Works by Haeusler, Aaron R

Results: 11

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.

Published in:

EMBO Reports, 2024, v. 25, n. 5, p. 2479, doi. 10.1038/s44319-024-00140-7

By:

Nelson, Andrew T;
Cicardi, Maria Elena;
Markandaiah, Shashirekha S;
Han, John YS;
Philp, Nancy J;
Welebob, Emily;
Haeusler, Aaron R;
Pasinelli, Piera;
Manfredi, Giovanni;
Kawamata, Hibiki;
Trotti, Davide

Publication type:

Article

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Published in:

Nature, 2015, v. 525, n. 7567, p. 56, doi. 10.1038/nature14973

By:

Zhang, Ke;
Donnelly, Christopher J.;
Haeusler, Aaron R.;
Grima, Jonathan C.;
Machamer, James B.;
Steinwald, Peter;
Daley, Elizabeth L.;
Miller, Sean J.;
Cunningham, Kathleen M.;
Vidensky, Svetlana;
Gupta, Saksham;
Thomas, Michael A.;
Hong, Ingie;
Chiu, Shu-Ling;
Huganir, Richard L.;
Ostrow, Lyle W.;
Matunis, Michael J.;
Wang, Jiou;
Sattler, Rita;
Lloyd, Thomas E.

Publication type:

Article

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

Published in:

Nature, 2014, v. 507, n. 7491, p. 195, doi. 10.1038/nature13124

By:

Haeusler, Aaron R.;
Donnelly, Christopher J.;
Periz, Goran;
Simko, Eric A. J.;
Shaw, Patrick G.;
Kim, Min-Sik;
Maragakis, Nicholas J.;
Troncoso, Juan C.;
Pandey, Akhilesh;
Sattler, Rita;
Rothstein, Jeffrey D.;
Wang, Jiou

Publication type:

Article

A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09593-z

By:

Verdone, Brandie Morris;
Cicardi, Maria Elena;
Wen, Xinmei;
Sriramoji, Sindhu;
Russell, Katelyn;
Markandaiah, Shashirekha S.;
Jensen, Brigid K.;
Krishnamurthy, Karthik;
Haeusler, Aaron R.;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-02041-4

By:

Ozcan, Kadir. A.;
Ghaffari, Layla T.;
Haeusler, Aaron R.

Publication type:

Article

G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 13, p. 7421, doi. 10.1093/nar/gkaa475

By:

Simko, Eric A J;
Liu, Honghe;
Zhang, Tao;
Velasquez, Adan;
Teli, Shraddha;
Haeusler, Aaron R;
Wang, Jiou

Publication type:

Article

FRET studies of a landscape of Lac repressor-mediated DNA loops.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 10, p. 4432, doi. 10.1093/nar/gks019

By:

Haeusler, Aaron R.;
Goodson, Kathy A.;
Lillian, Todd D.;
Wang, Xiaoyu;
Goyal, Sachin;
Perkins, Noel C.;
Kahn, Jason D.

Publication type:

Article

Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ALS/FTD is rescued by SV2 replenishment.

Published in:

EMBO Molecular Medicine, 2020, v. 12, n. 5, p. 1, doi. 10.15252/emmm.201910722

By:

Jensen, Brigid K;
Schuldi, Martin H;
McAvoy, Kevin;
Russell, Katelyn A;
Boehringer, Ashley;
Curran, Bridget M;
Krishnamurthy, Karthik;
Wen, Xinmei;
Westergard, Thomas;
Ma, Le;
Haeusler, Aaron R;
Edbauer, Dieter;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Breakdown of the central synapses in C9orf72-linked ALS/FTD.

Published in:

Frontiers in Molecular Neuroscience, 2022, v. 15, p. 1, doi. 10.3389/fnmol.2022.1005112

By:

Ghaffari, Layla T.;
Trotti, Davide;
Haeusler, Aaron R.;
Jensen, Brigid K.

Publication type:

Article

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis‐linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.

Published in:

Glia (0894-1491), 2022, v. 70, n. 7, p. 1426, doi. 10.1002/glia.24183

By:

Jensen, Brigid K.;
McAvoy, Kevin J.;
Heinsinger, Nicolette M.;
Lepore, Angelo C.;
Ilieva, Hristelina;
Haeusler, Aaron R.;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Emerging role of RNA•DNA hybrids in C9orf72 -linked neurodegeneration.

Published in:

Cell Cycle, 2015, v. 14, n. 4, p. 526, doi. 10.1080/15384101.2014.995490

By:

Wang, Jiou;
Haeusler, Aaron R;
Simko, Eric Aj

Publication type:

Article