Works by Härkönen, Pirkko

Results: 48

Oncolytic alphavirus SFV-VA7 efficiently eradicates subcutaneous and orthotopic human prostate tumours in mice.

Published in:

2017

By:

Martikainen, Miika;
Ruotsalainen, Janne;
Tuomela, Johanna;
Härkönen, Pirkko;
Essand, Magnus;
Heikkilä, Jari;
Hinkkanen, Ari;
Härkönen, Pirkko;
Heikkilä, Jari

Publication type:

journal article

Breast cancer in neurofibromatosis type 1: overrepresentation of unfavourable prognostic factors.

Published in:

2017

By:

Uusitalo, Elina;
Kallionpää, Roope A;
Kurki, Samu;
Rantanen, Matti;
Pitkäniemi, Janne;
Kronqvist, Pauliina;
Härkönen, Pirkko;
Huovinen, Riikka;
Carpen, Olli;
Pöyhönen, Minna;
Peltonen, Sirkku;
Peltonen, Juha;
Kallionpää, Roope A;
Pitkäniemi, Janne;
Härkönen, Pirkko;
Pöyhönen, Minna

Publication type:

journal article

68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats--comparison with FDG.

Published in:

2010

By:

Ujula, Tiina;
Salomäki, Satu;
Autio, Anu;
Luoto, Pauliina;
Tolvanen, Tuula;
Lehikoinen, Pertti;
Viljanen, Tapio;
Sipilä, Hannu;
Härkönen, Pirkko;
Roivainen, Anne;
Salomäki, Satu;
Sipilä, Hannu;
Härkönen, Pirkko

Publication type:

journal article

SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells.

Published in:

Inflammation, 2018, v. 41, n. 4, p. 1157, doi. 10.1007/s10753-018-0763-1

By:

Polari, Lauri;
Wiklund, Anu;
Sousa, Sofia;
Kangas, Lauri;
Linnanen, Tero;
Härkönen, Pirkko;
Määttä, Jorma

Publication type:

Article

<sup>68</sup>Ga-Labeled Oligonucleotides for In Vivo Imaging with PET.

Published in:

Journal of Nuclear Medicine, 2004, v. 45, n. 2, p. 347

By:

Roivainen, Anne;
Tolvanen, Tuula;
Salomäki, Satu;
Lendvai, Gabor;
Velikyan, Irina;
Numminen, Petri;
Välilä, Maria;
Sipilä, Hannu;
Bergström, Mats;
Härkönen, Pirkko;
Lönnberg, Harri;
Långström, Bengt

Publication type:

Article

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.

Published in:

Clinical & Experimental Metastasis, 2016, v. 33, n. 4, p. 325, doi. 10.1007/s10585-016-9781-2

By:

Valta, Maija;
Zhao, Hongjuan;
Saar, Matthias;
Tuomela, Johanna;
Nolley, Rosalie;
Linxweiler, Johannes;
Sandholm, Jouko;
Lehtimäki, Jaakko;
Härkönen, Pirkko;
Coleman, Ilsa;
Nelson, Peter;
Corey, Eva;
Peehl, Donna

Publication type:

Article

Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.

Published in:

Cell Biology International, 2010, v. 34, n. 8, p. 815, doi. 10.1042/CBI20090288

By:

Virtanen, Sanna S.;
Sandholm, Jouko;
Yegutkin, Gennady;
Väänänen, H. Kalervo;
Härkönen, Pirkko L.

Publication type:

Article

A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue.

Published in:

Biological Chemistry, 2007, v. 388, n. 3, p. 289, doi. 10.1515/BC.2007.032

By:

Valtonen-André, Camilla;
Bjartell, Anders;
Hellsten, Rebecka;
Lilja, Hans;
Härkönen, Pirkko;
Lundwall, Åke

Publication type:

Article

Interaction of male and female sex hormones in cultured rat prostate.

Published in:

Prostate, 1987, v. 11, n. 4, p. 291, doi. 10.1002/pros.2990110402

By:

Mäkelä, Sari I.;
Santti, Risto S. S.;
Härkönen, Pirkko L.;
Suominen, Jyrki J. O.;
Martikainen, Paula M.

Publication type:

Article

Morphological studies on the effect of taxol on cultured human prostatic cancer cells.

Published in:

Prostate, 1987, v. 11, n. 1, p. 95, doi. 10.1002/pros.2990110112

By:

Röyttä, Matias;
Laine, Kirsi-Marja;
Härkönen, Pirkko

Publication type:

Article

Tracer level electrophilic synthesis and pharmacokinetics of the hypoxia tracer [(18)F]EF5.

Published in:

2012

By:

Eskola O;
Grönroos TJ;
Forsback S;
Tuomela J;
Komar G;
Bergman J;
Härkönen P;
Haaparanta M;
Minn H;
Solin O;
Eskola, Olli;
Grönroos, Tove J;
Forsback, Sarita;
Tuomela, Johanna;
Komar, Gaber;
Bergman, Jörgen;
Härkönen, Pirkko;
Haaparanta, Merja;
Minn, Heikki;
Solin, Olof

Publication type:

journal article

Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [F]EF5.

Published in:

Molecular Imaging & Biology, 2012, v. 14, n. 2, p. 205, doi. 10.1007/s11307-011-0484-4

By:

Eskola, Olli;
Grönroos, Tove;
Forsback, Sarita;
Tuomela, Johanna;
Komar, Gaber;
Bergman, Jörgen;
Härkönen, Pirkko;
Haaparanta, Merja;
Minn, Heikki;
Solin, Olof

Publication type:

Article

Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice.

Published in:

International Journal of Cancer, 1991, v. 49, n. 4, p. 616, doi. 10.1002/ijc.2910490425

By:

Wärri, Anni M.;
Laine, Aire M.;
Majasuo, Karin E.;
Alitalo, Kari K.;
Härkönen, Pirkko L.

Publication type:

Article

Estrogen and Testosterone Use Different Cellular Pathways to Inhibit Osteoclastogenesis and Bone Resorption.

Published in:

Journal of Bone & Mineral Research, 2005, v. 20, n. 12, p. 2224, doi. 10.1359/JBMR.050803

By:

Michael, Husheem;
Härkönen, Pirkko L;
Väänänen, H Kalervo;
Hentunen, Teuvo A

Publication type:

Article

The Effects of Tamoxifen and Toremifene on Bone Cells Involve Changes in Plasma Membrane Ion Conductance.

Published in:

Journal of Bone & Mineral Research, 2003, v. 18, n. 3, p. 473, doi. 10.1359/jbmr.2003.18.3.473

By:

Lehenkari, Petri;
Parikka, Vilhelmiina;
Rautiala, Timo J;
Weckström, Matti;
Dahllund, Johanna;
Härkönen, Pirkko L;
Väänänen, H Kalervo

Publication type:

Article

Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells.

Published in:

Prostate, 2010, v. 70, n. 14, p. 1491, doi. 10.1002/pros.21184

By:

Tassidis, Helena;
Culig, Zoran;
Wingren, Anette Gjörloff;
Härkönen, Pirkko

Publication type:

Article

Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer.

Published in:

Breast Cancer Research & Treatment, 2012, v. 135, n. 2, p. 481, doi. 10.1007/s10549-012-2181-7

By:

Tuomela, Johanna;
Sandholm, Jouko;
Karihtala, Peeter;
Ilvesaro, Joanna;
Vuopala, Katri;
Kauppila, Joonas;
Kauppila, Saila;
Chen, Dongquan;
Pressey, Christine;
Härkönen, Pirkko;
Harris, Kevin;
Graves, David;
Auvinen, Päivi;
Soini, Ylermi;
Jukkola-Vuorinen, Arja;
Selander, Katri

Publication type:

Article

Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture.

Published in:

Journal of Cellular Biochemistry, 1999, v. 73, n. 4, p. 500, doi. 10.1002/(SICI)1097-4644(19990615)73:4<500::AID-JCB8>3.0.CO;2-E

By:

Qu, Qiang;
Härkönen, Pirkko L.;
Väänänen, H. Kalervo

Publication type:

Article

Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells.

Published in:

Growth Factors, 2010, v. 28, n. 4, p. 256, doi. 10.3109/08977191003745480

By:

Tarkkonen, Kati;
Ruohola, Johanna;
Härkönen, Pirkko

Publication type:

Article

VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors.

Published in:

International Journal of Cancer, 2002, v. 98, n. 6, p. 946, doi. 10.1002/ijc.10283

By:

Mattila, Mirjami M-T.;
Ruohola, Johanna K.;
Karpanen, Terhi;
Jackson, David G.;
Alitalo, Kari;
Härkönen, Pirkko L.

Publication type:

Article

Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors.

Published in:

International Journal of Cancer, 2000, v. 88, n. 5, p. 718, doi. 10.1002/1097-0215(20001201)88:5<718::AID-IJC6>3.0.CO;2-F

By:

Valve, Eeva;
Martikainen, Paula;
Seppänen, Jani;
Oksjoki, Sanna;
Hinkka, Susanna;
Anttila, Leena;
Grenman, Seija;
Klemi, Pekka;
Härkönen, Pirkko

Publication type:

Article

Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues.

Published in:

Cell Cycle, 2008, v. 7, n. 1, p. 71, doi. 10.4161/cc.7.1.5102

By:

Eigėlienė, Natalija;
Härkönen, Pirkko;
Erkkola, Risto

Publication type:

Article

FGF-8b induces growth and rich vascularization in an orthotopic PC-3 model of prostate cancer.

Published in:

Journal of Cellular Biochemistry, 2009, v. 107, n. 4, p. 769, doi. 10.1002/jcb.22175

By:

Valta, Maija P.;
Tuomela, Johanna;
Vuorikoski, Heikki;
Loponen, Niina;
Väänänen, Riina-Minna;
Pettersson, Kim;
Väänänen, H. Kalervo;
Härkönen, Pirkko L.

Publication type:

Article

Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro.

Published in:

1993

By:

Wärri, Anni M.;
Huovinen, Riikka L.;
Laine, Aire M.;
Martikainen, Paula M.;
Härkönen, Pirkko L.;
Wärri, A M;
Huovinen, R L;
Laine, A M;
Martikainen, P M;
Härkönen, P L

Publication type:

journal article

Cover Image.

Published in:

Cancer Medicine, 2024, v. 13, n. 18, p. 1, doi. 10.1002/cam4.70306

By:

Afshan, Syeda;
Kim, Yu Gang;
Mattsson, Jesse;
Åkerfelt, Malin;
Härkönen, Pirkko;
Baumgartner, Martin;
Nees, Matthias

Publication type:

Article

Targeting the cancer cells and cancer‐associated fibroblasts with next‐generation FGFR inhibitors in prostate cancer co‐culture models.

Published in:

Cancer Medicine, 2024, v. 13, n. 18, p. 1, doi. 10.1002/cam4.70240

By:

Afshan, Syeda;
Kim, Yu Gang;
Mattsson, Jesse;
Åkerfelt, Malin;
Härkönen, Pirkko;
Baumgartner, Martin;
Nees, Matthias

Publication type:

Article

Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy.

Published in:

International Journal of Cancer, 2016, v. 139, n. 1, p. 140, doi. 10.1002/ijc.30048

By:

Yu, Lan;
Toriseva, Mervi;
Tuomala, Miikka;
Seikkula, Heikki;
Elo, Teresa;
Tuomela, Johanna;
Kallajoki, Markku;
Mirtti, Tuomas;
Taimen, Pekka;
Boström, Peter J.;
Alanen, Kalle;
Nurmi, Martti;
Nees, Matthias;
Härkönen, Pirkko

Publication type:

Article

Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer.

Published in:

International Journal of Cancer, 2010, v. 126, n. 10, p. 2296, doi. 10.1002/ijc.24917

By:

Tassidis, Helena;
Brokken, Leon J.S.;
Jirström, Karin;
Ehrnström, Roy;
Pontén, Fredrik;
Ulmert, David;
Bjartell, Anders;
Härkönen, Pirkko;
Wingren, Anette Gjörloff

Publication type:

Article

FGF-8 is involved in bone metastasis of prostate cancer.

Published in:

International Journal of Cancer, 2008, v. 123, n. 1, p. 22, doi. 10.1002/ijc.23422

By:

Valta, Maija P.;
Tuomela, Johanna;
Bjartell, Anders;
Valve, Eeva;
Väänänen, H. Kalervo;
Härkönen, Pirkko

Publication type:

Article

Monocyte–Macrophage System as a Target for Estrogen and Selective Estrogen Receptor Modulators.

Published in:

Annals of the New York Academy of Sciences, 2006, v. 1089, n. 1, p. 218, doi. 10.1196/annals.1386.045

By:

HÄRKÖNEN, PIRKKO L.;
VÄÄNÄNEN, H. KALERVO

Publication type:

Article

Novel interaction of Rab13 and Rab8 with endospanins.

Published in:

FEBS Open Bio, 2013, v. 3, p. 83, doi. 10.1016/j.fob.2013.01.004

By:

Hirvonen, Mirkka J.;
Büki, Kálmán G.;
Sun, Yi;
Mulari, Mika T.K.;
Härkönen, Pirkko L.;
Väänänen, Kalervo H.

Publication type:

Article

Novel interaction of Rab13 and Rab8 with endospanins.

Published in:

FEBS Open Bio, 2013, v. 3, n. 1, p. 83, doi. 10.1016/j.fob.2013.01.004

By:

Hirvonen, Mirkka J.;
Büki, Kálmán G.;
Sun, Yi;
Mulari, Mika T. K.;
Härkönen, Pirkko L.;
Väänänen, Kalervo H.

Publication type:

Article

FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells.

Published in:

Oncogene, 2001, v. 20, n. 22, p. 2791, doi. 10.1038/sj.onc.1204430

By:

Mattila, Mirjami MT;
Ruohola, Johanna K;
Valve, Eeva M;
Tasanen, Merja J;
Seppänen, Jani A;
Härkönen, Pirkko L

Publication type:

Article

Fluorescent Molecularly Imprinted Polymer Layers against Sialic Acid on Silica-Coated Polystyrene Cores—Assessment of the Binding Behavior to Cancer Cells.

Published in:

Cancers, 2022, v. 14, n. 8, p. 1875, doi. 10.3390/cancers14081875

By:

Beyer, Sarah;
Kimani, Martha;
Zhang, Yuecheng;
Verhassel, Alejandra;
Sternbæk, Louise;
Wang, Tianyan;
Persson, Jenny L.;
Härkönen, Pirkko;
Johansson, Emil;
Caraballo, Remi;
Elofsson, Mikael;
Gawlitza, Kornelia;
Rurack, Knut;
Ohlsson, Lars;
El-Schich, Zahra;
Wingren, Anette Gjörloff;
Stollenwerk, Maria M.

Publication type:

Article

Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression.

Published in:

Cancers, 2022, v. 14, n. 2, p. 278, doi. 10.3390/cancers14020278

By:

Yu, Lan;
Toriseva, Mervi;
Afshan, Syeda;
Cangiano, Mario;
Fey, Vidal;
Erickson, Andrew;
Seikkula, Heikki;
Alanen, Kalle;
Taimen, Pekka;
Ettala, Otto;
Nurmi, Martti;
Boström, Peter J.;
Kallajoki, Markku;
Tuomela, Johanna;
Mirtti, Tuomas;
Beumer, Inès J.;
Nees, Matthias;
Härkönen, Pirkko

Publication type:

Article

Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice.

Published in:

FASEB Journal, 2013, v. 27, n. 2, p. 478, doi. 10.1096/fj.12-213587

By:

ä, Jorma A. Määtt;
Büki, Kalman G.;
Guoliang Gu;
Alanne, Maria H.;
Vääräniemi, Jukka;
Liljenbäck, Heidi;
Poutanen, Matti;
Härkönen, Pirkko;
Väänänen, Kalervo

Publication type:

Article

Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts.

Published in:

BMC Cancer, 2010, v. 10, p. 596, doi. 10.1186/1471-2407-10-596

By:

Tuomela, Johanna;
Grönroos, Tove J.;
Valta, Maija P.;
Sandholm, Jouko;
Schrey, Aleksi;
Seppänen, Jani;
Marjamäki, Päivi;
Forsback, Sarita;
Kinnunen, Ilpo;
Solin, Olof;
Minn, Heikki;
Härkönen, Pirkko L.

Publication type:

Article

Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice.

Published in:

2008

By:

Tuomela JM;
Valta MP;
Väänänen K;
Härkönen PL;
Tuomela, Johanna M;
Valta, Maija P;
Väänänen, Kalervo;
Härkönen, Pirkko L

Publication type:

journal article

Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice.

Published in:

BMC Cancer, 2008, v. 8, p. 1, doi. 10.1186/1471-2407-8-81

By:

Tuomela, Johanna M.;
Valta, Maija P.;
Väänänen, Kalervo;
Härkönen, Pirkko L.

Publication type:

Article

Effects of estradiol and medroxyprogesterone acetate on morphology, proliferation and apoptosis of human breast tissue in organ cultures.

Published in:

BMC Cancer, 2006, v. 6, p. 246, doi. 10.1186/1471-2407-6-246

By:

Eigeliene, Natalija;
Härkönen, Pirkko;
Erkkola, Risto

Publication type:

Article

Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer.

Published in:

Urological Research, 2001, v. 29, n. 1, p. 25, doi. 10.1007/s002400000148

By:

Uotila, Pekka;
Valve, Eeva;
Martikainen, Paula;
Nevalainen, Marja;
Nurmi, Martti;
Härkönen, Pirkko

Publication type:

Article

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0130340

By:

Santio, Niina M.;
Eerola, Sini K.;
Paatero, Ilkka;
Yli-Kauhaluoma, Jari;
Anizon, Fabrice;
Moreau, Pascale;
Tuomela, Johanna;
Härkönen, Pirkko;
Koskinen, Päivi J.

Publication type:

Article

Cyclin A1 Modulates the Expression of Vascular Endothelial Growth Factor and Promotes Hormone-Dependent Growth and Angiogenesis of Breast Cancer.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072210

By:

Syed Khaja, Azharuddin Sajid;
Dizeyi, Nishtman;
Kopparapu, Pradeep Kumar;
Anagnostaki, Lola;
Härkönen, Pirkko;
Persson, Jenny Liao

Publication type:

Article

Differential Roles of Fibroblast Growth Factor Receptors (FGFR) 1, 2 and 3 in the Regulation of S115 Breast Cancer Cell Growth.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049970

By:

Tarkkonen, Kati M.;
Nilsson, Emeli M.;
Kähkönen, Tiina E.;
Dey, Julien H.;
Heikkilä, Jari E.;
Tuomela, Johanna M.;
Qing Liu;
Hynes, Nancy E.;
Härkönen, Pirkko L.

Publication type:

Article

Quantitative detection of cell surface protein expression by time-resolved fluorimetry.

Published in:

Luminescence: Journal of Biological & Chemical Luminescence, 2007, v. 22, n. 3, p. 163, doi. 10.1002/bio.943

By:

Huttunen, Roope J.;
O'Riordan, Tomás C.;
Härkönen, Pirkko L.;
Soini, Juhani T.;
Meltola, Niko J.;
Hänninen, Pekka E.;
Soini, Aleksi E.

Publication type:

Article

Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.

Published in:

2008

By:

Wegiel B;
Bjartell A;
Tuomela J;
Dizeyi N;
Tinzl M;
Helczynski L;
Nilsson E;
Otterbein LE;
Härkönen P;
Persson JL;
Wegiel, Barbara;
Bjartell, Anders;
Tuomela, Johanna;
Dizeyi, Nishtman;
Tinzl, Martina;
Helczynski, Leszek;
Nilsson, Elise;
Otterbein, Leo E;
Härkönen, Pirkko;
Persson, Jenny Liao

Publication type:

journal article

Multiple Cellular Mechanisms Related to Cyclin A1 in Prostate Cancer Invasion and Metastasis.

Published in:

JNCI: Journal of the National Cancer Institute, 2008, v. 100, n. 14, p. 1022, doi. 10.1093/jnci/djn214

By:

Wegiel, Barbara;
Bjartell, Anders;
Tuomela, Johanna;
Dizeyi, Nishtman;
Tinzl, Martina;
Helczynski, Leszek;
Nilsson, Elise;
Otterbein, Leo E.;
Härkönen, Pirkko;
Persson, Jenny Liao

Publication type:

Article

Primary breast cancer biomarkers based on glycosylation and extracellular vesicles detected from human serum.

Published in:

Cancer Reports, 2022, v. 5, n. 8, p. 1, doi. 10.1002/cnr2.1540

By:

Terävä, Joonas;
Verhassel, Alejandra;
Botti, Orsola;
Islam, Md. Khirul;
Leivo, Janne;
Wittfooth, Saara;
Härkönen, Pirkko;
Pettersson, Kim;
Gidwani, Kamlesh

Publication type:

Article