Works by Haoxing Xu

Results: 41

A Spontaneous, Recurrent Mutation in Divalent Metal Transporter-1 Exposes a Calcium Entry Pathway.

Published in:

PLoS Biology, 2004, v. 2, n. 3, p. 1, doi. 10.1371/journal.pbio.0020050

By:

Xu, Haoxing;
Jin, Jie;
DeFelice, Louis J;
Andrews, Nancy C;
Clapham, David E

Publication type:

Article

A Spontaneous,Recurrent Mutation in Divalent Metal Transporter-1 Exposes a Calcium Entry Pathway.

Published in:

PLoS Biology, 2004, v. 2, n. 3, p. 378

By:

Haoxing Xu;
Jie Jin;
DeFelice, Louis J.;
Andrews, Nancy C.;
Clapham, David E.

Publication type:

Article

Release and uptake mechanisms of vesicular Ca2+ stores.

Published in:

Protein & Cell, 2019, v. 10, n. 1, p. 8, doi. 10.1007/s13238-018-0523-x

By:

Yang, Junsheng;
Zhao, Zhuangzhuang;
Gu, Mingxue;
Feng, Xinghua;
Xu, Haoxing

Publication type:

Article

Activation of TRPML1 Clears Intraneuronal Aβ in Preclinical Models of HIV Infection.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 34, p. 11485, doi. 10.1523/JNEUROSCI.0210-14.2014

By:

Mihyun Bae;
Patel, Neha;
Haoxing Xu;
Mingwaoh Lee;
Tominaga-Yamanaka, Kumiko;
Nath, Avindra;
Geiger, Jonathan;
Gorospe, Myriam;
Mattson, Mark P.;
Haughey, Norman J.

Publication type:

Article

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.

Published in:

Nature, 2008, v. 455, n. 7215, p. 992, doi. 10.1038/nature07311

By:

Xian-Ping Dong;
Xiping Cheng;
Mills, Eric;
Delling, Markus;
Wang, Fudi;
Kurz, Tino;
Haoxing Xu

Publication type:

Article

Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 39, p. 8924, doi. 10.1523/JNEUROSCI.2574-05.2005

By:

Haoxing Xu;
Blair, Nathaniel T.;
Clapham, David E.

Publication type:

Article

Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV 1 Sensitization.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 38, p. 8300, doi. 10.1523/JNEUROSCI.2893-04.2004

By:

Zhi-Ye Zhuang;
Haoxing Xu;
Clapham, David E.;
Ru-Rong Ji

Publication type:

Article

Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis.

Published in:

Plant & Cell Physiology, 2017, v. 58, n. 7, p. 1185, doi. 10.1093/pcp/pcx011

By:

Tomoko Hirano;
Stecker, Kelly;
Teun Munnik;
Haoxing Xu;
Masa H. Sato

Publication type:

Article

Denitrification of fuel oil by hydrogen‐sulfate pyrazolium‐based ionic liquids.

Published in:

ChemistrySelect, 2017, v. 2, n. 35, p. 11469, doi. 10.1002/slct.201701781

By:

Li, Jie;
Zeng, Kai;
Xu, Haoxing;
Jiang, Feng;
Zhang, Jianfeng

Publication type:

Article

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.

Published in:

PLoS Biology, 2019, v. 17, n. 5, p. 1, doi. 10.1371/journal.pbio.3000252

By:

Zhang, Xiaoli;
Chen, Wei;
Gao, Qiong;
Yang, Junsheng;
Yan, Xueni;
Zhao, Han;
Su, Lin;
Yang, Meimei;
Gao, Chenlang;
Yao, Yao;
Inoki, Ken;
Li, Dan;
Shao, Rong;
Wang, Shiyi;
Sahoo, Nirakar;
Kudo, Fumitaka;
Eguchi, Tadashi;
Ruan, Benfang;
Xu, Haoxing

Publication type:

Article

Allosteric modulation of the mouse kir6.2 channel by intracellular H+ and ATP.

Published in:

Journal of Physiology, 2002, v. 543, n. 2, p. 495, doi. 10.1113/jphysiol.2002.025247

By:

Wu, Jianping;
Cui, Ningren;
Piao, Hailan;
Wang, Ying;
Xu, Haoxing;
Mao, Jinzhe;
Jiang, Chun

Publication type:

Article

A single residue contributes to the difference between Kir4.1 and Kir1.1 channels in pH sensitivity, rectification and single channel conductance.

Published in:

Journal of Physiology, 2000, v. 528, n. 2, p. 267, doi. 10.1111/j.1469-7793.2000.00267.x

By:

Xu, Haoxing;
Yang, Zhenjiang;
Cui, Ningren;
Chanchevalap, Sengthong;
Valesky, Walter W.;
Jiang, Chun

Publication type:

Article

Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis.

Published in:

Journal of Physiology, 2000, v. 524, n. 3, p. 725, doi. 10.1111/j.1469-7793.2000.00725.x

By:

Xu, Haoxing;
Cui, Ningren;
Yang, Zhenjiang;
Qu, Zhiqiang;
Jiang, Chun

Publication type:

Article

The Acid Gate in the Lysosome.

Published in:

Autophagy, 2023, v. 19, n. 4, p. 1368, doi. 10.1080/15548627.2022.2125629

By:

Hu, Meiqin;
Chen, Jingzhi;
Liu, Siyu;
Xu, Haoxing

Publication type:

Article

MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx.

Published in:

Autophagy, 2021, v. 17, n. 12, p. 4401, doi. 10.1080/15548627.2021.1917132

By:

Qi, Jiansong;
Xing, Yanhong;
Liu, Yucheng;
Wang, Meng-Meng;
Wei, Xiangqing;
Sui, Zhongheng;
Ding, Lin;
Zhang, Yang;
Lu, Chen;
Fei, Yuan-Hui;
Liu, Nan;
Chen, Rong;
Wu, Mengmei;
Wang, Lijuan;
Zhong, Zhenyu;
Wang, Ting;
Liu, Yifan;
Wang, Yuqing;
Liu, Jiamei;
Xu, Haoxing

Publication type:

Article

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.

Published in:

Autophagy, 2021, v. 17, n. 4, p. 872, doi. 10.1080/15548627.2020.1739442

By:

Li, Dan;
Shao, Rong;
Wang, Na;
Zhou, Nan;
Du, Kaili;
Shi, Jiahui;
Wang, Yihan;
Zhao, Zhuangzhuang;
Ye, Xin;
Zhang, Xiaoli;
Xu, Haoxing

Publication type:

Article

Pairing phosphoinositides with calcium ions in endolysosomal dynamics.

Published in:

BioEssays, 2011, v. 33, n. 6, p. 448, doi. 10.1002/bies.201000152

By:

Dongbiao Shen;
Xiang Wang;
Haoxing Xu

Publication type:

Article

Mucolipins: Intracellular TRPML1-3 channels

Published in:

FEBS Letters, 2010, v. 584, n. 10, p. 2013, doi. 10.1016/j.febslet.2009.12.056

By:

Cheng, Xiping;
Shen, Dongbiao;
Samie, Mohammad;
Xu, Haoxing

Publication type:

Article

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.

Published in:

Nature Materials, 2014, v. 13, n. 6, p. 599, doi. 10.1038/nmat3945

By:

Sun, Yubing;
Yong, Koh Meng Aw;
Villa-Diaz, Luis G.;
Zhang, Xiaoli;
Chen, Weiqiang;
Philson, Renee;
Weng, Shinuo;
Xu, Haoxing;
Krebsbach, Paul H.;
Fu, Jianping

Publication type:

Article

A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation.

Published in:

PLoS Biology, 2021, v. 19, n. 7, p. 1, doi. 10.1371/journal.pbio.3001361

By:

Zhang, Weichao;
Yang, Xi;
Chen, Liang;
Liu, Yun-Yu;
Venkatarangan, Varsha;
Reist, Lucas;
Hanson, Phyllis;
Xu, Haoxing;
Wang, Yanzhuang;
Li, Ming

Publication type:

Article

Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 1, p. 1, doi. 10.1083/jcb.202403104

By:

Xinghua Feng;
Weijie Cai;
Qian Li;
Liding Zhao;
Yaping Meng;
Haoxing Xu

Publication type:

Article

Not just protons: Chloride also activates lysosomal acidic hydrolases.

Published in:

Journal of Cell Biology, 2023, v. 222, n. 6, p. 1, doi. 10.1083/jcb.202305007

By:

Xinghua Feng;
Siyu Liu;
Haoxing Xu

Publication type:

Article

Lysosomal solute and water transport.

Published in:

Journal of Cell Biology, 2022, v. 221, n. 11, p. 1, doi. 10.1083/jcb.202109133

By:

Meiqin Hu;
Nan Zhou;
Weijie Cai;
Haoxing Xu

Publication type:

Article

A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores.

Published in:

Journal of Cell Biology, 2017, v. 216, n. 6, p. 1715, doi. 10.1083/jcb.201612123

By:

Wuyang Wang;
Xiaoli Zhang;
Qiong Gao;
Lawas, Maria;
Lu Yu;
Xiping Cheng;
Mingxue Gu;
Sahoo, Nirakar;
Xinran Li;
Ireland, Stephen;
Haoxing Xu;
Ping Li;
Meredith, Andrea

Publication type:

Article

A painful TR(i)P to lysosomes.

Published in:

Journal of Cell Biology, 2016, v. 215, n. 3, p. 309, doi. 10.1083/jcb.201610067

By:

Mingxue Gu;
Haoxing Xu

Publication type:

Article

Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes.

Published in:

Journal of Physiology, 2013, v. 591, n. 18, p. 4389, doi. 10.1113/jphysiol.2013.258301

By:

Li, Xinran;
Garrity, Abigail G.;
Xu, Haoxing

Publication type:

Article

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Published in:

Nature Communications, 2016, v. 7, n. 6, p. 12109, doi. 10.1038/ncomms12109

By:

Zhang, Xiaoli;
Cheng, Xiping;
Yu, Lu;
Yang, Junsheng;
Calvo, Raul;
Patnaik, Samarjit;
Hu, Xin;
Gao, Qiong;
Yang, Meimei;
Lawas, Maria;
Delling, Markus;
Marugan, Juan;
Ferrer, Marc;
Xu, Haoxing

Publication type:

Article

Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels.

Published in:

Frontiers in Molecular Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnmol.2021.790435

By:

Fatima, Mahar;
Slade, Hannah;
Horwitz, Lorraine;
Shi, Angela;
Liu, Jingyi;
McKinstry, Delaney;
Villani, Troy;
Xu, Haoxing;
Duan, Bo

Publication type:

Article

Lysosome calcium in ROS regulation of autophagy.

Published in:

Autophagy, 2016, v. 12, n. 10, p. 1954, doi. 10.1080/15548627.2016.1212787

By:

Zhang, Xiaoli;
Yu, Lu;
Xu, Haoxing

Publication type:

Article

The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.

Published in:

Nature Medicine, 2014, v. 20, n. 10, p. 1187, doi. 10.1038/nm.3611

By:

Cheng, Xiping;
Zhang, Xiaoli;
Gao, Qiong;
Ali Samie, Mohammad;
Azar, Marlene;
Tsang, Wai Lok;
Dong, Libing;
Sahoo, Nirakar;
Li, Xinran;
Zhuo, Yue;
Garrity, Abigail G;
Wang, Xiang;
Ferrer, Marc;
Dowling, James;
Xu, Li;
Han, Renzhi;
Xu, Haoxing

Publication type:

Article

TRP channels of intracellular membranes.

Published in:

Journal of Neurochemistry, 2010, v. 113, n. 2, p. 313, doi. 10.1111/j.1471-4159.2010.06626.x

By:

Xian-Ping Dong;
Xiang Wang;
Haoxing Xu

Publication type:

Article

TRPV3 is a calcium-permeable temperature-sensitive cation channel.

Published in:

Nature, 2002, v. 418, n. 6894, p. 181, doi. 10.1038/nature00882

By:

Haoxing Xu;
Ramsey, I. Scott;
Kotecha, Suhas A.;
Moran, Magdalene M.;
Chong, Jayhong A.;
Lawson, Deborah;
Pei Ge;
Lilly, Jeremiah;
Silos-Santiago, Immaculada;
Yu Xie;
DiStefano, Peter S.;
Curtis, Rory;
Clapham, David E.

Publication type:

Article

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.

Published in:

Nature Cell Biology, 2015, v. 17, n. 3, p. 288, doi. 10.1038/ncb3114

By:

Medina, Diego L.;
Di Paola, Simone;
Peluso, Ivana;
Armani, Andrea;
De Stefani, Diego;
Venditti, Rossella;
Montefusco, Sandro;
Scotto-Rosato, Anna;
Prezioso, Carolina;
Forrester, Alison;
Settembre, Carmine;
Wang, Wuyang;
Gao, Qiong;
Xu, Haoxing;
Sandri, Marco;
Rizzuto, Rosario;
De Matteis, Maria Antonietta;
Ballabio, Andrea

Publication type:

Article

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.

Published in:

Nature Neuroscience, 2006, v. 9, n. 5, p. 628, doi. 10.1038/nn1692

By:

Haoxing Xu;
Delling, Markus;
Jun, Janice C.;
Clapham, David E.

Publication type:

Article

Saliency enhancement method for photoacoustic molecular imaging based on Grüneisen relaxation nonlinear effect.

Published in:

Journal of Biophotonics, 2024, v. 17, n. 6, p. 1, doi. 10.1002/jbio.202400004

By:

Wang, Xiatian;
Xie, Zhihua;
Lin, Riqiang;
Shu, Chengyou;
Lv, Shengmiao;
Guo, Pengkun;
Xu, Haoxing;
Zhang, Jinke;
Dong, Liquan;
Gong, Xiaojing

Publication type:

Article

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.15887

By:

Garrity, Abigail G.;
Wuyang Wang;
Collier, Crystal M. D.;
Levey, Sara A.;
Qiong Gao;
Haoxing Xu

Publication type:

Article

CO2 inhibits specific inward rectifier K+ channels by decreases in intra- and extracellular pH.

Published in:

Journal of Cellular Physiology, 2000, v. 183, n. 1, p. 53, doi. 10.1002/(SICI)1097-4652(200004)183:1<53::AID-JCP7>3.0.CO;2-R

By:

Zhu, Guoyun;
Liu, Congxiao;
Qu, Zhiqiang;
Chanchevalap, Sengthong;
Xu, Haoxing;
Jiang, Chun

Publication type:

Article

Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann–Pick type C disease fibroblasts.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 14, p. 3205, doi. 10.1093/hmg/dds145

By:

Yu, Ting;
Chung, Chan;
Shen, Dongbiao;
Xu, Haoxing;
Lieberman, Andrew P.

Publication type:

Article

Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12761-x

By:

Minckley, Taylor F.;
Zhang, Chen;
Fudge, Dylan H.;
Dischler, Anna M.;
LeJeune, Kate D.;
Xu, Haoxing;
Qin, Yan

Publication type:

Article

DNA nanodevices map intracellular ions.

Published in:

Nature Biotechnology, 2024, v. 42, n. 7, p. 1030, doi. 10.1038/s41587-023-02054-6

By:

Xu, Haoxing

Publication type:

Article

Characterization of the role of TMEM175 in an in vitro lysosomal H+ fluxes model.

Published in:

FEBS Journal, 2023, v. 290, n. 19, p. 4641, doi. 10.1111/febs.16814

By:

Yang, Chuanyan;
Tian, Fuyun;
Hu, Mei;
Kang, Chunlan;
Ping, Meixuan;
Liu, Yiyao;
Hu, Meiqin;
Xu, Haoxing;
Yu, Ye;
Gao, Zhaobing;
Li, Ping

Publication type:

Article