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Phosphoinositide 3-Kinases as Potential Targets for Thrombosis Prevention.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 4840, doi. 10.3390/ijms23094840
By:
- Setiabakti, Natasha M.;
- Larsson, Pia;
- Hamilton, Justin R.
Publication type:
Article
Using PAR4 Inhibition as an Anti-Thrombotic Approach: Why, How, and When?
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 22, p. 5629, doi. 10.3390/ijms20225629
By:
- Li, Simeng;
- Tarlac, Volga;
- Hamilton, Justin R.
Publication type:
Article
Differential Signaling by Protease-Activated Receptors: Implications for Therapeutic Targeting.
Published in:
International Journal of Molecular Sciences, 2014, v. 15, n. 4, p. 6169, doi. 10.3390/ijms15046169
By:
- Sidhu, Tejminder S.;
- French, Shauna L.;
- Hamilton, Justin R.
Publication type:
Article
Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteries.
Published in:
British Journal of Pharmacology, 2002, v. 136, n. 4, p. 492
By:
- Moffatt, James D.;
- Tatoulis, James;
- Cocks, Thomas M.;
- Hamilton, Justin R.
Publication type:
Article
Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery.
Published in:
British Journal of Pharmacology, 2000, v. 130, n. 1, p. 181, doi. 10.1038/sj.bjp.0703146
By:
- Hamilton, Justin R;
- Cocks, Thomas M
Publication type:
Article
An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients.
Published in:
BMC Biology, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12915-022-01274-7
By:
- Zainal Abidin, Nurul A.;
- Poon, Eric K. W.;
- Szydzik, Crispin;
- Timofeeva, Mariia;
- Akbaridoust, Farzan;
- Brazilek, Rose J.;
- Tovar Lopez, Francisco J.;
- Ma, Xiao;
- Lav, Chitrarth;
- Marusic, Ivan;
- Thompson, Philip E.;
- Mitchell, Arnan;
- Ooi, Andrew S. H.;
- Hamilton, Justin R.;
- Nesbitt, Warwick S.
Publication type:
Article
An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients.
Published in:
BMC Biology, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12915-022-01274-7
By:
- Zainal Abidin, Nurul A.;
- Poon, Eric K. W.;
- Szydzik, Crispin;
- Timofeeva, Mariia;
- Akbaridoust, Farzan;
- Brazilek, Rose J.;
- Tovar Lopez, Francisco J.;
- Ma, Xiao;
- Lav, Chitrarth;
- Marusic, Ivan;
- Thompson, Philip E.;
- Mitchell, Arnan;
- Ooi, Andrew S. H.;
- Hamilton, Justin R.;
- Nesbitt, Warwick S.
Publication type:
Article
Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation.
Published in:
Life Science Alliance, 2024, v. 7, n. 2, p. 1, doi. 10.26508/lsa.202302211
By:
- El-Mortada, Firas;
- Landelouci, Karima;
- Bertrand-Perron, Samuel;
- Aubé, Félix-Antoine;
- Poirier, Amélie;
- Bidias, Amel;
- Jourdi, Georges;
- Welman, Mélanie;
- Gantier, Michael P.;
- Hamilton, Justin R.;
- Kile, Benjamin;
- Lordkipanidzé, Marie;
- Pépin, Geneviève
Publication type:
Article
Analysis of the F2LR3 (PAR4) Single Nucleotide Polymorphism (rs773902) in an Indigenous Australian Population.
Published in:
Frontiers in Genetics, 2020, v. 11, p. 1, doi. 10.3389/fgene.2020.00432
By:
- Ningtyas, Dian;
- Thomson, Russell J.;
- Tarlac, Volga;
- Nagaraj, Shivashankar H.;
- Hoy, Wendy;
- Mathews, John D.;
- Foote, Simon J.;
- Gardiner, Elizabeth E.;
- Hamilton, Justin R.;
- McMorran, Brendan J.
Publication type:
Article
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
Published in:
Nature Communications, 2015, v. 6, n. 3, p. 6535, doi. 10.1038/ncomms7535
By:
- Mountford, Jessica K.;
- Petitjean, Claire;
- Putra, Harun W. Kusuma;
- McCafferty, Jonathan A.;
- Setiabakti, Natasha M.;
- Lee, Hannah;
- Tønnesen, Lotte L.;
- McFadyen, James D.;
- Schoenwaelder, Simone M.;
- Eckly, Anita;
- Gachet, Christian;
- Ellis, Sarah;
- Voss, Anne K.;
- Dickins, Ross A.;
- Hamilton, Justin R.;
- Jackson, Shaun P.
Publication type:
Article
Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.
Published in:
Science Translational Medicine, 2020, v. 12, n. 553, p. 1, doi. 10.1126/scitranslmed.aar8430
By:
- Selvadurai, Maria V.;
- Moon, Mitchell J.;
- Mountford, Simon J.;
- Ma, Xiao;
- Zheng, Zhaohua;
- Jennings, Ian G.;
- Setiabakti, Natasha M.;
- Iman, Rizani P.;
- Brazilek, Rose J.;
- Z. Abidin, Nurul Aisha;
- Chicanne, Gaëtan;
- Severin, Sonia;
- Nicholls, Alyce J.;
- Wong, Connie H.Y.;
- Rinckel, Jean-Yves;
- Eckly, Anita;
- Gachet, Christian;
- Nesbitt, Warwick S.;
- Thompson, Philip E.;
- Hamilton, Justin R.
Publication type:
Article
Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets.
Published in:
PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0165565
By:
- French, Shauna L.;
- Paramitha, Antonia C.;
- Moon, Mitchell J.;
- Dickins, Ross A.;
- Hamilton, Justin R.
Publication type:
Article
Protease-activated receptor 4: from structure to function and back again.
Published in:
2016
By:
- French, Shauna L;
- Hamilton, Justin R
Publication type:
journal article
The PI 3‐kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition.
Published in:
FEBS Letters, 2019, v. 593, n. 1, p. 88, doi. 10.1002/1873-3468.13295
By:
- Selvadurai, Maria V.;
- Brazilek, Rose J.;
- Moon, Mitchell J.;
- Rinckel, Jean‐Yves;
- Eckly, Anita;
- Gachet, Christian;
- Meikle, Peter J.;
- Nandurkar, Harshal H.;
- Nesbitt, Warwick S.;
- Hamilton, Justin R.
Publication type:
Article

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