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Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model.
Published in:
Journal of Neuroscience, 2023, v. 43, n. 26, p. 4941, doi. 10.1523/JNEUROSCI.1945-22.2023
By:
- Landry, Olivier;
- François, Arnaud;
- Mi-Mba, Méryl-Farelle Oye Mintsa;
- Traversy, Marie-Therese;
- Tremblay, Cyntia;
- Emond, Vincent;
- Bennett, David A.;
- Gylys, Karen H.;
- Buxbaum, Joseph D.;
- Calon, Frédéric
Publication type:
Article
Phenotypic Status Explored in Parietal Cortex of Alzheimer's Patients and Non‐Demented Controls that Vary on the Spectrum of Neuropathological AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073956
By:
- Melnik, Mikhail;
- Bilousova, Tina;
- Ma, Ricky;
- Matsuo, Yuriko;
- Atluri, Swetha;
- Kodavatikanti, Achyutha;
- Knitowski, Nina;
- Gylys, Karen H
Publication type:
Article
Brain extracellular vesicles from Alzheimer's Disease and Down Syndrome patients mediate spread of senescence‐like phenotype in vitro.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077514
By:
- Bilousova, Tina;
- Melnik, Mikhail;
- Matsuo, Yuriko;
- Kodavatikanti, Achyutha;
- Knitowski, Nina;
- Atluri, Swetha;
- Gylys, Karen H
Publication type:
Article
Brain extracellular vesicles from Alzheimer's Disease and Down Syndrome patients mediate spread of senescence‐like phenotype in vitro.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077514
By:
- Bilousova, Tina;
- Melnik, Mikhail;
- Matsuo, Yuriko;
- Kodavatikanti, Achyutha;
- Knitowski, Nina;
- Atluri, Swetha;
- Gylys, Karen H
Publication type:
Article
α‐Synuclein in oligodendroglia and neuron‐derived blood exosomes distinguishes between synucleinopathies.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.056619
By:
- Dutta, Suman;
- Hornung, Simon;
- Kruayatidee, Adira;
- Maina, Katherine M;
- del Rosario, Irish;
- Paul, Kimberly;
- Palma, Jose Alberto;
- Perlman, Susan L.;
- Poon, Wayne W.;
- Gylys, Karen H;
- Kaufmann, Horacio;
- Fogel, Brent L.;
- Bronstein, Jeff M.;
- Ritz, Beate;
- Bitan, Gal
Publication type:
Article
Shank3 loss in AD is associated with cognitive symptoms and neuropathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055260
By:
- Landry, Olivier;
- François, Arnaud;
- Tremblay, Cyntia;
- Emond, Vincent;
- Gylys, Karen H;
- Buxbaum, Joel N;
- Calon, Frederic
Publication type:
Article
Analysis of cell‐type specific exosomes isolated from cryopreserved human brain: Molecular and cell biology/neuroinflammation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045551
By:
- Bilousova, Tina;
- Melnik, Mikhail;
- Cohn, Whitaker;
- Huang, Calvin;
- Teter, Bruce;
- John, Varghese;
- Gylys, Karen H.
Publication type:
Article
Flow cytometry detection of inflammatory markers in glial cells and synaptosomes derived from AD cortex: Human neuropathology/clinico‐pathologic correlations.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.038338
By:
- Melnik, Mikhail;
- Bilousova, Tina;
- Huang, Calvin;
- Cole, Emma;
- Head, Elizabeth;
- Gylys, Karen H.
Publication type:
Article
P4‐057: PURIFICATION AND CHARACTERIZATION OF SUBPOPULATIONS OF EXTRACELLULAR VESICLES FROM AD AND PD BRAIN AND THEIR SUPPRESSION BY NSMASE2 INHIBITORS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1294, doi. 10.1016/j.jalz.2019.06.3717
By:
- Bilousova, Tina;
- Elias, Chris Jean;
- Melnik, Mikhail;
- Miyoshi, Emily;
- Campagna, Jesus J.;
- Simmons, Bryan;
- Hatami, Asa;
- Zhu, Chunni;
- Jun, Michael;
- Cohn, Whitaker;
- Jagodzinska, Barbara;
- Vadivel, Kanagasabai;
- Spilman, Patricia;
- Garg, Neil;
- Gylys, Karen H.;
- John, Varghese
Publication type:
Article
P2‐201: FLOW CYTOMETRY DETECTION OF MULTIPLE CELL TYPES AND EXOSOMAL ISOLATION FROM AD CORTEX.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P654, doi. 10.1016/j.jalz.2019.06.2608
By:
- Melnik, Mikhail;
- Miyoshi, Emily;
- Bilousova, Tina;
- Elias, Chris Jean;
- Sridhar, Mihika;
- Narain, Shreya;
- Cole, Emma;
- Huang, Calvin;
- John, Varghese;
- Gylys, Karen H.
Publication type:
Article
NEURONALLY-DERIVED EXOSOMAL PROTEINS CAN PREDICT BRAIN AMYLOIDOSIS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P893, doi. 10.1016/j.jalz.2016.06.1847
By:
- Apostolova, Liana G.;
- Goukasian, Naira;
- Gylys, Karen H.;
- Cole, Greg M.;
- Teng, Edmond;
- Bredesen, Dale E.;
- Goetzl, Edward J.
Publication type:
Article
NEURONALLY-DERIVED EXOSOMAL PROTEINS CAN PREDICT BRAIN AMYLOIDOSIS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P46, doi. 10.1016/j.jalz.2016.06.087
By:
- Apostolova, Liana G.;
- Goukasian, Naira;
- Gylys, Karen H.;
- Cole, Greg M.;
- Teng, Edmond;
- Bredesen, Dale E.;
- Goetzl, Edward J.
Publication type:
Article
Lipidation in cortical synapses of Alzheimer's disease versus normal controls.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P337, doi. 10.1016/j.jalz.2015.06.200
By:
- Gonzalez, Bianca L.;
- Gylys, Karen H.;
- Bilousova, Tina
Publication type:
Article
Release of c-terminal truncated and intact tau from Alzheimer's disease cortical synapses.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P186, doi. 10.1016/j.jalz.2015.07.161
By:
- Gylys, Karen H.;
- Bilousova, Tina;
- Teng, Edmond;
- Vinters, Harry V.;
- Miller, Carol A.;
- Poon, Wayne W.;
- Apostolova, Liana G.;
- Frautschy, Sally A.;
- John, Varghese;
- Bredesen, Dale E.;
- Cole, Greg M.
Publication type:
Article
CSF proteomic discovery in persons with autosomal dominant Alzheimer's disease mutations.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P326, doi. 10.1016/j.jalz.2015.07.473
By:
- Ringman, John M.;
- Cole, Greg M.;
- Gylys, Karen H.;
- Teng, Edmond;
- Elashoff, David;
- Coppola, Giovanni;
- Chelsky, Daniel;
- Wu, LinFeng;
- Schulman, Howard
Publication type:
Article
Glutamatergic (VGLUT1) synapses are not lost in Alzheimer's disease cerebral cortex, but preferentially accumulate amyloid-beta and p-tau pathology
Published in:
2010
By:
- Sokolow, Sophie;
- Luu, Sanh H.;
- Vinters, Harry V.;
- Miller, Carol A.;
- Gylys, Karen H.
Publication type:
Abstract
Apoliprotein-E is increased in Alzheimer's disease synapses and associates with amyloid beta
Published in:
2010
By:
- Gylys, Karen H.;
- Arold, Stephen P.;
- Henkins, Kristen M.;
- Poon, Wayne;
- Miller, Carol A.;
- Vinters, Harry V.;
- Cole, Greg M.
Publication type:
Abstract
Increased expression of sodium-calcium exchanger 3 (NCX3) in amyloid-beta positive synaptosomes
Published in:
2009
By:
- Sokolow, Sophie;
- Headley, Alison J.;
- Henkins, Kristen M.;
- Miller, Carol A.;
- Vinters, Harry V.;
- Frautschy, Sally A.;
- Cole, Gregory M.;
- Gylys, Karen H.
Publication type:
Abstract
A 56kD SDS-stable peptide assembly is prominent among multiple oligomers in Alzheimer synapses
Published in:
2009
By:
- Gylys, Karen H.;
- Henkins, Kristen;
- Rhoades, Chelsea;
- Sokolow, Sophie;
- Vinters, Harry V.;
- Miller, Carol A.;
- Cole, Gregory M.
Publication type:
Abstract
Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease.
Published in:
Scientific Reports, 2016, p. 18725, doi. 10.1038/srep18725
By:
- Zhang, Liang;
- Trushin, Sergey;
- Christensen, Trace A.;
- Bachmeier, Benjamin V.;
- Gateno, Benjamin;
- Schroeder, Andreas;
- Yao, Jia;
- Itoh, Kie;
- Sesaki, Hiromi;
- Poon, Wayne W.;
- Gylys, Karen H.;
- Patterson, Emily R.;
- Parisi, Joseph E.;
- Diaz Brinton, Roberta;
- Salisbury, Jeffrey L.;
- Trushina, Eugenia
Publication type:
Article
Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.766082
By:
- Cohn, Whitaker;
- Melnik, Mikhail;
- Huang, Calvin;
- Teter, Bruce;
- Chandra, Sujyoti;
- Zhu, Chunni;
- McIntire, Laura Beth;
- John, Varghese;
- Gylys, Karen H.;
- Bilousova, Tina
Publication type:
Article
Low Plasma ApoE Levels Are Associated with Smaller Hippocampal Size in the Alzheimer's Disease Neuroimaging Initiative Cohort.
Published in:
Dementia & Geriatric Cognitive Disorders, 2015, v. 39, n. 3/4, p. 154, doi. 10.1159/000368982
By:
- Teng, Edmond;
- Chow, Nicole;
- Hwang, Kristy S.;
- Thompson, Paul M.;
- Gylys, Karen H.;
- Cole, Gregory M.;
- Jack Jr., Clifford R.;
- Shaw, Leslie M.;
- Trojanowski, John Q.;
- Soares, Holly D.;
- Weiner, Michael W.;
- Apostolova, Liana G.
Publication type:
Article
Isolation of synaptic terminals from Alzheimer's disease cortex.
Published in:
Cytometry. Part A, 2012, v. 81A, n. 3, p. 248, doi. 10.1002/cyto.a.22009
By:
- Sokolow, Sophie;
- Henkins, Kristen M.;
- Williams, Iris A.;
- Vinters, Harry V.;
- Schmid, Ingrid;
- Cole, Gregory M.;
- Gylys, Karen H.
Publication type:
Article
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study.
Published in:
Alzheimer's Research & Therapy, 2012, v. 4, n. 5, p. 43, doi. 10.1186/alzrt146
By:
- Ringman, John M.;
- Frautschy, Sally A.;
- Teng, Edmond;
- Begum, Aynun N.;
- Bardens, Jenny;
- Beigi, Maryam;
- Gylys, Karen H.;
- Badmaev, Vladimir;
- Heath, Dennis D.;
- Apostolova, Liana G.;
- Porter, Verna;
- Vanek, Zeba;
- Marshall, Gad A.;
- Hellemann, Gerhard;
- Sugar, Catherine;
- Masterman, Donna L.;
- Montine, Thomas J.;
- Cummings, Jeffrey L.;
- Cole, Greg M.
Publication type:
Article
Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease.
Published in:
Journal of Neurochemistry, 2015, v. 133, n. 3, p. 368, doi. 10.1111/jnc.12991
By:
- Sokolow, Sophie;
- Henkins, Kristen M.;
- Bilousova, Tina;
- Gonzalez, Bianca;
- Vinters, Harry V.;
- Miller, Carol A.;
- Cornwell, Lindsey;
- Poon, Wayne W.;
- Gylys, Karen H.
Publication type:
Article
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Published in:
Acta Neuropathologica, 2021, v. 142, n. 3, p. 495, doi. 10.1007/s00401-021-02324-0
By:
- Dutta, Suman;
- Hornung, Simon;
- Kruayatidee, Adira;
- Maina, Katherine N.;
- del Rosario, Irish;
- Paul, Kimberly C.;
- Wong, Darice Y.;
- Duarte Folle, Aline;
- Markovic, Daniela;
- Palma, Jose-Alberto;
- Serrano, Geidy E.;
- Adler, Charles H.;
- Perlman, Susan L.;
- Poon, Wayne W.;
- Kang, Un Jung;
- Alcalay, Roy N.;
- Sklerov, Miriam;
- Gylys, Karen H.;
- Kaufmann, Horacio;
- Fogel, Brent L.
Publication type:
Article
Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Published in:
2021
By:
- Dutta, Suman;
- Hornung, Simon;
- Kruayatidee, Adira;
- Maina, Katherine N.;
- del Rosario, Irish;
- Paul, Kimberly C.;
- Wong, Darice Y.;
- Duarte Folle, Aline;
- Markovic, Daniela;
- Palma, Jose-Alberto;
- Serrano, Geidy E.;
- Adler, Charles H.;
- Perlman, Susan L.;
- Poon, Wayne W.;
- Kang, Un Jung;
- Alcalay, Roy N.;
- Sklerov, Miriam;
- Gylys, Karen H.;
- Kaufmann, Horacio;
- Fogel, Brent L.
Publication type:
Correction Notice
Conformation-Dependent Oligomers in Cerebrospinal Fluid of Presymptomatic Familial Alzheimer’s Disease Mutation Carriers.
Published in:
Dementia & Geriatric Cognitive Disorders Extra, 2012, v. 2, n. 1, p. 652, doi. 10.1159/000345771
By:
- Ringman, John M.;
- Tomic, Jennifer L.;
- Coppola, Giovanni;
- Elashoff, David;
- Gylys, Karen H.;
- Glabe, Charles G.
Publication type:
Article
Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses.
Published in:
Journal of Neuroscience, 2017, v. 37, n. 5, p. 1197, doi. 10.1523/JNEUROSCI.2774-16.2016
By:
- Prieto, G. Aleph;
- Dang, Cindy T.;
- Berchtold, Nicole C.;
- Cotman, Carl W.;
- Trieu, Brian H.;
- Lynch, Gary;
- Bilousova, Tina;
- Gylys, Karen H.
Publication type:
Article
Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-β protein into synaptic terminals.
Published in:
Journal of Neurochemistry, 2003, v. 84, n. 6, p. 1442, doi. 10.1046/j.1471-4159.2003.01643.x
By:
- Gylys, Karen H.;
- Fein, Jeffrey A.;
- Tan, Aiko M.;
- Cole, Gregory M.
Publication type:
Article

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