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A versatile, high-efficiency platform for CRISPR-based gene activation.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36452-w
By:
- Heidersbach, Amy J.;
- Dorighi, Kristel M.;
- Gomez, Javier A.;
- Jacobi, Ashley M.;
- Haley, Benjamin
Publication type:
Article
Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
Published in:
2022
By:
- Deng, Yexuan;
- Diepstraten, Sarah T.;
- Potts, Margaret A.;
- Giner, Göknur;
- Trezise, Stephanie;
- Ng, Ashley P.;
- Healey, Gerry;
- Kane, Serena R.;
- Cooray, Amali;
- Behrens, Kira;
- Heidersbach, Amy;
- Kueh, Andrew J.;
- Pal, Martin;
- Wilcox, Stephen;
- Tai, Lin;
- Alexander, Warren S.;
- Visvader, Jane E.;
- Nutt, Stephen L.;
- Strasser, Andreas;
- Haley, Benjamin
Publication type:
Correction Notice
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32485-9
By:
- Deng, Yexuan;
- Diepstraten, Sarah T.;
- Potts, Margaret A.;
- Giner, Göknur;
- Trezise, Stephanie;
- Ng, Ashley P.;
- Healey, Gerry;
- Kane, Serena R.;
- Cooray, Amali;
- Behrens, Kira;
- Heidersbach, Amy;
- Kueh, Andrew J.;
- Pal, Martin;
- Wilcox, Stephen;
- Tai, Lin;
- Alexander, Warren S.;
- Visvader, Jane E.;
- Nutt, Stephen L.;
- Strasser, Andreas;
- Haley, Benjamin
Publication type:
Article
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32485-9
By:
- Deng, Yexuan;
- Diepstraten, Sarah T.;
- Potts, Margaret A.;
- Giner, Göknur;
- Trezise, Stephanie;
- Ng, Ashley P.;
- Healey, Gerry;
- Kane, Serena R.;
- Cooray, Amali;
- Behrens, Kira;
- Heidersbach, Amy;
- Kueh, Andrew J.;
- Pal, Martin;
- Wilcox, Stephen;
- Tai, Lin;
- Alexander, Warren S.;
- Visvader, Jane E.;
- Nutt, Stephen L.;
- Strasser, Andreas;
- Haley, Benjamin
Publication type:
Article
Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum‐free media.
Published in:
Biotechnology Progress, 2020, v. 36, n. 3, p. 1, doi. 10.1002/btpr.2951
By:
- Louie, Salina;
- Heidersbach, Amy;
- Blanco, Noelia;
- Haley, Benjamin;
- Rose, Christopher M.;
- Liu, Peter S.;
- Yim, Mandy;
- Tang, Danming;
- Lam, Cynthia;
- Sandoval, Wendy N.;
- Shaw, David;
- Snedecor, Brad;
- Misaghi, Shahram
Publication type:
Article
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
Published in:
eLife, 2017, p. 1, doi. 10.7554/eLife.26435
By:
- Whiteley, Alexandra M.;
- Prado, Miguel A.;
- Peng, Ivan;
- Abbas, Alexander R.;
- Haley, Benjamin;
- Paulo, Joao A.;
- Reichelt, Mike;
- Katakam, Anand;
- Sagolla, Meredith;
- Modrusan, Zora;
- Dong Yun Lee;
- Roose-Girma, Merone;
- Kirkpatrick, Donald S.;
- McKenzie, Brent S.;
- Gygi, Steven P.;
- Finley, Daniel;
- Brown, Eric J.
Publication type:
Article
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29655-0
By:
- Savill, Kristin M. Zimmerman;
- Lee, Brian B.;
- Oeh, Jason;
- Lin, Jie;
- Lin, Eva;
- Chung, Wei-Jen;
- Young, Amy;
- Chen, Wennie;
- Miś, Monika;
- Mesh, Kathryn;
- Eastham, Jeffrey;
- Gnad, Florian;
- Jiang, Zhaoshi;
- Stawiski, Eric W.;
- Haley, Benjamin;
- Daemen, Anneleen;
- Wang, Xiaojing;
- Koeppen, Hartmut;
- Modrusan, Zora;
- Martin, Scott E.
Publication type:
Article
IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Published in:
Science Signaling, 2019, v. 12, n. 582, p. N.PAG, doi. 10.1126/scisignal.aax4917
By:
- Kayagaki, Nobuhiko;
- Lee, Bettina L.;
- Stowe, Irma B.;
- Kornfeld, Opher S.;
- O'Rourke, Karen;
- Mirrashidi, Kathleen M.;
- Haley, Benjamin;
- Watanabe, Colin;
- Roose-Girma, Merone;
- Modrusan, Zora;
- Kummerfeld, Sarah;
- Reja, Rohit;
- Zhang, Yafei;
- Cho, Vicky;
- Andrews, T. Daniel;
- Morris, Lucy X.;
- Goodnow, Christopher C.;
- Bertram, Edward M.;
- Dixit, Vishva M.
Publication type:
Article
Identifying transcriptional programs underlying cancer drug response with TraCe-seq.
Published in:
Nature Biotechnology, 2022, v. 40, n. 1, p. 86, doi. 10.1038/s41587-021-01005-3
By:
- Chang, Matthew T.;
- Shanahan, Frances;
- Nguyen, Thi Thu Thao;
- Staben, Steven T.;
- Gazzard, Lewis;
- Yamazoe, Sayumi;
- Wertz, Ingrid E.;
- Piskol, Robert;
- Yang, Yeqing Angela;
- Modrusan, Zora;
- Haley, Benjamin;
- Evangelista, Marie;
- Malek, Shiva;
- Foster, Scott A.;
- Ye, Xin
Publication type:
Article
A distinct class of small RNAs arises from pre-miRNA–proximal regions in a simple chordate.
Published in:
Nature Structural & Molecular Biology, 2009, v. 16, n. 2, p. 183, doi. 10.1038/nsmb.1536
By:
- Shi, Weiyang;
- Hendrix, David;
- Levine, Mike;
- Haley, Benjamin
Publication type:
Article
Kinetic analysis of the RNAi enzyme complex.
Published in:
Nature Structural & Molecular Biology, 2004, v. 11, n. 7, p. 599, doi. 10.1038/nsmb780
By:
- Haley, Benjamin;
- Zamore, Phillip D.
Publication type:
Article
The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose.
Published in:
PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0140989
By:
- Haley, Benjamin M.;
- Paunesku, Tatjana;
- Grdina, David J.;
- Woloschak, Gayle E.
Publication type:
Article
FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.
Published in:
Biotechnology & Bioengineering, 2017, v. 114, n. 3, p. 632, doi. 10.1002/bit.26188
By:
- Louie, Salina;
- Haley, Benjamin;
- Marshall, Brett;
- Heidersbach, Amy;
- Yim, Mandy;
- Brozynski, Martina;
- Tang, Danming;
- Lam, Cynthia;
- Petryniak, Bronislawa;
- Shaw, David;
- Shim, Jeongsup;
- Miller, Aaron;
- Lowe, John B.;
- Snedecor, Brad;
- Misaghi, Shahram
Publication type:
Article
Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.
Published in:
Biotechnology & Bioengineering, 2016, v. 113, n. 10, p. 2100, doi. 10.1002/bit.25977
By:
- Hu, Zhilan;
- Zhang, Henry;
- Haley, Benjamin;
- Macchi, Frank;
- Yang, Feng;
- Misaghi, Shahram;
- Elich, Joseph;
- Yang, Renee;
- Tang, Yun;
- Joly, John C.;
- Snedecor, Bradley R.;
- Shen, Amy
Publication type:
Article
Expansion of the ISWI chromatin remodeler family with new active complexes.
Published in:
EMBO Reports, 2017, v. 18, n. 10, p. 1697, doi. 10.15252/embr.201744011
By:
- Oppikofer, Mariano;
- Bai, Tianyi;
- Gan, Yutian;
- Haley, Benjamin;
- Liu, Peter;
- Sandoval, Wendy;
- Ciferri, Claudio;
- Cochran, Andrea G
Publication type:
Article
EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G<sup>12D</sup> tumor development and propagation.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.57648
By:
- Pribluda, Ariel;
- Daemen, Anneleen;
- Lima, Anthony Nelson;
- Xi Wang;
- Hafner, Marc;
- Chungkee Poon;
- Modrusan, Zora;
- Katakam, Anand Kumar;
- Foreman, Oded;
- Eastham, Jefferey;
- Hung, Jefferey;
- Haley, Benjamin;
- Garcia, Julia T.;
- Jackson, Erica L.;
- Junttila, Melissa R.
Publication type:
Article
S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.
Published in:
2019
By:
- Yuan, Wenlin;
- Goldstein, Leonard D.;
- Durinck, Steffen;
- Chen, Ying-Jiun;
- Nguyen, Thong T.;
- Kljavin, Noelyn M.;
- Sokol, Ethan S.;
- Stawiski, Eric W.;
- Haley, Benjamin;
- Ziai, James;
- Modrusan, Zora;
- Seshagiri, Somasekar
Publication type:
journal article
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.
Published in:
2016
By:
- McCleland, Mark L.;
- Mesh, Kathryn;
- Lorenzana, Edward;
- Chopra, Vivek S.;
- Segal, Ehud;
- Watanabe, Colin;
- Haley, Benjamin;
- Mayba, Oleg;
- Yaylaoglu, Murat;
- Gnad, Florian;
- Firestein, Ron
Publication type:
journal article
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.
Published in:
Nature Communications, 2017, v. 8, n. 2, p. 14572, doi. 10.1038/ncomms14572
By:
- Lau, Janet;
- Cheung, Jeanne;
- Navarro, Armando;
- Lianoglou, Steve;
- Haley, Benjamin;
- Totpal, Klara;
- Sanders, Laura;
- Koeppen, Hartmut;
- Caplazi, Patrick;
- McBride, Jacqueline;
- Chiu, Henry;
- Hong, Rebecca;
- Grogan, Jane;
- Javinal, Vincent;
- Yauch, Robert;
- Irving, Bryan;
- Belvin, Marcia;
- Mellman, Ira;
- Kim, Jeong M.;
- Schmidt, Maike
Publication type:
Article
Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.
Published in:
Nature Communications, 2016, v. 7, n. 8, p. 12351, doi. 10.1038/ncomms12351
By:
- Sahu, Nisebita;
- Stephan, Jean-Philippe;
- Cruz, Darlene Dela;
- Merchant, Mark;
- Haley, Benjamin;
- Bourgon, Richard;
- Classon, Marie;
- Settleman, Jeff
Publication type:
Article
Combination strategies for repair, plasticity, and regeneration using regulation of gene expression during the chronic phase after spinal cord injury.
Published in:
Synapse, 2011, v. 65, n. 12, p. 1255, doi. 10.1002/syn.20903
By:
- Gerin, Christine G.;
- Madueke, Ikenna C.;
- Perkins, Tina;
- Hill, Seritta;
- Smith, Kristin;
- Haley, Benjamin;
- Allen, Shannon A.;
- Garcia, Richard P.;
- Paunesku, Tanjana;
- Woloschak, Gayle
Publication type:
Article
CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing.
Published in:
Cell Death & Disease, 2018, v. 9, n. 3, p. 1, doi. 10.1038/s41419-018-0301-y
By:
- Callow, Marinella G.;
- Watanabe, Colin;
- Wickliffe, Katherine E.;
- Bainer, Russell;
- Kummerfield, Sarah;
- Weng, Julie;
- Cuellar, Trinna;
- Janakiraman, Vasantharajan;
- Chen, Honglin;
- Chih, Ben;
- Liang, Yuxin;
- Haley, Benjamin;
- Newton, Kim;
- Costa, Michael R.
Publication type:
Article
The Effects of Radiation and Dose-Fractionation on Cancer and Non-Tumor Disease Development.
Published in:
International Journal of Environmental Research & Public Health, 2012, v. 9, n. 12, p. 4688, doi. 10.3390/ijerph9124688
By:
- Liu, William;
- Haley, Benjamin M.;
- Kwasny, Mary J.;
- Jian-Jian Li;
- Grdina, David J.;
- Paunesku, Tatjana;
- Woloschak, Gayle E.
Publication type:
Article
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Published in:
Nature, 2015, v. 526, n. 7575, p. 666, doi. 10.1038/nature15541
By:
- Kayagaki, Nobuhiko;
- Stowe, Irma B.;
- Lee, Bettina L.;
- O'Rourke, Karen;
- Anderson, Keith;
- Warming, Søren;
- Cuellar, Trinna;
- Haley, Benjamin;
- Roose-Girma, Merone;
- Phung, Qui T.;
- Liu, Peter S.;
- Lill, Jennie R.;
- Li, Hong;
- Wu, Jiansheng;
- Kummerfeld, Sarah;
- Zhang, Juan;
- Lee, Wyne P.;
- Snipas, Scott J.;
- Salvesen, Guy S.;
- Morris, Lucy X.
Publication type:
Article
Non-canonical reader modules of BAZ1A promote recovery from DNA damage.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00866-0
By:
- Oppikofer, Mariano;
- Sagolla, Meredith;
- Haley, Benjamin;
- Zhang, Hui-Min;
- Kummerfeld, Sarah K.;
- Sudhamsu, Jawahar;
- Flynn, E. Megan;
- Bai, Tianyi;
- Zhang, Jennifer;
- Ciferri, Claudio;
- Cochran, Andrea G.
Publication type:
Article
PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2019, v. 39, n. 24, p. 4636, doi. 10.1523/JNEUROSCI.0116-19.2019
By:
- Fleck, Daniel;
- Phu, Lilian;
- Verschueren, Erik;
- Hinkle, Trent;
- Reichelt, Mike;
- Bhangale, Tushar;
- Haley, Benjamin;
- Yuanyuan Wang;
- Graham, Robert;
- Kirkpatrick, Donald S.;
- Sheng, Morgan;
- Bingol, Baris
Publication type:
Article
Plasmid‐Based Donor Templates for Nonviral CRISPR/Cas9‐Mediated Gene Knock‐In in Human T Cells.
Published in:
Current Protocols, 2022, v. 2, n. 9, p. 1, doi. 10.1002/cpz1.538
By:
- Senger, Kate;
- Akhmetzyanova, Ilseyar;
- Haley, Benjamin;
- Rutz, Sascha;
- Oh, Soyoung A.
Publication type:
Article
A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.
Published in:
PLoS ONE, 2018, v. 13, n. 6, p. 1, doi. 10.1371/journal.pone.0199264
By:
- Dompe, Nicholas;
- Klijn, Christiaan;
- Watson, Sara A.;
- Leng, Katherine;
- Port, Jenna;
- Cuellar, Trinna;
- Watanabe, Colin;
- Haley, Benjamin;
- Neve, Richard;
- Evangelista, Marie;
- Stokoe, David
Publication type:
Article
Pyruvate Kinase Muscle‐1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.
Published in:
Biotechnology Journal, 2019, v. 14, n. 4, p. N.PAG, doi. 10.1002/biot.201800332
By:
- Tang, Danming;
- Subramanian, Jayashree;
- Haley, Benjamin;
- Baker, Jordan;
- Luo, Lucas;
- Hsu, Wendy;
- Liu, Peter;
- Sandoval, Wendy;
- Laird, Michael W.;
- Snedecor, Brad;
- Shiratori, Masaru;
- Misaghi, Shahram
Publication type:
Article
Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases.
Published in:
Science Signaling, 2013, v. 6, n. 271, p. 1, doi. 10.1126/scisignal.2003572
By:
- Guanglei Zhuang;
- Kebing Yu;
- Zhaoshi Jiang;
- Alicia Chung;
- Jenny Yao;
- Connie Ha;
- Toy, Karen;
- Soriano, Robert;
- Haley, Benjamin;
- Blackwood, Elizabeth;
- Sampath, Deepak;
- Bais, Carlos;
- Lill, Jennie R.;
- Ferrara, Napoleone
Publication type:
Article

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