Article

Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.585146

By:

Zamyatina, Alla;
Heine, Holger

Publication type:

Article

Disaccharide‐Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide‐Induced Inflammation.

Published in:

ChemMedChem, 2018, v. 13, n. 21, p. 2317, doi. 10.1002/cmdc.201800505

By:

Borio, Alessio;
Holgado, Aurora;
Garate, Jose Antonio;
Beyaert, Rudi;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2007, v. 20, n. 6, p. 947, doi. 10.1159/000110455

By:

Walter, Silke;
Letiembre, Maryse;
Yang Liu;
Heine, Holger;
Penke, Botond;
Wenlin Hao;
Bode, Barbara;
Manietta, Nicole;
Walter, Jessica;
Schulz-Schäffer, Walter;
Faßbender, Klaus

Publication type:

Article

Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2.

Published in:

Glycobiology, 2011, v. 21, n. 12, p. 1588, doi. 10.1093/glycob/cwr071

By:

Fischer, Kathleen;
Stein, Karina;
Ulmer, Artur J;
Lindner, Buko;
Heine, Holger;
Holst, Otto

Publication type:

Article

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.

Published in:

Innate Immunity, 2015, v. 21, n. 5, p. 490, doi. 10.1177/1753425914550426

By:

Garate, Jose Antonio;
Stöckl, Johannes;
del Carmen Fernández-Alonso, María;
Artner, Daniel;
Haegman, Mira;
Oostenbrink, Chris;
Jiménez-Barbero, Jesús;
Beyaert, Rudi;
Heine, Holger;
Kosma, Paul;
Zamyatina, Alla

Publication type:

Article

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

Published in:

Innate Immunity, 2012, v. 18, n. 2, p. 279, doi. 10.1177/1753425911401055

By:

Brade, Lore;
Heine, Holger;
Raina, Satish;
Klein, Gracjana;
di Padova, Franco;
Brade, Helmut;
Müller-Loennies, Sven

Publication type:

Article

Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays.

Published in:

Innate Immunity, 2007, v. 13, n. 2, p. 126, doi. 10.1177/0968051907079122

By:

Heine, Holger;
Gronow, Sabine;
Zamyatina, Alla;
Kosma, Paul;
Brade, Helmut

Publication type:

Article

Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595.

Published in:

Innate Immunity, 2002, v. 8, n. 5, p. 343, doi. 10.1177/09680519020080050801

By:

Janusch, Holger;
Brecker, Lothar;
Lindner, Buko;
Alexander, Christian;
Gronow, Sabine;
Heine, Holger;
Ulmer, Artur J.;
Rietschel, Ernst Th.;
Zähringer, Ulrich

Publication type:

Article

Investigating pyroptosis as a mechanism of L. major cell‐to‐cell spread in the human BLaER1 infection model.

Published in:

Molecular Microbiology, 2024, v. 121, n. 3, p. 453, doi. 10.1111/mmi.15142

By:

Volkmar, Kerren;
Jaedtka, Moritz;
Baars, Iris;
Walber, Bianca;
Philipp, Marie‐Sophie;
Bagola, Katrin;
Müller, Andreas J.;
Heine, Holger;
van Zandbergen, Ger

Publication type:

Article

Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides.

Published in:

PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0185919

By:

Bang, Corinna;
Vierbuchen, Tim;
Gutsmann, Thomas;
Heine, Holger;
Schmitz, Ruth A.

Publication type:

Article

TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS

Published in:

Cardiovascular Research, 2002, v. 56, n. 1, p. 126, doi. 10.1016/S0008-6363(02)00512-6

By:

Zeuke, Stefanie;
Ulmer, Artur J.;
Kusumoto, Shoichi;
Katus, Hugo A.;
Heine, Holger

Publication type:

Article

Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia ( Pseudomonas) plantarii: immune cell stimulation and biophysical characterization.

Published in:

Biological Chemistry, 2006, v. 387, n. 3, p. 301, doi. 10.1515/BC.2006.040

By:

Andrä, Jörg;
Rademann, Jörg;
Howe, Jörg;
Koch, Michel H. J.;
Heine, Holger;
Zähringer, Ulrich;
Brandenburg, Klaus

Publication type:

Article

Allergy protection by cowshed bacteria - recent findings and future prospects.

Published in:

Pediatric Allergy & Immunology, 2016, v. 27, n. 4, p. 340, doi. 10.1111/pai.12559

By:

Kauth, Marion;
Heine, Holger

Publication type:

Article

The Lipid A from the Lipopolysaccharide of the Phototrophic Bacterium Rhodomicrobium vannielii ATCC 17100 Revisited.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 1, p. 258, doi. 10.3390/ijms22010258

By:

Komaniecka, Iwona;
Susniak, Katarzyna;
Choma, Adam;
Heine, Holger;
Holst, Otto

Publication type:

Article

Structural and Immunochemical Analysis of the Lipopolysaccharide from Acinetobacter lwoffii F78 Located Outside Chlamydiaceae with a Chlamydia-Specific Lipopolysaccharide Epitope.

Published in:

Chemistry - A European Journal, 2008, v. 14, n. 33, p. 10251, doi. 10.1002/chem.200800958

By:

Hanuszkiewicz, Anna;
Hübner, Göran;
Vinogradov, Evgeny;
Lindner, Buko;
Brade, Lore;
Brade, Helmut;
Debarry, Jennifer;
Heine, Holger;
Holst, Otto

Publication type:

Article

Nonreducing Sugar Scaffold Enables the Development of Immunomodulatory TLR4‐specific LPS Mimetics with Picomolar Potency.

Published in:

Angewandte Chemie, 2024, v. 136, n. 39, p. 1, doi. 10.1002/ange.202408421

By:

Strobl, Sebastian;
Zucchetta, Daniele;
Vašíček, Tomáš;
Monti, Alessandro;
Ruda, Alessandro;
Widmalm, Göran;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01535

By:

Vierbuchen, Tim;
Bang, Corinna;
Rosigkeit, Hanna;
Schmitz, Ruth A.;
Heine, Holger

Publication type:

Article

Total Synthesis of Five Lipoteichoic acids of Clostridium difficile.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 42, p. 13511, doi. 10.1002/chem.201404336

By:

Hogendorf, Wouter F. J.;
Gisch, Nicolas;
Schwudke, Dominik;
Heine, Holger;
Bols, Mikael;
Pedersen, Christian Marcus

Publication type:

Article

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides.

Published in:

Scientific Reports, 2015, p. 14292, doi. 10.1038/srep14292

By:

de Tejada, Guillermo Martinez;
Heinbockel, Lena;
Ferrer-Espada, Raquel;
Heine, Holger;
Alexander, Christian;
Bárcena-Varela, Sergio;
Goldmann, Torsten;
Correa, Wilmar;
Wiesmüller, Karl-Heinz;
Gisch, Nicolas;
Sánchez-Gómez, Susana;
Fukuoka, Satoshi;
Schürholz, Tobias;
Gutsmann, Thomas;
Brandenburg, Klaus

Publication type:

Article

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13756-4

By:

Herster, Franziska;
Bittner, Zsofia;
Archer, Nathan K.;
Dickhöfer, Sabine;
Eisel, David;
Eigenbrod, Tatjana;
Knorpp, Thomas;
Schneiderhan-Marra, Nicole;
Löffler, Markus W.;
Kalbacher, Hubert;
Vierbuchen, Tim;
Heine, Holger;
Miller, Lloyd S.;
Hartl, Dominik;
Freund, Lukas;
Schäkel, Knut;
Heister, Martin;
Ghoreschi, Kamran;
Weber, Alexander N. R.

Publication type:

Article

Recurrent Phases of Strict Protein Limitation Inhibit Tumor Growth and Restore Lifespan in A Drosophila Intestinal Cancer Model.

Published in:

Aging & Disease, 2024, v. 15, n. 1, p. 226, doi. 10.14336/AD.2023.0517

By:

Pfefferkorn, Roxana M.;
Mortzfeld, Benedikt M.;
Fink, Christine;
von Frieling, Jakob;
Bossen, Judith;
Esser, Daniela;
Kaleta, Christoph;
Rosenstiel, Philip;
Heine, Holger;
Roeder, Thomas

Publication type:

Article

Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 1, p. 23, doi. 10.3390/ph16010023

By:

Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Salmonella enterica serovar Typhimurium ΔmsbB Triggers Exacerbated Inflammation in Nod2 Deficient Mice.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0113645

By:

Claes, Anne-Kathrin;
Steck, Natalie;
Schultz, Dorothee;
Zähringer, Ulrich;
Lipinski, Simone;
Rosenstiel, Philip;
Geddes, Kaoru;
Philpott, Dana J.;
Heine, Holger;
Grassl, Guntram A.

Publication type:

Article

The Intestinal Archaea <i>Methanosphaera stadtmanae</i> and <i>Methanobrevibacter smithii</i> Activate Human Dendritic Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0099411

By:

Bang, Corinna;
Weidenbach, Katrin;
Gutsmann, Thomas;
Heine, Holger;
Schmitz, Ruth A.

Publication type:

Article

Histone Deacetylase (HDAC) 1 Controls the Expression of Beta Defensin 1 in Human Lung Epithelial Cells.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0050000

By:

Kallsen, Kimberley;
Andresen, Ellen;
Heine, Holger

Publication type:

Article

Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021898

By:

Andresen, Ellen;
Günther, Gunar;
Bullwinkel, Jörn;
Lange, Christoph;
Heine, Holger

Publication type:

Article

Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation.

Published in:

PLoS ONE, 2009, v. 4, n. 12, p. 1, doi. 10.1371/journal.pone.0008425

By:

Voynov, Vladimir;
Chennamsetty, Naresh;
Kayser, Veysel;
Helk, Bernhard;
Forrer, Kurt;
Zhang, Heidi;
Fritsch, Cornelius;
Heine, Holger;
Trout, Bernhardt L.

Publication type:

Article

Driver Mutations in Major Lung Cancer Oncogenes Can Be Analyzed in Drosophila Models.

Published in:

Altex, 2021, v. 38, n. 2, p. 235, doi. 10.14573/altex.1912131

By:

Bossen, Judith;
Uliczka, Karin;
Steen, Line;
Neugebauer, Pia;
Mong-Quyen Mai, Mandy;
Fink, Christine;
Stracke, Frank;
Heine, Holger;
Roeder, Thomas

Publication type:

Article

S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.

Published in:

BMC Pulmonary Medicine, 2011, v. 11, n. 1, p. 10, doi. 10.1186/1471-2466-11-10

By:

Andresen, Ellen;
Lange, Christoph;
Strodthoff, Daniela;
Goldmann, Torsten;
Fischer, Nicole;
Sahly, Hany;
Branscheid, Detlev;
Heine, Holger

Publication type:

Article

Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide.

Published in:

FEBS Journal, 2009, v. 276, n. 3, p. 649, doi. 10.1111/j.1742-4658.2008.06813.x

By:

Riekenberg, Sabine;
Farhat, Katja;
Debarry, Jennifer;
Heine, Holger;
Jung, Günther;
Wiesmüller, Karl-Heinz;
Ulmer, Artur J.

Publication type:

Article

Lipopeptide structure determines TLR2 dependent cell activation level.

Published in:

FEBS Journal, 2005, v. 272, n. 24, p. 6354, doi. 10.1111/j.1742-4658.2005.05029.x

By:

Buwitt-Beckmann, Ute;
Heine, Holger;
Wiesmüller, Karl-Heinz;
Jung, Gü nther;
Brock, Roland;
Ulmer, Artur J

Publication type:

Article

Accumulation of Inhibitory κB-α as a Mechanism Contributing to the Anti-Inflammatory Effects of Surfactant Protein-A.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2004, v. 31, n. 6, p. 587, doi. 10.1165/rcmb.2004-0003OC

By:

Yingda Wu;
Adam, Stefanie;
Hamann, Lutz;
Heine, Holger;
Ulmer, Artur J.;
Buwitt-Beckmann, Ute;
Stamme, Cordula

Publication type:

Article

Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons.

Published in:

Particle & Fibre Toxicology, 2017, v. 14, p. 1, doi. 10.1186/s12989-017-0189-1

By:

Lindner, Karina;
Ströbele, Michael;
Schlick, Sandra;
Webering, Sina;
Jenckel, André;
Kopf, Johannes;
Danov, Olga;
Sewald, Katherina;
Buj, Christian;
Creutzenberg, Otto;
Tillmann, Thomas;
Pohlmann, Gerhard;
Ernst, Heinrich;
Ziemann, Christina;
Hüttmann, Gereon;
Heine, Holger;
Bockhorn, Henning;
Hansen, Tanja;
König, Peter;
Fehrenbach, Heinz

Publication type:

Article

Isolation of Enterococcus faecium NM113, Enterococcus faecium NM213 and Lactobacillus casei NM512 as novel probiotics with immunomodulatory properties.

Published in:

Microbiology & Immunology, 2014, v. 58, n. 10, p. 559, doi. 10.1111/1348-0421.12187

By:

Mansour, Nahla M.;
Heine, Holger;
Abdou, Sania M.;
Shenana, Mohamed E.;
Zakaria, Mohamed K.;
El‐Diwany, Ahmed

Publication type:

Article

Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.631797

By:

Heine, Holger;
Adanitsch, Florian;
Peternelj, Tina Tinkara;
Haegman, Mira;
Kasper, Christoph;
Ittig, Simon;
Beyaert, Rudi;
Jerala, Roman;
Zamyatina, Alla

Publication type:

Article

Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways.

Published in:

2021

By:

Zamyatina, Alla;
Heine, Holger

Publication type:

Correction Notice

RNA is taking its Toll: Impact of RNA‐specific Toll‐like receptors on health and disease.

Published in:

Allergy, 2019, v. 74, n. 2, p. 223, doi. 10.1111/all.13680

By:

Vierbuchen, Tim;
Stein, Karina;
Heine, Holger

Publication type:

Article