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Silkworm model of bacterial infection facilitates the identification of lysocin E, a potent, ultra-rapid bactericidal antibiotic.
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- Journal of Antibiotics, 2024, v. 77, n. 8, p. 477, doi. 10.1038/s41429-024-00739-x
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- Article
Molecular Editing Enhances Oxidation Resistance of Menaquinone‐Targeting Antibiotics Lysocin E and WAP‐8294A2.
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- Chemistry - A European Journal, 2023, v. 29, n. 47, p. 1, doi. 10.1002/chem.202301224
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- Article
Construction of Five Tryptophan Isomers and Application of the Isomers to Solid‐Phase Total Syntheses of Lysocin E Derivatives.
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- Chemistry - A European Journal, 2023, v. 29, n. 43, p. 1, doi. 10.1002/chem.202301225
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- Article
Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.
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- Drug Discoveries & Therapeutics, 2022, v. 16, n. 6, p. 280, doi. 10.5582/ddt.2022.01088
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- Article
Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences.
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- Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.959063
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- Article
Transcriptome change of Staphylococcus aureus in infected mouse liver.
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- Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03674-5
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- Article
Serine and purine synthesis pathways are involved in the virulence of Burkholderia gladioli, the causative agent of gladiolus rot.
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- Journal of General Plant Pathology, 2022, v. 88, n. 1, p. 55, doi. 10.1007/s10327-021-01031-8
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- Article
An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics.
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- Journal of Antibiotics, 2021, v. 74, n. 12, p. 850, doi. 10.1038/s41429-021-00476-5
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- Article
Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26702-0
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- Article
Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.
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- Journal of Fungi, 2021, v. 7, n. 11, p. 1, doi. 10.3390/jof7110995
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- Article
Applying the silkworm model for the search of immunosuppressants.
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- Drug Discoveries & Therapeutics, 2021, v. 15, n. 3, p. 139, doi. 10.5582/ddt.2021.01041
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- Article
A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89882-1
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- Article
Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model.
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- Drug Discoveries & Therapeutics, 2021, v. 15, n. 2, p. 73, doi. 10.5582/ddt.2021.01035
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- Article
Development of an in vivo-mimic silkworm infection model with Mycobacterium avium complex.
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- Drug Discoveries & Therapeutics, 2020, v. 14, n. 6, p. 287, doi. 10.5582/ddt.2020.03099
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- Article
Evaluation of Anti-Mycobacterial Compounds in a Silkworm Infection Model with Mycobacteroides abscessus.
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- Molecules, 2020, v. 25, n. 21, p. 4971, doi. 10.3390/molecules25214971
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- Article
Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.
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- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18711-2
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- Article
A simple artificial diet available for research of silkworm disease models.
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- Drug Discoveries & Therapeutics, 2020, v. 14, n. 4, p. 177, doi. 10.5582/ddt.2020.03061
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- Article
β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66974-y
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- Article
Large-Scale Screening and Identification of Novel Pathogenic Staphylococcus aureus Genes Using a Silkworm Infection Model.
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- 2020
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- journal article
Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis.
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- Frontiers in Microbiology, 2019, p. 1, doi. 10.3389/fmicb.2019.01619
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- Article
Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.
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- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10754-4
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- Article
Pharmacokinetics of anti-infectious reagents in silkworms.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46013-1
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- Article
Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment.
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- Drug Discoveries & Therapeutics, 2019, v. 13, n. 3, p. 145, doi. 10.5582/ddt.2019.01031
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- Article
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
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- Cell Death & Disease, 2018, v. 9, n. 8, p. 1, doi. 10.1038/s41419-018-0815-3
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- Article
Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768.
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- Genome Biology & Evolution, 2018, v. 10, n. 8, p. 2017, doi. 10.1093/gbe/evy166
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- Article
Characterization of the chemical structure and innate immunestimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay.
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- Drug Discoveries & Therapeutics, 2017, v. 11, n. 5, p. 238, doi. 10.5582/ddt.2017.01045
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- Article
Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions.
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- Angewandte Chemie, 2017, v. 129, n. 39, p. 12027, doi. 10.1002/ange.201706671
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- Article
Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 39, p. 11865, doi. 10.1002/anie.201706671
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- Article
Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.
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- Journal of Antibiotics, 2017, v. 70, n. 5, p. 685, doi. 10.1038/ja.2017.23
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- Article
A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus.
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- Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00712
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- Article
Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori).
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- Drug Discoveries & Therapeutics, 2017, v. 11, n. 2, p. 64, doi. 10.5582/ddt.2017.01012
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- Article
Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract.
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- Drug Discoveries & Therapeutics, 2017, v. 11, n. 2, p. 70, doi. 10.5582/ddt.2017.01013
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- Article
Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates.
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- Drug Discoveries & Therapeutics, 2017, v. 11, n. 2, p. 78, doi. 10.5582/ddt.2017.01024
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- Article
Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.
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- Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00373
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- Article
In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-5.
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- Journal of Antibiotics, 2017, v. 70, n. 2, p. 204, doi. 10.1038/ja.2016.102
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- Article
Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.
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- Journal of Antibiotics, 2017, v. 70, n. 1, p. 41, doi. 10.1038/ja.2016.106
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- Article
Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.
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- Chemistry - A European Journal, 2016, v. 22, n. 47, p. 16912, doi. 10.1002/chem.201604022
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- Article
Lysobacter species: a potential source of novel antibiotics.
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- Archives of Microbiology, 2016, v. 198, n. 9, p. 839, doi. 10.1007/s00203-016-1278-5
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- Article
A silkworm infection model to investigate Vibrio vulnificus virulence genes.
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- Molecular Medicine Reports, 2016, v. 14, n. 5, p. 4243, doi. 10.3892/mmr.2016.5782
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- Article
Menaquinone as a potential target of antibacterial agents.
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- Drug Discoveries & Therapeutics, 2016, v. 10, n. 3, p. 123, doi. 10.5582/ddt.2016.01041
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- Article
Using silkworms as a laboratory animal to evaluate medicines and foods.
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- Drug Discoveries & Therapeutics, 2016, v. 10, n. 1, p. 1, doi. 10.5582/ddt.2016.01018
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- Article
Identification of lysocin E using a silkworm model of bacterial infection.
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- Drug Discoveries & Therapeutics, 2016, v. 10, n. 1, p. 24, doi. 10.5582/ddt.2016.01012
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- Publication type:
- Article
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.
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- Scientific Reports, 2015, p. 17092, doi. 10.1038/srep17092
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- Article
A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin.
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- Journal of Antibiotics, 2015, v. 68, n. 10, p. 646, doi. 10.1038/ja.2015.42
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- Article
Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies.
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- Drug Discoveries & Therapeutics, 2015, v. 9, n. 4, p. 238, doi. 10.5582/ddt.2015.01015
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- Article
Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research.
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- Drug Discoveries & Therapeutics, 2015, v. 9, n. 2, p. 133, doi. 10.5582/ddt.2015.01026
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- Article
Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide.
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- ChemMedChem, 2015, v. 10, n. 3, p. 540, doi. 10.1002/cmdc.201402473
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Back Cover: Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide (ChemMedChem 3/2015).
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- ChemMedChem, 2015, v. 10, n. 3, p. 584, doi. 10.1002/cmdc.201590006
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- Article
Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.
- Published in:
- Nature Chemical Biology, 2015, v. 11, n. 2, p. 127, doi. 10.1038/nchembio.1710
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- Article
Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E and Its Enantiomeric, Epimeric, and N-Demethylated Analogues.
- Published in:
- Angewandte Chemie, 2015, v. 127, n. 5, p. 1576, doi. 10.1002/ange.201410270
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- Article