Works by Handrick, René

Results: 30

mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex.

Published in:

Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02210

By:

Herdoiza Padilla, Estefania;
Crauwels, Peter;
Bergner, Tim;
Wiederspohn, Nicole;
Förstner, Sabrina;
Rinas, Rebecca;
Ruf, Anna;
Kleemann, Michael;
Handrick, René;
Tuckermann, Jan;
Otte, Kerstin;
Walther, Paul;
Riedel, Christian U.

Publication type:

Article

The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation.

Published in:

Radiation Oncology, 2010, v. 5, p. 108, doi. 10.1186/1748-717X-5-108

By:

Rudner, Justine;
Ruiner, Carola-Ellen;
Handrick, René;
Eibl, Hans-Jörg;
Belka, Claus;
Jendrossek, Verena

Publication type:

Article

The membrane targeted apoptosis modulators erucylphosphocholine and erucylphosphohomocholine increase the radiation response of human glioblastoma cell lines in vitro.

Published in:

Radiation Oncology, 2006, v. 1, p. 1, doi. 10.1186/1748-717X-1-6

By:

Rübel, Amelie;
Handrick, René;
Lindner, Lars H.;
Steiger, Matthias;
Eibl, Hansjörg;
Budach, Wilfried;
Belka, Claus;
Jendrossek, Verena

Publication type:

Article

Expression of the functional recombinant human glycosyltransferase GalNAcT2 in Escherichia coli.

Published in:

Microbial Cell Factories, 2015, v. 14, n. 1, p. 68, doi. 10.1186/s12934-014-0186-0

By:

Lauber, Jennifer;
Handrick, René;
Leptihn, Sebastian;
Dürre, Peter;
Gaisser, Sabine

Publication type:

Article

Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway.

Published in:

BMC Cancer, 2006, v. 6, p. 1, doi. 10.1186/1471-2407-6-14

By:

Habermehl, Daniel;
Kammerer, Bernd;
Handrick, René;
Eldh, Therese;
Gruber, Charlotte;
Cordes, Nils;
Daniel, Peter T.;
Plasswilm, Ludwig;
Bamberg, Michael;
Belka, Claus;
Jendrossek, Verena

Publication type:

Article

Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06272-x

By:

Zeh, Nikolas;
Bräuer, Melina;
Raab, Nadja;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Establishment of Lipofection for Studying miRNA Function in Human Adipocytes.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0098023

By:

Enlund, Eveliina;
Fischer, Simon;
Handrick, René;
Otte, Kerstin;
Debatin, Klaus-Michael;
Wabitsch, Martin;
Fischer-Posovszky, Pamela

Publication type:

Article

Protein Kinase C Delta (PKCδ) Affects Proliferation of Insulin-Secreting Cells by Promoting Nuclear Extrusion of the Cell Cycle Inhibitor p21<sup>Cip1/WAF1</sup>.

Published in:

PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028828

By:

Ranta, Felicia;
Leveringhaus, Johannes;
Theilig, Dorothea;
Schulz-Raffelt, Gabriele;
Hennige, Anita M.;
Hildebrand, Dominic G.;
Handrick, René;
Jendrossek, Verena;
Bosch, Fatima;
Schulze-Osthoff, Klaus;
Häring, Hans-Ulrich;
Ullrich, Susanne

Publication type:

Article

High level in vivo mucin-type glycosylation in Escherichia coli.

Published in:

Microbial Cell Factories, 2018, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12934-018-1013-9

By:

Mueller, Phillipp;
Gauttam, Rahul;
Raab, Nadja;
Handrick, René;
Wahl, Claudia;
Leptihn, Sebastian;
Zorn, Michael;
Kussmaul, Michaela;
Scheffold, Marianne;
Eikmanns, Bernhard;
Elling, Lothar;
Gaisser, Sabine

Publication type:

Article

Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells.

Published in:

Engineering in Life Sciences, 2024, v. 24, n. 6, p. 1, doi. 10.1002/elsc.202300234

By:

Schlossbauer, Patrick;
Naumann, Lukas;
Klingler, Florian;
Burkhart, Madina;
Handrick, René;
Korff, Kathrin;
Neusüß, Christian;
Otte, Kerstin;
Hesse, Friedemann

Publication type:

Article

High-throughput analysis of sub-visible mAb aggregate particles using automated fluorescence microscopy imaging.

Published in:

Analytical & Bioanalytical Chemistry, 2017, v. 409, n. 17, p. 4149, doi. 10.1007/s00216-017-0362-2

By:

Paul, Albert;
Bickel, Fabian;
Röhm, Martina;
Hospach, Lisa;
Halder, Bettina;
Rettich, Nina;
Handrick, René;
Herold, Eva;
Kiefer, Hans;
Hesse, Friedemann

Publication type:

Article

Fluorescence dye-based detection of mAb aggregates in CHO culture supernatants.

Published in:

Analytical & Bioanalytical Chemistry, 2015, v. 407, n. 16, p. 4849, doi. 10.1007/s00216-015-8672-8

By:

Paul, Albert;
Schwab, Karen;
Prokoph, Nina;
Haas, Elena;
Handrick, René;
Hesse, Friedemann

Publication type:

Article

Dihydroartemisinin is a hypoxia-active anti-cancer drug in colorectal carcinoma cells.

Published in:

Frontiers in Oncology, 2014, v. 4, p. 1, doi. 10.3389/fonc.2014.00116

By:

Ontikatze, Teona;
Rudner, Justine;
Handrick, René;
Belka, Claus;
Jendrossek, Verena

Publication type:

Article

Optimized fermentation conditions for improved antibody yield in hybridoma cells.

Published in:

BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-P74

By:

Stützle, Martina;
Moll, Alina;
Handrick, René;
Schindowski, Katharina

Publication type:

Article

CRISPR/Cas9‐Mediated Knockout of MicroRNA‐744 Improves Antibody Titer of CHO Production Cell Lines.

Published in:

Biotechnology Journal, 2019, v. 14, n. 5, p. N.PAG, doi. 10.1002/biot.201800477

By:

Raab, Nadja;
Mathias, Sven;
Alt, Kerstin;
Handrick, René;
Fischer, Simon;
Schmieder, Valerie;
Jadhav, Vaibhav;
Borth, Nicole;
Otte, Kerstin

Publication type:

Article

A functional high-content miRNA screen identifies miR-30 family to boost recombinant protein production in CHO cells.

Published in:

Biotechnology Journal, 2014, v. 9, n. 10, p. 1279, doi. 10.1002/biot.201400306

By:

Fischer, Simon;
Buck, Theresa;
Wagner, Andreas;
Ehrhart, Carolin;
Giancaterino, Julia;
Mang, Samuel;
Schad, Matthias;
Mathias, Sven;
Aschrafi, Armaz;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation.

Published in:

RNA Biology, 2015, v. 12, n. 3, p. 238, doi. 10.1080/15476286.2015.1017238

By:

Fischer, Simon;
Handrick, René;
Aschrafi, Armaz;
Otte, Kerstin

Publication type:

Article

Human CAP cells represent a novel source for functional, miRNA-loaded exosome production.

Published in:

PLoS ONE, 2019, v. 14, n. 8, p. 1, doi. 10.1371/journal.pone.0221679

By:

Zeh, Nikolas;
Schneider, Helga;
Mathias, Sven;
Raab, Nadja;
Kleemann, Michael;
Schmidt-Hertel, Sabine;
Weis, Benjamin;
Wissing, Silke;
Strempel, Nikola;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Harnessing the Potential of MicroRNAs to Enhance Performance of Biopharmaceutical Production Cell Factories.

Published in:

Pharmazeutische Industrie (Pharmind), 2016, v. 78, n. 12, p. 1760

By:

Fischer, Simon;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06272-x

By:

Zeh, Nikolas;
Bräuer, Melina;
Raab, Nadja;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation.

Published in:

Biotechnology & Bioengineering, 2024, v. 121, n. 4, p. 1355, doi. 10.1002/bit.28616

By:

Klingler, Florian;
Schlossbauer, Patrick;
Naumann, Lukas;
Handrick, René;
Hesse, Friedemann;
Neusüß, Christian;
Otte, Kerstin

Publication type:

Article

Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD.

Published in:

Biotechnology & Bioengineering, 2020, v. 117, n. 1, p. 5, doi. 10.1002/bit.27196

By:

Mathias, Sven;
Wippermann, Anna;
Raab, Nadja;
Zeh, Nikolas;
Handrick, René;
Gorr, Ingo;
Schulz, Patrick;
Fischer, Simon;
Gamer, Martin;
Otte, Kerstin

Publication type:

Article

Stable miRNA overexpression in human CAP cells: Engineering alternative production systems for advanced manufacturing of biologics using miR‐136 and miR‐3074.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 2027, doi. 10.1002/bit.26715

By:

Weis, Benjamin L.;
Guth, Nadine;
Fischer, Simon;
Wissing, Silke;
Fradin, Simon;
Holzmann, Karl‐Heinz;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 5, p. 1173, doi. 10.1002/bit.26534

By:

Paul, Albert J.;
Handrick, René;
Ebert, Sybille;
Hesse, Friedemann

Publication type:

Article

Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells.

Published in:

Biotechnology & Bioengineering, 2016, v. 113, n. 4, p. 830, doi. 10.1002/bit.25853

By:

Emmerling, Verena V.;
Fischer, Simon;
Stiefel, Fabian;
Holzmann, Karlheinz;
Handrick, René;
Hesse, Friedemann;
Hörer, Markus;
Kochanek, Stefan;
Otte, Kerstin

Publication type:

Article

miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality.

Published in:

Biotechnology & Bioengineering, 2015, v. 112, n. 10, p. 2142, doi. 10.1002/bit.25626

By:

Fischer, Simon;
Paul, Albert Jesuran;
Wagner, Andreas;
Mathias, Sven;
Geiss, Melanie;
Schandock, Franziska;
Domnowski, Martin;
Zimmermann, Jörg;
Handrick, René;
Hesse, Friedemann;
Otte, Kerstin

Publication type:

Article

Refolding and characterization of two G protein-coupled receptors purified from E. coli inclusion bodies.

Published in:

PLoS ONE, 2021, v. 16, n. 2, p. 1, doi. 10.1371/journal.pone.0247689

By:

Heim, Bastian;
Handrick, René;
Hartmann, Marcus D.;
Kiefer, Hans

Publication type:

Article

Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5.

Published in:

Cellular & Molecular Life Sciences, 2019, v. 76, n. 3, p. 539, doi. 10.1007/s00018-018-2958-x

By:

Kleemann, Michael;
Schneider, Helga;
Unger, Kristian;
Bereuther, Jeremias;
Fischer, Simon;
Sander, Philip;
Marion Schneider, E.;
Fischer-Posovszky, Pamela;
Riedel, Christian U.;
Handrick, René;
Otte, Kerstin

Publication type:

Article

miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.

Published in:

Biotechnology Progress, 2017, v. 33, n. 4, p. 1046, doi. 10.1002/btpr.2475

By:

Schoellhorn, Melanie;
Fischer, Simon;
Wagner, Andreas;
Handrick, René;
Otte, Kerstin

Publication type:

Article

Exploring the capabilities of fluorometric online monitoring on chinese hamster ovary cell cultivations producing a monoclonal antibody.

Published in:

Biotechnology Progress, 2016, v. 32, n. 6, p. 1592, doi. 10.1002/btpr.2326

By:

Schwab, Karen;
Amann, Thomas;
Schmid, Jakob;
Handrick, René;
Hesse, Friedemann

Publication type:

Article