Works by Hancox, Jules C.

Results: 95

Gender-related differences in ventricular myocyte repolarization in the guinea pig.

Published in:

Basic Research in Cardiology, 2004, v. 99, n. 3, p. 183, doi. 10.1007/s00395-003-0451-6

By:

James, Andrew F.;
Arberry, Lesley A.;
Hancox, Jules C.

Publication type:

Article

Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits.

Published in:

Experimental Physiology, 2012, v. 97, n. 10, p. 1131, doi. 10.1113/expphysiol.2012.065110

By:

Cheng, Hongwei;
Smith, Godfrey L.;
Orchard, Clive H.;
Hancox, Jules C.;
Burton, Francis L.

Publication type:

Article

Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node.

Published in:

Experimental Physiology, 2010, v. 95, n. 4, p. 508, doi. 10.1113/expphysiol.2009.050286

By:

Yuill, Kathryn H.;
Tosh, David;
Hancox, Jules C.

Publication type:

Article

QTc interval and ventricular action potential prolongation in the Mecp2Null/+ murine model of Rett syndrome.

Published in:

Physiological Reports, 2022, v. 10, n. 19, p. 1, doi. 10.14814/phy2.15437

By:

Cheng, Hongwei;
Charles, Ian;
James, Andrew F.;
Abdala, Ana P.;
Hancox, Jules C.

Publication type:

Article

An Update on the Structure of hERG.

Published in:

Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2019.01572

By:

Butler, Andrew;
Helliwell, Matthew V.;
Zhang, Yihong;
Hancox, Jules C.;
Dempsey, Christopher E.

Publication type:

Article

Emerging therapeutic targets in the short QT syndrome.

Published in:

Expert Opinion on Therapeutic Targets, 2018, v. 22, n. 5, p. 439, doi. 10.1080/14728222.2018.1470621

By:

Hancox, Jules C;
Whittaker, Dominic G;
Du, Chunyun;
Stuart, A. Graham;
Zhang, Henggui

Publication type:

Article

Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study.

Published in:

PLoS Computational Biology, 2021, v. 17, n. 3, p. 1, doi. 10.1371/journal.pcbi.1008177

By:

Li, Yacong;
Wang, Kuanquan;
Li, Qince;
Hancox, Jules C.;
Zhang, Henggui

Publication type:

Article

Characteristics of single cells isolated from the atrioventricular node of the adult guinea-pig heart.

Published in:

Pflügers Archiv: European Journal of Physiology, 2002, v. 445, n. 3, p. 311, doi. 10.1007/s00424-002-0932-8

By:

Yuill, Kathryn H.;
Hancox, Jules C.

Publication type:

Article

Cultured Adult Rabbit Myocytes: Effect of Adding Supplements to the Medium, and Response to Isoprenaline.

Published in:

Journal of Cardiovascular Electrophysiology, 1997, v. 8, n. 9, p. 1020, doi. 10.1111/j.1540-8167.1997.tb00626.x

By:

Mitcheson, John S.;
Hancox, Jules C.;
Levi, Allan J.

Publication type:

Article

Role of Intracellular Sodium Overload in the Genesis of Cardiac Arrhythmias.

Published in:

Journal of Cardiovascular Electrophysiology, 1997, v. 8, n. 6, p. 700, doi. 10.1111/j.1540-8167.1997.tb01834.x

By:

Levi, Allan J.;
Dalton, Geoff R.;
Hancox, Jules C.;
Mitcheson, John S.;
Issberner, Jon;
Bates, Jennifer A.;
Evans, Stephen J.;
Howarth, F. Chris;
Hobai, Ion A.;
Jones, John V.

Publication type:

Article

Na-Ca Exchange Tail Current Indicates Voltage Dependence of the Cai Transient in Rabbit Ventricular Myocytes.

Published in:

Journal of Cardiovascular Electrophysiology, 1995, v. 6, n. 6, p. 455, doi. 10.1111/j.1540-8167.1995.tb00419.x

By:

Hancox, Jules C.;
Levi, Allan J.

Publication type:

Article

The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2005, v. 32, n. 12, p. 1088, doi. 10.1111/j.1440-1681.2005.04312.x

By:

Zhan Gao;
Milnes, James T.;
Choisy, Stéphanie C. M.;
Leach, Michael J.;
Hancox, Jules C.;
James, Andrew F.

Publication type:

Article

Actions of the anti-oestrogen agent clomiphene on outward K+ currents in rat ventricular myocytes.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2004, v. 31, n. 1/2, p. 86, doi. 10.1111/j.1440-1681.2004.03956.x

By:

Borg, John J.;
Hancox, Jules C.;
Hogg, Dayle S.;
James, Andrew F.;
Kozlowski, Roland Z.

Publication type:

Article

FAMILIAL AND ACQUIRED LONG QT SYNDROME AND THE CARDIAC RAPID DELAYED RECTIFIER POTASSIUM CURRENT.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2000, v. 27, n. 10, p. 753, doi. 10.1046/j.1440-1681.2000.03337.x

By:

Witchel, Harry J.;
Hancox, Jules C.

Publication type:

Article

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome.

Published in:

Frontiers in Physiology, 2019, p. N.PAG, doi. 10.3389/fphys.2018.01888

By:

Whittaker, Dominic G.;
Hancox, Jules C.;
Zhang, Henggui

Publication type:

Article

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1 -Linked Short QT Syndrome: Insights From Computational Modelling.

Published in:

Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01402

By:

Whittaker, Dominic G.;
Colman, Michael A.;
Ni, Haibo;
Hancox, Jules C.;
Zhang, Henggui

Publication type:

Article

Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K+ Channel.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0052451

By:

Harchi, Aziza El;
Melgari, Dario;
Yi Hong Zhang;
Henggui Zhang;
Hancox, Jules C.

Publication type:

Article

Modulation by Endothelin-1 of Spontaneous Activity and Membrane Currents of Atrioventricular Node Myocytes from the Rabbit Heart.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033448

By:

Choisy, Stéphanie C.;
Cheng, Hongwei;
Smith, Godfrey L.;
James, Andrew F.;
Hancox, Jules C.

Publication type:

Article

Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes.

Published in:

Cardiovascular Research, 2014, v. 104, n. 1, p. 206, doi. 10.1093/cvr/cvu192

By:

Bond, Richard C.;
Choisy, Stéphanie C.M.;
Bryant, Simon M.;
Hancox, Jules C.;
James, Andrew F.

Publication type:

Article

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.

Published in:

Cardiovascular Research, 2012, v. 94, n. 1, p. 66, doi. 10.1093/cvr/cvs082

By:

Adeniran, Ismail;
El Harchi, Aziza;
Hancox, Jules C.;
Zhang, Henggui

Publication type:

Article

Sex, drugs and arrhythmia: are gender differences in risk of torsades de pointes simply a matter of testosterone?

Published in:

2003

By:

James, Andrew F.;
Hancox, Jules C.

Publication type:

Editorial

Cultured adult cardiac myocytes.

Published in:

Cardiovascular Research, 1998, v. 39, n. 2, p. 280, doi. 10.1016/S0008-6363(98)00128-X

By:

Mitcheson, John S;
Hancox, Jules C;
Levi, Allan J

Publication type:

Article

Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.

Published in:

Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05498-4

By:

Zhang, Yihong;
El Harchi, Aziza;
James, Andrew F.;
Oiki, Shigetoshi;
Dempsey, Christopher E.;
Hancox, Jules C.

Publication type:

Article

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study.

Published in:

PLoS Computational Biology, 2018, v. 14, n. 11, p. 1, doi. 10.1371/journal.pcbi.1006594

By:

Wang, Wei;
Zhang, Shanzhuo;
Ni, Haibo;
Garratt, Clifford J.;
Boyett, Mark R.;
Hancox, Jules C.;
Zhang, Henggui

Publication type:

Article

In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-53571-6

By:

Butler, Andrew S.;
Ascione, Raimondo;
Marrion, Neil V.;
Harmer, Stephen C.;
Hancox, Jules C.

Publication type:

Article

Modulation of hERG potassium channels by a novel small molecule activator.

Published in:

2017

By:

Mitcheson, John S;
Hancox, Jules C

Publication type:

journal article

High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.

Published in:

British Journal of Pharmacology, 2012, v. 165, n. 7, p. 2260, doi. 10.1111/j.1476-5381.2011.01688.x

By:

Cheng, Hongwei;
Zhang, Yihong;
Du, Chunyun;
Dempsey, Christopher E;
Hancox, Jules C

Publication type:

Article

Novel ion channel targets in atrial fibrillation.

Published in:

Expert Opinion on Therapeutic Targets, 2016, v. 20, n. 8, p. 947, doi. 10.1517/14728222.2016.1159300

By:

Hancox, Jules C.;
James, Andrew F.;
Marrion, Neil V.;
Zhang, Henggui;
Thomas, Dierk

Publication type:

Article

Cardiac background sodium current: Elusive but important.

Published in:

Channels (19336950), 2017, v. 11, n. 1, p. 3, doi. 10.1080/19336950.2016.1207476

By:

Cheng, Hongwei;
James, Andrew F.;
Boyett, Mark R.;
Hancox, Jules C.

Publication type:

Article

Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes.

Published in:

Journal of Cellular Biochemistry, 2002, v. 86, n. 2, p. 290, doi. 10.1002/jcb.10217

By:

Yellowley, Clare E.;
Hancox, Jules C.;
Donahue, Henry J.

Publication type:

Article

Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency.

Published in:

Annals of Noninvasive Electrocardiology, 2023, v. 28, n. 6, p. 1, doi. 10.1111/anec.13077

By:

Hanington, Oliver P.;
Armstrong, Catherine;
Pierre, Germaine;
Stuart, Graham;
Hancox, Jules C.

Publication type:

Article

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.

Published in:

2006

By:

Alexandrou, Ari J.;
Duncan, Rona S;
Sullivan, Anneli;
Hancox, Jules C;
Leishman, Derek J;
Witchel, Harry J;
Leaney, Joanne L

Publication type:

journal article

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine.

Published in:

2002

By:

Paul, Ashok A.;
Witchel, Harry J.;
Hancox, Jules C.

Publication type:

journal article

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline.

Published in:

1999

By:

Teschemacher, Anja G;
Seward, Elizabeth P;
Hancox, Jules C;
Witchel, Harry J;
Teschemacher, A G;
Seward, E P;
Hancox, J C;
Witchel, H J

Publication type:

journal article

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart.

Published in:

Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.546508

By:

Alghamdi, Aaazh M.;
Boyett, Mark R.;
Hancox, Jules C.;
Zhang, Henggui

Publication type:

Article

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study.

Published in:

Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.547577

By:

Alghamdi, Azzah M.;
Testrow, Craig P.;
Whittaker, Dominic G.;
Boyett, Mark R.;
Hancox, Jules. C.;
Zhang, Henggui

Publication type:

Article

Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine.

Published in:

Expert Opinion on Drug Safety, 2014, v. 13, n. 1, p. 131, doi. 10.1517/14740338.2014.851193

By:

Doggrell, Sheila A;
Hancox, Jules C

Publication type:

Article

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656

Published in:

FEBS Letters, 2006, v. 580, n. 8, p. 1999, doi. 10.1016/j.febslet.2006.02.073

By:

Ridley, John M.;
Milnes, James T.;
Duncan, Rona S.;
McPate, Mark J.;
James, Andrew F.;
Witchel, Harry J.;
Hancox, Jules C.

Publication type:

Article

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

Published in:

FEBS Letters, 2003, v. 547, n. 1-3, p. 20, doi. 10.1016/S0014-5793(03)00662-8

By:

Milnes, James T.;
Dempsey, Christopher E.;
Ridley, John M.;
Crociani, Olivia;
Arcangeli, Annarosa;
Hancox, Jules C.;
Witchel, Harry J.

Publication type:

Article

ATL>Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents.

Published in:

FEBS Letters, 2002, v. 512, n. 1-3, p. 59, doi. 10.1016/S0014-5793(01)03320-8

By:

Witchel, Harry J.;
Pabbathi, Vijay K.;
Hofmann, Giovanna;
Paul, Ashok A.;
Hancox, Jules C.

Publication type:

Article

Global Air Pollutant Phenanthrene and Arrhythmic Outcomes in a Mouse Model.

Published in:

Environmental Health Perspectives, 2023, v. 131, n. 11, p. 117002-1, doi. 10.1289/EHP12775

By:

Yaar, Sana;
Filatova, Tatiana S.;
England, Ellie;
Kompella, Shiva N.;
Hancox, Jules C.;
Bechtold, David A.;
Venetucci, Luigi;
Abramochkin, Denis V.;
Shiels, Holly A.

Publication type:

Article

Torsades de pointes following clarithromycin treatment.

Published in:

Expert Review of Cardiovascular Therapy, 2013, v. 11, n. 11, p. 1485, doi. 10.1586/14779072.2013.840535

By:

Gysel, Michael;
Vieweg, W Victor R;
Hasnain, Mehrul;
Hancox, Jules C;
Kunanithy, Vitharani;
Baranchuk, Adrian

Publication type:

Article

Comment: postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2.

Published in:

2019

By:

Hancox, Jules C;
James, Andrew F

Publication type:

journal article

A multicentre study of patients with Timothy syndrome.

Published in:

2018

By:

Walsh, Mark A.;
Turner, Christian;
Timothy, Katherine W.;
Seller, Neil;
Hares, Dominic L.;
James, Andrew F.;
Hancox, Jules C.;
Uzun, Orhan;
Boyce, Dean;
Stuart, Alan. G.;
Brennan, Paul;
Sarton, Caroline;
McGuire, Karen;
Newbury-Ecob, Ruth A.;
Mcleod, Karen

Publication type:

journal article

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model.

Published in:

EP: Europace, 2014, v. 16, n. 3, p. 416, doi. 10.1093/europace/eut349

By:

Colman, Michael A.;
Varela, Marta;
Hancox, Jules C.;
Zhang, Henggui;
Aslanidi, Oleg V.

Publication type:

Article

Electrophysiological characterization of the modified hERGT potassium channel used to obtain the first cryo‐EM hERG structure.

Published in:

Physiological Reports, 2020, v. 8, n. 20, p. 1, doi. 10.14814/phy2.14568

By:

Zhang, Yihong;
Dempsey, Christopher E.;
Hancox, Jules C.

Publication type:

Article

Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes.

Published in:

Physiological Reports, 2020, v. 8, n. 9, p. 1, doi. 10.14814/phy2.14432

By:

Bond, Richard C.;
Choisy, Stéphanie C.;
Bryant, Simon M.;
Hancox, Jules C.;
James, Andrew F.

Publication type:

Article

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.

Published in:

Physiological Reports, 2020, v. 8, n. 5, p. 1, doi. 10.14814/phy2.14385

By:

El Harchi, Aziza;
Butler, Andrew S.;
Zhang, Yihong;
Dempsey, Christopher E.;
Hancox, Jules C.

Publication type:

Article

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome.

Published in:

Physiological Reports, 2018, v. 6, n. 17, p. 1, doi. 10.14814/phy2.13845

By:

Butler, Andrew;
Zhang, Yihong;
Stuart, Alan G.;
Dempsey, Christopher E.;
Hancox, Jules C.

Publication type:

Article

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806.

Published in:

Physiological Reports, 2017, v. 5, n. 5, p. 1, doi. 10.14814/phy2.13172

By:

Cheng, Hongwei;
Cannell, Mark B.;
Hancox, Jules C.

Publication type:

Article