Works by Hecht, J. Randolph

Results: 27

Detecting HLA loss of heterozygosity within a standard diagnostic sequencing workflow for prognostic and therapeutic opportunities.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00665-z

By:

Lozac'hmeur, Ariane;
Danek, Tyler;
Yang, Qidi;
Rosasco, Mario G.;
Welch, John S.;
Go, William Y.;
Ng, Eric W.;
Mardiros, Armen;
Maloney, David G.;
Garon, Edward B.;
Kirtane, Kedar;
Simeone, Diane M.;
Molina, Julian R.;
Salahudeen, Ameen A.;
Stein, Michelle M.;
Hecht, J. Randolph

Publication type:

Article

A Phase 1b/2 Study of the Anti-CD47 Antibody Magrolimab with Cetuximab in Patients with Colorectal Cancer and Other Solid Tumors.

Published in:

Targeted Oncology, 2025, v. 20, n. 3, p. 519, doi. 10.1007/s11523-025-01130-y

By:

Eng, Cathy;
Lakhani, Nehal J.;
Philip, Philip A.;
Schneider, Charles;
Johnson, Benny;
Kardosh, Adel;
Chao, Mark P.;
Patnaik, Amita;
Shihadeh, Fadi;
Lee, Yeonju;
Song, Kai;
Jin, Denise;
Huo, Yanan;
Howland, Michael;
Fisher, George A.;
Hecht, J. Randolph

Publication type:

Article

A Randomized, Placebo-Controlled Phase II Study Evaluating the Reduction of Neutropenia and Febrile Neutropenia in Patients With Colorectal Cancer Receiving Pegfilgrastim With Every-2-Week Chemotherapy.

Published in:

Clinical Colorectal Cancer, 2010, v. 9, n. 2, p. 95, doi. 10.3816/CCC.2010.n.013

By:

Hecht, J. Randolph;
Pillai, Madhavan;
Gollard, Russell;
Heim, William;
Swan, Forrest;
Patel, Ravi;
Dreiling, Lyndah;
Mo, May;
Malik, Imtiaz

Publication type:

Article

Threshold Change in CEA as a Predictor of Non-Progression to First-Line Systemic Therapy in Metastatic Colorectal Cancer Patients With Elevated CEA.

Published in:

2020

By:

Gulhati, Pat;
Yin, Jun;
Pederson, Levi;
Schmoll, Hans-Joachim;
Hoff, Paulo;
Douillard, Jean-Yves;
Hecht, J Randolph;
Tournigand, Christophe;
Tebbut, Niall;
Chibaudel, Benoist;
Gramont, Aimery De;
Shi, Qian;
Overman, Michael James

Publication type:

journal article

Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer.

Published in:

2007

By:

Hecht, J. Randolph;
Patnaik, Amita;
Berlin, Jordan;
Venook, Alan;
Malik, Imtiaz;
Tchekmedyian, Simon;
Navale, Lynn;
Amado, Rafael G.;
Meropol, Neal J.

Publication type:

journal article

Phase II trial of irinotecan in combination with amifostine in patients with advanced colorectal carcinoma.

Published in:

2002

By:

Delioukina, Maria L.;
Prager, Diane;
Parson, Mandy;
Hecht, J. Randolph;
Rosen, Peter;
Rosen, Lee S.

Publication type:

journal article

Panitumumab in colorectal cancer.

Published in:

2007

By:

Wainberg, Zev A.;
Hecht, J. Randolph

Publication type:

journal article

A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 61, n. 3, p. 515, doi. 10.1007/s00280-007-0498-4

By:

Britten, Carolyn D.;
Kabbinavar, Fairooz;
Hecht, J. Randolph;
Bello, Carlo L.;
Li, Jim;
Baum, Charles;
Slamon, Dennis

Publication type:

Article

Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis.

Published in:

Therapeutic Advances in Medical Oncology, 2021, p. 1, doi. 10.1177/17588359211020547

By:

Yin, Jun;
Dawood, Shaheenah;
Cohen, Romain;
Meyers, Jeff;
Zalcberg, John;
Yoshino, Takayuki;
Seymour, Matthew;
Maughan, Tim;
Saltz, Leonard;
Van Cutsem, Eric;
Venook, Alan;
Schmoll, Hans-Joachim;
Goldberg, Richard;
Hoff, Paulo;
Hecht, J. Randolph;
Hurwitz, Herbert;
Punt, Cornelis;
Diaz Rubio, Eduard;
Koopman, Miriam;
Cremolini, Chiara

Publication type:

Article

Clinical development of talimogene laherparepvec (T-VEC): a modified herpes simplex virus type-1-derived oncolytic immunotherapy.

Published in:

2015

By:

Harrington, Kevin J;
Puzanov, Igor;
Hecht, J. Randolph;
Hodi, F. Stephen;
Szabo, Zsolt;
Murugappan, Swami;
Kaufman, Howard L

Publication type:

journal article

Most of the Intended Management Changes After <sup>68</sup>Ga-DOTATATE PET/CT Are Implemented.

Published in:

Journal of Nuclear Medicine, 2017, v. 58, n. 11, p. 1793, doi. 10.2967/jnumed.117.192450

By:

Calais, Jeremie;
Czernin, Johannes;
Eiber, Matthias;
Fendler, Wolfgang P.;
Gartmann, Jeannine;
Heaney, Anthony P.;
Hendifar, Andrew E.;
Pisegna, Joseph R.;
Hecht, J. Randolph;
Wolin, Edward M.;
Slavik, Roger;
Gupta, Pawan;
Quon, Andrew;
Schiepers, Christiaan;
Allen-Auerbach, Martin S.;
Herrmann, Ken

Publication type:

Article

Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCAD Database.

Published in:

Cancers, 2023, v. 15, n. 16, p. 4117, doi. 10.3390/cancers15164117

By:

Ou, Fang-Shu;
Ahn, Daniel H.;
Dixon, Jesse G.;
Grothey, Axel;
Lou, Yiyue;
Kasi, Pashtoon M.;
Hubbard, Joleen M.;
Van Cutsem, Eric;
Saltz, Leonard B.;
Schmoll, Hans-Joachim;
Goldberg, Richard M.;
Venook, Alan P.;
Hoff, Paulo;
Douillard, Jean-Yves;
Hecht, J. Randolph;
Hurwitz, Herbert;
Punt, Cornelis J. A.;
Koopman, Miriam;
Bokemeyer, Carsten;
Fuchs, Charles S.

Publication type:

Article

A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRASMutant Colorectal Adenocarcinoma.

Published in:

Oncologist, 2017, v. 22, n. 3, p. 243, doi. 10.1634/theoncologist.2016-0479

By:

Hecht, J. Randolph;
Benson, Al B.;
Vyushkov, Dmitry;
Yang, Yingsi;
Bendell, Johanna;
Verma, Udit

Publication type:

Article

A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma.

Published in:

Oncologist, 2017, v. 22, n. 3, p. 241, doi. 10.1634/theoncologist.2017-0024

By:

Benson, Al B.;
Wainberg, Zev A.;
Hecht, J. Randolph;
Vyushkov, Dmitry;
Dong, Hua;
Bendell, Johanna;
Kudrik, Fred

Publication type:

Article

5-Fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study.

Published in:

Cancer Management & Research, 2015, v. 7, p. 165, doi. 10.2147/CMAR.S61408

By:

Randolph Hecht, J.;
Mitchell, Edith P.;
Takayuki Yoshino;
Welslau, Manfred;
Xun Lin;
Maneval, Edna Chow;
Paolini, Jolanda;
Lechuga, Maria Jose;
Kretzschmar, Albrecht

Publication type:

Article

Prolonged nausea and vomiting after high dose chemotherapy and autologous peripheral stem cell transplantation in the treatment of high risk breast carcinoma.

Published in:

1997

By:

Hecht, J. Randolph;
Lembo, Tony;
Chap, Linnea;
Hecht, J R;
Lembo, T;
Chap, L

Publication type:

journal article

Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis.

Published in:

Therapeutic Advances in Medical Oncology, 2021, p. 1, doi. 10.1177/17588359211020547

By:

Yin, Jun;
Dawood, Shaheenah;
Cohen, Romain;
Meyers, Jeff;
Zalcberg, John;
Yoshino, Takayuki;
Seymour, Matthew;
Maughan, Tim;
Saltz, Leonard;
Van Cutsem, Eric;
Venook, Alan;
Schmoll, Hans-Joachim;
Goldberg, Richard;
Hoff, Paulo;
Hecht, J. Randolph;
Hurwitz, Herbert;
Punt, Cornelis;
Diaz Rubio, Eduard;
Koopman, Miriam;
Cremolini, Chiara

Publication type:

Article

Current and emerging therapies for metastatic colorectal cancer: Applying research findings to clinical practice.

Published in:

American Journal of Health-System Pharmacy, 2008, v. 65, n. S4, p. S15, doi. 10.2146/ajhp080102

By:

Hecht, J. Randolph

Publication type:

Article

Targeted lymph node evaluation in colorectal cancer: A decade of progress!

Published in:

Journal of Surgical Oncology, 2009, v. 99, n. 5, p. 273, doi. 10.1002/jso.21231

By:

Bilchik, Anton J.;
Stojadinovic, Alexander;
Wainberg, Zev;
Hecht, J. Randolph

Publication type:

Article

SPIRITT: A Randomized, Multicenter, Phase II Study of Panitumumab with FOLFIRI and Bevacizumab with FOLFIRI as Second-Line Treatment in Patients with Unresectable Wild Type KRAS Metastatic Colorectal Cancer.

Published in:

Clinical Colorectal Cancer, 2015, v. 14, n. 2, p. 72, doi. 10.1016/j.clcc.2014.12.009

By:

Hecht, J. Randolph;
Cohn, Allen;
Dakhil, Shaker;
Saleh, Mansoor;
Piperdi, Bilal;
Cline-Burkhardt, Mika;
Ying Tian;
Go, William Y.

Publication type:

Article

Immunologic and tumor responses of pegilodecakin with 5-FU/LV and oxaliplatin (FOLFOX) in pancreatic ductal adenocarcinoma (PDAC).

Published in:

Investigational New Drugs, 2021, v. 39, n. 1, p. 182, doi. 10.1007/s10637-020-01000-6

By:

Hecht, J. Randolph;
Papadopoulos, Kyriakos P.;
Falchook, Gerald S.;
Patel, Manish R.;
Infante, Jeffrey R.;
Aljumaily, Raid;
Wong, Deborah J.;
Autio, Karen A.;
Wainberg, Zev A.;
Bauer, Todd M.;
Javle, Milind;
Pant, Shubham;
Bendell, Johanna;
Hung, Annie;
Ratti, Navneet;
VanVlasselaer, Peter;
Verma, Rakesh;
Leveque, Joseph;
Rao, Sujata;
Oft, Martin

Publication type:

Article

Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer.

Published in:

JAMA Network Open, 2019, v. 29, p. e1911750, doi. 10.1001/jamanetworkopen.2019.11750

By:

Burzykowski, Tomasz;
Coart, Elisabeth;
Saad, Everardo D.;
Shi, Qian;
Sommeijer, Dirkje W.;
Bokemeyer, Carsten;
Díaz-Rubio, Eduardo;
Douillard, Jean-Yves;
Falcone, Alfredo;
Fuchs, Charles S.;
Goldberg, Richard M.;
Hecht, J. Randolph;
Hoff, Paulo M.;
Hurwitz, Herbert;
Kabbinavar, Fairooz F.;
Koopman, Miriam;
Maughan, Timothy S.;
Punt, Cornelis J. A.;
Saltz, Leonard;
Schmoll, Hans-Joachim

Publication type:

Article

Fecal and Tissue Microbiota Are Associated with Tumor T-Cell Infiltration and Mesenteric Lymph Node Involvement in Colorectal Cancer.

Published in:

Nutrients, 2023, v. 15, n. 2, p. 316, doi. 10.3390/nu15020316

By:

Luu, Kayti;
Ye, Jason Y.;
Lagishetty, Venu;
Liang, Fengting;
Hauer, Megan;
Sedighian, Farzaneh;
Kwaan, Mary R.;
Kazanjian, Kevork K.;
Hecht, J. Randolph;
Lin, Anne Y.;
Jacobs, Jonathan P.

Publication type:

Article

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.

Published in:

Nature, 2012, v. 486, n. 7404, p. 537, doi. 10.1038/nature11219

By:

Diaz Jr, Luis A.;
Williams, Richard T.;
Wu, Jian;
Kinde, Isaac;
Hecht, J. Randolph;
Berlin, Jordan;
Allen, Benjamin;
Bozic, Ivana;
Reiter, Johannes G.;
Nowak, Martin A.;
Kinzler, Kenneth W.;
Oliner, Kelly S.;
Vogelstein, Bert

Publication type:

Article

Association of K-ras Mutational Status and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Receiving Panitumumab Alone.

Published in:

Clinical Cancer Update, 2008, v. 2, n. 1, p. 36, doi. 10.3816/CCU.2008.n.006

By:

Freeman, Daniel J.;
Juan, Todd;
Reiner, Maureen;
Hecht, J. Randolph;
Meropol, Neal J.;
Berlin, Jordan;
Mitchell, Edith;
Sarosi, Ildiko;
Radinsky, Robert;
Amado, Rafael G.

Publication type:

Article

Panitumumab with Irinotecan/Leucovorin/5-Fluorouracil for First-Line Treatment of Metastatic Colorectal Cancer.

Published in:

Clinical Cancer Update, 2007, v. 1, n. 1, p. 50, doi. 10.3816/CCU.2007.n.008

By:

Berlin, Jordan;
Posey, James;
Tchekmedyian, Simon;
Hu, Eddie;
Chan, David;
Malik, Imtiaz;
Yang, Liqiang;
Amado, Rafael G.;
Hecht, J. Randolph

Publication type:

Article

Meta-analysis examining overall survival in patients with pancreatic cancer treated with second-line 5-fluorouracil and oxaliplatin-based therapy after failing first-line gemcitabine-containing therapy: effect of performance status and comparison with other regimens.

Published in:

2020

By:

Wainberg, Zev A.;
Feeney, Kynan;
Lee, Myung Ah;
Muñoz, Andrés;
Gracián, Antonio Cubillo;
Lonardi, Sara;
Ryoo, Baek-Yeol;
Hung, Annie;
Lin, Yong;
Bendell, Johanna;
Hecht, J. Randolph

Publication type:

journal article