Works by Hawkins, Alastair R.

Results: 33

Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins.

Published in:

Proteins, 2002, v. 48, n. 2, p. 161, doi. 10.1002/prot.10157

By:

Watts, Carys;
Si-Hoe, Shi Ming;
Lamb, Heather K.;
Levett, Lisa J.;
Coggins, John R.;
Hawkins, Alastair R.

Publication type:

Article

The slow step of folding of Staphylococcus aureus PC1 β-lactamase involves the collapse of a surface loop rate limited by the Trans to Cis isomerization of a non-proline peptide bond.

Published in:

Proteins, 1998, v. 33, n. 4, p. 550, doi. 10.1002/(SICI)1097-0134(19981201)33:4<550::AID-PROT7>3.0.CO;2-9

By:

Wheeler, Kerry A.;
Hawkins, Alastair R.;
Pain, Roger;
Virden, Richard

Publication type:

Article

Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms.

Published in:

Arthritis & Rheumatology, 2017, v. 69, n. 8, p. 1601, doi. 10.1002/art.40133

By:

Wilkinson, David J.;
Habgood, Angela;
Lamb, Heather K.;
Thompson, Paul;
Hawkins, Alastair R.;
Désilets, Antoine;
Leduc, Richard;
Steinmetzer, Torsten;
Hammami, Maya;
Lee, Melody S.;
Craik, Charles S.;
Watson, Sharon;
Lin, Hua;
Milner, Jennifer M.;
Rowan, Andrew D.

Publication type:

Article

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase.

Published in:

Protein Science: A Publication of the Protein Society, 2010, v. 19, n. 10, p. 1897, doi. 10.1002/pro.475

By:

Stamp, Anna L.;
Owen, Paul;
Omari, Kamel El;
Nichols, Charles E.;
Lockyer, Michael;
Lamb, Heather K.;
Charles, Ian G.;
Hawkins, Alastair R.;
Stammers, David K.

Publication type:

Article

The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases.

Published in:

Protein Science: A Publication of the Protein Society, 2010, v. 19, n. 7, p. 1405, doi. 10.1002/pro.421

By:

Zhao, Xiao;
Hume, Samantha L.;
Johnson, Christopher;
Thompson, Paul;
Huang, Junyong;
Gray, Joe;
Lamb, Heather K.;
Hawkins, Alastair R.

Publication type:

Article

Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

Published in:

Protein Science: A Publication of the Protein Society, 2007, v. 16, n. 11, p. 2391, doi. 10.1110/ps.072900907

By:

Lamb, Heather K.;
Thompson, Paul;
Elliott, Catherine;
Charles, Ian G.;
Richards, Jamie;
Lockyer, Michael;
Watkins, Nicholas;
Nichols, Charles;
Stammers, David K.;
Bagshaw, Clive R.;
Cooper, Alan;
Hawkins, Alastair R.

Publication type:

Article

Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.

Published in:

Protein Science: A Publication of the Protein Society, 2006, v. 15, n. 4, p. 774, doi. 10.1110/ps.052002406

By:

Kotaka, Masayo;
Dhaliwal, Balvinder;
Ren, Jingshan;
Nichols, Charles E.;
Angell, Richard;
Lockyer, Michael;
Hawkins, Alastair R.;
Stammers, David K.

Publication type:

Article

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 12, p. 3127, doi. 10.1110/ps.04958904

By:

Lamb, Heather K.;
Ren, Jingshan;
Park, Alison;
Johnson, Christopher;
Leslie, Kris;
Cocklin, Simon;
Thompson, Paul;
Mee, Christopher;
Cooper, Alan;
Stammers, David K.;
Hawkins, Alastair R.

Publication type:

Article

Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 8, p. 2108, doi. 10.1110/ps.04705404

By:

Park, Alison;
Lamb, Heather K.;
Nichols, Charlie;
Moore, Jonathan D.;
Brown, Katherine A.;
Cooper, Alan;
Charles, Ian G.;
Stammers, David K.;
Hawkins, Alastair R.

Publication type:

Article

Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1

Published in:

FEBS Letters, 2012, v. 586, n. 6, p. 675, doi. 10.1016/j.febslet.2012.01.060

By:

Varsaki, Athanasia;
Lamb, Heather K.;
Eleftheriadou, Olga;
Vandera, Elpiniki;
Thompson, Paul;
Moncalián, Gabriel;
de la Cruz, Fernando;
Hawkins, Alastair R.;
Drainas, Constantin

Publication type:

Article

Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase

Published in:

FEBS Letters, 2004, v. 574, n. 1-3, p. 49, doi. 10.1016/j.febslet.2004.08.005

By:

Dhaliwal, Balvinder;
Nichols, Charles E.;
Ren, Jingshan;
Lockyer, Michael;
Charles, Ian;
Hawkins, Alastair R.;
Stammers, David K.

Publication type:

Article

Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.

Published in:

Proteins, 2011, v. 79, n. 7, p. 2352, doi. 10.1002/prot.23060

By:

Stamp, Anna L.;
Owen, Paul;
El Omari, Kamel;
Lockyer, Michael;
Lamb, Heather K.;
Charles, Ian G.;
Hawkins, Alastair R.;
Stammers, David K.

Publication type:

Article

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.

Published in:

Proteins, 2007, v. 68, n. 1, p. 13, doi. 10.1002/prot.21386

By:

Nichols, Charlie E.;
Lamb, Heather K.;
Lockyer, Mike;
Charles, Ian G.;
Pyne, Susan;
Hawkins, Alastair R.;
Stammers, David K.

Publication type:

Article

Cover Feature: Self‐Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product (Chem. Eur. J. 36/2020).

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 36, p. 7962, doi. 10.1002/chem.202002101

By:

Lence, Emilio;
Maneiro, María;
Sanz‐Gaitero, Marta;
Raaij, Mark J.;
Thompson, Paul;
Hawkins, Alastair R.;
González‐Bello, Concepción

Publication type:

Article

Self‐Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 36, p. 8035, doi. 10.1002/chem.202000759

By:

Lence, Emilio;
Maneiro, María;
Sanz‐Gaitero, Marta;
Raaij, Mark J.;
Thompson, Paul;
Hawkins, Alastair R.;
González‐Bello, Concepción

Publication type:

Article

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 50, p. 17988, doi. 10.1002/chem.201602923

By:

Prado, Verónica;
Lence, Emilio;
Thompson, Paul;
Hawkins, Alastair R.;
González‐Bello, Concepción

Publication type:

Article

Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 50, p. n/a, doi. 10.1002/chem.201685062

By:

Prado, Verónica;
Lence, Emilio;
Thompson, Paul;
Hawkins, Alastair R.;
González‐Bello, Concepción

Publication type:

Article

Corrigendum: Glycan complexity dictates microbial resource allocation in the large intestine.

Published in:

Nature Communications, 2016, v. 7, n. 2, p. 10705, doi. 10.1038/ncomms10705

By:

Rogowski, Artur;
Briggs, Jonathon A.;
Mortimer, Jennifer C.;
Tryfona, Theodora;
Terrapon, Nicolas;
Lowe, Elisabeth C.;
Baslé, Arnaud;
Morland, Carl;
Day, Alison M.;
Zheng, Hongjun;
Rogers, Theresa E.;
Thompson, Paul;
Hawkins, Alastair R.;
Yadav, Madhav P.;
Henrissat, Bernard;
Martens, Eric C.;
Dupree, Paul;
Gilbert, Harry J.;
Bolam, David N.

Publication type:

Article

Glycan complexity dictates microbial resource allocation in the large intestine.

Published in:

Nature Communications, 2015, v. 6, n. 6, p. 7481, doi. 10.1038/ncomms8481

By:

Rogowski, Artur;
Briggs, Jonathon A.;
Mortimer, Jennifer C.;
Tryfona, Theodora;
Terrapon, Nicolas;
Lowe, Elisabeth C.;
Baslé, Arnaud;
Morland, Carl;
Day, Alison M.;
Zheng, Hongjun;
Rogers, Theresa E.;
Thompson, Paul;
Hawkins, Alastair R.;
Yadav, Madhav P.;
Henrissat, Bernard;
Martens, Eric C.;
Dupree, Paul;
Gilbert, Harry J.;
Bolam, David N.

Publication type:

Article

Dinucleotide-Sensing Proteins: Linking Signaling Networks and Regulating Transcription.

Published in:

Science Signaling, 2008, v. 1, n. 33, p. 1, doi. 10.1126/scisignal.133pe38

By:

Lamb, Heather K.;
Stammers, David K.;
Hawkins, Alastair R.

Publication type:

Article

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

Published in:

ChemMedChem, 2017, v. 12, n. 18, p. 1512, doi. 10.1002/cmdc.201700396

By:

Peón, Antonio;
Robles, Adrián;
Blanco, Beatriz;
Convertino, Marino;
Thompson, Paul;
Hawkins, Alastair R.;
Caflisch, Amedeo;
González‐Bello, Concepción

Publication type:

Article

Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase.

Published in:

ChemMedChem, 2011, v. 6, n. 2, p. 266, doi. 10.1002/cmdc.201000343

By:

Paz, Sonia;
Tizón, Lorena;
Otero, José M.;
Llamas-Saiz, Antonio L.;
Fox, Gavin C.;
van Raaij, Mark J.;
Lamb, Heather;
Hawkins, Alastair R.;
Lapthorn, Adrian J.;
Castedo, Luis;
González-Bello, Concepción

Publication type:

Article

2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase.

Published in:

ChemMedChem, 2009, v. 4, n. 12, p. 1980, doi. 10.1002/cmdc.200900319

By:

Prazeres, Verónica F. V.;
Castedo, Luis;
Lamb, Heather;
Hawkins, Alastair R.;
González-Bello, Concepción

Publication type:

Article

Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies.

Published in:

ChemMedChem, 2008, v. 3, n. 5, p. 756, doi. 10.1002/cmdc.200700307

By:

Sánchez-Sixto, Cristina;
Prazeres, Verónica F. V.;
Castedo, Luis;
Suh, Se Won;
Lamb, Heather;
Hawkins, Alastair R.;
Cañada, Francisco Javier;
Jiménez-Barbero, Jesús;
González-Bello, Concepción

Publication type:

Article

Cover Picture: Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase (ChemMedChem 2/2007).

Published in:

ChemMedChem, 2007, v. 2, n. 2, p. 141, doi. 10.1002/cmdc.200790000

By:

Prazeres, Verónica F. V.;
Sánchez-Sixto, Cristina;
Castedo, Luis;
Lamb, Heather;
Hawkins, Alastair R.;
Riboldi-Tunnicliffe, Alan;
Coggins, John R.;
Lapthorn, Adrian J.;
González-Bello, Concepción

Publication type:

Article

Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase.

Published in:

ChemMedChem, 2007, v. 2, n. 2, p. 194, doi. 10.1002/cmdc.200600208

By:

Prazeres, Verónica F. V.;
Sánchez-Sixto, Cristina;
Castedo, Luis;
Lamb, Heather;
Hawkins, Alastair R.;
Riboldi-Tunnicliffe, Alan;
Coggins, John R.;
Lapthorn, Adrian J.;
González-Bello, Concepción

Publication type:

Article

Determination of the Bound Conformation of a Competitive Nanomolar Inhibitor of Mycobacterium tuberculosis Type II Dehydroquinase by NMR Spectroscopy.

Published in:

ChemMedChem, 2006, v. 1, n. 9, p. 990, doi. 10.1002/cmdc.200600100

By:

Prazeres, Verónica F. V.;
Sánchez-Sixto, Cristina;
Castedo, Luis;
Canales, Ángeles;
Cañada, Francisco Javier;
Jiménez-Barbero, Jesús;
Lamb, Heather;
Hawkins, Alastair R.;
González-Bello, Concepción

Publication type:

Article

The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.

Published in:

Nature Structural Biology, 1999, v. 6, n. 6, p. 521

By:

Gourley, David G.;
Shrive, Annette K.;
Polikarpov, Igor;
Krell, Tino;
Coggins, John R.;
Hawkins, Alastair R.;
Isaacs, Neil W.;
Sawyer, Lindsay

Publication type:

Article

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 8, p. 2758, doi. 10.1002/chem.201504438

By:

Prado, Verónica;
Lence, Emilio;
Vallejo, Juan A.;
Beceiro, Alejandro;
Thompson, Paul;
Hawkins, Alastair R.;
González‐Bello, Concepción

Publication type:

Article

Crystal structure of NucB, a biofilm-degrading endonuclease.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 1, p. 473, doi. 10.1093/nar/gkx1170

By:

Baslé, Arnaud;
Hewitt, Lorraine;
Koh, Alan;
Lamb, Heather K;
Thompson, Paul;
Burgess, J Grant;
Hall, Michael J;
Hawkins, Alastair R;
Murray, Heath;
Lewis, Richard J

Publication type:

Article

Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.

Published in:

Nature, 1998, v. 394, n. 6690, p. 299, doi. 10.1038/28431

By:

Carpenter, Elisabeth P.;
Hawkins, Alastair R.;
Frost, John W.;
Brown, Katherine A.

Publication type:

Article

Insights into substrate binding and catalysis in bacterial type I dehydroquinase.

Published in:

Biochemical Journal, 2014, v. 462, n. 3, p. 415, doi. 10.1042/BJ20140614

By:

MANEIRO, María;
PEON, Antonio;
LENCE, Emilio;
OTERO, José M.;
VAN RAAIJ, Mark J.;
THOMPSON, Paul;
HAWKINS, Alastair R.;
GONZALEZ-BELLO, Concepción

Publication type:

Article

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.

Published in:

Biochemical Journal, 2014, v. 458, n. 3, p. 547, doi. 10.1042/BJ20131103

By:

CODERCH, Claire;
LENCE, Emilio;
PEON, Antonio;
LAMB, Heather;
HAWKINS, Alastair R.;
GAGO, Federico;
GONZALEZ-BELLO, Concepcion

Publication type:

Article