Works by Heck, Albert J. R.

Results: 228

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β- Catenin Coactivators Essential for Intestinal Homeostasis.

Published in:

PLoS Biology, 2010, v. 8, n. 11, p. 1, doi. 10.1371/journal.pbio.1000539

By:

Mahmoudi, Tokameh;
Boj, Sylvia F.;
Hatzis, Pantelis;
Li, Vivian S. W.;
Taouatas, Nadia;
Vries, Robert G. J.;
Teunissen, Hans;
Begthel, Harry;
Korving, Jeroen;
Mohammed, Shabaz;
Heck, Albert J. R.;
Clevers, Hans

Publication type:

Article

Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes.

Published in:

PLoS Biology, 2010, v. 8, n. 1, p. 1, doi. 10.1371/journal.pbio.1000283

By:

Hoogenraad, Casper C.;
Popa, Ioana;
Futai, Kensuke;
Sanchez-Martinez, Emma;
Wulf, Phebe S.;
van Vlijmen, Thijs;
Dortland, Bjorn R.;
Oorschot, Viola;
Govers, Roland;
Monti, Maria;
Heck, Albert J. R.;
Sheng, Morgan;
Klumperman, Judith;
Rehmann, Holger;
Jaarsma, Dick;
Kapitein, Lukas C.;
van der Sluijs, Peter

Publication type:

Article

Moderne biomolekulare Massenspektrometrie und ihre Bedeutung für die Erforschung der Struktur, der Dynamik und des Aufbaus von Viren.

Published in:

Angewandte Chemie, 2011, v. 123, n. 36, p. 8398, doi. 10.1002/ange.201008120

By:

Uetrecht, Charlotte;
Heck, Albert J. R.

Publication type:

Article

A case series exploring the human milk polyclonal IgA1 response to repeated SARS-CoV-2 vaccinations by LC-MS based fab profiling.

Published in:

Frontiers in Nutrition, 2024, p. 1, doi. 10.3389/fnut.2023.1305086

By:

de Graaf, Sebastiaan C.;
Bondt, Albert;
van Rijswijck, Danique M. H.;
Juncker, Hannah G.;
Mulleners, Sien J.;
Damen, Mirjam J. A.;
Hoek, Max;
van Keulen, Britt J.;
van Goudoever, Johannes B.;
Heck, Albert J. R.;
Dingess, Kelly A.

Publication type:

Article

Erratum: Interrogating viral capsid assembly with ion mobility-mass spectrometry.

Published in:

Nature Chemistry, 2014, v. 6, n. 8, p. 745, doi. 10.1038/nchem.2025

By:

Uetrecht, Charlotte;
Barbu, Ioana M.;
Shoemaker, Glen K.;
van Duijn, Esther;
Heck, Albert J. R.

Publication type:

Article

Interrogating viral capsid assembly with ion mobility-mass spectrometry.

Published in:

Nature Chemistry, 2011, v. 3, n. 2, p. 126, doi. 10.1038/nchem.947

By:

Uetrecht, Charlotte;
Barbu, Ioana M.;
Shoemaker, Glen K.;
van Duijn, Esther;
Heck, Albert J. R.

Publication type:

Article

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

Published in:

Pigment Cell & Melanoma Research, 2015, v. 28, n. 3, p. 307, doi. 10.1111/pcmr.12364

By:

Vogel, Celia J.;
Smit, Marjon A.;
Maddalo, Gianluca;
Possik, Patricia A.;
Sparidans, Rolf W.;
Burg, Sjoerd H.;
Verdegaal, Els M.;
Heck, Albert J. R.;
Samatar, Ahmed A.;
Beijnen, Jos H.;
Altelaar, A. F. Maarten;
Peeper, Daniel S.

Publication type:

Article

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics.

Published in:

Nature Biotechnology, 2003, v. 21, n. 8, p. 927, doi. 10.1038/nbt848

By:

Krijgsveld, Jeroen;
Ketting, René F;
Mahmoudi, Tokameh;
Johansen, Janik;
Artal-Sanz, Marta;
Verrijzer, C Peter;
Plasterk, Ronald H A;
Heck, Albert J R

Publication type:

Article

On-the-fly targeted selection of labeled peptides in liquid chromatography/mass spectrometry based quantitative proteomics.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2010, v. 24, n. 2, p. 239, doi. 10.1002/rcm.4385

By:

Barbu, Ioana M. Taban;
Smith, Donald F.;
van Breukelen, Bas;
van der Burgt, Yuri E. M.;
Duursma, Marc C.;
Heck, Albert. J. R.;
Heeren, Ron M. A.;
Krijgsveld, Jeroen

Publication type:

Article

Thermal activation of the co-chaperonins GroES and gp31 probed by mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2008, v. 22, n. 22, p. 3633, doi. 10.1002/rcm.3782

By:

Geels, Rimco B. J.;
Calmat, Stephane;
Heck, Albert J. R.;
van der Vies, Saskia M.;
Heeren, Ron M. A.

Publication type:

Article

A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.

Published in:

BMC Biology, 2016, v. 14, p. 1, doi. 10.1186/s12915-016-0286-x

By:

Waaijers, Selma;
Muñoz, Javier;
Berends, Christian;
Ramalho, João J.;
Goerdayal, Soenita S.;
Zoumaro-Djayoon, Adja D.;
Hoffmann, Michael;
Koorman, Thijs;
Tas, Roderick P.;
Harterink, Martin;
Seelk, Stefanie;
Kerver, Jana;
Hoogenraad, Casper C.;
Bossinger, Olaf;
Tursun, Baris;
van den Heuvel, Sander;
Heck, Albert J. R.;
Boxem, Mike;
Low, Teck Y.

Publication type:

Article

LysNDeNovo: An algorithm enabling de novo sequencing of Lys-N generated peptides fragmented by electron transfer dissociation.

Published in:

Proteomics, 2010, v. 10, n. 6, p. 1196, doi. 10.1002/pmic.200900405

By:

van Breukelen, Bas;
Georgiou, Alexandros;
Drugan, Madalina M.;
Taouatas, Nadia;
Mohammed, Shabaz;
Heck, Albert J. R.

Publication type:

Article

A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions.

Published in:

Proteomics, 2009, v. 9, n. 20, p. 4787, doi. 10.1002/pmic.200800951

By:

Helbig, Andreas O.;
de Groot, Marco J. L.;
van Gestel, Renske A.;
Mohammed, Shabaz;
de Hulster, Erik A. F.;
Luttik, Marijke A. H.;
Daran-Lapujade, Pascale;
Pronk, Jack T.;
Heck, Albert J. R.;
Slijper, Monique

Publication type:

Article

Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates.

Published in:

Proteomics, 2008, v. 8, n. 22, p. 4624, doi. 10.1002/pmic.200800297

By:

Boersema, Paul J.;
Aye, Thin Thin;
van Veen, Toon A. B.;
Heck, Albert J. R.;
Mohammed, Shabaz

Publication type:

Article

A practical guide for the identification of membrane and plasma membrane proteins in human embryonic stem cells and human embryonal carcinoma cells.

Published in:

Proteomics, 2008, v. 8, n. 19, p. 4036, doi. 10.1002/pmic.200800143

By:

Dormeyer, Wilma;
van Hoof, Dennis;
Mummery, Christine L.;
Krijgsveld, Jeroen;
Heck, Albert J. R.

Publication type:

Article

Suction blister fluid as potential body fluid for biomarker proteins.

Published in:

Proteomics, 2007, v. 7, n. 20, p. 3638, doi. 10.1002/pmic.200600938

By:

Kool, Jeroen;
Reubsaet, Léon;
Wesseldijk, Feikje;
Maravilha, Raquel T.;
Pinkse, Martijn W.;
D'Santos, Clive S.;
van Hilten, Jacobus J.;
Zijlstra, Freek J.;
Heck, Albert J. R.

Publication type:

Article

Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides.

Published in:

Proteomics, 2006, v. 6, n. 24, p. 6394, doi. 10.1002/pmic.200600373

By:

Poot, Alex J.;
Ruijter, Eelco;
Nuijens, Timo;
Dirksen, Eef H. C.;
Heck, Albert J. R.;
Slijper, Monique;
Rijkers, Dirk T. S.;
Liskamp, Rob M. J.

Publication type:

Article

Identification of proteins in activated human neutrophils susceptible to tyrosyl radical attack. A proteomic study using a tyrosylating fluorophore.

Published in:

Proteomics, 2004, v. 4, n. 8, p. 2397, doi. 10.1002/pmic.200300755

By:

Diana Avram;
Edwin P. Romijn;
Everard H. W. Pap;
Albert J. R. Heck;
Karel W. A. Wirtz

Publication type:

Article

Lung proteome alterations in a mouse model for nonallergic asthma.

Published in:

Proteomics, 2003, v. 3, n. 10, p. 2008, doi. 10.1002/pmic.200300469

By:

René Houtman;
Jeroen Krijgsveld;
Mirjam Kool;
Edwin P. Romijn;
Frank A. Redegeld;
Frans P. Nijkamp;
Albert J. R. Heck;
Ian Humphery-Smith

Publication type:

Article

A Protein‐Based Encapsulation System with Calcium‐Controlled Cargo Loading and Detachment.

Published in:

Angewandte Chemie, 2018, v. 130, n. 35, p. 11504, doi. 10.1002/ange.201806466

By:

Lizatović, Robert;
Assent, Marvin;
Barendregt, Arjan;
Dahlin, Jonathan;
Bille, Anna;
Satzinger, Katharina;
Tupina, Dagnija;
Heck, Albert J. R.;
Wennmalm, Stefan;
André, Ingemar

Publication type:

Article

A serum proteome signature to predict mortality in severe COVID-19 patients.

Published in:

Life Science Alliance, 2021, v. 4, n. 9, p. 1, doi. 10.26508/lsa.202101099

By:

Völlmy, Franziska;
Henk van den Toorn;
Chiozzi, Riccardo Zenezini;
Zucchetti, Ottavio;
Papi, Alberto;
Volta, Carlo Alberto;
Marracino, Luisa;
Sega, Francesco Vieceli Dalla;
Fortini, Francesca;
Demichev, Vadim;
Tober-Lau, Pinkus;
Campo, Gianluca;
Contoli, Marco;
Ralser, Markus;
Kurth, Florian;
Spadaro, Savino;
Rizzo, Paola;
Heck, Albert J. R.

Publication type:

Article

Neutrophil azurophilic granule glycoproteins are distinctively decorated by atypical pauci- and phosphomannose glycans.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02555-7

By:

Reiding, Karli R.;
Lin, Yu-Hsien;
van Alphen, Floris P. J.;
Meijer, Alexander B.;
Heck, Albert J. R.

Publication type:

Article

HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02364-y

By:

Bauzá-Martinez, Julia;
Heck, Albert J. R.;
Wu, Wei

Publication type:

Article

Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 4, p. 1446, doi. 10.1093/nar/gkr802

By:

Choukrallah, Mohamed-Amin;
Kobi, Dominique;
Martianov, Igor;
Pijnappel, W. W. M. Pim;
Mischerikow, Nikolai;
Ye, Tao;
Heck, Albert J. R.;
Timmers, H. Th. Marc;
Davidson, Irwin

Publication type:

Article

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 18, p. 8052, doi. 10.1093/nar/gkr498

By:

Monti, Maria Chiara;
Cohen, Serge X.;
Fish, Alexander;
Winterwerp, Herrie H. K.;
Barendregt, Arjan;
Friedhoff, Peter;
Perrakis, Anastassis;
Heck, Albert J. R.;
Sixma, Titia K.;
van den Heuvel, Robert H. H.;
Lebbink, Joyce H. G.

Publication type:

Article

Preparation and topology of the Mediator middle module.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 10, p. 3186, doi. 10.1093/nar/gkq029

By:

Koschubs, Tobias;
Lorenzen, Kristina;
Baumli, Sonja;
Sandström, Saana;
Heck, Albert J. R.;
Cramer, Patrick

Publication type:

Article

Interactions of Kid–Kis toxin–antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid–Kis oligomers.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 5, p. 1737, doi. 10.1093/nar/gkm073

By:

Monti, Maria C.;
Hernández-Arriaga, Ana M.;
Kamphuis, Monique B.;
López-Villarejo, Juan;
Heck, Albert J. R.;
Boelens, Rolf;
Díaz-Orejas, Ramón;
van den Heuvel, Robert H. H.

Publication type:

Article

Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry.

Published in:

Nucleic Acids Research, 2005, v. 33, n. 10, p. e96, doi. 10.1093/nar/gni099

By:

van den Heuvel, Robert H. H.;
Gato, Sara;
Versluis, Cees;
Gerbaux, Pascal;
Kleanthous, Colin;
Heck, Albert J. R.

Publication type:

Article

Structural basis of soluble membrane attack complex packaging for clearance.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26366-w

By:

Menny, Anaïs;
Lukassen, Marie V.;
Couves, Emma C.;
Franc, Vojtech;
Heck, Albert J. R.;
Bubeck, Doryen

Publication type:

Article

Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited.

Published in:

FEBS Letters, 2016, v. 590, n. 5, p. 595, doi. 10.1002/1873-3468.12091

By:

Schuller, Jan M.;
Beck, Florian;
Lössl, Philip;
Heck, Albert J. R.;
Förster, Friedrich

Publication type:

Article

The hinge region operates as a stability switch in cGMP-dependent protein kinase Iα.

Published in:

FEBS Journal, 2007, v. 274, n. 9, p. 2274, doi. 10.1111/j.1742-4658.2007.05764.x

By:

Scholten, Arjen;
Fuß, Hendrik;
Heck, Albert J. R.;
Dostmann, Wolfgang R.

Publication type:

Article

γ9δ2T cell diversity and the receptor interface with tumor cells.

Published in:

2020

By:

Vyborova, Anna;
Beringer, Dennis X.;
Fasci, Domenico;
Karaiskaki, Froso;
van Diest, Eline;
Kramer, Lovro;
de Haas, Aram;
Sanders, Jasper;
Janssen, Anke;
Straetemans, Trudy;
Olive, Daniel;
Leusen, Jeanette;
Boutin, Lola;
Nedellec, Steven;
Schwartz, Samantha L.;
Wester, Michael J.;
Lidke, Keith A.;
Scotet, Emmanuel;
Lidke, Diane S.;
Heck, Albert J. R.

Publication type:

journal article

Interactions of α- and β-avoparcin with bacterial cell-wall receptor-mimicking peptides studied by electrospray ionization mass spectrometry.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 1999, v. 44, n. 5, p. 593, doi. 10.1093/jac/44.5.593

By:

van de Kerk-van Hoof, Anca;
Heck, Albert J. R.

Publication type:

Article

Uncovering the abilities of A garicus bisporus to degrade plant biomass throughout its life cycle.

Published in:

Environmental Microbiology, 2015, v. 17, n. 8, p. 3098, doi. 10.1111/1462-2920.12967

By:

Patyshakuliyeva, Aleksandrina;
Post, Harm;
Zhou, Miaomiao;
Jurak, Edita;
Heck, Albert J. R.;
Hildén, Kristiina S.;
Kabel, Mirjam A.;
Mäkelä, Miia R.;
Altelaar, Maarten A. F.;
Vries, Ronald P.

Publication type:

Article

A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins.

Published in:

PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0152231

By:

Soni, Siddarth;
Raaijmakers, Antonia J. A.;
Raaijmakers, Linsey M.;
Damen, J. Mirjam A.;
van Stuijvenberg, Leonie;
Vos, Marc A.;
Heck, Albert J. R.;
van Veen, Toon A. B.;
Scholten, Arjen

Publication type:

Article

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 52, p. 12992, doi. 10.1002/anie.201206745

By:

Rosati, Sara;
Rose, Rebecca J.;
Thompson, Natalie J.;
van Duijn, Esther;
Damoc, Eugen;
Denisov, Eduard;
Makarov, Alexander;
Heck, Albert J. R.

Publication type:

Article

Modern Biomolecular Mass Spectrometry and its Role in Studying Virus Structure, Dynamics, and Assembly.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 36, p. 8248, doi. 10.1002/anie.201008120

By:

Uetrecht, Charlotte;
Heck, Albert J. R.

Publication type:

Article

Stability and Shape of Hepatitis B Virus Capsids In Vacuo.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 33, p. 6247, doi. 10.1002/anie.200802410

By:

Uetrecht, Charlotte;
Versluis, Cees;
Watts, Norman R.;
Wingfield, Paul T.;
Steven, Alasdair C.;
Heck, Albert J. R.

Publication type:

Article

Inside Cover: Stability and Shape of Hepatitis B Virus Capsids In Vacuo (Angew. Chem. Int. Ed. 33/2008).

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 33, p. 6090, doi. 10.1002/anie.200890161

By:

Uetrecht, Charlotte;
Versluis, Cees;
Watts, Norman R.;
Wingfield, Paul T.;
Steven, Alasdair C.;
Heck, Albert J. R.

Publication type:

Article

Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition Open Access.

Published in:

Cardiovascular Research, 2025, v. 121, n. 4, p. 585, doi. 10.1093/cvr/cvaf021

By:

Timmer, Louk T;
Hertog, Elvira den;
Versteeg, Danielle;
Post, Harm;
Verdonschot, Job A J;
Monshouwer-Kloots, Jantine;
Kyriakopoulou, Eirini;
Perini, Ilaria;
Koopmans, Tim;
van der Kraak, Petra;
Zentilin, Lorena;
Heymans, Stephane R B;
Vink, Aryan;
Giacca, Mauro;
Heck, Albert J R;
Rooij, Eva van

Publication type:

Article

Monitoring Human Milk β-Casein Phosphorylation and O -Glycosylation Over Lactation Reveals Distinct Differences between the Proteome and Endogenous Peptidome.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 15, p. 8140, doi. 10.3390/ijms22158140

By:

Dingess, Kelly A.;
Gazi, Inge;
van den Toorn, Henk W. P.;
Mank, Marko;
Stahl, Bernd;
Reiding, Karli R.;
Heck, Albert J. R.

Publication type:

Article

Proteomic Profiling of Mouse Helper T Cell Differentiation.

Published in:

Proteomics, 2019, v. 19, n. 7, p. N.PAG, doi. 10.1002/pmic.201800045

By:

den Ham, Henk‐Jan;
Binai, Nadine A.;
Zaaraoui‐Boutahar, Fatiha;
Heck, Albert J. R.;
Andeweg, Arno C.

Publication type:

Article

Minimal Information About an Immuno‐Peptidomics Experiment (MIAIPE).

Published in:

Proteomics, 2018, v. 18, n. 12, p. 1, doi. 10.1002/pmic.201800110

By:

Lill, Jennie R.;
van Veelen, Peter A.;
Tenzer, Stefan;
Admon, Arie;
Caron, Etienne;
Elias, Joshua E.;
Heck, Albert J. R.;
Marcilla, Miguel;
Marino, Fabio;
Müller, Markus;
Peters, Bjoern;
Purcell, Anthony;
Sette, Alessandro;
Sturm, Theo;
Ternette, Nicola;
Vizcaíno, Juan Antonio;
Bassani‐Sternberg, Michal

Publication type:

Article

Assessment of SRM, MRM<sup>3</sup>, and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer.

Published in:

Proteomics, 2016, v. 16, n. 15/16, p. 2193, doi. 10.1002/pmic.201500453

By:

Schmidlin, Thierry;
Garrigues, Luc;
Lane, Catherine S.;
Mulder, T. Celine;
Doorn, Sander;
Post, Harm;
Graaf, Erik L.;
Lemeer, Simone;
Heck, Albert J. R.;
Altelaar, A. F. Maarten

Publication type:

Article

Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics.

Published in:

Proteomics, 2015, v. 15, n. 16, p. 2756, doi. 10.1002/pmic.201400462

By:

Gautier, Violette;
Boumeester, Anja J.;
Lössl, Philip;
Heck, Albert J. R.

Publication type:

Article

Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics.

Published in:

Proteomics, 2013, v. 13, n. 3/4, p. 526, doi. 10.1002/pmic.201200244

By:

Low, Teck Yew;
Magliozzi, Roberto;
Guardavaccaro, Daniele;
Heck, Albert J. R.

Publication type:

Article

Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle.

Published in:

Proteomics, 2011, v. 11, n. 23, p. 4477, doi. 10.1002/pmic.201100224

By:

Vogels, Mijke W.;
van Balkom, Bas W. M.;
Heck, Albert J. R.;
de Haan, Cornelis A. M.;
Rottier, Peter J. M.;
Batenburg, Joseph J.;
Kaloyanova, Dora V.;
Helms, J. Bernd

Publication type:

Article

Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling.

Published in:

Proteomics, 2011, v. 11, n. 20, p. 3962, doi. 10.1002/pmic.201100048

By:

Zoumaro-Djayoon, Adja D.;
Ding, Vanessa;
Foong, Leong-Yan;
Choo, Andre;
Heck, Albert J. R.;
Muñoz, Javier

Publication type:

Article

Targeted large-scale analysis of protein acetylation.

Published in:

Proteomics, 2011, v. 11, n. 4, p. 571, doi. 10.1002/pmic.201000397

By:

Mischerikow, Nikolai;
Heck, Albert J. R.

Publication type:

Article

Modification and Inhibition of Vancomycin Group Antibiotics by Formaldehyde and Acetaldehyde.

Published in:

Chemistry - A European Journal, 2001, v. 7, n. 4, p. 910, doi. 10.1002/1521-3765(20010216)7:4<910::AID-CHEM910>3.0.CO;2-U

By:

Heck, Albert J. R.;
Bonnici, Pauline J.;
Breukink, Eefjan;
Morris, David;
Wills, Martin

Publication type:

Article