Works by Hantel, Constanze

Results: 37

Development and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma.

Published in:

Endocrinology, 2025, v. 166, n. 1, p. 1, doi. 10.1210/endocr/bqae159

By:

Feely, Sarah;
Mullen, Nathan;
Donlon, Padraig T;
Reidy, Eileen;
Challapalli, Ritihaas Surya;
Hassany, Mariam;
Sorushanova, Anna;
Martinez, Eduardo Ribes;
Owens, Peter;
Quinn, Anne Marie;
Pandit, Abhay;
Harhen, Brendan;
Finn, David P;
Hantel, Constanze;
O'Halloran, Martin;
Prakash, Punit;
Dennedy, Michael C

Publication type:

Article

Zona Glomerulosa–Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.

Published in:

Endocrinology, 2024, v. 165, n. 5, p. 1, doi. 10.1210/endocr/bqae040

By:

Daryadel, Arezoo;
Tang, Cong;
Xie, Ye;
Peitzsch, Mirko;
Fisi, Viktoria;
Hantel, Constanze;
Loffing-Cueni, Dominique;
Breault, David T;
Penton, David;
Loffing, Johannes;
Beuschlein, Felix

Publication type:

Article

Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma.

Published in:

Endocrinology, 2022, v. 163, n. 9, p. 1, doi. 10.1210/endocr/bqac102

By:

Warde, Kate M;
Lim, Yi Jan;
Martinez, Eduardo Ribes;
Beuschlein, Felix;
O'Shea, Paula;
Hantel, Constanze;
Dennedy, Michael Conall

Publication type:

Article

Ribociclib Cytotoxicity Alone or Combined With Progesterone and/or Mitotane in in Vitro Adrenocortical Carcinoma Cells.

Published in:

Endocrinology, 2022, v. 163, n. 2, p. 1, doi. 10.1210/endocr/bqab248

By:

Abate, Andrea;
Rossini, Elisa;
Tamburello, Mariangela;
Laganà, Marta;
Cosentini, Deborah;
Grisanti, Salvatore;
Fiorentini, Chiara;
Tiberio, Guido A M;
Scatolini, Maria;
Grosso, Enrico;
Hantel, Constanze;
Memo, Maurizio;
Berruti, Alfredo;
Sigala, Sandra

Publication type:

Article

Correction: Sigala et al. A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma. Cells 2022, 11 , 1439.

Published in:

2023

By:

Sigala, Sandra;
Bothou, Christina;
Penton, David;
Abate, Andrea;
Peitzsch, Mirko;
Cosentini, Deborah;
Tiberio, Guido A. M.;
Bornstein, Stefan R.;
Berruti, Alfredo;
Hantel, Constanze

Publication type:

Correction Notice

A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma.

Published in:

Cells (2073-4409), 2022, v. 11, n. 9, p. N.PAG, doi. 10.3390/cells11091439

By:

Sigala, Sandra;
Bothou, Christina;
Penton, David;
Abate, Andrea;
Peitzsch, Mirko;
Cosentini, Deborah;
Tiberio, Guido A. M.;
Bornstein, Stefan R.;
Berruti, Alfredo;
Hantel, Constanze

Publication type:

Article

Mitotane Nanocarriers for the Treatment of Adrenocortical Carcinoma: Evaluation of Albumin-Stabilized Nanoparticles and Liposomes in a Preclinical In Vitro Study with 3D Spheroids.

Published in:

Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091891

By:

Langer, Carolin;
Köll-Weber, Monika;
Holzer, Martin;
Hantel, Constanze;
Süss, Regine

Publication type:

Article

Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression.

Published in:

Journal of Personalized Medicine, 2021, v. 11, n. 11, p. 1097, doi. 10.3390/jpm11111097

By:

Cantini, Giulia;
Fei, Laura;
Canu, Letizia;
Lazzeri, Elena;
Sottili, Mariangela;
Francalanci, Michela;
Angelotti, Maria Lucia;
De Filpo, Giuseppina;
Ercolino, Tonino;
Gelmini, Stefania;
Mangoni, Monica;
Nesi, Gabriella;
Hantel, Constanze;
Mannelli, Massimo;
Maggi, Mario;
Luconi, Michaela

Publication type:

Article

Preclinical Evidence of Progesterone as a New Pharmacological Strategy in Human Adrenocortical Carcinoma Cell Lines.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6829, doi. 10.3390/ijms24076829

By:

Tamburello, Mariangela;
Abate, Andrea;
Rossini, Elisa;
Basnet, Ram Manohar;
Zizioli, Daniela;
Cosentini, Deborah;
Hantel, Constanze;
Laganà, Marta;
Tiberio, Guido Alberto Massimo;
Grisanti, Salvatore;
Memo, Maurizio;
Berruti, Alfredo;
Sigala, Sandra

Publication type:

Article

Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma.

Published in:

Endocrines, 2024, v. 5, n. 3, p. 261, doi. 10.3390/endocrines5030019

By:

Luca, Edlira;
Abate, Andrea;
Wang, Katharina;
Bornstein, Stefan;
Sigala, Sandra;
Beuschlein, Felix;
Nölting, Svenja;
Hantel, Constanze

Publication type:

Article

Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency.

Published in:

Xenotransplantation, 2023, v. 30, n. 5, p. 1, doi. 10.1111/xen.12819

By:

Malyukov, Maria;
Gelfgat, Evgeny;
Ruiz‐Babot, Gerard;
Schmid, Janine;
Lehmann, Susann;
Spinas, Giatgen;
Beuschlein, Felix;
Hantel, Constanze;
Reisch, Nicole;
Nawroth, Peter P.;
Bornstein, Stefan R.;
Steenblock, Charlotte;
Ludwig, Barbara

Publication type:

Article

An update on adrenocortical cell lines of human origin.

Published in:

Endocrine (1355008X), 2022, v. 77, n. 3, p. 432, doi. 10.1007/s12020-022-03112-w

By:

Sigala, Sandra;
Rossini, Elisa;
Abate, Andrea;
Tamburello, Mariangela;
Bornstein, Stefan R.;
Hantel, Constanze

Publication type:

Article

Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.795116

By:

Sbiera, Iuliu;
Kircher, Stefan;
Altieri, Barbara;
Lenz, Kerstin;
Hantel, Constanze;
Fassnacht, Martin;
Sbiera, Silviu;
Kroiss, Matthias

Publication type:

Article

Cytotoxic Effect of Trabectedin In Human Adrenocortical Carcinoma Cell Lines and Primary Cells.

Published in:

Cancers, 2020, v. 12, n. 4, p. 928, doi. 10.3390/cancers12040928

By:

Abate, Andrea;
Rossini, Elisa;
Bonini, Sara Anna;
Fragni, Martina;
Cosentini, Deborah;
Tiberio, Guido Albero Massimo;
Benetti, Diego;
Hantel, Constanze;
Laganà, Marta;
Grisanti, Salvatore;
Terzolo, Massimo;
Memo, Maurizio;
Berruti, Alfredo;
Sigala, Sandra

Publication type:

Article

Anti Insulin-Like Growth Factor I Receptor Immunoliposomes: A Single Formulation Combining Two Anticancer Treatments with Enhanced Therapeutic Efficiency.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 2, p. 943, doi. 10.1210/jc.2009-1980

By:

Hantel, Constanze;
Lewrick, Felicitas;
Schneider, Sebastian;
Zwermann, Oliver;
Perren, Aurel;
Reincke, Martin;
Süss, Regine;
Beuschlein, Felix

Publication type:

Article

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02115-0

By:

Catalano, Rosa;
Nozza, Emma;
Altieri, Barbara;
Esposito, Emanuela;
Croci, Giorgio A.;
Barbieri, Anna Maria;
Treppiedi, Donatella;
Di Bari, Sonia;
Kimpel, Otilia;
Detomas, Mario;
Tamburello, Mariangela;
Schauer, Marc P.;
Herterich, Sabine;
Angelousi, Anna;
Luconi, Michaela;
Canu, Letizia;
Nesi, Gabriella;
Hantel, Constanze;
Sigala, Sandra;
Landwehr, Laura-Sophie

Publication type:

Article

Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma <italic>in vitro</italic> and <italic>in vivo</italic>.

Published in:

International Journal of Cancer, 2018, v. 143, n. 1, p. 199, doi. 10.1002/ijc.31296

By:

Hasanovic, Anida;
Ruggiero, Carmen;
Jung, Sara;
Rapa, Ida;
Signetti, Laurie;
Ben Hadj, Monia;
Terzolo, Massimo;
Beuschlein, Felix;
Volante, Marco;
Hantel, Constanze;
Lalli, Enzo;
Mus‐Veteau, Isabelle

Publication type:

Article

Cytotoxic Effect of Progesterone, Tamoxifen and Their Combination in Experimental Cell Models of Human Adrenocortical Cancer.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.669426

By:

Rossini, Elisa;
Tamburello, Mariangela;
Abate, Andrea;
Beretta, Silvia;
Fragni, Martina;
Cominelli, Manuela;
Cosentini, Deborah;
Hantel, Constanze;
Bono, Federica;
Grisanti, Salvatore;
Poliani, Pietro Luigi;
Tiberio, Guido A. M.;
Memo, Maurizio;
Sigala, Sandra;
Berruti, Alfredo

Publication type:

Article

Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma.

Published in:

Frontiers in Endocrinology, 2020, v. 11, p. 1, doi. 10.3389/fendo.2020.00219

By:

Liang, Raimunde;
Weigand, Isabel;
Lippert, Juliane;
Kircher, Stefan;
Altieri, Barbara;
Steinhauer, Sonja;
Hantel, Constanze;
Rost, Simone;
Rosenwald, Andreas;
Kroiss, Matthias;
Fassnacht, Martin;
Sbiera, Silviu;
Ronchi, Cristina L.

Publication type:

Article

Responses to systemic therapy in metastatic pheochromocytoma/paraganglioma: a retrospective multicenter cohort study.

Published in:

European Journal of Endocrinology, 2023, v. 189, n. 5, p. 546, doi. 10.1093/ejendo/lvad146

By:

Fischer, Alessa;
Kloos, Simon;
Remde, Hanna;
Dischinger, Ulrich;
Pamporaki, Christina;
Timmers, Henri J. L. M.;
Robledo, Mercedes;
Fliedner, Stephanie M. J.;
Wang, Katharina;
Maurer, Julian;
Reul, Astrid;
Bechmann, Nicole;
Hantel, Constanze;
Mohr, Hermine;
Pellegata, Natalia S.;
Bornstein, Stefan R.;
Kroiss, Matthias;
Auernhammer, Christoph J.;
Reincke, Martin;
Pacak, Karel

Publication type:

Article

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma.

Published in:

Cancer Communications, 2025, v. 45, n. 6, p. 663, doi. 10.1002/cac2.70012

By:

Mariniello, Katia;
Pittaway, James F. H.;
Altieri, Barbara;
Borges, Kleiton Silva;
Hadjidemetriou, Irene;
Ribeiro, Claudio;
Ruiz‐Babot, Gerard;
Tourigny, David S.;
Lim, Jiang A.;
Foster, Julie;
Cleaver, Julie;
Sosabowski, Jane;
Rahman, Nafis;
Doroszko, Milena;
Hantel, Constanze;
Sigala, Sandra;
Abate, Andrea;
Tamburello, Mariangela;
Kiseljak‐Vassiliades, Katja;
Wierman, Margaret

Publication type:

Article

Cover Image, Volume 45, Issue 6.

Published in:

Cancer Communications, 2025, v. 45, n. 6, p. 1, doi. 10.1002/cac2.12561

By:

Mariniello, Katia;
Pittaway, James F. H.;
Altieri, Barbara;
Borges, Kleiton Silva;
Hadjidemetriou, Irene;
Ribeiro, Claudio;
Ruiz‐Babot, Gerard;
Tourigny, David S.;
Lim, Jiang A.;
Foster, Julie;
Cleaver, Julie;
Sosabowski, Jane;
Rahman, Nafis;
Doroszko, Milena;
Hantel, Constanze;
Sigala, Sandra;
Abate, Andrea;
Tamburello, Mariangela;
Kiseljak‐Vassiliades, Katja;
Wierman, Margaret

Publication type:

Article

PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization.

Published in:

Cancers, 2023, v. 15, n. 21, p. 5199, doi. 10.3390/cancers15215199

By:

Fischer, Alessa;
Maccio, Umberto;
Wang, Katharina;
Friemel, Juliane;
Broglie Daeppen, Martina A.;
Vetter, Diana;
Lehmann, Kuno;
Reul, Astrid;
Robledo, Mercedes;
Hantel, Constanze;
Bechmann, Nicole;
Pacak, Karel;
Zitzmann, Kathrin;
Auernhammer, Christoph J.;
Grossman, Ashley B.;
Beuschlein, Felix;
Nölting, Svenja

Publication type:

Article

Three Dimensional Models of Endocrine Organs and Target Tissues Regulated by the Endocrine System.

Published in:

Cancers, 2023, v. 15, n. 18, p. 4601, doi. 10.3390/cancers15184601

By:

Luca, Edlira;
Zitzmann, Kathrin;
Bornstein, Stefan;
Kugelmeier, Patrick;
Beuschlein, Felix;
Nölting, Svenja;
Hantel, Constanze

Publication type:

Article

The Vault Complex Is Significantly Involved in Therapeutic Responsiveness of Endocrine Tumors and Linked to Autophagy under Chemotherapeutic Conditions.

Published in:

Cancers, 2023, v. 15, n. 6, p. 1783, doi. 10.3390/cancers15061783

By:

Bornstein, Stefan;
Shapiro, Igor;
Mazumdar, Alekhya;
Zitzmann, Kathrin;
Nölting, Svenja;
Luca, Edlira;
Beuschlein, Felix;
Sharma, Ashish;
Hantel, Constanze

Publication type:

Article

Adrenocortical Carcinoma (ACC) Cells Rewire Their Metabolism to Overcome Curcumin Antitumoral Effects Opening a Window of Opportunity to Improve Treatment.

Published in:

Cancers, 2023, v. 15, n. 4, p. 1050, doi. 10.3390/cancers15041050

By:

Nocito, Marta Claudia;
Avena, Paola;
Zavaglia, Lucia;
De Luca, Arianna;
Chimento, Adele;
Hamad, Tarig;
La Padula, Davide;
Stancati, Davide;
Hantel, Constanze;
Sirianni, Rosa;
Casaburi, Ivan;
Pezzi, Vincenzo

Publication type:

Article

Estrogen Related Receptor Alpha (ERRα) a Bridge between Metabolism and Adrenocortical Cancer Progression.

Published in:

Cancers, 2022, v. 14, n. 16, p. 3885, doi. 10.3390/cancers14163885

By:

Avena, Paola;
De Luca, Arianna;
Chimento, Adele;
Nocito, Marta Claudia;
Sculco, Sara;
La Padula, Davide;
Zavaglia, Lucia;
Giulietti, Matteo;
Hantel, Constanze;
Sirianni, Rosa;
Casaburi, Ivan;
Pezzi, Vincenzo

Publication type:

Article

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment.

Published in:

Cancers, 2021, v. 13, n. 16, p. 4200, doi. 10.3390/cancers13164200

By:

Bothou, Christina;
Sharma, Ashish;
Oo, Adrian;
Kim, Baek;
Perge, Pal;
Igaz, Peter;
Ronchi, Cristina L.;
Shapiro, Igor;
Hantel, Constanze

Publication type:

Article

DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma.

Published in:

Clinical Epigenetics, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13148-023-01534-5

By:

Kerdivel, Gwenneg;
Amrouche, Floriane;
Calmejane, Marie-Ange;
Carallis, Floriane;
Hamroune, Juliette;
Hantel, Constanze;
Bertherat, Jérôme;
Assié, Guillaume;
Boeva, Valentina

Publication type:

Article

Therapeutic potential of targeting the FLNA‐regulated Wee1 kinase in adrenocortical carcinomas.

Published in:

International Journal of Cancer, 2025, v. 156, n. 6, p. 1256, doi. 10.1002/ijc.35239

By:

Esposito, Emanuela;
Marra, Giusy;
Catalano, Rosa;
Maioli, Sara;
Nozza, Emma;
Barbieri, Anna Maria;
Hantel, Constanze;
Di Dalmazi, Guido;
Sigala, Sandra;
Geginat, Jens;
Cassinotti, Elisa;
Baldari, Ludovica;
Palmieri, Serena;
Mangone, Alessandra;
Berruti, Alfredo;
Ferrante, Emanuele;
Mantovani, Giovanna;
Peverelli, Erika

Publication type:

Article

FSCN1 as a new druggable target in adrenocortical carcinoma.

Published in:

International Journal of Cancer, 2023, v. 153, n. 1, p. 210, doi. 10.1002/ijc.34526

By:

Ruggiero, Carmen;
Tamburello, Mariangela;
Rossini, Elisa;
Zini, Silvia;
Durand, Nelly;
Cantini, Giulia;
Cioppi, Francesca;
Hantel, Constanze;
Kiseljak‐Vassiliades, Katja;
Wierman, Margaret E.;
Landwehr, Laura‐Sophie;
Weigand, Isabel;
Kurlbaum, Max;
Zizioli, Daniela;
Turtoi, Andrei;
Yang, Shengyu;
Berruti, Alfredo;
Luconi, Michaela;
Sigala, Sandra;
Lalli, Enzo

Publication type:

Article

Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma.

Published in:

Frontiers in Endocrinology, 2019, p. 1, doi. 10.3389/fendo.2019.00487

By:

Siebert, Claudia;
Ciato, Denis;
Murakami, Masanori;
Frei-Stuber, Ludwig;
Perez-Rivas, Luis Gustavo;
Monteserin-Garcia, José Luis;
Nölting, Svenja;
Maurer, Julian;
Feuchtinger, Annette;
Walch, Axel K.;
Haak, Harm R.;
Bertherat, Jérôme;
Mannelli, Massimo;
Fassnacht, Martin;
Korpershoek, Esther;
Reincke, Martin;
Stalla, Günter K.;
Hantel, Constanze;
Beuschlein, Felix

Publication type:

Article

Silencing Mutated <i>β-Catenin</i> Inhibits Cell Proliferation and Stimulates Apoptosis in the Adrenocortical Cancer Cell Line H295R.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055743

By:

Gaujoux, Sébastien;
Hantel, Constanze;
Launay, Pierre;
Bonnet, Stéphane;
Perlemoine, Karine;
Lefèvre, Lucile;
Guillaud-Bataille, Marine;
Beuschlein, Felix;
Tissier, Frédérique;
Bertherat, Jérôme;
Rizk-Rabin, Marthe;
Ragazzon, Bruno

Publication type:

Article

A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis.

Published in:

Cell Death & Disease, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41419-025-07607-y

By:

Nocito, Marta C.;
Hantel, Constanze;
Lerario, Antonio M.;
Mastrorocco, Fabrizio;
De Martino, Luca;
Musicco, Clara;
Perrotta, Ida D.;
Scalise, Mariafrancesca;
Indiveri, Cesare;
Giannattasio, Sergio;
Val, Pierre;
Lanzino, Marilena;
Pezzi, Vincenzo;
Casaburi, Ivan;
Sirianni, Rosa

Publication type:

Article

Innovative multidimensional models in a high-through-put-format for different cell types of endocrine origin.

Published in:

Cell Death & Disease, 2022, v. 13, n. 7, p. 1, doi. 10.1038/s41419-022-05096-x

By:

Bornstein, Stefan;
Shapiro, Igor;
Malyukov, Maria;
Züllig, Richard;
Luca, Edlira;
Gelfgat, Evgeny;
Beuschlein, Felix;
Nölting, Svenja;
Berruti, Alfredo;
Sigala, Sandra;
Peitzsch, Mirko;
Steenblock, Charlotte;
Ludwig, Barbara;
Kugelmeier, Patrick;
Hantel, Constanze

Publication type:

Article

Opposing Effects of Cannabidiol in Patient-derived Neuroendocrine Tumor, Pheochromocytoma/Paraganglioma Primary Cultures.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 11, p. 2892, doi. 10.1210/clinem/dgae241

By:

Wang, Katharina;
Schober, Laura;
Fischer, Alessa;
Bechmann, Nicole;
Maurer, Julian;
Peischer, Lea;
Reul, Astrid;
Hantel, Constanze;
Reincke, Martin;
Beuschlein, Felix;
Robledo, Mercedes;
Mohr, Hermine;
Pellegata, Natalia S;
Schilbach, Katharina;
Knösel, Thomas;
Ilmer, Matthias;
Angele, Martin;
Kroiss, Matthias;
Maccio, Umberto;
Broglie-Däppen, Martina

Publication type:

Article

Metastatic Pheochromocytoma and Paraganglioma: Somatostatin Receptor 2 Expression, Genetics, and Therapeutic Responses.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2023, v. 108, n. 10, p. 2676, doi. 10.1210/clinem/dgad166

By:

Fischer, Alessa;
Kloos, Simon;
Maccio, Umberto;
Friemel, Juliane;
Remde, Hanna;
Fassnacht, Martin;
Pamporaki, Christina;
Eisenhofer, Graeme;
Timmers, Henri J. L. M.;
Robledo, Mercedes;
Fliedner, Stephanie M. J.;
Wang, Katharina;
Maurer, Julian;
Reul, Astrid;
Zitzmann, Kathrin;
Bechmann, Nicole;
Žygienė, Gintarė;
Richter, Susan;
Hantel, Constanze;
Vetter, Diana

Publication type:

Article