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PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1418870
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- Article
Primary skeletal muscle cells cultured on gelatin bead microcarriers develop structural and biochemical features characteristic of adult skeletal muscle.
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- Cell Biology International, 2016, v. 40, n. 4, p. 364, doi. 10.1002/cbin.10565
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- Article
Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network.
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- Pharmaceutics, 2021, v. 13, n. 3, p. 331, doi. 10.3390/pharmaceutics13030331
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- Article
Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach.
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- Pharmaceutics, 2021, v. 13, n. 2, p. 270, doi. 10.3390/pharmaceutics13020270
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- Article
Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions.
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- Pharmaceutics, 2020, v. 12, n. 12, p. 1200, doi. 10.3390/pharmaceutics12121200
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- Article
A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions.
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- Pharmaceutics, 2020, v. 12, n. 11, p. 1074, doi. 10.3390/pharmaceutics12111074
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- Article
A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies.
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- Pharmaceutics, 2020, v. 12, n. 6, p. 556, doi. 10.3390/pharmaceutics12060556
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- Article
Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients.
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- Pharmaceutics, 2019, v. 11, n. 4, p. 152, doi. 10.3390/pharmaceutics11040152
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- Article
Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions.
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- Pharmaceutical Research, 2021, v. 38, n. 10, p. 1645, doi. 10.1007/s11095-021-03109-6
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- Article
Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions.
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- Pharmaceutical Research, 2020, v. 37, n. 12, p. 1, doi. 10.1007/s11095-020-02964-z
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- Article
Significant impact of time-of-day variation on metformin pharmacokinetics.
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- Diabetologia, 2023, v. 66, n. 6, p. 1024, doi. 10.1007/s00125-023-05898-4
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- Article
Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication Regimens.
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- AAPS Journal, 2017, v. 19, n. 1, p. 298, doi. 10.1208/s12248-016-0009-9
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- Article
Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors.
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- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065988
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- Article
The Most Recently Discovered Carbonic Anhydrase, CA XV, Is Expressed in the Thick Ascending Limb of Henle and in the Collecting Ducts of Mouse Kidney.
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- PLoS ONE, 2010, v. 5, n. 3, p. 1, doi. 10.1371/journal.pone.0009624
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- Article
ATIM-13. ASUNERCEPT PLUS RADIOTHERAPY IN RELAPSED GLIOBLASTOMA. UPDATE ON FIVE YEARS OVERALL SURVIVAL OF STUDY NCT01071837 AND DEVELOPMENT OF A POPULATION-PK - TUMOR GROWTH INHIBITION - SURVIVAL MODEL.
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- Neuro-Oncology, 2018, v. 20, p. vi3, doi. 10.1093/neuonc/noy148.008
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- Article
A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis.
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- 2018
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- Publication type:
- journal article
Physiologically‐Based Pharmacokinetic Models for CYP1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 5, p. 296, doi. 10.1002/psp4.12397
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- Article
PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 10, p. 647, doi. 10.1002/psp4.12343
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- Publication type:
- Article
A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals.
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- Clinical Pharmacokinetics, 2020, v. 59, n. 11, p. 1419, doi. 10.1007/s40262-020-00896-w
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- Article
Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis.
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- 2020
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- Publication type:
- journal article
A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Model of Dabigatran Etexilate, Dabigatran and Dabigatran Glucuronide in Healthy Adults and Renally Impaired Patients.
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- 2019
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- Publication type:
- journal article
Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole.
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- 2019
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- Publication type:
- journal article
Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits.
- Published in:
- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1427325
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- Publication type:
- Article
Population nutrikinetics of green tea extract.
- Published in:
- PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0193074
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- Article