Works by Hardwidge, Philip

Results: 48

Methionine deficiency reduces autophagy and accelerates death in intestinal epithelial cells infected with enterotoxigenic Escherichia coli.

Published in:

Amino Acids, 2015, v. 47, n. 10, p. 2199, doi. 10.1007/s00726-014-1781-4

By:

Tang, Yulong;
Tan, Bie;
Xiong, Xia;
Li, Fengna;
Ren, Wenkai;
Kong, Xiangfeng;
Qiu, Wei;
Hardwidge, Philip;
Yin, Yulong

Publication type:

Article

Quorum-sensing gene luxS regulates flagella expression and Shiga-like toxin production in F18ab Escherichia coli.

Published in:

Canadian Journal of Microbiology, 2014, v. 60, n. 6, p. 355, doi. 10.1139/cjm-2014-0178

By:

Yang, Yang;
Zhou, Mingxu;
Hou, Huayan;
Zhu, Jun;
Yao, Fenghua;
Zhang, Xinjun;
Zhu, Xiaofang;
Hardwidge, Philip R.;
Zhu, Guoqiang

Publication type:

Article

Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function.

Published in:

PLoS Pathogens, 2009, v. 5, n. 12, p. 1, doi. 10.1371/journal.ppat.1000708

By:

Xiaofei Gao;
Fengyi Wan;
Mateo, Kristina;
Callegari, Eduardo;
Dan Wang;
Wanyin Deng;
Puente, Jose;
Feng Li;
Chaussee, Michael S.;
Finlay, B. Brett;
Lenardo, Michael J.;
Hardwidge, Philip R.

Publication type:

Article

Reflections on apparent DNA bending by charge variants of bZIP proteins.

Published in:

Biopolymers, 2003, v. 69, n. 1, p. 110, doi. 10.1002/bip.10321

By:

Hardwidge, Philip R.;
Parkhurst, Kay M.;
Parkhurst, Lawrence J.;
Maher, L. James

Publication type:

Article

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7.

Published in:

Nature Immunology, 2011, v. 12, n. 4, p. 335, doi. 10.1038/ni.2007

By:

Wan, Fengyi;
Weaver, Amanda;
Gao, Xiaofei;
Bern, Michael;
Hardwidge, Philip R;
Lenardo, Michael J

Publication type:

Article

Contribution of Crk adaptor proteins to host cell and bacteria interactions.

Published in:

2014

By:

Martinez-Quiles, Narcisa;
Feuerbacher, Leigh Ann;
Benito-León, María;
Hardwidge, Philip R

Publication type:

journal article

Arginine glycosylation regulates UDP-GlcNAc biosynthesis in Salmonella enterica.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09276-9

By:

El Qaidi, Samir;
Scott, Nichollas E.;
Hays, Michael P.;
Hardwidge, Philip R.

Publication type:

Article

Heat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence.

Published in:

Cellular Microbiology, 2012, v. 14, n. 8, p. 1231, doi. 10.1111/j.1462-5822.2012.01793.x

By:

Wang, Xiaogang;
Gao, Xiaofei;
Hardwidge, Philip R.

Publication type:

Article

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.

Published in:

Cellular Microbiology, 2010, v. 12, n. 9, p. 1322, doi. 10.1111/j.1462-5822.2010.01470.x

By:

Shames, Stephanie R.;
Wanyin Deng;
Guttman, Julian A.;
de Hoog, Carmen L.;
Yuling Li;
Hardwidge, Philip R.;
Sham, Ho Pan;
Vallance, Bruce A.;
Foster, Leonard J.;
Finlay, B. Brett

Publication type:

Article

Salmonella T3SS effector SseK1 arginine-glycosylates the two-component response regulator OmpR to alter bile salt resistance.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-36057-9

By:

Hasan, Md Kamrul;
Scott, Nichollas E.;
Hays, Michael P.;
Hardwidge, Philip R.;
El Qaidi, Samir

Publication type:

Article

Pasteurella multocida Pm0442 Affects Virulence Gene Expression and Targets TLR2 to Induce Inflammatory Responses.

Published in:

Frontiers in Microbiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fmicb.2020.01972

By:

He, Fang;
Qin, Xiaobin;
Xu, Na;
Li, Pan;
Wu, Xiaoyan;
Duan, Lijie;
Du, Yiyang;
Fang, Rendong;
Hardwidge, Philip R.;
Li, Nengzhang;
Peng, Yuanyi

Publication type:

Article

Construction and sequencing of an infectious clone of the goose embryo-adapted Muscovy duck parvovirus vaccine strain FZ91-30.

Published in:

Virology Journal, 2016, v. 13, n. 1, p. 1, doi. 10.1186/s12985-016-0564-9

By:

Jianye Wang;
Yu Huang;
Mingxu Zhou;
Hardwidge, Philip R.;
Guoqiang Zhu

Publication type:

Article

Near-infrared fluorescence detection of ATP-biotin-mediated phosphoprotein labeling.

Published in:

Biotechnology Letters, 2009, v. 31, n. 1, p. 113, doi. 10.1007/s10529-008-9824-0

By:

Xiaofei Gao;
Schutz-Geschwender, Amy;
Hardwidge, Philip R.

Publication type:

Article

Deleting qseC downregulates virulence and promotes cross-protection in Pasteurella multocida.

Published in:

Veterinary Research, 2021, v. 52, n. 1, p. 1, doi. 10.1186/s13567-021-01009-6

By:

Yang, Yang;
Hu, Pei;
Gao, Lixu;
Yuan, Xiang;
Hardwidge, Philip R.;
Li, Tian;
Li, Pan;
He, Fang;
Peng, Yuanyi;
Li, Nengzhang

Publication type:

Article

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06680-6

By:

Park, Jun Bae;
Kim, Young Hun;
Yoo, Youngki;
Kim, Juyeon;
Jun, Sung-Hoon;
Cho, Jin Won;
El Qaidi, Samir;
Walpole, Samuel;
Monaco, Serena;
García-García, Ana A.;
Wu, Miaomiao;
Hays, Michael P.;
Hurtado-Guerrero, Ramon;
Angulo, Jesus;
Hardwidge, Philip R.;
Shin, Jeon-Soo;
Cho, Hyun-Soo

Publication type:

Article

Characterization of the fecal microbiome of healthy adult beagle dogs supplemented with graded levels of bacillus coagulans GBI-30, 6086.

Published in:

Journal of Animal Science, 2021, v. 99, p. 337, doi. 10.1093/jas/skab235.620

By:

Acuff, Heather L.;
Gaire, Tara N.;
Doerksen, Tyler;
Lu, Andrea;
Hays, Michael P.;
Palinski, Rachel M.;
Hardwidge, Philip R.;
Aldrich, Charles G.

Publication type:

Article

Arginine glycosylation enhances methylglyoxal detoxification.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83437-0

By:

El Qaidi, Samir;
Scott, Nichollas E.;
Hardwidge, Philip R.

Publication type:

Article

Porcine aminopeptidase N binds to F4<sup>+</sup> enterotoxigenic Escherichia coli fimbriae.

Published in:

Veterinary Research, 2016, v. 47, p. 1, doi. 10.1186/s13567-016-0313-5

By:

Pengpeng Xia;
Yiting Wang;
Congrui Zhu;
Yajie Zou;
Ying Yang;
Wei Liu;
Hardwidge, Philip R.;
Guoqiang Zhu

Publication type:

Article

Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases.

Published in:

Pathogens, 2022, v. 11, n. 3, p. 370, doi. 10.3390/pathogens11030370

By:

Hasan, Md Kamrul;
El Qaidi, Samir;
McDonald, Peter;
Roy, Anuradha;
Hardwidge, Philip R.

Publication type:

Article

The T3SS Effector Protease NleC Is Active within Citrobacter rodentium.

Published in:

Pathogens, 2021, v. 10, n. 5, p. 589, doi. 10.3390/pathogens10050589

By:

Hasan, Md Kamrul;
El Qaidi, Samir;
Hardwidge, Philip R.

Publication type:

Article

YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity.

Published in:

Pathogens, 2021, v. 10, n. 2, p. 253, doi. 10.3390/pathogens10020253

By:

Zhu, Congrui;
El Qaidi, Samir;
McDonald, Peter;
Roy, Anuradha;
Hardwidge, Philip R.

Publication type:

Article

Hsp90 Interacts with the Bacterial Effector NleH1.

Published in:

Pathogens, 2018, v. 7, n. 4, p. 87, doi. 10.3390/pathogens7040087

By:

Wu, Miaomiao;
Hardwidge, Philip R.

Publication type:

Article

SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation.

Published in:

Pathogens, 2018, v. 7, n. 4, p. 86, doi. 10.3390/pathogens7040086

By:

Wu, Miaomiao;
El Qaidi, Samir;
Hardwidge, Philip R.

Publication type:

Article

Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice.

Published in:

Pathogens, 2018, v. 7, n. 2, p. 35, doi. 10.3390/pathogens7020035

By:

Wang, Gaochan;
Feuerbacher, Leigh Ann;
Hardwidge, Philip R.

Publication type:

Article

Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells.

Published in:

Pathogens, 2017, v. 6, n. 2, p. 18, doi. 10.3390/pathogens6020018

By:

Gaochan Wang;
Geisbrecht, Brian V.;
Rueter, Christian;
Hardwidge, Philip R.

Publication type:

Article

Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens.

Published in:

Frontiers in Cellular & Infection Microbiology, 2018, p. 1, doi. 10.3389/fcimb.2018.00314

By:

Zhendong Li;
Guomei Quan;
Xinyi Jiang;
Yang Yang;
Xueyan Ding;
Dong Zhang;
Xiuqing Wang;
Hardwidge, Philip R.;
Wenkai Ren;
Guoqiang Zhu

Publication type:

Article

Membrane cholesterol plays an important role in enteropathogen adhesion and the activation of innate immunity via flagellin-TLR5 signaling.

Published in:

Archives of Microbiology, 2015, v. 197, n. 6, p. 797, doi. 10.1007/s00203-015-1115-2

By:

Zhou, Mingxu;
Duan, Qiangde;
Li, Yinchau;
Yang, Yang;
Hardwidge, Philip;
Zhu, Guoqiang

Publication type:

Article

The Role of Innate Immunity in Pulmonary Infections.

Published in:

BioMed Research International, 2021, p. 1, doi. 10.1155/2021/6646071

By:

Zhang, Huihui;
He, Fang;
Li, Pan;
Hardwidge, Philip R.;
Li, Nengzhang;
Peng, Yuanyi

Publication type:

Article

Identification of Host Factors for Rift Valley Fever Phlebovirus.

Published in:

Viruses (1999-4915), 2023, v. 15, n. 11, p. 2251, doi. 10.3390/v15112251

By:

Balaraman, Velmurugan;
Indran, Sabarish V.;
Li, Yonghai;
Meekins, David A.;
Jakkula, Laxmi U. M. R.;
Liu, Heidi;
Hays, Micheal P.;
Souza-Neto, Jayme A.;
Gaudreault, Natasha N.;
Hardwidge, Philip R.;
Wilson, William C.;
Weber, Friedemann;
Richt, Juergen A.

Publication type:

Article

The role of bacterial cell envelope structures in acid stress resistance in E. coli.

Published in:

Applied Microbiology & Biotechnology, 2020, v. 104, n. 7, p. 2911, doi. 10.1007/s00253-020-10453-x

By:

Li, Zhendong;
Jiang, Boyu;
Zhang, Xinyi;
Yang, Yang;
Hardwidge, Philip R.;
Ren, Wenkai;
Zhu, Guoqiang

Publication type:

Article

Enhanced D-lactic acid production from renewable resources using engineered Lactobacillus plantarum.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 1, p. 279, doi. 10.1007/s00253-015-7016-0

By:

Zhang, Yixing;
Vadlani, Praveen;
Kumar, Amit;
Hardwidge, Philip;
Govind, Revathi;
Tanaka, Tsutomu;
Kondo, Akihiko

Publication type:

Article

More than a locomotive organelle: flagella in Escherichia coli.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 21, p. 8883, doi. 10.1007/s00253-015-6946-x

By:

Zhou, Mingxu;
Yang, Yang;
Chen, Panlin;
Hu, Huijie;
Hardwidge, Philip;
Zhu, Guoqiang

Publication type:

Article

An intra-bacterial activity for a T3SS effector.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58062-y

By:

El Qaidi, Samir;
Scott, Nichollas E.;
Hays, Michael P.;
Geisbrecht, Brian V.;
Watkins, Shelby;
Hardwidge, Philip R.

Publication type:

Article

Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection.

Published in:

Frontiers in Immunology, 2017, v. 7, p. 1, doi. 10.3389/fimmu.2016.00685

By:

Wenkai Ren;
Jie Yin;
Hao Xiao;
Shuai Chen;
Gang Liu;
Bie Tan;
Nengzhang Li;
Yuanyi Peng;
Tiejun Li;
Benhua Zeng;
Wenxia Li;
Hong Wei;
Zhinan Yin;
Guoyao Wu;
Hardwidge, Philip R.;
Yulong Yin;
Bigwood, Douglas W.;
Myles, Ian Antheni

Publication type:

Article

Secretome Analysis of High- and Low-Virulent Bovine Pasteurella multocida Cultured in Different Media.

Published in:

Animals (2076-2615), 2023, v. 13, n. 23, p. 3683, doi. 10.3390/ani13233683

By:

Qiu, Yangyang;
Wang, Jianan;
He, Fang;
Wu, Xiaoyan;
Dan, Ruitong;
Hardwidge, Philip R.;
Li, Nengzhang;
Peng, Yuanyi

Publication type:

Article

Charge neutralization and DNA bending by the Escherichia coli catabolite activator protein.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 9, p. 1879, doi. 10.1093/nar/30.9.1879

By:

Hardwidge, Philip R.;
Zimmerman, Jeff M.;
Maher III, L. James

Publication type:

Article

Experimental evaluation of the Liu–Beveridge dinucleotide step model of DNA structure.

Published in:

Nucleic Acids Research, 2001, v. 29, n. 12, p. 2619, doi. 10.1093/nar/29.12.2619

By:

Hardwidge, Philip R.;
Maher, L. James

Publication type:

Article

Design and calibration of a semi-synthetic DNA phasing assay.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 23, p. e102, doi. 10.1093/nar/28.23.e102

By:

Hardwidge, Philip R.;
Zimmerman, Jeff M.;
Maher, III, L. James

Publication type:

Article

Improved quantitation of DNA curvature using ligation ladders.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 21, p. 4135, doi. 10.1093/nar/27.21.4135

By:

Ross, Eric D.;
Den, Robert B.;
Hardwidge, Philip R.;
III, L. James

Publication type:

Article

Vaccinating with conserved Escherichia coli antigens does not alter the mouse intestinal microbiome.

Published in:

BMC Research Notes, 2016, v. 9, p. 1, doi. 10.1186/s13104-016-2208-y

By:

Hays, Michael P.;
Ericsson, Aaron C.;
Yang Yang;
Hardwidge, Philip R.

Publication type:

Article

Protective Enterotoxigenic Escherichia coli Antigens in a Murine Intranasal Challenge Model.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 8, p. 1, doi. 10.1371/journal.pntd.0003924

By:

Kumar, Amit;
Hays, Mike;
Lim, Francis;
Foster, Leonard J.;
Zhou, Mingxu;
Zhu, Guoqiang;
Miesner, Tracy;
Hardwidge, Philip R.

Publication type:

Article

Loss to gain: pseudogenes in microorganisms, focusing on eubacteria, and their biological significance.

Published in:

Applied Microbiology & Biotechnology, 2024, v. 108, n. 1, p. 1, doi. 10.1007/s00253-023-12971-w

By:

Yang, Yi;
Wang, Pengzhi;
Qaidi, Samir El;
Hardwidge, Philip R.;
Huang, Jinlin;
Zhu, Guoqiang

Publication type:

Article

Isolation and Characterization of N-acyl Homoserine Lactone-Producing Bacteria From Cattle Rumen and Swine Intestines.

Published in:

Frontiers in Cellular & Infection Microbiology, 2018, v. 8, p. N.PAG, doi. 10.3389/fcimb.2018.00155

By:

Yang, Yang;
Zhou, Mingxu;
Hardwidge, Philip R.;
Cui, Hengmi;
Zhu, Guoqiang

Publication type:

Article

Immunization With Skp Delivered on Outer Membrane Vesicles Protects Mice Against Enterotoxigenic Escherichia coli Challenge.

Published in:

Frontiers in Cellular & Infection Microbiology, 2018, v. 8, p. 1, doi. 10.3389/fcimb.2018.00132

By:

Hays, Michael P.;
Houben, Diane;
Yang, Yang;
Luirink, Joen;
Hardwidge, Philip R.

Publication type:

Article

Immunization with the MipA, Skp, or ETEC_2479 Antigens Confers Protection against Enterotoxigenic E. coli Strains Expressing Different Colonization Factors in a Mouse Pulmonary Challenge Model.

Published in:

Frontiers in Cellular & Infection Microbiology, 2016, v. 6, p. 1, doi. 10.3389/fcimb.2016.00181

By:

Hays, Michael P.;
Kumar, Amit;
Martinez-Becerra, Francisco J.;
Hardwidge, Philip R.

Publication type:

Article

Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic <italic>Escherichia coli</italic> F4 fimbriae.

Published in:

Veterinary Research, 2018, v. 49, p. 1, doi. 10.1186/s13567-018-0519-9

By:

Xia, Pengpeng;
Quan, Guomei;
Yang, Yi;
Zhao, Jing;
Wang, Yiting;
Zhou, Mingxu;
Hardwidge, Philip R.;
Zhu, Jianzhong;
Liu, Siguo;
Zhu, Guoqiang

Publication type:

Article

Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors.

Published in:

Cellular & Molecular Life Sciences, 2018, v. 75, n. 12, p. 2273, doi. 10.1007/s00018-017-2733-4

By:

Norkowski, Stefanie;
Körner, Britta;
Greune, Lilo;
Stolle, Anne-Sophie;
Lubos, Marie-Luise;
Hardwidge, Philip R.;
Schmidt, M. Alexander;
Rüter, Christian

Publication type:

Article

d-lactic acid production from renewable lignocellulosic biomass via genetically modified Lactobacillus plantarum.

Published in:

Biotechnology Progress, 2016, v. 32, n. 2, p. 271, doi. 10.1002/btpr.2212

By:

Zhang, Yixing;
Kumar, Amit;
Hardwidge, Philip R.;
Tanaka, Tsutomu;
Kondo, Akihiko;
Vadlani, Praveen V.

Publication type:

Article