Works by Hata, Saori

Results: 41

Abnormal menstruation after radical trachelectomy and its effects on fertility.

Published in:

Journal of Obstetrics & Gynaecology Research, 2019, v. 45, n. 9, p. 1906, doi. 10.1111/jog.14032

By:

Matsuoka, Mari;
Taga, Atsuko;
Hata, Saori;
Yamamoto, Rumiko;
Ando, Yukiko;
Kozono, Yuki;
Tsuji, Natsuki;
Sekiyama, Kentaro;
Higuchi, Toshihiro;
Nagano, Tadayoshi

Publication type:

Article

Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-69400-9

By:

Honda, Keiko;
Takahashi, Hiroo;
Hata, Saori;
Abe, Ruriko;
Saito, Takashi;
Saido, Takaomi C.;
Taru, Hidenori;
Sobu, Yuriko;
Ando, Kanae;
Yamamoto, Tohru;
Suzuki, Toshiharu

Publication type:

Article

The cytoplasmic region of the amyloid β‐protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin‐1.

Published in:

FEBS Letters, 2018, v. 592, n. 16, p. 2716, doi. 10.1002/1873-3468.13204

By:

Tsukamoto, Maoko;
Chiba, Kyoko;
Sobu, Yuriko;
Shiraki, Yuzuha;
Okumura, Yuka;
Hata, Saori;
Kitamura, Akira;
Nakaya, Tadashi;
Uchida, Seiichi;
Kinjo, Masataka;
Taru, Hidenori;
Suzuki, Toshiharu

Publication type:

Article

Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E.

Published in:

FEBS Letters, 2015, v. 589, n. 18, p. 2394, doi. 10.1016/j.febslet.2015.07.017

By:

Kimura, Ayano;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Article

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 16, doi. 10.1186/1750-1326-7-16

By:

Hata, Saori;
Taniguchi, Miyako;
Yi Piao;
Ikeuchi, Takeshi;
Fagan, Anne M.;
Holtzman, David M.;
Bateman, Randall;
Sohrabi, Hamid R.;
Martins, Ralph N.;
Gandy, Sam;
Urakami, Katsuya;
Suzuki, Toshiharu

Publication type:

Article

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain.

Published in:

Molecular Neurodegeneration, 2010, v. 5, p. 35, doi. 10.1186/1750-1326-5-35

By:

Kondo, Maho;
Shiono, Maki;
Itoh, Genzo;
Takei, Norio;
Matsushima, Takahide;
Maeda, Masahiro;
Taru, Hidenori;
Hata, Saori;
Yamamoto, Tohru;
Saito, Yuhki;
Suzuki, Toshiharu

Publication type:

Article

Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide.

Published in:

EMBO Molecular Medicine, 2023, v. 15, n. 5, p. 1, doi. 10.15252/emmm.202217052

By:

Hata, Saori;
Saito, Haruka;
Kakiuchi, Takeharu;
Fukumoto, Dai;
Yamamoto, Shigeyuki;
Kasuga, Kensaku;
Kimura, Ayano;
Moteki, Koichi;
Abe, Ruriko;
Adachi, Shungo;
Kinoshita, Shoich;
Yoshizawa‐Kumagaye, Kumiko;
Nishio, Hideki;
Saito, Takashi;
Saido, Takaomi C;
Yamamoto, Tohru;
Nishimura, Masaki;
Taru, Hidenori;
Sobu, Yuriko;
Ohba, Hiroyuki

Publication type:

Article

γ-Secretase structure and activity are modified by alterations in its membrane localization and ambient environment.

Published in:

Journal of Biochemistry, 2022, v. 171, n. 3, p. 253, doi. 10.1093/jb/mvab132

By:

Suzuki, Toshiharu;
Sobu, Yuriko;
Hata, Saori

Publication type:

Article

Suppression of amyloid‐β secretion from neurons by cis‐9, trans‐11‐octadecadienoic acid, an isomer of conjugated linoleic acid.

Published in:

Journal of Neurochemistry, 2021, v. 159, n. 3, p. 603, doi. 10.1111/jnc.15490

By:

Hata, Saori;
Kano, Kuniyuki;
Kikuchi, Kazunori;
Kinoshita, Shoichi;
Sobu, Yuriko;
Saito, Haruka;
Saito, Takashi;
Saido, Takaomi C.;
Sano, Yoshitake;
Taru, Hidenori;
Aoki, Junken;
Komano, Hiroto;
Tomita, Taisuke;
Natori, Shunji;
Suzuki, Toshiharu

Publication type:

Article

X11 and X11‐like proteins regulate the level of extrasynaptic glutamate receptors.

Published in:

Journal of Neurochemistry, 2019, v. 148, n. 4, p. 480, doi. 10.1111/jnc.14623

By:

Motodate, Rika;
Saito, Haruka;
Sobu, Yuriko;
Hata, Saori;
Saito, Yuhki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Article

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and alzheimer's disease: Evidence for γ-secretase dysfunction.

Published in:

Annals of Neurology, 2011, v. 69, n. 6, p. 1026, doi. 10.1002/ana.22343

By:

Hata, Saori;
Fujishige, Sayaka;
Araki, Yoichi;
Taniguchi, Miyako;
Urakami, Katsuya;
Peskind, Elaine;
Akatsu, Hiroyasu;
Araseki, Masahiko;
Yamamoto, Kazuo;
Martins, Ralph N.;
Maeda, Masahiro;
Nishimura, Masaki;
Levey, Allan;
Chung, Kathryn A.;
Montine, Thomas;
Leverenz, James;
Fagan, Anne;
Goate, Alison;
Bateman, Randall;
Holtzman, David M.

Publication type:

Article

Regulated axonal transport of APP and alcadein by kinesin‐1 (783.1).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.783.1

By:

Suzuki, Toshiharu;
Chiba, Kyoko;
Okumura, Yuka;
Shiraki, Yuzuha;
Sobu, Yuriko;
Kinjo, Masataka;
Hata, Saori;
Taru, Hidenori

Publication type:

Article

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062431

By:

Piao, Yi;
Kimura, Ayano;
Urano, Satomi;
Saito, Yuhki;
Taru, Hidenori;
Yamamoto, Tohru;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Article

Constitutive Cleavage of the Single-Pass Transmembrane Protein Alcadeina Prevents Aberrant Peripheral Retention of Kinesin-1.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043058

By:

Maruta, Chiaki;
Saito, Yuhki;
Hata, Saori;
Gotoh, Naoya;
Suzuki, Toshiharu;
Yamamoto, Tohru;
Iijima, Koichi M.

Publication type:

Article

Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease.

Published in:

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2019, v. 5, n. 1, p. 740, doi. 10.1016/j.trci.2019.09.015

By:

Hata, Saori;
Omori, Chiori;
Kimura, Ayano;
Saito, Haruka;
Kimura, Nobuyuki;
Gupta, Veer;
Pedrini, Steve;
Hone, Eugene;
Chatterjee, Pratishtha;
Taddei, Kevin;
Kasuga, Kensaku;
Ikeuchi, Takeshi;
Waragai, Masaaki;
Nishimura, Masaki;
Hu, Anqi;
Nakaya, Tadashi;
Meijer, Laurent;
Maeda, Masahiro;
Yamamoto, Tohru;
Masters, Colin L.

Publication type:

Article

P3‐184: ALTERED LEVELS OF P3‐ALCβ PEPTIDES IN THE CSF OF AGED MONKEYS AND ALZHEIMER'S DISEASE PATIENTS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1000, doi. 10.1016/j.jalz.2019.06.3213

By:

Hata, Saori;
Kimura, Ayano;
Saito, Haruka;
Waragai, Masaaki;
Ikeuchi, Takeshi;
Martins, Ralph N.;
Kimura, Nobuyuki;
Nishimura, Masaki;
Suzuki, Toshiharu

Publication type:

Article

P1‐176: ENHANCED β‐ AND β'‐CLEAVAGES OF APP IN ALCADEIN α KNOCKOUT MOUSE BRAIN.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P304, doi. 10.1016/j.jalz.2019.06.731

By:

Suzuki, Toshiharu;
Goto, Naoya;
Saito, Haruka;
Hata, Saori;
Yamamoto, Tohru

Publication type:

Article

P1‐158: PREVENTION OF NEURON FROM TOXICITY INDUCED BY Aβ42 BY P3‐ALCβ PEPTIDES AND THEIR PHARMACOKINETICS IN MICE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P297, doi. 10.1016/j.jalz.2019.06.713

By:

Saito, Haruka;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Article

LEVEL OF P3-ALCβ PEPTIDES ALTER IN CSF OF AD PATIENTS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1013, doi. 10.1016/j.jalz.2017.06.1415

By:

Hata, Saori;
Kimura, Ayano;
Waragai, Masaaki;
Ikeuchi, Takeshi;
Martins, Ralph N.;
Kimura, Nobuyuki;
Nishimura, Masaki;
Suzuki, Toshiharu

Publication type:

Article

REGULATION AND FUNCTION OF APP AS A CARGO-RECEPTOR OF KINESIN-1 IN NEURONS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P659, doi. 10.1016/j.jalz.2017.06.788

By:

Suzuki, Toshiharu;
Chiba, Kyoko;
Shiraki, Yuzuha;
Sobu, Yuriko;
Hata, Saori

Publication type:

Article

NOVEL BIOMARKER P3-ALCα, PEPTIDES PRODUCED BY γ-SECRETASE CLEAVAGE, ALTERED IN AD PATIENTS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1021, doi. 10.1016/j.jalz.2017.06.1430

By:

Omori, Chiori;
Hata, Saori;
Waragai, Masaaki;
Suzuki, Toshiharu;
Yamamoto, Kazuo

Publication type:

Article

PROTECTIVE PROPERTY OF P3-ALCβ AGAINST A NEUROTOXICITY INDUCED BY Aβ OLIGOMER.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P318, doi. 10.1016/j.jalz.2017.06.019

By:

Saitoh, Haruka;
Omori, Chiori;
Kimura, Ayano;
Waragai, Masaaki;
Maeda, Masahiro;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Article

ABERRANT MICRO-MEMBRANE LOCALIZATION OF γ -SECRETASE COMPONENTS BY CHANGES IN CELLULAR CHOLESTEROL LEVEL ALTERS E- AND/OR γ -CLEAVAGE OF APP AND ALCADEINα.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P455, doi. 10.1016/j.jalz.2016.06.882

By:

Hu, Anqi;
Piao, Yi;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Article

ALTERNATIVE CLEAVAGE MECHANISM OF HUMAN APP BY BACE1.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1037, doi. 10.1016/j.jalz.2016.06.2150

By:

Suzuki, Toshiharu;
Kimura, Ayano;
Hata, Saori

Publication type:

Article

INCREASE OF P3-ALCA38 TO P3-ALCA35, PRODUCTS BY Γ-SECRETASE CLEAVAGE, IN CSF OF ALZHEIMER'S DISEASE PATIENTS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P891, doi. 10.1016/j.jalz.2016.06.1844

By:

Omori, Chiori;
Hata, Saori;
Waragai, Masaaki;
Yamamoto, Kazuo;
Suzuki, Toshiharu

Publication type:

Article

Membrane microdomain localization of APP c-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue

Published in:

2012

By:

Matsushima, Takahide;
Saito, Yuhki;
Nishimura, Masaki;
Kimura, Nobuyuki;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Abstract

Increase of p3-Alc peptides in the CSF and plasma of sporadic Alzheimer's disease patients

Published in:

2012

By:

Hata, Saori;
Konno, Tomoko;
Urakami, Katsuya;
Ikeuchi, Takeshi;
Akatsu, Hiroyasu;
Suzuki, Toshiharu

Publication type:

Abstract

Enhanced amyloidogenic processing of APP in alcadeina-deficient mice

Published in:

2011

By:

Gotoh, Naoya;
Saito, Yuhki;
Hata, Saori;
Yamamoto, Tohru;
Suzuki, Toshiharu

Publication type:

Abstract

Alternative gamma-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of alcadein

Published in:

2011

By:

Hata, Saori;
Urakami, Katsuya;
Taniguchi, Miyako;
Akatsu, Hiroyasu;
Gandy, Sam;
Suzuki, Toshiharu

Publication type:

Abstract

Quantification of plasma p3-Alca level with sELISA systems

Published in:

2011

By:

Fang, Jia;
Konno, Tomoko;
Horikoshi-Sakuraba, Yuko;
Hata, Saori;
Saito, Yuhki;
Maeda, Masahiro;
Akatsu, Hiroyasu;
Suzuki, Toshiharu

Publication type:

Abstract

Alcadein epsilon-cleavage followed by gamma-cleavage

Published in:

2011

By:

Piao, Yi;
Hata, Saori;
Suzuki, Toshiharu

Publication type:

Abstract

APP metabolism in brain of Alcadein alpha CTF transgenic mice

Published in:

2011

By:

Kimura, Ayano;
Takei, Norio;
Hata, Saori;
Saito, Yuhki;
Suzuki, Toshiharu

Publication type:

Abstract

Gamma-secretase dysfunction in sporadic Alzhemer's disease suggested by p3-Alc peptide, metabolic product of Alcadein

Published in:

2010

By:

Hata, Saori;
Urakami, Katsuya;
Fagan, Anne;
Peskind, Elaine;
Akatsu, Hiroyasu;
Maeda, Masahiro;
Levey, Allan;
Chung, Kathryn A.;
Montine, Thomas;
Leverenz, James;
Goate, Alison;
Bateman, Randall;
Holtzman, David M.;
Gandy, Sam;
Suzuki, Toshiharu

Publication type:

Abstract

Expression and localization of Alcadein along with X11L and APP in mouse brain

Published in:

2010

By:

Piao, Yi;
Gotoh, Naoya;
Kondo, Maho;
Saito, Yuhki;
Hata, Saori;
Yamamoto, Tohru;
Suzuki, Toshiharu

Publication type:

Abstract

p3-Alc peptides produced by covariant processing of Alcadein and APP implicate γ-secretase dysfunction in sporadic Alzheimer's disease

Published in:

2009

By:

Hata, Saori;
Maeda, Masahiro;
Nishimura, Masaki;
Levey, Allan;
Chung, Kathryn A.;
Montine, Thomas;
Fagan, Anne;
Goate, Alison;
Bateman, Randall;
Holtzman, David M.;
Nakaya, Tadashi;
Gandy, Sam;
Suzuki, Toshiharu

Publication type:

Abstract

P3-072: Analysis of β-Alc; Alcadein processing yields fragment homologous to APP P3 peptide

Published in:

2008

By:

Hata, Saori;
Araki, Yoichi;
Urakami, Katsuya;
Akatsu, Hiroyasu;
Nishimura, Masaki;
Gandy, Sam;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P1-384: Analysis of Alcadein metabolic fragments in brain

Published in:

2008

By:

Araseki, Masahiko;
Hata, Saori;
Nakaya, Tadashi;
Gandy, Sam;
Martins, Ralph N.;
Suzuki, Toshiharu

Publication type:

Abstract

P4-020: β-Alc, metabolic products of alcadein, as a novel diagnostic marker in CSF of Alzheimer’s disease

Published in:

2006

By:

Hata, Saori;
Araki, Yoichi;
Akatsu, Hiroyasu;
Urakami, Katsuya;
Nishimura, Masaki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P4-020: β-Alc, metabolic products of alcadein, as a novel diagnostic marker in CSF of Alzheimer’s disease

Published in:

2006

By:

Hata, Saori;
Araki, Yoichi;
Akatsu, Hiroyasu;
Urakami, Katsuya;
Nishimura, Masaki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease.

Published in:

Nutritional Neuroscience, 2017, v. 20, n. 9, p. 538, doi. 10.1080/1028415X.2016.1199114

By:

Omori, Chiori;
Motodate, Rika;
Shiraki, Yuzuha;
Chiba, Kyoko;
Sobu, Yuriko;
Kimura, Ayano;
Nakaya, Tadashi;
Kondo, Hikaru;
Kurumiya, Satoshi;
Tanaka, Toru;
Yamamoto, Kazuo;
Nakajima, Motowo;
Suzuki, Toshiharu;
Hata, Saori

Publication type:

Article

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.

Published in:

Human Molecular Genetics, 2020, v. 29, n. 3, p. 382, doi. 10.1093/hmg/ddz297

By:

Hata, Saori;
Hu, Anqi;
Piao, Yi;
Nakaya, Tadashi;
Taru, Hidenori;
Morishima-Kawashima, Maho;
Murayama, Shigeo;
Nishimura, Masaki;
Suzuki, Toshiharu

Publication type:

Article