Works by Heeman, Bavo

Results: 14

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

Published in:

Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0024-9

By:

Bettens, Karolien;
Vermeulen, Steven;
Van Cauwenberghe, Caroline;
Heeman, Bavo;
Asselbergh, Bob;
Robberecht, Caroline;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter Paul;
Cruts, Marc;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Limbic-predominant age-related TDP-43 proteinopathy (LATE-NC) is associated with abundant TMEM106B pathology.

Published in:

Acta Neuropathologica, 2023, v. 146, n. 1, p. 163, doi. 10.1007/s00401-023-02580-2

By:

Neumann, Manuela;
Perneel, Jolien;
Cheung, Simon;
Van den Broeck, Marleen;
Nygaard, Haakon;
Hsiung, Ging-Yuek R.;
Wynants, Sarah;
Heeman, Bavo;
Rademakers, Rosa;
Mackenzie, Ian R. A.

Publication type:

Article

Correction to: Accumulation of TMEM106B C‑terminal fragments in neurodegenerative disease and aging.

Published in:

2023

By:

Perneel, Jolien;
Neumann, Manuela;
Heeman, Bavo;
Cheung, Simon;
Van den Broeck, Marleen;
Wynants, Sarah;
Baker, Matt;
Vicente, Cristina T.;
Faura, Júlia;
Rademakers, Rosa;
Mackenzie, Ian R. A.

Publication type:

Correction Notice

Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 3, p. 285, doi. 10.1007/s00401-022-02531-3

By:

Perneel, Jolien;
Neumann, Manuela;
Heeman, Bavo;
Cheung, Simon;
Van den Broeck, Marleen;
Wynants, Sarah;
Baker, Matt;
Vicente, Cristina T.;
Faura, Júlia;
Rademakers, Rosa;
Mackenzie, Ian R. A.

Publication type:

Article

Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 6, p. 1001, doi. 10.1007/s00401-020-02145-7

By:

Martin, Shaun;
Smolders, Stefanie;
Van den Haute, Chris;
Heeman, Bavo;
van Veen, Sarah;
Crosiers, David;
Beletchi, Igor;
Verstraeten, Aline;
Gossye, Helena;
Gelders, Géraldine;
Pals, Philippe;
Hamouda, Norin Nabil;
Engelborghs, Sebastiaan;
Martin, Jean-Jacques;
Eggermont, Jan;
De Deyn, Peter Paul;
Cras, Patrick;
Baekelandt, Veerle;
Vangheluwe, Peter;
Van Broeckhoven, Christine

Publication type:

Article

Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 6, p. 901, doi. 10.1007/s00401-019-01976-3

By:

Cacace, Rita;
Heeman, Bavo;
De Roeck, Arne;
Hoogmartens, Julie;
De Vos, Kristof;
Geerts, Nathalie;
Peeters, Karin;
van der Zee, Julie;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Van Mossevelde, Sara;
Gossye, Helena;
Sieben, Anne;
De Rijk, Peter;
De Coster, Wouter;
Strazisar, Mojca;
De Pooter, Tim;
Vandenberghe, Rik;
C. van Swieten, John;
M. van Duijn, Cornelia

Publication type:

Article

Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 3, p. 475, doi. 10.1007/s00401-017-1714-x

By:

Roeck, Arne;
Bossche, Tobi;
Zee, Julie;
Verheijen, Jan;
Coster, Wouter;
Dongen, Jasper;
Dillen, Lubina;
Baradaran-Heravi, Yalda;
Heeman, Bavo;
Sanchez-Valle, Raquel;
Lladó, Albert;
Nacmias, Benedetta;
Sorbi, Sandro;
Gelpi, Ellen;
Grau-Rivera, Oriol;
Gómez-Tortosa, Estrella;
Pastor, Pau;
Ortega-Cubero, Sara;
Pastor, Maria;
Graff, Caroline

Publication type:

Article

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00831-2

By:

Perneel, Jolien;
Lastra Osua, Miranda;
Alidadiani, Sara;
Peeters, Nele;
De Witte, Linus;
Heeman, Bavo;
Manzella, Simona;
De Rycke, Riet;
Brooks, Mieu;
Perkerson, Ralph B.;
Calus, Elke;
De Coster, Wouter;
Neumann, Manuela;
Mackenzie, Ian R. A.;
Van Dam, Debby;
Asselbergh, Bob;
Ellender, Tommas;
Zhou, Xiaolai;
Rademakers, Rosa

Publication type:

Article

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 10, p. 4055, doi. 10.1093/brain/awad133

By:

Vicente, Cristina T.;
Perneel, Jolien;
Wynants, Sarah;
Heeman, Bavo;
Broeck, Marleen Van den;
Baker, Matt;
Cheung, Simon;
Faura, Júlia;
Mackenzie, Ian R A;
Rademakers, Rosa

Publication type:

Article

Analysis of the splicing landscape of the frontal cortex in FTLD-TDP reveals subtype specific patterns and cryptic splicing.

Published in:

Acta Neuropathologica, 2025, v. 149, n. 1, p. 1, doi. 10.1007/s00401-025-02901-7

By:

Faura, Júlia;
Heeman, Bavo;
Pottier, Cyril;
Baker, Matthew C.;
DeJesus-Hernandez, Mariely;
Küçükali, Fahri;
Heiß, Laura;
Wynants, Sarah;
Van den Broeck, Marleen;
De Rijk, Peter;
De Pooter, Tim;
Joris, Geert;
Finch, NiCole A.;
Asmann, Yan;
Strazisar, Mojca;
Murray, Melissa E.;
Petrucelli, Leonard;
Oskarsson, Björn;
Sleegers, Kristel;
Josephs, Keith A.

Publication type:

Article

Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson's disease.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01121-w

By:

Smolders, Stefanie;
Philtjens, Stéphanie;
Crosiers, David;
Sieben, Anne;
Hens, Elisabeth;
Heeman, Bavo;
Van Mossevelde, Sara;
Pals, Philippe;
Asselbergh, Bob;
Dos Santos Dias, Roberto;
Vermeiren, Yannick;
Vandenberghe, Rik;
Engelborghs, Sebastiaan;
De Deyn, Peter Paul;
Martin, Jean-Jacques;
Cras, Patrick;
Annaert, Wim;
Van Broeckhoven, Christine;
BELNEU consortium;
van der Linden, Chris

Publication type:

Article

P1‐210: INVESTIGATING THE INVOLVEMENT OF THE DPP6‐KV4.2 PROTEIN COMPLEX IN DEMENTIA.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P316, doi. 10.1016/j.jalz.2019.06.765

By:

Cacace, Rita;
De Vos, Kristof;
Heeman, Bavo;
Van Mossevelde, Sara;
Sieben, Anne;
Engelborghs, Sebastiaan;
De Deyn, Peter Paul;
Martin, Jean-Jacques;
Van Broeckhoven, Christine

Publication type:

Article

Loss-of-function mutations in TBK1 are frequently associated with frontotemporal lobar degeneration in a belgian patient cohort.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P333, doi. 10.1016/j.jalz.2015.08.157

By:

Gijselinck, Ilse;
Van Mossevelde, Sara;
Sieben, Anne;
Heeman, Bavo;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Cuijt, Ivy;
Van den Broeck, Marleen;
Peeters, Karin;
Mattheijssens, Maria;
Vandenberghe, Rik;
De Jonghe, Peter;
Cras, Patrick;
De Deyn, Peter P.;
Martin, Jean-Jacques;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Published in:

Human Mutation, 2017, v. 38, n. 3, p. 297, doi. 10.1002/humu.23161

By:

der Zee, Julie;
Gijselinck, Ilse;
Mossevelde, Sara;
Perrone, Federica;
Dillen, Lubina;
Heeman, Bavo;
Bäumer, Veerle;
Engelborghs, Sebastiaan;
Bleecker, Jan;
Baets, Jonathan;
Gelpi, Ellen;
Rojas‐García, Ricardo;
Clarimón, Jordi;
Lleó, Alberto;
Diehl‐Schmid, Janine;
Alexopoulos, Panagiotis;
Perneczky, Robert;
Synofzik, Matthis;
Just, Jennifer;
Schöls, Ludger

Publication type:

Article