Works by Harden, T. Kendall

Results: 32

Crystal structure of the multifunctional Gβ5–RGS9 complex.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 2, p. 155, doi. 10.1038/nsmb.1377

By:

Cheever, Matthew L.;
Snyder, Jason T.;
Gershburg, Svetlana;
Siderovski, David P.;
Harden, T. Kendall;
Sondek, John

Publication type:

Article

Crystal structure of Rac1 bound to its effector phospholipase C-β2.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 12, p. 1135, doi. 10.1038/nsmb1175

By:

Jezyk, Mark R.;
Snyder, Jason T.;
Gershberg, Svetlana;
Worthylake, David K.;
Harden, T. Kendall;
Sondek, John

Publication type:

Article

Regulation of Cyclic AMP Accumulation by Peptide Hormone Receptors in Immunocytochemically: Defined Astroglial Cells.

Published in:

Journal of Neurochemistry, 1984, v. 43, n. 1, p. 131, doi. 10.1111/j.1471-4159.1984.tb06688.x

By:

Evans, Tony;
McCarthy, Ken D.;
Harden, T. Kendall

Publication type:

Article

UDP is an antagonist at the hP2Y14 receptor.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A424, doi. 10.1096/fasebj.21.5.a424-c

By:

Fricks, Ingrid P.;
Maddileti, Savitri;
Lazarowski, Eduardo R.;
Nicholas, Robert A.;
Jacobson, Kenneth A.;
Harden, T. Kendall

Publication type:

Article

Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells.

Published in:

Journal of Cellular Physiology, 1989, v. 139, n. 1, p. 100, doi. 10.1002/jcp.1041390115

By:

Roe, Michael W.;
Hepler, John R.;
Harden, T. Kendall;
Herman, Brian

Publication type:

Article

Studies of cAMP metabolism in cultured hepatoma cells: Presence of functional adenylate cyclase despite low camp content and lack of hormonal responsiveness.

Published in:

Journal of Cellular Physiology, 1978, v. 96, n. 2, p. 215, doi. 10.1002/jcp.1040960210

By:

Leichtling, Ben H.;
Su, Y.-F.;
Wimalasena, Jayantha;
Harden, T. Kendall;
Wolfe, Barry B.;
Wicks, Wesley D.

Publication type:

Article

Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors.

Published in:

Drug Development Research, 2001, v. 53, n. 2/3, p. 66, doi. 10.1002/ddr.1172

By:

Lazarowski, Eduardo R.;
Boucher, Richard C.;
Harden, T. Kendall

Publication type:

Article

Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5′-phosphate and phosphonate derivatives as P2 receptor antagonists.

Published in:

Drug Development Research, 1998, v. 45, n. 2, p. 52, doi. 10.1002/(SICI)1098-2299(199810)45:2<52::AID-DDR2>3.0.CO;2-V

By:

Kim, Yong-Chul;
Camaioni, Emidio;
Ziganshin, Airat U.;
Ji, Xiao-duo;
King, Brian F.;
Wildman, Scott S.;
Rychkov, Alexei;
Yoburn, Joshua;
Kim, Heaok;
Mohanram, Arvind;
Harden, T. Kendall;
Boyer, José L.;
Burnstock, Geoffrey;
Jacobson, Kenneth A.

Publication type:

Article

Receptor nomenclature.

Published in:

Drug Development Research, 1996, v. 39, n. 3/4, p. 461, doi. 10.1002/(SICI)1098-2299(199611/12)39:3/4<461::AID-DDR28>3.0.CO;2-2

By:

Fredholm, Bertil B.;
Burnstock, Geoffrey;
Harden, T. Kendall;
Spedding, Michael

Publication type:

Article

Avian and human homologues of the P2Y1 receptor: Pharmacological, signaling, and molecular properties.

Published in:

Drug Development Research, 1996, v. 39, n. 3/4, p. 253, doi. 10.1002/(SICI)1098-2299(199611/12)39:3/4<253::AID-DDR4>3.0.CO;2-Q

By:

Boyer, Jose L.;
Schachter, Joel B.;
Sromek, Susan M.;
Palmer, R. Kyle;
Jacobson, Kenneth A.;
Nicholas, Robert A.;
Harden, T. Kendall

Publication type:

Article

Structure activity relationships for derivatives of adenosine-5′-triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes.

Published in:

Drug Development Research, 1994, v. 31, n. 3, p. 206, doi. 10.1002/ddr.430310308

By:

Burnstock, Geoffrey;
Fischer, Bilha;
Hoyle, Charles H. V.;
Maillard, Michel;
Ziganshin, Airat U.;
Brizzolara, Antonia L.;
von Isakovics, Amy;
Boyer, José L.;
Harden, T. Kendall;
Jacobson, Kenneth A.

Publication type:

Article

Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells.

Published in:

2011

By:

Qi, Ai-Dong;
Houston-Cohen, Dayle;
Naruszewicz, Isabella;
Harden, T Kendall;
Nicholas, Robert A

Publication type:

journal article

Enigmatic GPCR Finds a Stimulating Drug.

Published in:

Science Signaling, 2013, v. 6, n. 298, p. 1, doi. 10.1126/scisignal.2004755

By:

Harden, T. Kendall

Publication type:

Article

G Protein-Coupled Receptor-Mediated Activation of p110b by Gβγ Is Required for Cellular Transformation and Invasiveness.

Published in:

Science Signaling, 2012, v. 5, n. 253, p. 1, doi. 10.1126/scisignal.2003264

By:

Dbouk, Hashem A.;
Vadas, Oscar;
Shymanets, Aliaksei;
Burke, John E.;
Salamon, Rachel S.;
Khalil, Bassem D.;
Barrett, Mathew O.;
Waldo, Gary L.;
Surve, Chinmay;
Hsueh, Christine;
Perisic, Olga;
Harteneck, Christian;
Shepherd, Peter R.;
Harden, T. Kendall;
Smrcka, Alan V.;
Taussig, Ronald;
Bresnick, Anne R.;
Nürnberg, Bernd;
Williams, Roger L.;
Backer, Jonathan M.

Publication type:

Article

[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.

Published in:

2006

By:

Houston, Dayle;
Ohno, Michihiro;
Nicholas, Robert A.;
Jacobson, Kenneth A.;
Harden, T. Kendall

Publication type:

journal article

2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.

Published in:

2002

By:

Boyer, José L;
Adams, Mary;
Ravi, R Gnana;
Jacobson, Kenneth A;
Harden, T Kendall

Publication type:

journal article

2-Chloro N[sup6]-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphophate is a selective high affinity P2Y[sub1] receptor antagonist.

Published in:

British Journal of Pharmacology, 2002, v. 135, n. 8, p. 2004, doi. 10.1038/sj.bjp.0704673

By:

Boyer, Jose L.;
Adams, Mary;
Ravi, R. Gnana;
Jacobson, Kenneth A.;
Harden, T. Kendall

Publication type:

Article

Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase.

Published in:

British Journal of Pharmacology, 2001, v. 132, n. 1, p. 318, doi. 10.1038/sj.bjp.0703788

By:

Qi, Ai-Dong;
Kennedy, Charles;
Harden, T Kendall;
Nicholas, Robert A

Publication type:

Article

The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery.

Published in:

British Journal of Pharmacology, 2000, v. 131, n. 1, p. 51, doi. 10.1038/sj.bjp.0703536

By:

Malmsjö, Malin;
Adner, Mikael;
Harden, T Kendall;
Pendergast, William;
Edvinsson, Lars;
Erlinge, David

Publication type:

Article

Functional expression of a cDNA encoding a human ecto-ATPase.

Published in:

1999

By:

Mateo, Jesús;
Harden, T Kendall;
Boyer, José L;
Mateo, J;
Harden, T K;
Boyer, J L

Publication type:

journal article

Quantitation of extracellular UTP using a sensitive enzymatic assay.

Published in:

1999

By:

Lazarowski, Eduardo R;
Harden, T Kendall;
Lazarowski, E R;
Harden, T K

Publication type:

journal article

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.

Published in:

1998

By:

Boyer, José L;
Mohanram, Arvind;
Camaioni, Emidio;
Jacobson, Kenneth A;
Harden, T Kendall;
Boyer, J L;
Mohanram, A;
Camaioni, E;
Jacobson, K A;
Harden, T K

Publication type:

journal article

An examination of deoxyadenosine 5′( α-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor.

Published in:

British Journal of Pharmacology, 1997, v. 121, n. 2, p. 338, doi. 10.1038/sj.bjp.0701136

By:

Schachter, Joel B;
Kendall Harden, T

Publication type:

Article

A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq.

Published in:

Nature Structural Biology, 2002, v. 9, n. 1, p. 32, doi. 10.1038/nsb731

By:

Singer, Alex U.;
Waldo, Gary L.;
Harden, T. Kendall;
Sondek, John

Publication type:

Article

DRUG ANALYSIS BASED ON SIGNALING RESPONSES TO G-PROTEIN-COUPLED RECEPTORS.

Published in:

Journal of Receptors & Signal Transduction, 2001, v. 21, n. 2/3, p. 167, doi. 10.1081/RRS-100107427

By:

Harden, T. Kendall;
Boyer, José L.;
Dougherty, Robert W.

Publication type:

Article

Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats.

Published in:

Clinical Pharmacology & Therapeutics, 1984, v. 35, n. 5, p. 576, doi. 10.1038/clpt.1984.80

By:

Cubeddu, Luigi X;
Cloutier, Gilles;
Gross, Kirsten;
Grippo, Richard;
Tanner, Laura;
Lerea, Leslie;
Shakarjian, Michael;
Knowlton, Gail;
Harden, T Kendall;
Arendshorst, William;
Rogers, John F

Publication type:

Article

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.

Published in:

Nature, 2009, v. 461, n. 7261, p. 282, doi. 10.1038/nature08296

By:

Elliott, Michael R.;
Chekeni, Faraaz B.;
Trampont, Paul C.;
Lazarowski, Eduardo R.;
Kadl, Alexandra;
Walk, Scott F.;
Park, Daeho;
Woodson, Robin I.;
Ostankovich, Marina;
Sharma, Poonam;
Lysiak, Jeffrey J.;
Harden, T. Kendall;
Leitinger, Norbert;
Ravichandran, Kodi S.

Publication type:

Article

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.

Published in:

Molecular Carcinogenesis, 2008, v. 47, n. 5, p. 326, doi. 10.1002/mc.20389

By:

Healy, Kevin D.;
Hodgson, Louis;
Kim, Tai-Young;
Shutes, Adam;
Maddileti, Savitri;
Juliano, Rudolph L.;
Hahn, Klaus M.;
Harden, T. Kendall;
Bang, Yung-Jue;
Der, Channing J.

Publication type:

Article

Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand.

Published in:

Molecules, 2014, v. 19, n. 4, p. 4313, doi. 10.3390/molecules19044313

By:

Lijun Song;
Risseeuw, Martijn D. P.;
Karalic, Izet;
Barrett, Matthew O.;
Brown, Kyle A.;
Kendall Harden, T.;
Van Calenbergh, Serge

Publication type:

Article

Irreversible Activation and Photoaffinity Labeling of a P2Y-Purinergic Receptor Coupled to Phospholipase C Activation in Turkey Erythrocyte Membranes.

Published in:

Annals of the New York Academy of Sciences, 1990, v. 603, n. 1, p. 478, doi. 10.1111/j.1749-6632.1990.tb37711.x

By:

BOYER, JOSÉ L.;
COOPER, CRISTY L.;
HARDEN, T. KENDALL

Publication type:

Article

Biochemical Properties of a P2Y-Purinergic Receptor.

Published in:

Annals of the New York Academy of Sciences, 1990, v. 603, n. 1, p. 256, doi. 10.1111/j.1749-6632.1990.tb37677.x

By:

HARDEN, T. KENDALL;
BOYER, JOSÉ LUIS;
BROWN, H. ALEXANDER;
COOPER, CHRISTY L.;
JEFFS, ROGER A.;
MARTIN, MICHAEL W.

Publication type:

Article

HETEROGENEOUS RESPONSES OF CELL Ca[sup 2+] IN HUMAN AIRWAY EPITHELIUM.

Published in:

Experimental Lung Research, 1999, v. 25, n. 4, p. 277, doi. 10.1080/019021499270196

By:

Paradiso, Anthony M.;
Brown, H. Alex;
Ye, Hong;
Harden, T. Kendall;
Boucher, Richard C.

Publication type:

Article

Works by Harden, T. Kendall

Crystal structure of the multifunctional Gβ5–RGS9 complex.

Crystal structure of Rac1 bound to its effector phospholipase C-β2.

Regulation of Cyclic AMP Accumulation by Peptide Hormone Receptors in Immunocytochemically: Defined Astroglial Cells.

UDP is an antagonist at the hP2Y14 receptor.

Platelet-derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells.

Studies of cAMP metabolism in cultured hepatoma cells: Presence of functional adenylate cyclase despite low camp content and lack of hormonal responsiveness.

Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors.

Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5′-phosphate and phosphonate derivatives as P2 receptor antagonists.

Receptor nomenclature.

Avian and human homologues of the P2Y<sub>1</sub> receptor: Pharmacological, signaling, and molecular properties.

Structure activity relationships for derivatives of adenosine-5′-triphosphate as agonists at P<sub>2</sub> purinoceptors: Heterogeneity within P<sub>2x</sub> and P<sub>2y</sub> subtypes.

Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells.

Enigmatic GPCR Finds a Stimulating Drug.

G Protein-Coupled Receptor-Mediated Activation of p110b by Gβγ Is Required for Cellular Transformation and Invasiveness.

[32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.

2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.

2-Chloro N[sup6]-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphophate is a selective high affinity P2Y[sub1] receptor antagonist.

Differential coupling of the human P2Y<sub>11</sub> receptor to phospholipase C and adenylyl cyclase.

The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery.

Functional expression of a cDNA encoding a human ecto-ATPase.

Quantitation of extracellular UTP using a sensitive enzymatic assay.

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.

An examination of deoxyadenosine 5′( α-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y<sub>1</sub> receptor.

A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq.

DRUG ANALYSIS BASED ON SIGNALING RESPONSES TO G-PROTEIN-COUPLED RECEPTORS.

Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats.

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.

Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y<sub>2</sub> Receptor Ligand.

Irreversible Activation and Photoaffinity Labeling of a P<sub>2Y</sub>-Purinergic Receptor Coupled to Phospholipase C Activation in Turkey Erythrocyte Membranes.

Biochemical Properties of a P<sub>2Y</sub>-Purinergic Receptor.

HETEROGENEOUS RESPONSES OF CELL Ca[sup 2+] IN HUMAN AIRWAY EPITHELIUM.