Works by Hajjar, Roger J.

Results: 99

Enhancing atrial‐specific gene expression using a calsequestrin cis‐regulatory module 4 with a sarcolipin promoter.

Published in:

Journal of Gene Medicine, 2018, v. 20, n. 12, p. N.PAG, doi. 10.1002/jgm.3060

By:

Yoo, Jimeen;
Kohlbrenner, Erik;
Kim, Okkil;
Hajjar, Roger J.;
Jeong, Dongtak

Publication type:

Article

Gene delivery methods in cardiac gene therapy.

Published in:

Journal of Gene Medicine, 2011, v. 13, n. 10, p. 566, doi. 10.1002/jgm.1609

By:

Ishikawa, Kiyotake;
Tilemann, Lisa;
Fish, Kenneth;
Hajjar, Roger J.

Publication type:

Article

Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis.

Published in:

Basic Research in Cardiology, 2010, v. 105, n. 5, p. 573, doi. 10.1007/s00395-010-0106-3

By:

Guoli Chen;
Xiaoyang Zhou;
Florea, Stela;
Jiang Qian;
Wenfeng Cai;
Zhiguo Zhang;
Guo-Chang Fan;
Lorenz, John;
Hajjar, Roger J.;
Kranias, Evangelia G.

Publication type:

Article

Targeting Ca<sup>2+</sup> cycling proteins and the action potential in heart failure by gene transfer.

Published in:

Basic Research in Cardiology, 2002, v. 97, p. I136, doi. 10.1007/s003950200042

By:

Kaprielian, Roger;
del Monte, Federica;
Hajjar, Roger J.

Publication type:

Article

Targeting calcium cycling proteins in heart failure through gene transfer.

Published in:

Journal of Physiology, 2003, v. 546, n. 1, p. 49, doi. 10.1113/jphysiol.2002.026732

By:

Monte, Federica;
Hajjar, Roger J.

Publication type:

Article

A role for calcium in resistin transcriptional activation in diabetic hearts.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34112-4

By:

Singh, Rajvir;
Moreno, Pedro;
Hajjar, Roger J.;
Lebeche, Djamel

Publication type:

Article

Ventricular Arrhythmias after Left Ventricular Assist Device Implantation.

Published in:

Pacing & Clinical Electrophysiology, 2008, v. 31, n. 10, p. 1246, doi. 10.1111/j.1540-8159.2008.01173.x

By:

REFAAT, MARWAN;
CHEMALY, ELIE;
LEBECHE, DJAMEL;
GWATHMEY, JUDITH K.;
HAJJAR, ROGER J.

Publication type:

Article

The heart of the matter.

Published in:

2011

By:

Hajjar, Roger J.

Publication type:

Book Review

Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair.

Published in:

Nature Medicine, 2007, v. 13, n. 8, p. 962, doi. 10.1038/nm1619

By:

Kühn, Bernhard;
del Monte, Federica;
Hajjar, Roger J.;
Yuh-Shin Chang;
Lebeche, Djamel;
Arab, Shima;
Keating, Mark T.

Publication type:

Article

RAF1 mutations in childhood-onset dilated cardiomyopathy.

Published in:

Nature Genetics, 2014, v. 46, n. 6, p. 635, doi. 10.1038/ng.2963

By:

Dhandapany, Perundurai S;
Razzaque, Md Abdur;
Muthusami, Uthiralingam;
Kunnoth, Sreejith;
Edwards, Jonathan J;
Mulero-Navarro, Sonia;
Riess, Ilan;
Pardo, Sherly;
Sheng, Jipo;
Rani, Deepa Selvi;
Rani, Bindu;
Govindaraj, Periyasamy;
Flex, Elisabetta;
Yokota, Tomohiro;
Furutani, Michiko;
Nishizawa, Tsutomu;
Nakanishi, Toshio;
Robbins, Jeffrey;
Limongelli, Giuseppe;
Hajjar, Roger J

Publication type:

Article

AKT signalling in the failing heart.

Published in:

European Journal of Heart Failure, 2011, v. 13, n. 8, p. 825, doi. 10.1093/eurjhf/hfr080

By:

Chaanine, Antoine H.;
Hajjar, Roger J.

Publication type:

Article

Surgical and physiological challenges in the development of left and right heart failure in rat models.

Published in:

2019

By:

Katz, Michael G.;
Fargnoli, Anthony S.;
Gubara, Sarah M.;
Chepurko, Elena;
Bridges, Charles R.;
Hajjar, Roger J.

Publication type:

journal article

Experimental models of cardiac physiology and pathology.

Published in:

2019

By:

Oh, Jae Gyun;
Kho, Changwon;
Hajjar, Roger J.;
Ishikawa, Kiyotake

Publication type:

journal article

Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.

Published in:

Biological Research, 2021, v. 54, n. 1, p. 1, doi. 10.1186/s40659-021-00342-6

By:

Ramos-Kuri, Manuel;
Meka, Sri Harika;
Salamanca-Buentello, Fabio;
Hajjar, Roger J.;
Lipskaia, Larissa;
Chemaly, Elie R.

Publication type:

Article

PRESERVATION OF MECHANICAL AND ENERGETIC FUNCTION AFTER ADENOVIRAL GENE TRANSFER IN NORMAL RAT HEARTS.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2007, v. 34, n. 12, p. 1300, doi. 10.1111/j.1440-1681.2007.04742.x

By:

Sakata, Susumu;
Liang, Lifan;
Sakata, Naoya;
Sakata, Yuri;
Chemaly, Elie R.;
Lebeche, Djamel;
Takewa, Yoshiaki;
Jiqiu Chen;
Woo Jin Park;
Kawase, Yoshiaki;
Hajjar, Roger J.

Publication type:

Article

Combination Proximal Pulmonary Artery Coiling and Distal Embolization Induces Chronic Elevations in Pulmonary Artery Pressure in Swine.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0124526

By:

Aguero, Jaume;
Ishikawa, Kiyotake;
Fish, Kenneth M.;
Hammoudi, Nadjib;
Hadri, Lahouaria;
Garcia-Alvarez, Ana;
Ibanez, Borja;
Fuster, Valentin;
Hajjar, Roger J.;
Leopold, Jane A.

Publication type:

Article

Active Inhibitor-1 Maintains Protein Hyper-Phosphorylation in Aging Hearts and Halts Remodeling in Failing Hearts.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0080717

By:

Pritchard, Tracy J.;
Kawase, Yoshiaki;
Haghighi, Kobra;
Anjak, Ahmad;
Cai, Wenfeng;
Jiang, Min;
Nicolaou, Persoulla;
Pylar, George;
Karakikes, Ioannis;
Rapti, Kleopatra;
Rubinstein, Jack;
Hajjar, Roger J.;
Kranias, Evangelia G.

Publication type:

Article

Stimulating Myocardial Regeneration with Periostin Peptide in Large Mammals Improves Function Post-Myocardial Infarction but Increases Myocardial Fibrosis

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0059656

By:

Ladage, Dennis;
Yaniz-Galende, Elisa;
Rapti, Kleopatra;
Ishikawa, Kiyotake;
Tilemann, Lisa;
Shapiro, Scott;
Takewa, Yoshiaki;
Muller-Ehmsen, Jochen;
Schwarz, Martin;
Garcia, Mario J.;
Sanz, Javier;
Hajjar, Roger J.;
Kawase, Yoshiaki

Publication type:

Article

AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction- Induced Heart Failure.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043282

By:

Chang Sik Park;
Hyeseon Cha;
Eun Jeong Kwon;
Dongtak Jeong;
Hajjar, Roger J.;
Kranias, Evangelia G.;
Chunghee Cho;
Woo Jin Park;
Do Han Kim;
Kirchmair, Rudolf

Publication type:

Article

Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027417

By:

Ji-Dong Fu;
Rushing, Stephanie N.;
Lieu, Deborah K.;
Chan, Camie W.;
Chi-Wing Kong;
Lin Geng;
Wilson, Kitchener D.;
Chiamvimonvat, Nipavan;
Boheler, Kenneth R.;
Wu, Joseph C.;
Keller, Gordon;
Hajjar, Roger J.;
Li, Ronald A.

Publication type:

Article

Assessment of Cardiovascular Fibrosis Using Novel Fluorescent Probes.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019097

By:

Jiqiu Chen;
Seung Koo Lee;
Abd-Elgaliel, Wael R.;
Lifan Liang;
Galende, Elisa-Yaniz;
Hajjar, Roger J.;
Ching-Hsuan Tung

Publication type:

Article

Gene Remodeling in Type 2 Diabetic Cardiomyopathy and Its Phenotypic Rescue with SERCA2a.

Published in:

PLoS ONE, 2009, v. 4, n. 7, p. 1, doi. 10.1371/journal.pone.0006474

By:

Karakikes, Ioannis;
Kim, Maengjo;
Hadri, Lahouaria;
Sakata, Susumu;
Yezhou Sun;
Weijia Zhang;
Chemaly, Elie R.;
Hajjar, Roger J.;
Lebeche, Djamel

Publication type:

Article

In vivo myocardial distribution of multipotent progenitor cells following intracoronary delivery in a swine model of myocardial infarction.

Published in:

European Heart Journal, 2009, v. 30, n. 23, p. 2861, doi. 10.1093/eurheartj/ehp322

By:

Ly, Hung Q.;
Hoshino, Kozo;
Pomerantseva, Irina;
Kawase, Yoshiaki;
Yoneyama, Ryuichi;
Takewa, Yoshiaki;
Fortier, Annik;
Gibbs-Strauss, Summer L.;
Vooght, Carrie;
Frangioni, John V.;
Hajjar, Roger J.

Publication type:

Article

CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia–reperfusion injury

Published in:

Cardiovascular Research, 2007, v. 73, n. 4, p. 689, doi. 10.1016/j.cardiores.2006.12.003

By:

Vila-Petroff, Martin;
Salas, Margarita A.;
Said, Matilde;
Valverde, Carlos A.;
Sapia, Luciana;
Portiansky, Enrique;
Hajjar, Roger J.;
Kranias, Evangelia G.;
Mundiña-Weilenmann, Cecilia;
Mattiazzi, Alicia

Publication type:

Article

In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts

Published in:

Cardiovascular Research, 2005, v. 66, n. 2, p. 318, doi. 10.1016/j.cardiores.2004.06.028

By:

Schmidt, Ulrich;
Zhu, Xinsheng;
Lebeche, Djamel;
Huq, Fawzia;
Guerrero, J. Luis;
Hajjar, Roger J.

Publication type:

Article

Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss.

Published in:

Cardiovascular Research, 1996, v. 31, n. 2, p. 249, doi. 10.1016/S0008-6363(95)00195-6

By:

Paige, John A.;
Liao, Ronligh;
Hajjar, Roger J.;
Foisy, Rebecca L.;
Cory, C.Robert;
O'Brien, Peter J.;
Gwathmey, Judith K.

Publication type:

Article

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.

Published in:

FASEB Journal, 2014, v. 28, n. 2, p. 644, doi. 10.1096/fj.13-228007

By:

Turnbull, Irene C.;
Karakikes, Ioannis;
Serrao, Gregory W.;
Backeris, Peter;
Jia-Jye Lee;
Chaoqin Xie;
Senyei, Grant;
Gordon, Ronald E.;
Li, Ronald A.;
Akar, Fadi G.;
Hajjar, Roger J.;
Hulot, Jean-Sébastien;
Costa, Kevin D.

Publication type:

Article

Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy.

Published in:

FASEB Journal, 2010, v. 24, n. 2, p. 451, doi. 10.1096/fj.09-136622

By:

Hongwei Jin;
Chemaly, Elie R.;
Ahyoung Lee;
Changwon Kho;
Hadri, Lahouaria;
Hajjar, Roger J.;
Akar, Fadi G.

Publication type:

Article

Transcriptional changes following restoration of SERCA2a levels in failing rat hearts.

Published in:

FASEB Journal, 2004, v. 18, n. 12, p. 1474, doi. 10.1096/fj.04-1714fje

By:

Del Monte, Federica;
Dalal, Rishikesh;
Tabchy, Adel;
Couget, Jennifer;
Bloch, Kenneth D.;
Peterson, Randall;
Hajjar, Roger J.

Publication type:

Article

Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes.

Published in:

Stem Cells Translational Medicine, 2014, v. 3, n. 1, p. 18, doi. 10.5966/sctm.2013-0110

By:

KARAKIKES, IOANNIS;
SENYEI, GRANT D.;
HANSEN, JENS;
CHI-WING KONG;
AZELOGLU, EVREN U.;
STILLITANO, FRANCESCA;
LIEU, DEBORAH K.;
JIAXIAN WANG;
LIHUAN REN;
HULOT, JEAN-SEBASTIEN;
IYENGAR, RAVI;
LI, RONALD A.;
HAJJAR, ROGER J.

Publication type:

Article

Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 3, p. 1329, doi. 10.1172/JCI71059

By:

Cook, Jason R.;
Carta, Luca;
Bénard, Ludovic;
Chemaly, Elie R.;
Chiu, Emily;
Rao, Satish K.;
Hampton, Thomas G.;
Yurchenco, Peter;
Costa, Kevin D.;
Hajjar, Roger J.;
Ramirez, Francesco

Publication type:

Article

Potential of gene therapy as a treatment for heart failure.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 1, p. 53, doi. 10.1172/JCI62837

By:

Hajjar, Roger J.

Publication type:

Article

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.

Published in:

2011

By:

Goonasekera, Sanjeewa A.;
Lam, Chi K.;
Millay, Douglas P.;
Sargent, Michelle A.;
Hajjar, Roger J.;
Kranias, Evangelia G.;
Molkentin, Jeffery D.

Publication type:

journal article

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy.

Published in:

Scientific Reports, 2015, p. 18132, doi. 10.1038/srep18132

By:

Das, Subhash K.;
Wang, Wang;
Zhabyeyev, Pavel;
Basu, Ratnadeep;
McLean, Brent;
Fan, Dong;
Parajuli, Nirmal;
DesAulniers, Jessica;
Patel, Vaibhav B.;
Hajjar, Roger J.;
Dyck, Jason R. B.;
Kassiri, Zamaneh;
Oudit, Gavin Y.

Publication type:

Article

Multimodality Imaging of Chronic Ischemia.

Published in:

Cardiology Research & Practice, 2011, p. 1, doi. 10.4061/2011/739702

By:

Ishikawa, Kiyotake;
Ladage, Dennis;
Rapti, Kleopatra;
Fernandez-Friera, Leticia;
Garcia-Lopez, Ana Maria;
Sanz, Javier;
Hajjar, Roger J.;
Kawase, Yoshiaki;
Garcia, Mario J.

Publication type:

Article

Cytokine-Like 1 Regulates Cardiac Fibrosis via Modulation of TGF-β Signaling.

Published in:

PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0166480

By:

Kim, Jooyeon;
Kim, Jihwa;
Lee, Seung Hee;
Kepreotis, Sacha V.;
Yoo, Jimeen;
Chun, Jang-Soo;
Hajjar, Roger J.;
Jeong, Dongtak;
Park, Woo Jin

Publication type:

Article

Deletion of delta-like 1 homologue accelerates fibroblast–myofibroblast differentiation and induces myocardial fibrosis.

Published in:

European Heart Journal, 2019, v. 40, n. 12, p. 967, doi. 10.1093/eurheartj/ehy188

By:

Rodriguez, Patricia;
Sassi, Yassine;
Troncone, Luca;
Benard, Ludovic;
Ishikawa, Kiyotake;
Gordon, Ronald E;
Lamas, Santiago;
Laborda, Jorge;
Hajjar, Roger J;
Lebeche, Djamel

Publication type:

Article

Genetic maneuvers to ameliorate ventricular function in heart failure: therapeutic potential and future implications.

Published in:

Expert Review of Cardiovascular Therapy, 2005, v. 3, n. 1, p. 85, doi. 10.1586/14779072.3.1.85

By:

Bukhari, Fariya;
MacGillivray, Thomas;
del Monte, Federica;
Hajjar, Roger J.

Publication type:

Article

Quantitation of CXCR4 Expression in Myocardial Infarction Using <sup>99m</sup>Tc-Labeled SDF-1α.

Published in:

Journal of Nuclear Medicine, 2008, v. 49, n. 6, p. 963, doi. 10.2967/jnumed.107.050054

By:

Misra, Preeti;
Lebeche, Djamel;
Hung Ly;
Schwarzkopf, Martina;
Diaz, George;
Hajjar, Roger J.;
Schecter, Alison D.;
Frangioni, John V.

Publication type:

Article

Molecular targets in heart failure gene therapy: current controversies and translational perspectives.

Published in:

Annals of the New York Academy of Sciences, 2012, v. 1254, n. 1, p. 42, doi. 10.1111/j.1749-6632.2012.06520.x

By:

Kairouz, Victor;
Lipskaia, Larissa;
Hajjar, Roger J.;
Chemaly, Elie R.

Publication type:

Article

Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives.

Published in:

Advanced Materials, 2011, v. 23, n. 48, p. 5785, doi. 10.1002/adma.201103463

By:

Chen, Aaron;
Lieu, Deborah K.;
Freschauf, Lauren;
Lew, Valerie;
Sharma, Himanshu;
Wang, Jiaxian;
Nguyen, Diep;
Karakikes, Ioannis;
Hajjar, Roger J.;
Gopinathan, Ajay;
Botvinick, Elliot;
Fowlkes, Charless C.;
Li, Ronald A.;
Khine, Michelle

Publication type:

Article

3444 Development of human engineered cardiac tissue (hECT)-based screening assay to explore cardiac contractile properties in response to pharmacological challenge with proarrhythmic drugs.

Published in:

2019

By:

Stillitano, Francesca;
Turnbull, Irene C.;
Dave, Jaydev;
Hulot, Jean-Sébastien;
Hajjar, Roger J.

Publication type:

Abstract

High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy.

Published in:

Physiological Reports, 2015, v. 3, n. 7, p. 1, doi. 10.14814/phy2.12413

By:

Chaanine, Antoine H.;
Gordon, Ronald E.;
Nonnenmacher, Mathieu;
Kohlbrenner, Erik;
Benard, Ludovic;
Hajjar, Roger J.

Publication type:

Article

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.

Published in:

European Heart Journal, 2016, v. 37, n. 43, p. 3282, doi. 10.1093/eurheartj/ehw307

By:

Stillitano, Francesca;
Turnbull, Irene C.;
Karakikes, Ioannis;
Nonnenmacher, Mathieu;
Backeris, Peter;
Hulot, Jean-Sébastien;
Kranias, Evangelia G.;
Hajjar, Roger J.;
Costa, Kevin D.

Publication type:

Article

Gene therapy for the treatment of heart failure: promise postponed.

Published in:

European Heart Journal, 2016, v. 37, n. 21, p. 1651, doi. 10.1093/eurheartj/ehw019

By:

Hulot, Jean-Sebastien;
Ishikawa, Kiyotake;
Hajjar, Roger J.

Publication type:

Article

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway.

Published in:

European Heart Journal, 2012, v. 33, n. 9, p. 1067, doi. 10.1093/eurheartj/ehs043

By:

Kumarswamy, Regalla;
Lyon, Alexander R.;
Volkmann, Ingo;
Mills, Adam M.;
Bretthauer, Julia;
Pahuja, Aanchal;
Geers-Knörr, Cornelia;
Kraft, Theresia;
Hajjar, Roger J.;
Macleod, Kenneth T.;
Harding, Sian E.;
Thum, Thomas

Publication type:

Article

Echocardiographic and hemodynamic assessment for predicting early clinical events in severe acute mitral regurgitation.

Published in:

2018

By:

Watanabe, Shin;
Fish, Kenneth;
Bonnet, Guillaume;
Santos-Gallego, Carlos G.;
Leonardson, Lauren;
Hajjar, Roger J.;
Ishikawa, Kiyotake

Publication type:

journal article

High Capsid-Genome Correlation Facilitates Creation of AAV Libraries for Directed Evolution.

Published in:

Molecular Therapy, 2015, v. 23, n. 4, p. 675, doi. 10.1038/mt.2015.3

By:

Nonnenmacher, Mathieu;
van Bakel, Harm;
Hajjar, Roger J;
Weber, Thomas

Publication type:

Article

Cardiac I-1c Overexpression With Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure.

Published in:

Molecular Therapy, 2014, v. 22, n. 12, p. 2038, doi. 10.1038/mt.2014.127

By:

Ishikawa, Kiyotake;
Fish, Kenneth M;
Tilemann, Lisa;
Rapti, Kleopatra;
Aguero, Jaume;
Santos-Gallego, Carlos G;
Lee, Ahyoung;
Karakikes, Ioannis;
Xie, Chaoqin;
Akar, Fadi G;
Shimada, Yuichi J;
Gwathmey, Judith K;
Asokan, Aravind;
McPhee, Scott;
Samulski, Jade;
Samulski, Richard Jude;
Sigg, Daniel C;
Weber, Thomas;
Kranias, Evangelia G;
Hajjar, Roger J

Publication type:

Article

Concomitant Intravenous Nitroglycerin With Intracoronary Delivery of AAV1.SERCA2a Enhances Gene Transfer in Porcine Hearts.

Published in:

Molecular Therapy, 2012, v. 20, n. 3, p. 565, doi. 10.1038/mt.2011.268

By:

Karakikes, Ioannis;
Hadri, Lahouaria;
Rapti, Kleopatra;
Ladage, Dennis;
Ishikawa, Kiyotake;
Tilemann, Lisa;
Yi, Geng-Hua;
Morel, Charlotte;
Gwathmey, Judith K;
Zsebo, Krisztina;
Weber, Thomas;
Kawase, Yoshiaki;
Hajjar, Roger J

Publication type:

Article