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The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression.
Published in:
Blood Cancer Journal, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41408-024-01053-3
By:
- Medina-Herrera, A.;
- Vazquez, I.;
- Cuenca, I.;
- Rosa-Rosa, J. M.;
- Ariceta, B.;
- Jimenez, C.;
- Fernandez-Mercado, M.;
- Larrayoz, M. J.;
- Gutierrez, N. C.;
- Fernandez-Guijarro, M.;
- Gonzalez-Calle, V.;
- Rodriguez-Otero, P.;
- Oriol, A.;
- Rosiñol, L.;
- Alegre, A.;
- Escalante, F.;
- De La Rubia, J.;
- Teruel, A. I.;
- De Arriba, F.;
- Hernandez, M. T.
Publication type:
Article
Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization.
Published in:
2001
By:
- Gutiérrez, N C;
- Hernández, J M;
- García, J L;
- Cañizo, M C;
- González, M;
- Hernández, J;
- González, M B;
- García-Marcos, M A;
- San Miguel, J F;
- Garciá-Marcos, M A
Publication type:
journal article
Quantitative PCR: an alternative approach to detect common copy number alterations in multiple myeloma.
Published in:
2017
By:
- Chillón, M.;
- Jiménez, C.;
- García-Sanz, R.;
- Alcoceba, M.;
- Prieto, I.;
- García-Alvarez, M.;
- Antón, A.;
- Maldonado, R.;
- Hernández-Ruano, M.;
- González, M.;
- Gutiérrez, N.;
- Sarasquete, M.;
- Chillón, M C;
- Jiménez, C;
- García-Sanz, R;
- García-Alvarez, M;
- Antón, A;
- Hernández-Ruano, M;
- González, M;
- Gutiérrez, N C
Publication type:
journal article
Monoclonal free light chains can be found in heavy chain diseases.
Published in:
Annals of Clinical Biochemistry, 2010, v. 47, n. 6, p. 570, doi. 10.1258/acb.2010.010146
By:
- López-Anglada, L.;
- Puig, N.;
- Díez-Campelo, M.;
- Alonso-Ralero, L.;
- Barrena, S.;
- Aparicio, M. A.;
- Gutiérrez, N. C.;
- García-Sanz, R.
Publication type:
Article
The predominant myeloma clone at diagnosis, CDR3 defined, is constantly detectable across all stages of disease evolution.
Published in:
Leukemia (08876924), 2015, v. 29, n. 6, p. 1435, doi. 10.1038/leu.2015.7
By:
- Puig, N;
- Conde, I;
- Jiménez, C;
- Sarasquete, M E;
- Balanzategui, A;
- Alcoceba, M;
- Quintero, J;
- Chillón, M C;
- Sebastián, E;
- Corral, R;
- Marín, L;
- Gutiérrez, N C;
- Mateos, M-V;
- González-Díaz, M;
- San-Miguel, J F;
- García-Sanz, R
Publication type:
Article
In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.
Published in:
Leukemia (08876924), 2015, v. 29, n. 3, p. 705, doi. 10.1038/leu.2014.238
By:
- Ocio, E M;
- Fernández-Lázaro, D;
- San-Segundo, L;
- López-Corral, L;
- Corchete, L A;
- Gutiérrez, N C;
- Garayoa, M;
- Paíno, T;
- García-Gómez, A;
- Delgado, M;
- Montero, J C;
- Díaz-Rodríguez, E;
- Mateos, M V;
- Pandiella, A;
- Couto, S;
- Wang, M;
- Bjorklund, C C;
- San-Miguel, J F
Publication type:
Article
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms.
Published in:
Leukemia (08876924), 2014, v. 28, n. 2, p. 384, doi. 10.1038/leu.2013.199
By:
- Walker, B A;
- Wardell, C P;
- Melchor, L;
- Brioli, A;
- Johnson, D C;
- Kaiser, M F;
- Mirabella, F;
- Lopez-Corral, L;
- Humphray, S;
- Murray, L;
- Ross, M;
- Bentley, D;
- Gutiérrez, N C;
- Garcia-Sanz, R;
- San Miguel, J;
- Davies, F E;
- Gonzalez, D;
- Morgan, G J
Publication type:
Article
A multiparameter flow cytometry immunophenotypic algorithm for the identification of newly diagnosed symptomatic myeloma with an MGUS-like signature and long-term disease control.
Published in:
Leukemia (08876924), 2013, v. 27, n. 10, p. 2112, doi. 10.1038/leu.2013.213
By:
- Paiva, B;
- Vídriales, M-B;
- Rosiñol, L;
- Martínez-López, J;
- Mateos, M-V;
- Ocio, E M;
- Montalbán, M-Á;
- Cordón, L;
- Gutiérrez, N C;
- Corchete, L;
- Oriol, A;
- Terol, M-J;
- Echeveste, M-A;
- De Paz, R;
- De Arriba, F;
- Palomera, L;
- de la Rubia, J;
- Díaz-Mediavilla, J;
- Granell, M;
- Gorosquieta, A
Publication type:
Article
A multiparameter flow cytometry immunophenotypic algorithm for the identification of newly diagnosed symptomatic myeloma with an MGUS-like signature and long-term disease control.
Published in:
Leukemia (08876924), 2013, v. 27, n. 10, p. 2056, doi. 10.1038/leu.2013.166
By:
- Paiva, B;
- Vídriales, M-B;
- Rosiñol, L;
- Martínez-López, J;
- Mateos, M-V;
- Ocio, E M;
- Montalbán, M-Á;
- Cordón, L;
- Gutiérrez, N C;
- Corchete, L;
- Oriol, A;
- Terol, M-J;
- Echeveste, M-A;
- De Paz, R;
- De Arriba, F;
- Palomera, L;
- de la Rubia, J;
- Díaz-Mediavilla, J;
- Granell, M;
- Gorosquieta, A
Publication type:
Article
MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenström's macroglobulinemia.
Published in:
Leukemia (08876924), 2013, v. 27, n. 8, p. 1722, doi. 10.1038/leu.2013.62
By:
- Jiménez, C;
- Sebastián, E;
- Chillón, M C;
- Giraldo, P;
- Mariano Hernández, J;
- Escalante, F;
- González-López, T J;
- Aguilera, C;
- de Coca, A G;
- Murillo, I;
- Alcoceba, M;
- Balanzategui, A;
- Sarasquete, M E;
- Corral, R;
- Marín, L A;
- Paiva, B;
- Ocio, E M;
- Gutiérrez, N C;
- González, M;
- San Miguel, J F
Publication type:
Article
Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.
Published in:
Leukemia (08876924), 2013, v. 27, n. 3, p. 610, doi. 10.1038/leu.2012.253
By:
- del Rey, M;
- O'Hagan, K;
- Dellett, M;
- Aibar, S;
- Colyer, H A A;
- Alonso, M E;
- Díez-Campelo, M;
- Armstrong, R N;
- Sharpe, D J;
- Gutiérrez, N C;
- García, J L;
- De Las Rivas, J;
- Mills, K I;
- Hernández-Rivas, J M
Publication type:
Article
SNP-based mapping arrays reveal high genomic complexity in monoclonal gammopathies, from MGUS to myeloma status.
Published in:
Leukemia (08876924), 2012, v. 26, n. 12, p. 2521, doi. 10.1038/leu.2012.128
By:
- López-Corral, L;
- Sarasquete, M E;
- Beà, S;
- García-Sanz, R;
- Mateos, M V;
- Corchete, L A;
- Sayagués, J M;
- García, E M;
- Bladé, J;
- Oriol, A;
- Hernández-García, M T;
- Giraldo, P;
- Hernández, J;
- González, M;
- Hernández-Rivas, J M;
- San Miguel, J F;
- Gutiérrez, N C
Publication type:
Article
Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients.
Published in:
Leukemia (08876924), 2012, v. 26, n. 8, p. 1862, doi. 10.1038/leu.2012.42
By:
- Paiva, B;
- Gutiérrez, N-C;
- Chen, X;
- Vídriales, M-B;
- Montalbán, M-Á;
- Rosiñol, L;
- Oriol, A;
- Martínez-López, J;
- Mateos, M-V;
- López-Corral, L;
- Díaz-Rodríguez, E;
- Pérez, J-J;
- Fernández-Redondo, E;
- de Arriba, F;
- Palomera, L;
- Bengoechea, E;
- Terol, M-J;
- de Paz, R;
- Martin, A;
- Hernández, J
Publication type:
Article
Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma.
Published in:
Leukemia (08876924), 2011, v. 25, n. 4, p. 697, doi. 10.1038/leu.2010.320
By:
- Paiva, B.;
- Pérez-Andrés, M.;
- Vídriales, M.-B.;
- Almeida, J.;
- Heras, N. de las;
- Mateos, M.-V.;
- López-Corral, L.;
- Gutiérrez, N. C.;
- Blanco, J.;
- Oriol, A.;
- Hernández, M. T.;
- de Arriba, F.;
- de Coca, A. G.;
- Terol, M.-J.;
- de la Rubia, J.;
- González, Y.;
- Martín, A.;
- Sureda, A.;
- Schmidt-Hieber, M.;
- Schmitz, A.
Publication type:
Article
Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling.
Published in:
Leukemia (08876924), 2010, v. 24, n. 3, p. 629, doi. 10.1038/leu.2009.274
By:
- Gutiérrez, N C;
- Sarasquete, M E;
- Misiewicz-Krzeminska, I;
- Delgado, M;
- De Las Rivas, J;
- Ticona, F V;
- Fermiñán, E;
- Martín-Jiménez, P;
- Chillón, C;
- Risueño, A;
- Hernández, J M;
- García-Sanz, R;
- González, M;
- San Miguel, J F
Publication type:
Article
Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors.
Published in:
Leukemia (08876924), 2009, v. 23, n. 8, p. 1515, doi. 10.1038/leu.2009.65
By:
- Garayoa, M.;
- Garcia, J. L.;
- Santamaria, C.;
- Garcia-Gomez, A.;
- Blanco, J. F.;
- Pandiella, A.;
- Hernández, J. M.;
- Sanchez-Guijo, F. M.;
- del Cañizo, M.-C.;
- Gutiérrez, N. C.;
- Miguel, J. F. San
Publication type:
Article
Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma.
Published in:
2008
By:
- Schilling, G;
- Hansen, T;
- Shimoni, A;
- Zabelina, T;
- Pérez-Simón, J-A;
- Gutierrez, N C;
- Bethge, W;
- Liebisch, P;
- Schwerdtfeger, R;
- Bornhäuser, M;
- Otterstetter, S;
- Penas, E M M;
- Dierlamm, J;
- Ayuk, F;
- Atanackovic, D;
- Bacher, U;
- Bokemeyer, C;
- Zander, A;
- San Miguel, J;
- Nagler, A
Publication type:
Correction Notice
Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma.
Published in:
Leukemia (08876924), 2008, v. 22, n. 6, p. 1250, doi. 10.1038/leu.2008.88
By:
- Schilling, G.;
- Hansen, T.;
- Shimoni, A.;
- Zabelina, T.;
- Simon-Perez, J.-A.;
- Gutierrez, N. C.;
- Bethge, W.;
- Liebisch, P.;
- Schwerdtfeger, R.;
- Bornhäuser, M.;
- Otterstetter, S.;
- Penas, E. M. M.;
- Dierlamm, J.;
- Ayuk, F.;
- Atanackovic, D.;
- Bacher, U.;
- Bokemeyer, C.;
- Zander, A.;
- Miguel, J. S.;
- Nagler, A.
Publication type:
Article
Gene expression profiling of B lymphocytes and plasma cells from Waldenström's macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals.
Published in:
Leukemia (08876924), 2007, v. 21, n. 3, p. 541, doi. 10.1038/sj.leu.2404520
By:
- Gutiérrez, N. C.;
- Ocio, E. M.;
- de las Rivas, J.;
- Maiso, P.;
- Delgado, M.;
- Fermiñ&;#x00E1;n, E.;
- Arcos, M. J.;
- Sánchez, M. L.;
- Hernández, J. M.;
- San Miguel, J. F.
Publication type:
Article
Prognostic and biological implications of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation: t(4;14) is the most relevant adverse prognostic factor, whereas RB deletion as a unique abnormality is not associated with adverse prognosis
Published in:
Leukemia (08876924), 2007, v. 21, n. 1, p. 143, doi. 10.1038/sj.leu.2404413
By:
- Gutiérrez, N. C.;
- Castellanos, M. V.;
- Martín, M. L.;
- Mateos, M. V.;
- Hernández, J. M.;
- Fernández, M.;
- Carrera, D.;
- Rosiñol, L.;
- Ribera, J. M.;
- Ojanguren, J. M.;
- Palomera, L.;
- Gardella, S.;
- Escoda, L.;
- Hernández-Boluda, J. C.;
- Bello, J. L.;
- de la Rubia, J;
- Lahuerta, J. J.;
- San Miguel, J. F.
Publication type:
Article
Mobilisation with G-CSF in healthy donors promotes a high but temporal deregulation of genes.
Published in:
2005
By:
- Hernández, J. M.;
- Castilla, C.;
- Gutiérrez, N. C.;
- Isidro, I. M.;
- Delgado, M.;
- de las Rivas, J.;
- Fermiñán, E.;
- García, J. L.;
- Ocio, E. M.;
- del Cañizo, M. C.;
- San Miguel, J. F.
Publication type:
Letter
Genetic heterogeneity of BCR/ABL<sup>+</sup> adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics.
Published in:
Leukemia (08876924), 2005, v. 19, n. 5, p. 713, doi. 10.1038/sj.leu.2403714
By:
- Primo, D.;
- Tabernero, M. D.;
- Perez, J. J.;
- Rasillo, A.;
- Sayagués, J. M.;
- Espinosa, A. B.;
- Lopez-Berges, M. C.;
- García-Sanz, R.;
- Gutierrez, N. C.;
- Hernandez, J. M.;
- Romero, M.;
- Osuna, C. S.;
- Giralt, M.;
- Barbon, M.;
- San Miguel, J. F.;
- Orfao, A.
Publication type:
Article
Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia.
Published in:
Leukemia (08876924), 2005, v. 19, n. 3, p. 402, doi. 10.1038/sj.leu.2403625
By:
- Gutiérrez, N. C;
- López-Pérez, R;
- Hernández, J. M;
- Isidro, I;
- González, B;
- Delgado, M;
- Fermiñán, E;
- García, J. L;
- Vázquez, L;
- González, M;
- San Miguel, J. F
Publication type:
Article
Induction (MATRix) Followed by Transplantation in Primary Central Nervous System Lymphoma. Experience of the GELTAMO (Grupo Español de Linfoma y Trasplante de Medula Ósea).
Published in:
Hematological Oncology, 2023, v. 41, p. 401, doi. 10.1002/hon.3164_293
By:
- Lopez‐Pereira, P.;
- Romero‐Dominguez, S.;
- Martin‐Moro, F.;
- Caballero‐Gonzalez, A. C.;
- Lopez‐Garcia, A.;
- Cruz‐Benito, B. de la;
- Franch‐Sarto, M.;
- Cruz‐Vicente, F. de la;
- Lopez‐Marin, J.;
- Pinzon‐Marino, S.;
- Jimenez‐Ubieto, A.;
- Cabirta‐Touzon, A.;
- Gutierrez‐Gutierrez, N. C.;
- Lis‐Chulvi, M. J.;
- Puyuelo, A.;
- Muntañola‐Prat, A.;
- Penedo‐Coello, A.;
- Encuentra‐Marti, M. T.;
- Mercadal‐Vilchez, S.
Publication type:
Article
Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma.
Published in:
British Journal of Haematology, 2008, v. 141, n. 2, p. 212, doi. 10.1111/j.1365-2141.2007.06956.x
By:
- Armellini, A.;
- Sarasquete, M. E.;
- García-Sanz, R.;
- Chillón, M. C.;
- Balanzategui, A.;
- Alcoceba, M.;
- Fuertes, M.;
- López, R.;
- Hernández, J. M.;
- Fernández-Calvo, J.;
- Sierra, M.;
- Megido, M.;
- Orfão, A.;
- Gutiérrez, N. C.;
- González, M.;
- San Miguel, J. F.
Publication type:
Article
6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis.
Published in:
British Journal of Haematology, 2007, v. 136, n. 1, p. 80, doi. 10.1111/j.1365-2141.2006.06389.x
By:
- Ocio, E. M.;
- Schop, R. F. J.;
- Gonzalez, B.;
- Van Wier, S. A.;
- Hernandez-Rivas, J. M.;
- Gutierrez, N. C.;
- Garcia-Sanz, R.;
- Moro, M. J.;
- Aguilera, C.;
- Hernandez, J.;
- Xu, R.;
- Greipp, P. R.;
- Dispenzieri, A.;
- Jalal, S. M.;
- Lacy, M. Q.;
- Gonzalez-Paz, N.;
- Gertz, M. A.;
- San Miguel, J. F.;
- Fonseca, R.
Publication type:
Article
Monocyte counts: an early index of haemopoietic reconstitution after peripheral blood stem cell transplantation.
Published in:
British Journal of Haematology, 2000, v. 111, n. 3, p. 987, doi. 10.1046/j.1365-2141.2000.02393-4.x
By:
- Arroyo, J. L.;
- Gutierrez, N. C.;
- García-Marcos, M. A.;
- Villarroel, R.;
- Galindo, P.;
- Fernández, M. E.;
- Izarra, A.;
- del Cañizo, M. C.;
- Caballero, M. D.;
- San Miguel, J. F.
Publication type:
Article

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