Works by Hegi, Monika

Results: 94

MGMT promoter methylation in malignant gliomas.

Published in:

2010

By:

Riemenschneider, Markus;
Hegi, Monika;
Reifenberger, Guido;
Riemenschneider, Markus J;
Hegi, Monika E

Publication type:

journal article

Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells.

Published in:

Cancers, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/cancers14092233

By:

Beltzig, Lea;
Schwarzenbach, Christian;
Leukel, Petra;
Frauenknecht, Katrin B. M.;
Sommer, Clemens;
Tancredi, Alessandro;
Hegi, Monika E.;
Christmann, Markus;
Kaina, Bernd

Publication type:

Article

Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma.

Published in:

Genome Biology, 2015, v. 16, n. 1, p. 316, doi. 10.1186/s13059-015-0583-7

By:

Kurscheid, Sebastian;
Bady, Pierre;
Sciuscio, Davide;
Samarzija, Ivana;
Shay, Tal;
Vassallo, Irene;
van Criekinge, Wim;
Daniel, Roy T.;
van den Bent, Martin J.;
Marosi, Christine;
Weller, Michael;
Mason, Warren P.;
Domany, Eytan;
Stupp, Roger;
Delorenzi, Mauro;
Hegi, Monika E.

Publication type:

Article

An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples.

Published in:

Nature Protocols, 2021, v. 16, n. 10, p. 4692, doi. 10.1038/s41596-021-00594-2

By:

Maas, Roeltje R.;
Soukup, Klara;
Klemm, Florian;
Kornete, Mara;
Bowman, Robert L.;
Bedel, Romain;
Marie, Damien N.;
Álvarez-Prado, Ángel F.;
Labes, Danny;
Wilson, Anne;
Brouland, Jean-Philippe;
Daniel, Roy T.;
Hegi, Monika E.;
Joyce, Johanna A.

Publication type:

Article

Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG.

Published in:

Molecular Oncology, 2023, v. 17, n. 9, p. 1744, doi. 10.1002/1878-0261.13494

By:

Nguyen, Thi Tham;
Rajakannu, Premnath;
Pham, Minh Diêu Thanh;
Weman, Leo;
Jucht, Alexander;
Buri, Michelle C.;
Van Dommelen, Kristof;
Hegi, Monika E.

Publication type:

Article

Anti-O6-Methylguanine-Methyltransferase (MGMT) Immunohistochemistry in Glioblastoma Multiforme: Observer Variability and Lack of Association with Patient Survival Impede Its Use as Clinical Biomarker.

Published in:

Brain Pathology, 2008, v. 18, n. 4, p. 520, doi. 10.1111/j.1750-3639.2008.00153.x

By:

Preusser, Matthias;
Janzer, Robert Charles;
Felsberg, Jörg;
Reifenberger, Guido;
Hamou, Marie-France;
Diserens, Annie-Claire;
Stupp, Roger;
Gorlia, Thierry;
Marosi, Christine;
Heinzl, Harald;
Hainfellner, Johannes A.;
Hegi, Monika

Publication type:

Article

Expression of O-methylguanine-DNA methyltransferase in childhood medulloblastoma.

Published in:

Journal of Neuro-Oncology, 2011, v. 103, n. 1, p. 59, doi. 10.1007/s11060-010-0366-7

By:

Faoro, Denis;
Bueren, André;
Shalaby, Tarek;
Sciuscio, Davide;
Hürlimann, Marie-Louise;
Arnold, Lucia;
Gerber, Nicolas;
Haybaeck, Johannes;
Mittelbronn, Michel;
Rutkowski, Stefan;
Hegi, Monika;
Grotzer, Michael

Publication type:

Article

Comparison of pulmonary O6-methylguanine dna adduct levels and Ki- ras activation in lung tumors from resistant and susceptible mouse strains.

Published in:

Molecular Carcinogenesis, 1993, v. 8, n. 3, p. 177, doi. 10.1002/mc.2940080308

By:

Devereux, Theodora R.;
White, Catherine M.;
Hegi, Monika E.;
Patel, Arti C.;
Anderson, Marshall W.;
Maronpot, Robert R.;
Foley, Julie F.;
Greenwell, Arnold;
Belinsky, Steven A.

Publication type:

Article

Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85339-7

By:

Mishkovsky, Mor;
Gusyatiner, Olga;
Lanz, Bernard;
Cudalbu, Cristina;
Vassallo, Irene;
Hamou, Marie-France;
Bloch, Jocelyne;
Comment, Arnaud;
Gruetter, Rolf;
Hegi, Monika E.

Publication type:

Article

No benefit from TMZ treatment in glioblastoma with truly unmethylated MGMT promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly glioblastoma patients.

Published in:

Neuro-Oncology, 2024, v. 26, n. 10, p. 1867, doi. 10.1093/neuonc/noae108

By:

Hegi, Monika E;
Oppong, Felix B;
Perry, James R;
Wick, Wolfgang;
Henriksson, Roger;
Laperriere, Norman J;
Gorlia, Thierry;
Malmström, Annika;
Weller, Michael

Publication type:

Article

Towards more Diversity in Neuro-oncology Leadership—the DivINe Initiative.

Published in:

Neuro-Oncology, 2023, v. 25, n. 12, p. 2302, doi. 10.1093/neuonc/noad157

By:

Kurz, Sylvia C;
Stammberger, Anja;
Rosahl, Steffen K;
Abrey, Lauren E;
Albert, Nathalie L;
Baumgarten, Louisa von;
Gempt, Jens;
Grosu, Anca-L;
Leidgens, Verena;
McLean, Anna;
Renovanz, Mirjam;
Schwarzenberger, Julia;
Sevenich, Lisa;
Purkart, Tadeja Urbanic;
Combs, Stephanie E;
Tabatabai, Ghazaleh;
Hegi, Monika;
Nowosielski, Martha

Publication type:

Article

Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline.

Published in:

Neuro-Oncology, 2023, v. 25, n. 10, p. 1731, doi. 10.1093/neuonc/noad100

By:

Sahm, Felix;
Brandner, Sebastian;
Bertero, Luca;
Capper, David;
French, Pim J;
Figarella-Branger, Dominique;
Giangaspero, Felice;
Haberler, Christine;
Hegi, Monika E;
Kristensen, Bjarne W;
Kurian, Kathreena M;
Preusser, Matthias;
Tops, Bastiaan B J;
van den Bent, Martin;
Wick, Wolfgang;
Reifenberger, Guido;
Wesseling, Pieter

Publication type:

Article

EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection.

Published in:

Neuro-Oncology, 2023, v. 25, n. 5, p. 813, doi. 10.1093/neuonc/noad008

By:

Capper, David;
Reifenberger, Guido;
French, Pim J;
Schweizer, Leonille;
Weller, Michael;
Touat, Mehdi;
Niclou, Simone P;
Euskirchen, Philipp;
Haberler, Christine;
Hegi, Monika E;
Brandner, Sebastian;
Rhun, Emilie Le;
Rudà, Roberta;
Sanson, Marc;
Tabatabai, Ghazaleh;
Sahm, Felix;
Wen, Patrick Y;
Wesseling, Pieter;
Preusser, Matthias;
Bent, Martin J van den

Publication type:

Article

BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression.

Published in:

Cell Death & Disease, 2022, v. 13, n. 12, p. 1, doi. 10.1038/s41419-022-05497-y

By:

Tancredi, Alessandro;
Gusyatiner, Olga;
Bady, Pierre;
Buri, Michelle C.;
Lomazzi, Rémy;
Chiesi, Davide;
Messerer, Mahmoud;
Hegi, Monika E.

Publication type:

Article

Current concepts and management of glioblastoma.

Published in:

Annals of Neurology, 2011, v. 70, n. 1, p. 9, doi. 10.1002/ana.22425

By:

Preusser, Matthias;
de Ribaupierre, Sandrine;
Wöhrer, Adelheid;
Erridge, Sara C.;
Hegi, Monika;
Weller, Michael;
Stupp, Roger

Publication type:

Article

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.

Published in:

Oncogene, 2002, v. 21, n. 27, p. 4212, doi. 10.1038/sj.onc.1205610

By:

Albertoni, Michele;
Shaw, Phillip H.;
Nozaki, Michimasa;
Godard, Sophie;
Tenan, Mirna;
Hamou, Marie-France;
Fairlie, Douglas W.;
Breit, Samuel N.;
Paralkar, Vishwas M.;
De Tribolet, Nicolas;
Van Meir, Erwin G.;
Hegi, Monika E.

Publication type:

Article

Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas.

Published in:

Oncogene, 2001, v. 20, n. 9, p. 1103, doi. 10.1038/sj.onc.1204197

By:

Labuhn, Martin;
Jones, Graham;
Speel, Ernst JM;
Maier, Daniel;
Zweifel, Christian;
Gratzl, Otmar;
Van Meir, Erwin G;
Hegi, Monika E;
Merlo, Adrian

Publication type:

Article

Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant.

Published in:

Oncogene, 2000, v. 19, n. 47, p. 5329, doi. 10.1038/sj.onc.1203941

By:

Klein, Michael A;
Rüedi, Daniela;
Nozaki, Michimasa;
Dell, Elizabeth W;
Diserens, Annie-Claire;
Seelentag, Walter;
Janzer, Robert C;
Aguzzi, Adriano;
Hegi, Monika E

Publication type:

Article

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

Published in:

Oncogene, 2000, v. 19, n. 33, p. 3816, doi. 10.1038/sj.onc.1203700

By:

Fulci, Giulia;
Labuhn, Martin;
Maier, Daniel;
Lachat, Yan;
Hausmann, Oliver;
Hegi, Monika E;
Janzer, Robert C;
Merlo, Adrian;
Van Meir, Erwin G

Publication type:

Article

Functional analyses of a unique p53 germline mutant (y236Δ) associated with a familial brain tumor syndrome.

Published in:

International Journal of Cancer, 1999, v. 82, n. 1, p. 17, doi. 10.1002/(SICI)1097-0215(19990702)82:1<17::AID-IJC4>3.0.CO;2-6

By:

Chène, Patrick;
Ory, Katherine;
Rüedi, Daniela;
Soussi, Thierry;
Hegi, Monika E.

Publication type:

Article

Genetic Alterations in Brain Tumors Following 1,3-Butadiene Exposure in B6C3F1 Mice.

Published in:

Toxicologic Pathology, 2005, v. 33, n. 3, p. 307, doi. 10.1080/01926230590922848

By:

Yongbaek Kim;
Hong, Hue-Hua l.;
Lachat, Yan;
Clayton, Natasha P.;
Devereux, Theodora R.;
Melnick, Ronald L.;
Hegi, Monika E.;
Sills, Robert E.

Publication type:

Article

BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma.

Published in:

Neuro-Oncology, 2021, v. 23, n. 10, p. 1680, doi. 10.1093/neuonc/noab115

By:

Gusyatiner, Olga;
Bady, Pierre;
Pham, Minh D T;
Lei, Yvonne;
Park, Jungyeon;
Daniel, Roy T;
Delorenzi, Mauro;
Hegi, Monika E

Publication type:

Article

MGMT testing always worth an emotion.

Published in:

Neuro-Oncology, 2021, v. 23, n. 9, p. 1417, doi. 10.1093/neuonc/noab163

By:

Hegi, Monika E;
Ichimura, Koichi

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2021, v. 23, n. 1, p. 14, doi. 10.1093/neuonc/noaa271

By:

Soffietti, Riccardo;
Khasraw, Mustafa;
Huse, Jason;
Hegi, Monika

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2020, v. 22, n. 11, p. 1564, doi. 10.1093/neuonc/noaa220

By:

Soffietti, Riccardo;
Viapiano, Mariano;
Hegi, Monika;
Ghosh, Sourav;
Purow, Benjamin

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2020, v. 22, n. 8, p. 1070, doi. 10.1093/neuonc/noaa147

By:

Ghosh, Sourav;
Hegi, Monika;
Wright, Karen;
Khasraw, Mustafa

Publication type:

Article

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.

Published in:

Neuro-Oncology, 2020, v. 22, n. 8, p. 1073, doi. 10.1093/neuonc/noaa106

By:

Wen, Patrick Y;
Weller, Michael;
Lee, Eudocia Quant;
Alexander, Brian M;
Barnholtz-Sloan, Jill S;
Barthel, Floris P;
Batchelor, Tracy T;
Bindra, Ranjit S;
Chang, Susan M;
Chiocca, E Antonio;
Cloughesy, Timothy F;
DeGroot, John F;
Galanis, Evanthia;
Gilbert, Mark R;
Hegi, Monika E;
Horbinski, Craig;
Huang, Raymond Y;
Lassman, Andrew B;
Rhun, Emilie Le;
Lim, Michael

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2020, v. 22, n. 2, p. 177, doi. 10.1093/neuonc/noz242

By:

Ghosh, Sourav;
Huse, Jason;
Hegi, Monika;
Gerstner, Elizabeth

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2019, v. 21, n. 12, p. 1495, doi. 10.1093/neuonc/noz211

By:

Purow, Benjamin;
Charest, Alain;
Gerstner, Elizabeth;
Hegi, Monika;
Aldape, Kenneth

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2019, v. 21, n. 10, p. 1223, doi. 10.1093/neuonc/noz149

By:

Hegi, Monika;
Huse, Jason;
Ghosh, Sourav;
Wright, Karen

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2019, v. 21, n. 8, p. 965, doi. 10.1093/neuonc/noz113

By:

Hegi, Monika;
Huse, Jason;
Gerstner, Elizabeth;
Wright, Karen;
Purow, Benjamin

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2019, v. 21, n. 3, p. 293, doi. 10.1093/neuonc/noz020

By:

Abounader, Roger;
Bhat, Krishna;
Hegi, Monika;
Soffietti, Riccardo;
Viapiano, Mariano

Publication type:

Article

MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges.

Published in:

Neuro-Oncology, 2019, v. 21, n. 2, p. 167, doi. 10.1093/neuonc/noy132

By:

Mansouri, Alireza;
Hachem, Laureen D;
Mansouri, Sheila;
Nassiri, Farshad;
Laperriere, Normand J;
Xia, Daniel;
Lindeman, Neal I;
Wen, Patrick Y;
Chakravarti, Arnab;
Mehta, Minesh P;
Hegi, Monika E;
Stupp, Roger;
Aldape, Kenneth D;
Zadeh, Gelareh

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2018, v. 20, n. 12, p. 1563, doi. 10.1093/neuonc/noy175

By:

Viapiano, Mariano;
Bhat, Krishna;
Abounader, Roger;
Huse, Jason;
Hegi, Monika

Publication type:

Article

CBMT-15. METABOLIC AND TRANSCRIPTIONAL PROFILES OF GBM INVASION: COMPARISON OF PATIENTS AND PAIRED PATIENT DERIVED XENOGRAFTS USING1H MAGNETIC RESONANCE SPECTROSCOPY AND IMAGING (7T AND 14T) AND RNA-SEQUENCING.

Published in:

Neuro-Oncology, 2018, v. 20, p. vi35, doi. 10.1093/neuonc/noy148.134

By:

Hegi, Monika;
Cudalbu, Cristina;
Bady, Pierre;
Lai, Marta;
Xin, Lijing;
Gusyatiner, Olga;
Hamou, Marie-France;
Lepore, Mario;
Daniel, Roy;
Gruetter, Rolf

Publication type:

Article

Toward methylation-based classification of central nervous system tumors.

Published in:

Neuro-Oncology, 2018, v. 20, n. 5, p. 579, doi. 10.1093/neuonc/noy023

By:

Hegi, Monika E;
Kleihues, Paul;
Wen, Patrick Y;
Suvà, Mario L

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2018, v. 20, n. 4, p. 441, doi. 10.1093/neuonc/noy030

By:

Soffietti, Riccardo;
Wick, Wolfgang;
Viapiano, Mariano;
Pope, Whitney;
Hegi, Monika;
Wright, Karen

Publication type:

Article

Highlights from the Literature.

Published in:

Neuro-Oncology, 2018, v. 20, n. 2, p. 153, doi. 10.1093/neuonc/nox247

By:

Bhat, Krishna;
Gerstner, Elizabeth;
Hegi, Monika;
Viapiano, Mariano

Publication type:

Article

Resolving Intertumor Heterogeneity Within Medulloblastoma Subgroups.

Published in:

Neuro-Oncology, 2017, v. 19, n. 11, p. 1434, doi. 10.1093/neuonc/nox185

By:

Schiff, David;
Soffietti, Riccardo;
Huse, Jason;
Lawler, Sean;
Hegi, Monika

Publication type:

Article

Uncovering Evolutionary Relationships Between Transcriptional Subtypes and Infiltrating Immune Cells in Glioblastoma.

Published in:

Neuro-Oncology, 2017, v. 19, n. 11, p. 1433, doi. 10.1093/neuonc/nox185

By:

Schiff, David;
Soffietti, Riccardo;
Huse, Jason;
Lawler, Sean;
Hegi, Monika

Publication type:

Article

Characterizing and Combating EGFR Inhibitor Resistance in Glioblastoma.

Published in:

Neuro-Oncology, 2017, v. 19, n. 11, p. 1433, doi. 10.1093/neuonc/nox185

By:

Schiff, David;
Soffietti, Riccardo;
Huse, Jason;
Lawler, Sean;
Hegi, Monika

Publication type:

Article

Efficacy of Anti-PD-1 Therapy in Patients With Melanoma Brain Metastases.

Published in:

Neuro-Oncology, 2017, v. 19, n. 11, p. 1432, doi. 10.1093/neuonc/nox185

By:

Schiff, David;
Soffietti, Riccardo;
Huse, Jason;
Lawler, Sean;
Hegi, Monika

Publication type:

Article

The Clinical Value of ATRX and TERT Mutations in Diffuse Adult Gliomas.

Published in:

Neuro-Oncology, 2017, v. 19, n. 11, p. 1432, doi. 10.1093/neuonc/nox185

By:

Schiff, David;
Soffietti, Riccardo;
Huse, Jason;
Lawler, Sean;
Hegi, Monika

Publication type:

Article

Correlation of immune phenotype with IDH mutation in diffuse glioma.

Published in:

Neuro-Oncology, 2017, v. 19, n. 11, p. 1460, doi. 10.1093/neuonc/nox054

By:

Berghoff, Anna Sophie;
Kiesel, Barbara;
Widhalm, Georg;
Wilhelm, Dorothee;
Rajky, Orsolya;
Kurscheid, Sebastian;
Kresl, Philip;
Wöhrer, Adelheid;
Marosi, Christine;
Hegi, Monika E.;
Preusser, Matthias

Publication type:

Article

Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG.

Published in:

Neuro-Oncology, 2017, v. 19, n. 8, p. 1119, doi. 10.1093/neuonc/nox025

By:

Blumenthal, Deborah T.;
Gorlia, Thierry;
Gilbert, Mark R.;
Kim, Michelle M.;
Nabors, L. Burt;
Mason, Warren P.;
Hegi, Monika E.;
Zhang, Peixin;
Golfinopoulos, Vassilis;
Perry, James R.;
Nam, Do Hyun;
Erridge, Sara C.;
Corn, Benjamin W.;
Mirimanoff, René O.;
Brown, Paul D.;
Baumert, Brigitta G.;
Mehta, Minesh P.;
van den Bent, Martin J.;
Reardon, David A.;
Weller, Michael

Publication type:

Article

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Published in:

Neuro-Oncology, 2017, v. 19, n. 5, p. 611, doi. 10.1093/neuonc/nox047

By:

Chamberlain, Marc;
Hegi, Monika;
Bhat, Krishna;
Viapiano, Mariano;
Soffietti, Riccardo

Publication type:

Article

High-dose Methotrexate-based Immuno-chemotherapy for Elderly Primary CNS Lymphoma Patients (PRIMAIN Study).

Published in:

Neuro-Oncology, 2017, v. 19, n. 5, p. 613, doi. 10.1093/neuonc/nox047

By:

Chamberlain, Marc;
Hegi, Monika;
Bhat, Krishna;
Viapiano, Mariano;
Soffietti, Riccardo

Publication type:

Article

The IDH1 Mutation Reduces Glioblastoma Invasion but is Overruled by Increased Tissue Stiffness at Recurrence.

Published in:

Neuro-Oncology, 2017, v. 19, n. 5, p. 613, doi. 10.1093/neuonc/nox047

By:

Chamberlain, Marc;
Hegi, Monika;
Bhat, Krishna;
Viapiano, Mariano;
Soffietti, Riccardo

Publication type:

Article

Clonal Variation in Drug and Radiation Response Among Glioma-initiating Cells is Linked to Proneural-mesenchymal Transition.

Published in:

Neuro-Oncology, 2017, v. 19, n. 5, p. 612, doi. 10.1093/neuonc/nox047

By:

Chamberlain, Marc;
Hegi, Monika;
Bhat, Krishna;
Viapiano, Mariano;
Soffietti, Riccardo

Publication type:

Article

Medulloblastoma: Through the Looking Glass of Molecular Biology.

Published in:

Neuro-Oncology, 2017, v. 19, n. 5, p. 611, doi. 10.1093/neuonc/nox047

By:

Chamberlain, Marc;
Hegi, Monika;
Bhat, Krishna;
Viapiano, Mariano;
Soffietti, Riccardo

Publication type:

Article