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The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma.
- Published in:
- Investigational New Drugs, 2022, v. 40, n. 3, p. 529, doi. 10.1007/s10637-022-01222-w
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- Article
Cell death and barrier disruption by clinically used iodine concentrations.
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- Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201875
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- Publication type:
- Article
Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age.
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- Cells (2073-4409), 2020, v. 9, n. 2, p. 266, doi. 10.3390/cells9020266
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- Publication type:
- Article
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest.
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- Oncogene, 2000, v. 19, n. 31, p. 3487, doi. 10.1038/sj.onc.1203690
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- Publication type:
- Article
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
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- PLoS Neglected Tropical Diseases, 2017, v. 11, n. 3, p. 1, doi. 10.1371/journal.pntd.0005432
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- Publication type:
- Article
UBF levels determine the number of active ribosomal RNA genes in mammals.
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- Journal of Cell Biology, 2008, v. 183, n. 7, p. 1259, doi. 10.1083/jcb.200805146
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- Publication type:
- Article
Comprehensive translational profiling and STE AI uncover rapid control of protein biosynthesis during cell stress.
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- Nucleic Acids Research, 2024, v. 52, n. 13, p. 7925, doi. 10.1093/nar/gkae365
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- Publication type:
- Article
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
- Published in:
- Nature Communications, 2015, v. 6, n. 6, p. 7404, doi. 10.1038/ncomms8404
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- Publication type:
- Article
Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA.
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- International Journal of Molecular Sciences, 2019, v. 20, n. 18, p. 4464, doi. 10.3390/ijms20184464
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- Publication type:
- Article
The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.
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- International Journal of Molecular Sciences, 2017, v. 18, n. 1, p. 210, doi. 10.3390/ijms18010210
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- Publication type:
- Article
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
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- Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0284-y
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- Publication type:
- Article
Cohesin mutations are synthetic lethal with stimulation of WNT signaling.
- Published in:
- eLife, 2020, p. 1, doi. 10.7554/eLife.61405
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- Publication type:
- Article
The Ribosomal Gene Loci—The Power behind the Throne.
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- Genes, 2021, v. 12, n. 5, p. 763, doi. 10.3390/genes12050763
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- Publication type:
- Article
Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.
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- Enzyme Research, 2011, p. 1, doi. 10.4061/2011/720985
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- Publication type:
- Article
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
- Published in:
- 2021
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- Publication type:
- journal article
Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis.
- Published in:
- PLoS Genetics, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.pgen.1003279
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- Publication type:
- Article
Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone.
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- PLoS Genetics, 2011, v. 7, n. 12, p. 1, doi. 10.1371/journal.pgen.1002408
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- Publication type:
- Article
Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.
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- Frontiers in Oncology, 2015, v. 5, p. 1, doi. 10.3389/fonc.2015.00013
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- Publication type:
- Article
Therapeutic Approaches Targeting MYC-Driven Prostate Cancer.
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- Genes, 2017, v. 8, n. 2, p. 71, doi. 10.3390/genes8020071
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- Publication type:
- Article
Signaling to the ribosome in cancer-It is more than just mTORC1.
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- IUBMB Life, 2011, v. 63, n. 2, p. 79, doi. 10.1002/iub.428
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- Publication type:
- Article
Signaling to the ribosome in cancer-It is more than just mTORC1.
- Published in:
- 2011
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- Publication type:
- Other
The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461.
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- Australian Journal of Chemistry, 2021, v. 74, n. 7, p. 540, doi. 10.1071/CH21049
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- Publication type:
- Article
Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells.
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- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0088950
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- Publication type:
- Article
Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart
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- PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064579
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- Publication type:
- Article
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.
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- British Journal of Haematology, 2015, v. 171, n. 4, p. 517, doi. 10.1111/bjh.13632
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- Publication type:
- Article
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
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- 2013
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- Publication type:
- journal article
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
- Published in:
- Nature Reviews Cancer, 2013, v. 13, n. 5, p. 299, doi. 10.1038/nrc3496
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- Publication type:
- Article
The renin-angiotensin system and cancer: old dog, new tricks.
- Published in:
- 2010
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- Publication type:
- journal article
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.
- Published in:
- EMBO Journal, 2004, v. 23, n. 16, p. 3325, doi. 10.1038/sj.emboj.7600335
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- Publication type:
- Article
Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.963066
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- Publication type:
- Article
Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 16, p. 7646, doi. 10.1093/nar/gkw461
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- Publication type:
- Article
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation.
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- Nucleic Acids Research, 2011, v. 39, n. 8, p. 3267, doi. 10.1093/nar/gkq1205
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- Publication type:
- Article
AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer.
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- Science Signaling, 2011, v. 4, n. 188, p. 1, doi. 10.1126/scisignal.2001754
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- Publication type:
- Article
High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology.
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- Assay & Drug Development Technologies, 2018, v. 16, n. 6, p. 320, doi. 10.1089/adt.2018.861
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- Publication type:
- Article
Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.
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- Assay & Drug Development Technologies, 2016, v. 14, n. 7, p. 416, doi. 10.1089/adt.2016.739
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- Publication type:
- Article
Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies.
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- Biomedicines, 2023, v. 11, n. 4, p. 1133, doi. 10.3390/biomedicines11041133
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- Publication type:
- Article
Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system.
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- Nucleic Acids Research, 1999, v. 27, n. 18, p. 3720, doi. 10.1093/nar/27.18.3720
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- Publication type:
- Article
Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: A possible role for SGK1
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- Cardiovascular Research, 2006, v. 70, n. 3, p. 555, doi. 10.1016/j.cardiores.2006.02.010
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- Publication type:
- Article
The ‘Odd Pols’ are even when it comes to controlling cell function. Conference on RNA Polymerases I and III.
- Published in:
- EMBO Reports, 2008, v. 9, n. 12, p. 1188, doi. 10.1038/embor.2008.201
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- Publication type:
- Article
AKT-independent PI3-K signaling in cancer -emerging role for SGK3.
- Published in:
- Cancer Management & Research, 2013, v. 5, p. 281, doi. 10.2147/CMAR.S35178
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- Publication type:
- Article
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.
- Published in:
- International Journal of Cancer, 2018, v. 142, n. 10, p. 2139, doi. 10.1002/ijc.31220
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- Publication type:
- Article
Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF
- Published in:
- FEBS Letters, 2003, v. 548, n. 1-3, p. 79, doi. 10.1016/S0014-5793(03)00744-0
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- Publication type:
- Article
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
- Published in:
- EMBO Journal, 2020, v. 39, n. 21, p. 1, doi. 10.15252/embj.2020105111
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- Publication type:
- Article
AKT signalling is required for ribosomal RNA synthesis and progression of Eμ- Myc B-cell lymphoma in vivo.
- Published in:
- FEBS Journal, 2013, v. 280, n. 21, p. 5307, doi. 10.1111/febs.12135
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- Publication type:
- Article
Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches.
- Published in:
- FEBS Journal, 2013, v. 280, n. 21, p. 5258, doi. 10.1111/febs.12509
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- Publication type:
- Article