Works by Hartmann, Rune

Results: 34

Characterization of the 2′–5′‐oligoadenylate synthetase ubiquitin‐like family.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 12, p. 3166, doi. 10.1093/nar/gkg427

By:

Eskildsen, Signe;
Justesen, Just;
Schierup, Mikkel Heide;
Hartmann, Rune

Publication type:

Article

p59OASL, a 2′–5′ oligoadenylate synthetase like protein: a novel human gene related to the 2′–5′ oligoadenylate synthetase family.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 18, p. 4121, doi. 10.1093/nar/26.18.4121

By:

Hartmann, Rune;
Olsen, Henrik Steen;
Widder, Stefanie;
Jørgensen, René;
Justesen, Just

Publication type:

Article

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses.

Published in:

EMBO Journal, 2013, v. 32, n. 23, p. 3055, doi. 10.1038/emboj.2013.232

By:

Hamming, Ole J;
Terczyńska‐Dyla, Ewa;
Vieyres, Gabrielle;
Dijkman, Ronald;
Jørgensen, Sanne E;
Akhtar, Hashaam;
Siupka, Piotr;
Pietschmann, Thomas;
Thiel, Volker;
Hartmann, Rune

Publication type:

Article

Conformational diversity in prion protein variants influences intermolecular β-sheet formation.

Published in:

EMBO Journal, 2010, v. 29, n. 1, p. 251, doi. 10.1038/emboj.2009.333

By:

Lee, Seungjoo;
Antony, Lizamma;
Hartmann, Rune;
Knaus, Karen J.;
Surewicz, Krystyna;
Surewicz, Witold K.;
Yee, Vivien C.

Publication type:

Article

Correction: SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.

Published in:

2021

By:

Shemesh, Maya;
Aktepe, Turgut E.;
Deerain, Joshua M.;
McAuley, Julie L.;
Audsley, Michelle D.;
David, Cassandra T.;
Purcell, Damian F. J.;
Urin, Victoria;
Hartmann, Rune;
Moseley, Gregory W.;
Mackenzie, Jason M.;
Schreiber, Gideon;
Harari, Daniel

Publication type:

Correction Notice

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.

Published in:

PLoS Pathogens, 2021, v. 17, n. 8, p. 1, doi. 10.1371/journal.ppat.1009800

By:

Shemesh, Maya;
Aktepe, Turgut E.;
Deerain, Joshua M.;
McAuley, Julie L.;
Audsley, Michelle D.;
David, Cassandra T.;
Purcell, Damian F. J.;
Urin, Victoria;
Hartmann, Rune;
Moseley, Gregory W.;
Mackenzie, Jason M.;
Schreiber, Gideon;
Harari, Daniel

Publication type:

Article

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium.

Published in:

PLoS Biology, 2021, v. 19, n. 3, p. 1, doi. 10.1371/journal.pbio.3001158

By:

V'kovski, Philip;
Gultom, Mitra;
Kelly, Jenna N.;
Steiner, Silvio;
Russeil, Julie;
Mangeat, Bastien;
Cora, Elisa;
Pezoldt, Joern;
Holwerda, Melle;
Kratzel, Annika;
Laloli, Laura;
Wider, Manon;
Portmann, Jasmine;
Tran, Thao;
Ebert, Nadine;
Stalder, Hanspeter;
Hartmann, Rune;
Gardeux, Vincent;
Alpern, Daniel;
Deplancke, Bart

Publication type:

Article

Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza.

Published in:

Medical Microbiology & Immunology, 2019, v. 208, n. 6, p. 869, doi. 10.1007/s00430-019-00623-8

By:

Thomsen, Michelle M.;
Jørgensen, Sofie E.;
Gad, Hans Henrik;
Storgaard, Merete;
Gjedsted, Jakob;
Christiansen, Mette;
Hartmann, Rune;
Mogensen, Trine H.

Publication type:

Article

Interferon lambda 4 genotype and pathway in alcoholic hepatitis.

Published in:

Scandinavian Journal of Gastroenterology, 2021, v. 56, n. 3, p. 304, doi. 10.1080/00365521.2021.1874046

By:

Støy, Sidsel;
Terczynska-Dyla, Ewa;
Veidal, Sanne Skovgård;
Rigbolt, Kristoffer;
Vilstrup, Hendrik;
Grønbaek, Henning;
Hartmann, Rune;
Sandahl, Thomas D.

Publication type:

Article

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

Published in:

EMBO Molecular Medicine, 2016, v. 8, n. 9, p. 1099, doi. 10.15252/emmm.201606413

By:

Davidson, Sophia;
McCabe, Teresa M;
Crotta, Stefania;
Gad, Hans Henrik;
Hessel, Edith M;
Beinke, Soren;
Hartmann, Rune;
Wack, Andreas

Publication type:

Article

Viral recognition and the antiviral interferon response.

Published in:

EMBO Journal, 2023, v. 42, n. 14, p. 1, doi. 10.15252/embj.2022112907

By:

Dalskov, Louise;
Gad, Hans Henrik;
Hartmann, Rune

Publication type:

Article

Cryo‐EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.

Published in:

EMBO Journal, 2022, v. 41, n. 23, p. 1, doi. 10.15252/embj.2021110169

By:

Neumann, Caroline;
Rosenbæk, Lena Lindtoft;
Flygaard, Rasmus Kock;
Habeck, Michael;
Karlsen, Jesper Lykkegaard;
Wang, Yong;
Lindorff‐Larsen, Kresten;
Gad, Hans Henrik;
Hartmann, Rune;
Lyons, Joseph Anthony;
Fenton, Robert A;
Nissen, Poul

Publication type:

Article

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.

Published in:

EMBO Journal, 2016, v. 35, n. 13, p. 1385, doi. 10.15252/embj.201593458

By:

Christensen, Maria H;
Jensen, Søren B;
Miettinen, Juho J;
Luecke, Stefanie;
Prabakaran, Thaneas;
Reinert, Line S;
Mettenleiter, Thomas;
Chen, Zhijian J;
Knipe, David M;
Sandri‐Goldin, Rozanne M;
Enquist, Lynn W;
Hartmann, Rune;
Mogensen, Trine H;
Rice, Stephen A;
Nyman, Tuula A;
Matikainen, Sampsa;
Paludan, Søren R

Publication type:

Article

SARS‐CoV‐2 evades immune detection in alveolar macrophages.

Published in:

EMBO Reports, 2020, v. 21, n. 12, p. 1, doi. 10.15252/embr.202051252

By:

Dalskov, Louise;
Møhlenberg, Michelle;
Thyrsted, Jacob;
Blay‐Cadanet, Julia;
Poulsen, Ebbe Toftgaard;
Folkersen, Birgitte Holst;
Skaarup, Søren Helbo;
Olagnier, David;
Reinert, Line;
Enghild, Jan Johannes;
Hoffmann, Hans Jürgen;
Holm, Christian Kanstrup;
Hartmann, Rune

Publication type:

Article

cGAS is activated by DNA in a length-dependent manner.

Published in:

EMBO Reports, 2017, v. 18, n. 10, p. 1707, doi. 10.15252/embr.201744017

By:

Luecke, Stefanie;
Holleufer, Andreas;
Christensen, Maria H;
Jønsson, Kasper L;
Boni, Gerardo A;
Sørensen, Lambert K;
Johannsen, Mogens;
Jakobsen, Martin R;
Hartmann, Rune;
Paludan, Søren R

Publication type:

Article

Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1.

Published in:

Pakistan Journal of Pharmaceutical Sciences, 2016, v. 29, n. 3, p. 795

By:

Akhtar, Hashaam;
Hamming, Ole Jensen;
Jan, Syed Umer;
Akhtar, Samar;
Terczyn'ska-Dyla, Ewa;
Siupka, Piotr;
Shafique, Adeena;
Hartmann, Rune;
Sadia, Hajra

Publication type:

Article

Identification of essential regulatory elements responsible for the explicit expression of IL-28Rα and their effect on critical SNPs using in-Silico methods.

Published in:

Pakistan Journal of Pharmaceutical Sciences, 2015, v. 28, p. 1523

By:

Akhtar, Hashaam;
Islam, Gibrail;
Jan, Syed Umer;
Nawaz, Ayesha;
Akhtar, Samar;
Hartmann, Rune;
Sadia, Hajra

Publication type:

Article

Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses.

Published in:

Science Immunology, 2021, v. 6, n. 59, p. 1, doi. 10.1126/sciimmunol.abd5318

By:

Schnepf, Daniel;
Crotta, Stefania;
Thamamongood, Thiprampai;
Stanifer, Megan;
Polcik, Laura;
Ohnemus, Annette;
Vier, Juliane;
Jakob, Celia;
Llorian, Miriam;
Gad, Hans Henrik;
Hartmann, Rune;
Strobl, Birgit;
Kirschnek, Susanne;
Boulant, Steeve;
Schwemmle, Martin;
Wack, Andreas;
Staeheli, Peter

Publication type:

Article

Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-13777-y

By:

Gultom, Mitra;
Kratzel, Annika;
Portmann, Jasmine;
Stalder, Hanspeter;
Chanfon Bätzner, Astrid;
Gantenbein, Hans;
Gurtner, Corinne;
Ebert, Nadine;
Gad, Hans Henrik;
Hartmann, Rune;
Posthaus, Horst;
Zanolari, Patrik;
Pfaender, Stephanie;
Thiel, Volker;
Dijkman, Ronald

Publication type:

Article

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila.

Published in:

Science Signaling, 2020, v. 13, n. 660, p. 1, doi. 10.1126/scisignal.abc4537

By:

Cai, Hua;
Holleufer, Andreas;
Simonsen, Bine;
Schneider, Juliette;
Lemoine, Aurélie;
Gad, Hans Henrik;
Huang, Jingxian;
Huang, Jieqing;
Chen, Di;
Peng, Tao;
Marques, João T.;
Hartmann, Rune;
Martins, Nelson E.;
Imler, Jean-Luc

Publication type:

Article

Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 20, p. 11421, doi. 10.1093/nar/gkaa873

By:

Dalskov, Louise;
Narita, Ryo;
Andersen, Line L;
Jensen, Nanna;
Assil, Sonia;
Kristensen, Kennith H;
Mikkelsen, Jacob G;
Fujita, Takashi;
Mogensen, Trine H;
Paludan, Søren R;
Hartmann, Rune

Publication type:

Article

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 10, p. 5236, doi. 10.1093/nar/gkv389

By:

Ibsen, Mikkel Søes;
Gad, Hans Henrik;
Andersen, Line Lykke;
Hornung, Veit;
Julkunen, Ilkka;
Sarkar, Saumendra N.;
Hartmann, Rune

Publication type:

Article

Weak Induction of Interferon Expression by Severe Acute Respiratory Syndrome Coronavirus 2 Supports Clinical Trials of Interferon-λ to Treat Early Coronavirus Disease 2019.

Published in:

2020

By:

O'Brien, Thomas R;
Thomas, David L;
Jackson, Sarah S;
Prokunina-Olsson, Ludmila;
Donnelly, Raymond P;
Hartmann, Rune

Publication type:

Editorial

HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6.

Published in:

PLoS Pathogens, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.ppat.1002250

By:

Gonzalez-Dosal, Regina;
Horan, Kristy A.;
Rahbek, Stine H.;
Ichijo, Hidenori;
Chen, Zhijian J.;
Mieyal, John J.;
Hartmann, Rune;
Paludan, Søren R.

Publication type:

Article

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.

Published in:

Nature Reviews Immunology, 2014, v. 14, n. 8, p. 521, doi. 10.1038/nri3719

By:

Hornung, Veit;
Hartmann, Rune;
Ablasser, Andrea;
Hopfner, Karl-Peter

Publication type:

Article

What makes the hepatitis C virus evolve?

Published in:

eLife, 2019, p. 1, doi. 10.7554/eLife.50148

By:

O’BRIEN, THOMAS R.;
HARTMANN, RUNE;
PROKUNINA-OLSSON, LUDMILA

Publication type:

Article

Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation.

Published in:

Rheumatology, 2020, v. 59, n. 10, p. 3099, doi. 10.1093/rheumatology/keaa242

By:

Jørgensen, Sofie E;
Christiansen, Mette;
Høst, Christian;
Glerup, Mia;
Mahler, Birgitte;
Lausten, Mira M;
Gad, Hans Henrik;
Hartmann, Rune;
Herlin, Troels;
Mogensen, Trine H

Publication type:

Article

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

Published in:

Nature Biotechnology, 2006, v. 24, n. 5, p. 559, doi. 10.1038/nbt1205

By:

Marques, Joao Trindade;
Devosse, Thalie;
Die Wang;
Zamanian-Daryoush, Maryam;
Serbinowski, Paul;
Hartmann, Rune;
Fujita, Takashi;
Behlke, Mark A.;
Williams, Bryan R. G.

Publication type:

Article

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein.

Published in:

PLoS Pathogens, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.ppat.1006937

By:

Bussey, Kendra A.;
Lau, Ulrike;
Schumann, Sophie;
Gallo, Antonio;
Osbelt, Lisa;
Stempel, Markus;
Arnold, Christine;
Wissing, Josef;
Gad, Hans Henrik;
Hartmann, Rune;
Brune, Wolfram;
Jänsch, Lothar;
Whitehouse, Adrian;
Brinkmann, Melanie M.

Publication type:

Article

Guarding the frontiers: the biology of type III interferons.

Published in:

Nature Immunology, 2015, v. 16, n. 8, p. 802, doi. 10.1038/ni.3212

By:

Wack, Andreas;
Terczyńska-Dyla, Ewa;
Hartmann, Rune

Publication type:

Article

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.782558

By:

Green, Kenneth;
Wittenborn, Thomas R.;
Fahlquist-Hagert, Cecilia;
Terczynska-Dyla, Ewa;
van Campen, Nina;
Jensen, Lisbeth;
Reinert, Line;
Hartmann, Rune;
Paludan, Søren R.;
Degn, Søren E.

Publication type:

Article

Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.749325

By:

Ye, Liang;
Schnepf, Daniel;
Ohnemus, Annette;
Ong, Li Ching;
Gad, Hans Henrik;
Hartmann, Rune;
Lycke, Nils;
Staeheli, Peter

Publication type:

Article

Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza.

Published in:

European Journal of Immunology, 2019, v. 49, n. 11, p. 2111, doi. 10.1002/eji.201848083

By:

Thomsen, Michelle M.;
Jørgensen, Sofie E.;
Storgaard, Merete;
Kristensen, Lasse S.;
Gjedsted, Jakob;
Christiansen, Mette;
Gad, Hans Henrik;
Hartmann, Rune;
Mogensen, Trine H.

Publication type:

Article

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27192-w

By:

Pennemann, Friederike L.;
Mussabekova, Assel;
Urban, Christian;
Stukalov, Alexey;
Andersen, Line Lykke;
Grass, Vincent;
Lavacca, Teresa Maria;
Holze, Cathleen;
Oubraham, Lila;
Benamrouche, Yasmine;
Girardi, Enrico;
Boulos, Rasha E.;
Hartmann, Rune;
Superti-Furga, Giulio;
Habjan, Matthias;
Imler, Jean-Luc;
Meignin, Carine;
Pichlmair, Andreas

Publication type:

Article