Works matching AU Hartmann, Rolf

Results: 111

Cover Feature: Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics (Chem. Eur. J. 32/2020).

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7141, doi. 10.1002/chem.202002127

By:

Elgaher, Walid A. M.;
Hamed, Mostafa M.;
Baumann, Sascha;
Herrmann, Jennifer;
Siebenbürger, Lorenz;
Krull, Jana;
Cirnski, Katarina;
Kirschning, Andreas;
Brönstrup, Mark;
Müller, Rolf;
Hartmann, Rolf W.

Publication type:

Article

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7219, doi. 10.1002/chem.202000117

By:

Elgaher, Walid A. M.;
Hamed, Mostafa M.;
Baumann, Sascha;
Herrmann, Jennifer;
Siebenbürger, Lorenz;
Krull, Jana;
Cirnski, Katarina;
Kirschning, Andreas;
Brönstrup, Mark;
Müller, Rolf;
Hartmann, Rolf W.

Publication type:

Article

Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing.

Published in:

Angewandte Chemie, 2014, v. 126, n. 4, p. 1127, doi. 10.1002/ange.201307547

By:

Lu, Cenbin;
Maurer, Christine K.;
Kirsch, Benjamin;
Steinbach, Anke;
Hartmann, Rolf W.

Publication type:

Article

Use of high-performance liquid chromatography/electrospray ionization collision-induced dissociation mass spectrometry for structural identification of monohydroxylated progesterones.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2004, v. 18, n. 23, p. 2795, doi. 10.1002/rcm.1694

By:

Kang, Min-Jung;
Lisurek, Michael;
Bernhardt, Rita;
Hartmann, Rolf W.

Publication type:

Article

Inhibition of CYP 17, a New Strategy for the Treatment of Prostate Cancer.

Published in:

Archiv der Pharmazie, 2002, v. 335, n. 4, p. 119, doi. 10.1002/1521-4184(200204)335:4<119::AID-ARDP119>3.0.CO;2-#

By:

Hartmann, Rolf W.;
Ehmer, Peter B.;
Haidar, Samer;
Hector, Markus;
Jose, Joachim;
Klein, Christian D. P.;
Seidel, Stefanie B.;
Sergejew, Tom F.;
Wachall, Bertil G.;
Wächter, Gerald A.;
Zhuang, Yan

Publication type:

Article

Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2.

Published in:

Archiv der Pharmazie, 2002, v. 335, n. 2/3, p. 83, doi. 10.1002/1521-4184(200203)335:2/3<83::AID-ARDP83>3.0.CO;2-3

By:

Salem, Ola I. A.;
Schulz, Tobias;
Hartmann, Rolf W.

Publication type:

Article

Novel steroidal pyrimidyl inhibitors of P450 17 (17α-hydroxylase/C17-20-lyase).

Published in:

Archiv der Pharmazie, 2001, v. 334, n. 12, p. 373, doi. 10.1002/1521-4184(200112)334:12<373::AID-ARDP373>3.0.CO;2-X

By:

Haidar, Samer;
Ehmer, Peter B.;
Hartmann, Rolf W.

Publication type:

Article

Synthesis and Evaluation of Steroidal Hydroxamic Acids as Inhibitors of P450 17 (17α-Hydroxylase/C17-20-Lyase).

Published in:

Archiv der Pharmazie, 2001, v. 334, n. 4, p. 138, doi. 10.1002/1521-4184(200104)334:4<138::AID-ARDP138>3.0.CO;2-Y

By:

Haidar, Samer;
Klein, Christian D.P.;
Hartmann, Rolf W.

Publication type:

Article

1-(2,6-Dichloro-4-hydroxyphenyl)-2-phenylethanes - New Biological Response Modifiers for the Therapy of Breast Cancer. Synthesis and Evaluation of Estrogenic/Antiestrogenic Properties.

Published in:

Archiv der Pharmazie, 2001, v. 334, n. 4, p. 125, doi. 10.1002/1521-4184(200104)334:4<125::AID-ARDP125>3.0.CO;2-D

By:

Schertl, Sabine;
Hartmann, Rolf W.;
Batzl-Hartmann, Christine;
Schlemmer, Richard;
Spruß, Thilo;
Bernhardt, Günther;
Gust, Ronald;
Schönenberger, Helmut

Publication type:

Article

5α-Reductase in Intact DU145 Cells: Evidence for Isozyme I and Evaluation of Novel Inhibitors.

Published in:

Archiv der Pharmazie, 2000, v. 333, n. 7, p. 201, doi. 10.1002/1521-4184(20007)333:7<201::AID-ARDP201>3.0.CO;2-D

By:

Reichert, Wolfgang;
Jose, Joachim;
Hartmann, Rolf W.

Publication type:

Article

New Nonsteroidal Steroid 5α-Reductase Inhibitors. Syntheses and Structure-Activity Studies on Carboxamide Phenylalkyl-Substituted Pyridones and Piperidones.

Published in:

Archiv der Pharmazie, 2000, v. 333, n. 5, p. 145, doi. 10.1002/(SICI)1521-4184(20005)333:5<145::AID-ARDP145>3.0.CO;2-Q

By:

Hartmann, Rolf W.;
Reichert, Martin

Publication type:

Article

1-Imidazolylcarbonyloxy-substituted Tetrahydroquinolines and Pyridines: Synthesis and Evaluation of P450 TxA2 Inhibition.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 10, p. 358, doi. 10.1002/(SICI)1521-4184(199910)332:10<358::AID-ARDP358>3.0.CO;2-D

By:

Hartmann, Rolf W.;
Frotscher, Martin

Publication type:

Article

Synthesis of 2-[2-(1-Imidazolyl)ethyl]-4-phenylcycloalka[ g]phthalazin-1(2 H)-ones as Thromboxane A2 Synthase Inhibitors.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 11, p. 408, doi. 10.1002/(SICI)1521-4184(199911)332:11<408::AID-ARDP408>3.0.CO;2-P

By:

Haider, Norbert;
Hartmann, Rolf W.;
Steinwender, Andreas

Publication type:

Article

Synthesis and Evaluation of Azole-substituted 2-Aryl-6-methoxy-3,4-dihydronaphthalenes and -naphthalenes as Inhibitors of 17α-Hydroxylase-C17,20-Lyase (P450 17.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 1, p. 25, doi. 10.1002/(SICI)1521-4184(19991)332:1<25::AID-ARDP25>3.0.CO;2-7

By:

Zhuang, Yan;
Hartmann, Rolf W.

Publication type:

Article

Spectrofluorimetric Quantification of Malondialdehyde for Evaluation of Cyclooxygenase-1/Thromboxane Synthase Inhibition.

Published in:

Archiv der Pharmazie, 1998, v. 331, n. 11, p. 359, doi. 10.1002/(SICI)1521-4184(199811)331:11<359::AID-ARDP359>3.0.CO;2-B

By:

Dannhardt, Gerd;
Flemmer, Linda;
Hartmann, Rolf W.;
Kleber, Alice;
Schulze, Elfriede

Publication type:

Article

Synthesis of Novel Oximes of 2-Aryl-6-methoxy-3,4-dihydronaphthalene and Their Evaluation as Inhibitors of 17α-Hydroxylase-C17,20-Lyase (P450 17).

Published in:

Archiv der Pharmazie, 1998, v. 331, n. 1, p. 36, doi. 10.1002/(SICI)1521-4184(199801)331:1<36::AID-ARDP36>3.0.CO;2-0

By:

Zhuang, Yan;
Hartmann, Rolf W.

Publication type:

Article

Novel Highly Active Thromboxane A2 Synthase Inhibitors Devoid of Carboxylic Groups.

Published in:

Archiv der Pharmazie, 1997, v. 330, n. 1/2, p. 1, doi. 10.1002/ardp.19973300102

By:

Ledergerber, Dorothea;
Frotscher, Martin;
Hartmann, Rolf W.

Publication type:

Article

Synthesis and In Vitro Evaluation of 3-(1-Azolylmethyl)-1 H-indoles and 3-(1-Azolyl-1-phenylmethyl)-1 H-indoles as Inhibitors of P450 arom.

Published in:

Archiv der Pharmazie, 1997, v. 330, n. 5, p. 141, doi. 10.1002/ardp.19973300506

By:

Borgne, Marc Le;
Marchand, Pascal;
Duflos, Muriel;
Delevoye-Seiller, Bénédicte;
Piessard-Robert, Sylvie;
Baut, Guillaume Le;
Hartmann, Rolf W.;
Palzer, M.

Publication type:

Article

Synthesis of Z- and E-1-Methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and Evaluation as Inhibitors of 17α-Hydroxylase-C17,20-Lyase (P450 17).

Published in:

Archiv der Pharmazie, 1997, v. 330, n. 11, p. 359, doi. 10.1002/ardp.19973301108

By:

Zhuang, Yan;
Zapp, Josef;
Hartmann, Rolf W.

Publication type:

Article

Synthesis and Evaluation of Azole-Substituted Tetrahydronaphthalenes as Inhibitors of P450 arom, P450 17, and P450 TxA2.

Published in:

Archiv der Pharmazie, 1996, v. 329, n. 5, p. 251, doi. 10.1002/ardp.19963290506

By:

Hartmann, Rolf W.;
Frotscher, Martin;
Ledergerber, Dorothea;
Wächter, Gerald A.;
Grün, Gertrud L.;
Sergejew, Tom F.

Publication type:

Article

Editorial.

Published in:

Archiv der Pharmazie, 1996, v. 329, n. 1, p. 1, doi. 10.1002/ardp.19963290102

By:

Hartmann, Rolf W.

Publication type:

Article

4,5-Dihydro-3-(2-pyrazinyl)naphtho[1,2- c]pyrazole: A Potent and Selective Inhibitor of Steroid-17α-Hydroxylase-C17,20-Lyase (P450 17).

Published in:

Archiv der Pharmazie, 1995, v. 328, n. 7/8, p. 573, doi. 10.1002/ardp.19953280703

By:

Hartmann, Rolf W.;
Wächter, Gerald A.;
Sergejew, Tom;
Würtz, Rieka;
Düerkop, Jörg

Publication type:

Article

Synthesis and Biochemical Evaluation of (Carbamoylalkenyl)phenyloxy Carboxylic Acid Derivatives as Non-steroidal 5α-Reductase Inhibitors.

Published in:

Archiv der Pharmazie, 1995, v. 328, n. 3, p. 239, doi. 10.1002/ardp.19953280307

By:

Kattner, Lars;
Göhring, Sigrid;
Hartmann, Rolf W.

Publication type:

Article

Synthesis and Evaluation of Sulfur-Containing Glutethimide Derivatives for Aromatase and Desmolase Inhibitory Activity.

Published in:

Archiv der Pharmazie, 1993, v. 326, n. 7, p. 391, doi. 10.1002/ardp.19933260704

By:

Bednarski, Patrick J.;
Hartmann, Rolf W.

Publication type:

Article

Neue Hemmstoffe der Aromatase: Synthese und biologische Aktivität pyridyl-substituierter Phenanthrenonderivate.

Published in:

Archiv der Pharmazie, 1991, v. 324, n. 11, p. 833, doi. 10.1002/ardp.2503241102

By:

Bayer, Herbert;
Hartmann, Rolf W.

Publication type:

Article

Pyridyl-Substituierte Tetralonderivate: Eine Neue Klasse Nichtsteroidaler Aromatase-Inhibitoren.

Published in:

Archiv der Pharmazie, 1991, v. 324, n. 10, p. 815, doi. 10.1002/ardp.2503241008

By:

Bayer, Herbert;
Hartmann, Rolf W.

Publication type:

Article

Potentielle Antiöstrogene vom Typ des 1,2-Diphenyl-1-pyridyl-but-1-ens. Teil 2: Biologische Prüfung.

Published in:

Archiv der Pharmazie, 1991, v. 324, n. 4, p. 231, doi. 10.1002/ardp.19913240408

By:

Schwarz, Walter;
Hartmann, Rolf W.;
Schönenberger, Helmut

Publication type:

Article

Potentielle Antiöstrogene vom Typ des 1,2-Diphenyl-1-pyridyl-but-1-ens Teil 1: Synthese.

Published in:

Archiv der Pharmazie, 1991, v. 324, n. 4, p. 223, doi. 10.1002/ardp.19913240407

By:

Schwarz, Walter;
Hartmann, Rolf W.;
Schönenberger, Helmut

Publication type:

Article

Antiestrogene N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxybenzamide: Beeinflussung der Wirkung durch hydrophobe Reste in ortho-Position des Benzamidfragments.

Published in:

Archiv der Pharmazie, 1990, v. 323, n. 2, p. 73, doi. 10.1002/ardp.19903230204

By:

Hartmann, Rolf W.;
Orde, Hans-Dieter Vom;
Schönenberger, Helmut

Publication type:

Article

Cytotoxic Ester Derivatives of the Mammary Tumor Inhibiting Antiestrogen 2,3-Bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane.

Published in:

Archiv der Pharmazie, 1990, v. 323, n. 2, p. 121, doi. 10.1002/ardp.19903230213

By:

Schwarz, Walter;
Hartmann, Rolf W.;
Engel, Jürgen;
Schneider, Martin R.;
Schönenberger, Helmut

Publication type:

Article

N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxybenzamid: Synthese und pharmakologische Bewertung eines neues Antiestrogens.

Published in:

Archiv der Pharmazie, 1988, v. 321, n. 8, p. 497, doi. 10.1002/ardp.19883210814

By:

Hartmann, Rolf W.;
Orde, Hans-Dieter Vom;
Heindl, Alexander;
Schönenberger, Helmut

Publication type:

Article

Hemmstoffe der Aromatase. Synthese und pharmakologische Bewertung von potentiellen mammatumorhemmenden 4-Alkyl-3-(4-aminophenyl)-3-ethylpiperidin-2,6-dionen.

Published in:

Archiv der Pharmazie, 1987, v. 320, n. 1, p. 51, doi. 10.1002/ardp.19873200109

By:

Batzl, Christine;
Hartmann, Rolf W.

Publication type:

Article

Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives.

Published in:

Biopolymers, 2004, v. 73, n. 5, p. 631, doi. 10.1002/bip.10559

By:

Aboul-Enein, Hassan Y.;
Kladna, Alexandra;
Kruk, Irena;
Lichszteld, Krzysztof;
Marchlewicz, Mariola;
Michalska, Teresa;
Salem, Ola I. A.;
Hartmann, Rolf W.

Publication type:

Article

Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies.

Published in:

Journal of Cancer Research & Clinical Oncology, 2007, v. 133, n. 3, p. 153, doi. 10.1007/s00432-006-0151-3

By:

Schertl, Sabine;
Hartmann, Rolf W.;
Batzl-Hartmann, Christine;
Spruß, Thilo;
Maucher, Anton;
Von Angerer, Erwin;
Schiller, Claus D.;
Schneider, Martin R.;
Gust, Ronald;
Schönenberger, Helmut

Publication type:

Article

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0134754

By:

Gargano, Emanuele M.;
Allegretta, Giuseppe;
Perspicace, Enrico;
Carotti, Angelo;
Van Koppen, Chris;
Frotscher, Martin;
Marchais-Oberwinkler, Sandrine;
Hartmann, Rolf W.

Publication type:

Article

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0087851

By:

Schmitt, Christian;
Kail, Dagmar;
Mariano, Marica;
Empting, Martin;
Weber, Nadja;
Paul, Tamara;
Hartmann, Rolf W.;
Engel, Matthias

Publication type:

Article

3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048048

By:

Lina Yin;
Qingzhong Hu;
Hartmann, Rolf W.

Publication type:

Article

Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation.

Published in:

PLoS ONE, 2010, v. 5, n. 8, p. 1, doi. 10.1371/journal.pone.0012026

By:

Negri, Matthias;
Recanatini, Maurizio;
Hartmann, Rolf W.

Publication type:

Article

A Detective Story in Drug Discovery: Elucidation of a Screening Artifact Reveals Polymeric Carboxylic Acids as Potent Inhibitors of RNA Polymerase.

Published in:

Chemistry - A European Journal, 2013, v. 19, n. 26, p. 8397, doi. 10.1002/chem.201301289

By:

Zhu, Weixing;
Groh, Matthias;
Haupenthal, Jörg;
Hartmann, Rolf W.

Publication type:

Article

N-(4-Biphenylmethyl)imidazoles as Potential Therapeutics for the Treatment of Prostate Cancer: Metabolic Robustness Due to Fluorine Substitution?

Published in:

Helvetica Chimica Acta, 2003, v. 86, n. 7, p. 2671

By:

Frédéric Leroux;
Tilman U. Hutschenreuter;
Céline Charrière;
Rosario Scopelliti;
Rolf W. Hartmann

Publication type:

Article

Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 5, p. 1, doi. 10.1002/anie.202112295

By:

Kaya, Cansu;
Walter, Isabell;
Yahiaoui, Samir;
Sikandar, Asfandyar;
Alhayek, Alaa;
Konstantinović, Jelena;
Kany, Andreas M.;
Haupenthal, Jörg;
Köhnke, Jesko;
Hartmann, Rolf W.;
Hirsch, Anna K. H.

Publication type:

Article

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.

Published in:

Journal of Molecular Modeling, 2014, v. 20, n. 6, p. 1, doi. 10.1007/s00894-014-2255-z

By:

Hutter, Michael;
Brengel, Christian;
Negri, Matthias;
Henn, Claudia;
Zimmer, Christina;
Hartmann, Rolf;
Empting, Martin;
Steinbach, Anke

Publication type:

Article

Enantiomeric resolution of some human aldosterone synthase [CYP 11 B2] inhibitors on derivatized polysaccharide chiral stationary phases.

Published in:

Journal of Separation Science, 2003, v. 26, n. 15/16, p. 1455, doi. 10.1002/jssc.200301558

By:

Hassan Y. Aboul-Enein;
Mohamed M. Hefnawy;
Peter B. Ehmer;
Rolf W. Hartmann

Publication type:

Article

Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 4, p. 695, doi. 10.3109/14756366.2012.672414

By:

Berényi, Ágnes;
Frotscher, Martin;
Marchais-Oberwinkler, Sandrine;
Hartmann, Rolf W.;
Minorics, Renáta;
Ocsovszki, Imre;
Falkay, George;
Zupkó, István

Publication type:

Article

Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(α-azolylbenzyl)-1H-indoles as selective aromatase inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2007, v. 22, n. 5, p. 667, doi. 10.1080/14756360701652658

By:

BORGNE, MARC LE;
MARCHAND, PASCAL;
NOURRISSON, MARIE-RENEE;
LOQUET, DENIS;
PALZER, MARTINA;
LE BAUT, GUILLAUME;
HARTMANN, ROLF W.

Publication type:

Article

A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2006, v. 21, n. 5, p. 547, doi. 10.1080/14756360600774637

By:

Drăgan, Călin-Aurel;
Hartmann, Rolf W.;
Bureik, Matthias

Publication type:

Article

Three-dimensional model of cytochrome P450 human aromatase.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2005, v. 20, n. 6, p. 581, doi. 10.1080/14756360500220574

By:

Loge, Cedric;
Le Borgne, Marc;
Marchand, Pascal;
Robert, Jean-Michel;
Le Baut, Guillaume;
Palzer, Martina;
Hartmann, Rolf W.

Publication type:

Article

Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3,4-dihydronaphthalen-1(2 H )-one on all- trans and 13- cis -retinoic acid levels in plasma quantified by high perfomance liquid chromatography coupled to tandem mass spectrometry.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2005, v. 20, n. 3, p. 219, doi. 10.1080/14756360400008889

By:

Angotti, Marc;
Hartmann, Rolf W.;
Kirby, Andrew J.;
Simons, Claire;
Nicholls, Paul J.;
Sewell, Robert D.E.;
John Smith, H.

Publication type:

Article

2- and 3-[(Aryl)(azolyl)methyl]indoles as Potential Non-steroidal Aromatase Inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2004, v. 19, n. 6, p. 549, doi. 10.1080/14756360400004631

By:

Lézé, Marie-Pierre;
Le Borgne, Marc;
Marchand, Pascal;
Loquet, Denis;
Kogler, Manuela;
Le Baut, Guillaume;
Palusczak, Anja;
Hartmann, Rolf W.

Publication type:

Article

Evaluation of Cell Permeation of a Potent 5α-Reductase Inhibitor Using MALDI-TOF MS.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2004, v. 19, n. 5, p. 425, doi. 10.1080/14756360410001733739

By:

Mathur, Sonal;
Picard, Frank;
Dossou, Ulrich;
Barassin, Catherine;
Seidel, Stefanie B.;
Min-Jung Kang;
Hartmann, Rolf W.

Publication type:

Article