Works by Gunewardena, Sumedha

Results: 44

Heat-induced increases in body temperature in lactating dairy cows: impact on the cumulus and granulosa cell transcriptome of the periovulatory follicle.

Published in:

Journal of Animal Science, 2022, v. 100, n. 7, p. 1, doi. 10.1093/jas/skac121

By:

Klabnik, Jessica L;
Christenson, Lane K;
Gunewardena, Sumedha S A;
Pohler, Ky G;
Rispoli, Louisa A;
Payton, Rebecca R;
Moorey, Sarah E;
Schrick, F Neal;
Edwards, J Lannett

Publication type:

Article

Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8‐DNA interactions and effectively inhibits prostate tumor growth in mice.

Published in:

Molecular Oncology, 2024, v. 18, n. 8, p. 1966, doi. 10.1002/1878-0261.13637

By:

Karan, Dev;
Dubey, Seema;
Gunewardena, Sumedha;
Iczkowski, Kenneth A.;
Singh, Manohar;
Liu, Pengyuan;
Poletti, Angelo;
Choo, Yeun‐Mun;
Chen, Hui‐Zi;
Hamann, Mark T.

Publication type:

Article

Evaluating the role of RNA binding protein CELF2 in modulating immune cells in colitis.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02846

By:

Sayed, Afreen Asif Ali;
Subramaniam, Dharmalingam;
Choudhury, Sonali;
Gunewardena, Sumedha;
Dandawate, Prasad;
Umar, Shahid;
Jensen, Roy;
Thomas, Sufi;
Anant, Shrikant

Publication type:

Article

The Tie2 antagonist rebastinib reduces ovarian cancer growth in a syngeneic murine model.

Published in:

BMC Cancer, 2025, v. 24, p. 1, doi. 10.1186/s12885-025-13640-z

By:

Gupta, Vijayalaxmi G.;
Roby, Katherine F.;
Pathak, Harsh B.;
Godwin, Andrew K.;
Gunewardena, Sumedha;
Khabele, Dineo

Publication type:

Article

Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice.

Published in:

Archives of Toxicology, 2024, v. 98, n. 9, p. 3063, doi. 10.1007/s00204-024-03789-0

By:

Robarts, Dakota R.;
Paine-Cabrera, Diego;
Kotulkar, Manasi;
Venneman, Kaitlyn K.;
Gunewardena, Sumedha;
Foquet, Lander;
Bial, Greg;
Apte, Udayan

Publication type:

Article

Identification of follicle‐stimulating hormone‐responsive genes in Sertoli cells during early postnatal mouse testis development.

Published in:

Andrology, 2023, v. 11, n. 5, p. 860, doi. 10.1111/andr.13459

By:

Wang, Huizhen;
Liu, Zhenghui;
Larsen, Mark;
Hastings, Richard;
Gunewardena, Sumedha;
Kumar, T. Rajendra

Publication type:

Article

Resistance exercise in early-stage ALS patients, ALSFRS-R, Sickness Impact Profile ALS-19, and muscle transcriptome: a pilot study.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-72355-6

By:

Jawdat, Omar;
Rucker, Jason;
Nakano, Tomoki;
Takeno, Kotaro;
Statland, Jeffery;
Pasnoor, Mamatha;
Dimachkie, Mazen M.;
Sabus, Carla;
Badawi, Yomna;
Hunt, Suzanne L.;
Tomioka, Naoko H.;
Gunewardena, Sumedha;
Bloomer, Clark;
Wilkins, Heather M.;
Herbelin, Laura;
Barohn, Richard J.;
Nishimune, Hiroshi

Publication type:

Article

Analysis of MicroRNA Cargo in Circulating Extracellular Vesicles from HIV-Infected Individuals with Pulmonary Hypertension.

Published in:

Cells (2073-4409), 2024, v. 13, n. 11, p. 886, doi. 10.3390/cells13110886

By:

Mahajan, Aatish;
Gunewardena, Sumedha;
Morris, Alison;
Clauss, Matthias;
Dhillon, Navneet K.

Publication type:

Article

ChIPing the cistrome of PXR in mouse liver.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 22, p. 7943, doi. 10.1093/nar/gkq654

By:

Cui, Julia Yue;
Gunewardena, Sumedha S.;
Rockwell, Cheryl E.;
Klaassen, Curtis D.

Publication type:

Article

A hybrid model for robust detection of transcription factor binding sites.

Published in:

Bioinformatics, 2008, v. 24, n. 4, p. 484, doi. 10.1093/bioinformatics/btm629

By:

Sumedha Gunewardena;
Zhaolei Zhang

Publication type:

Article

CCN5 activation by free or encapsulated EGCG is required to render triple-negative breast cancer cell viability and tumor progression.

Published in:

Pharmacology Research & Perspectives, 2021, v. 9, n. 2, p. 1, doi. 10.1002/prp2.753

By:

Das, Amlan;
Haque, Inamul;
Ray, Priyanka;
Ghosh, Arnab;
Dutta, Debasmita;
Quadir, Mohiuddin;
De, Archana;
Gunewardena, Sumedha;
Chatterjee, Indranil;
Banerjee, Snigdha;
Weir, Scott;
Banerjee, Sushanta K.

Publication type:

Article

Differential Gene Expression and Pathway Analysis in Juvenile Nasopharyngeal Angiofibroma Using RNA Sequencing.

Published in:

2018

By:

Jones, Joel W.;
Usman, Shireen;
New, Jacob;
Holcomb, Andrew;
Gunewardena, Sumedha;
Tawfik, Ossama;
Hoover, Larry;
Bruegger, Daniel;
Thomas, Sufi Mary

Publication type:

journal article

LH/hCG Regulation of Circular RNA in Mural Granulosa Cells during the Periovulatory Period in Mice.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13078, doi. 10.3390/ijms241713078

By:

Chakravarthi, V. Praveen;
Hung, Wei-Ting;
Yellapu, Nanda Kumar;
Gunewardena, Sumedha;
Christenson, Lane K.

Publication type:

Article

Genomic, Clinical, and Behavioral Characterization of 15q11.2 BP1-BP2 Deletion (Burnside-Butler) Syndrome in Five Families.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1660, doi. 10.3390/ijms22041660

By:

Baldwin, Isaac;
Shafer, Robin L.;
Hossain, Waheeda A.;
Gunewardena, Sumedha;
Veatch, Olivia J.;
Mosconi, Matthew W.;
Butler, Merlin G.;
Bonsi, Paola

Publication type:

Article

Motor, Somatosensory, Viscerosensory and Metabolic Impairments in a Heterozygous Female Rat Model of Rett Syndrome.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 1, p. 97, doi. 10.3390/ijms19010097

By:

Bhattacherjee, Aritra;
Winter, Michelle K.;
Eggimann, Linda S.;
Mu, Ying;
Gunewardena, Sumedha;
Liao, Zhaohui;
Christianson, Julie A.;
Smith, Peter G.

Publication type:

Article

Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 3, p. 642, doi. 10.3390/ijms18030642

By:

Garimella, Rama;
Tadikonda, Priyanka;
Tawfik, Ossama;
Gunewardena, Sumedha;
Rowe, Peter;
Van Veldhuizen, Peter

Publication type:

Article

Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression.

Published in:

2022

By:

Cloud, Ashley S.;
Vargheese, Aditya M.;
Gunewardena, Sumedha;
Shimak, Raeann M.;
Ganeshkumar, Sornakala;
Kumaraswamy, Easwari;
Jensen, Roy A.;
Chennathukuzhi, Vargheese M.

Publication type:

journal article

RNA Sequencing of Human Peripheral Nerve in Response to Injury: Distinctive Analysis of the Nerve Repair Pathways.

Published in:

Cell Transplantation, 2020, v. 29, p. 1, doi. 10.1177/0963689720926157

By:

Welleford, Andrew S.;
Quintero, Jorge E.;
Seblani, Nader El;
Blalock, Eric;
Gunewardena, Sumedha;
Shapiro, Steven M.;
Riordan, Sean M.;
Huettl, Peter;
Guduru, Zain;
Stanford, John A.;
van Horne, Craig G.;
Gerhardt, Greg A.

Publication type:

Article

TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33465-9

By:

Matye, David;
Gunewardena, Sumedha;
Chen, Jianglei;
Wang, Huaiwen;
Wang, Yifeng;
Hasan, Mohammad Nazmul;
Gu, Lijie;
Clayton, Yung Dai;
Du, Yanhong;
Chen, Cheng;
Friedman, Jacob E.;
Lu, Shelly C.;
Ding, Wen-Xing;
Li, Tiangang

Publication type:

Article

Histone lysine demethylase 4B regulates general and unique gene expression signatures in hypoxic cancer cells.

Published in:

MedComm, 2021, v. 2, n. 3, p. 414, doi. 10.1002/mco2.85

By:

Lei Qiu;
Yang Meng;
Lingli Wang;
Gunewardena, Sumedha;
Sicheng Liu;
Junhong Han;
Krieg, Adam J.

Publication type:

Article

Analysis of lncRNA-miRNA-mRNA Interactions in Hyper-proliferative Human Pulmonary Arterial Smooth Muscle Cells.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46981-4

By:

Chinnappan, Mahendran;
Gunewardena, Sumedha;
Chalise, Prabhakar;
Dhillon, Navneet K.

Publication type:

Article

Modulation of β-Catenin promotes WNT expression in macrophages and mitigates intestinal injury.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02065-7

By:

Chugh, Rishi Man;
Bhanja, Payel;
Zitter, Ryan;
Gunewardena, Sumedha;
Badkul, Rajeev;
Saha, Subhrajit

Publication type:

Article

Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury.

Published in:

Toxicological Sciences, 2021, v. 184, n. 2, p. 276, doi. 10.1093/toxsci/kfab115

By:

Poudel, Samikshya;
Cabrera, Diego Paine;
Bhushan, Bharat;
Manley, Michael W;
Gunewardena, Sumedha;
Jaeschke, Hartmut;
Apte, Udayan

Publication type:

Article

RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver Development.

Published in:

Toxicological Sciences, 2012, v. 127, n. 2, p. 592, doi. 10.1093/toxsci/kfs107

By:

Cui, Julia Yue;
Gunewardena, Sumedha S.;
Yoo, Byunggil;
Liu, Jie;
Renaud, Helen J.;
Lu, Hong;
Zhong, Xiao-bo;
Klaassen, Curtis D.

Publication type:

Article

Exploring Whether Iron Sequestration within the CNS of Patients with Alzheimer's Disease Causes a Functional Iron Deficiency That Advances Neurodegeneration.

Published in:

Brain Sciences (2076-3425), 2023, v. 13, n. 3, p. 511, doi. 10.3390/brainsci13030511

By:

LeVine, Steven M.;
Tsau, Sheila;
Gunewardena, Sumedha

Publication type:

Article

The START domain mediates Arabidopsis GLABRA2 dimerization and turnover independently of homeodomain DNA binding.

Published in:

Plant Physiology, 2022, v. 190, n. 4, p. 2315, doi. 10.1093/plphys/kiac383

By:

Mukherjee, Thiya;
Subedi, Bibek;
Khosla, Aashima;
Begler, Erika M.;
Stephens, Preston M.;
Warner, Adara L.;
Lerma-Reyes, Ruben;
Thompson, Kyle A.;
Gunewardena, Sumedha;
Schrick, Kathrin

Publication type:

Article

Targeting FGFR Attenuates Tumor Growth in an Anal Squamous Cell Carcinoma Patient Derived Xenograft Model.

Published in:

Molecular Carcinogenesis, 2025, v. 64, n. 7, p. 1236, doi. 10.1002/mc.23919

By:

Ly, Thuc;
Golfinos‐Owens, Athena E.;
Raja, Naren;
Arnold, Levi;
Arjunan, Pachiappan;
Ashcraft, John;
Martin, Benjamin;
Anant, Shrikant;
Gunewardena, Sumedha;
Wang, Rong;
Dinh, Huy Q.;
Thomas, Sufi Mary

Publication type:

Article

Doublecortin‐like kinase 1 is a therapeutic target in squamous cell carcinoma.

Published in:

Molecular Carcinogenesis, 2023, v. 62, n. 2, p. 145, doi. 10.1002/mc.23472

By:

Standing, David;
Arnold, Levi;
Dandawate, Prasad;
Ottemann, Brendan;
Snyder, Vusala;
Ponnurangam, Sivapriya;
Sayed, Afreen;
Subramaniam, Dharmalingam;
Srinivasan, Pugazhendhi;
Choudhury, Sonali;
New, Jacob;
Kwatra, Deep;
Ramamoorthy, Prabhu;
Roy, Badal C.;
Shadoin, Melissa;
Al‐Rajabi, Raed;
O'Neil, Maura;
Gunewardena, Sumedha;
Ashcraft, John;
Umar, Shahid

Publication type:

Article

Pleotropic role of RNA binding protein CELF2 in autophagy induction.

Published in:

Molecular Carcinogenesis, 2019, v. 58, n. 8, p. 1400, doi. 10.1002/mc.23023

By:

New, Jacob;
Subramaniam, Dharmalingam;
Ramalingam, Satish;
Enders, Jonathan;
Sayed, Afreen Asif Ali;
Ponnurangam, Sivapriya;
Standing, David;
Ramamoorthy, Prabhu;
O'Neil, Maura;
Dixon, Dan A.;
Saha, Subhrajit;
Umar, Shahid;
Gunewardena, Sumedha;
Jensen, Roy A.;
Thomas, Sufi Mary;
Anant, Shrikant

Publication type:

Article

Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse.

Published in:

FASEB Journal, 2018, v. 32, n. 9, p. 5174, doi. 10.1096/fj.201701558R

By:

Sharma, Himanshu;
Chinnappan, Mahendran;
Agarwal, Stuti;
Dalvi, Pranjali;
Gunewardena, Sumedha;
O'Brien-Ladner, Amy;
Dhillon, Navneet K.

Publication type:

Article

Characterization of a hepatocyte nuclear factor 4 alpha gene signature in hepatocellular carcinoma (144.11).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.144.11

By:

Walesky, Chad;
Gunewardena, Sumedha;
Yoo, Byunggil;
Li, Ren;
Edwards, Genea;
Apte, Udayan

Publication type:

Article

Role of Hepatocyte Nuclear Factor 4 alpha in Promotion of Hepatocellular Carcinoma.

Published in:

FASEB Journal, 2013, v. 27, p. 387.11, doi. 10.1096/fasebj.27.1_supplement.387.11

By:

Walesky, Chad;
Gunewardena, Sumedha;
Edwards, Genea;
Borude, Prachi;
Apte, Udayan

Publication type:

Article

Micro-RNAs involved in cellular proliferation have altered expression profiles in granulosa of young women with diminished ovarian reserve.

Published in:

Journal of Assisted Reproduction & Genetics, 2018, v. 35, n. 10, p. 1777, doi. 10.1007/s10815-018-1239-9

By:

Woo, Irene;
Christenson, Lane K.;
Gunewardena, Sumedha;
Ingles, Sue Ann;
Thomas, Semara;
Ahmady, Ali;
Chung, Karine;
Bendikson, Kristin;
Paulson, Richard;
McGinnis, Lynda K.

Publication type:

Article

Circulating microRNA as candidates for early embryonic viability in cattle.

Published in:

Molecular Reproduction & Development, 2017, v. 84, n. 8, p. 731, doi. 10.1002/mrd.22856

By:

Pohler, Ky G.;
Green, Jonathan A.;
Moley, Laura A.;
Gunewardena, Sumedha;
Hung, Wei‐Ting;
Payton, Rebecca R.;
Hong, Xiaoman;
Christenson, Lane K.;
Geary, Tom W.;
Smith, Michael F.

Publication type:

Article

Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22021-6

By:

Zhang, Xiaoyu;
Gunewardena, Sumedha;
Wang, Ning

Publication type:

Article

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17363-6

By:

Wang, Yifeng;
Gunewardena, Sumedha;
Li, Feng;
Matye, David J.;
Chen, Cheng;
Chao, Xiaojuan;
Jung, Taeyoon;
Zhang, Yuxia;
Czerwiński, Maciej;
Ni, Hong-Min;
Ding, Wen-Xing;
Li, Tiangang

Publication type:

Article

Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141220

By:

Gunewardena, Sumedha S.;
Yoo, Byunggil;
Peng, Lai;
Lu, Hong;
Zhong, Xiaobo;
Klaassen, Curtis D.;
Cui, Julia Yue

Publication type:

Article

Cell-Specific Post-Transcriptional Regulation of γ-Synuclein Gene by Micro-RNAs.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0073786

By:

Surgucheva, Irina;
Gunewardena, Sumedha;
Rao, H. Shanker;
Surguchov, Andrei

Publication type:

Article

An RNA Interference Lethality Screen of the Human Druggable Genome to Identify Molecular Vulnerabilities in Epithelial Ovarian Cancer.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047086

By:

Sethi, Geetika;
Pathak, Harsh B.;
Hong Zhang;
Yan Zhou;
Einarson, Margret B.;
Vathipadiekal, Vinod;
Gunewardena, Sumedha;
Birrer, Michael J.;
Godwin, Andrew K.

Publication type:

Article

Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity.

Published in:

PLoS ONE, 2021, v. 16, n. 2, p. 1, doi. 10.1371/journal.pone.0246989

By:

Rafi, Syed K.;
Goering, Jeremy P.;
Olm-Shipman, Adam J.;
Hipp, Lauren A.;
Ernst, Nicholas J.;
Wilson, Nathan R.;
Hall, Everett G.;
Gunewardena, Sumedha;
Saadi, Irfan

Publication type:

Article

Development and Characterization of an In Vitro Model for Radiation-Induced Fibrosis.

Published in:

Radiation Research, 2018, v. 189, n. 3, p. 326, doi. 10.1667/RR14926.1

By:

Kumar, Dhruv;
Yalamanchali, Sreeya;
New, Jacob;
Parsel, Sean;
New, Natalie;
Holcomb, Andrew;
Gunewardena, Sumedha;
Tawfik, Ossama;
Lominska, Chris;
Kimler, Bruce F.;
Anant, Shrikant;
Kakarala, Kiran;
Tsue, Terance;
Shnayder, Yelizaveta;
Sykes, Kevin;
Padhye, Subhash;
Thomas, Sufi Mary

Publication type:

Article

Characterization and Small RNA Content of Extracellular Vesicles in Follicular Fluid of Developing Bovine Antral Follicles.

Published in:

Scientific Reports, 2016, p. 25486, doi. 10.1038/srep25486

By:

Navakanitworakul, Raphatphorn;
Hung, Wei-Ting;
Gunewardena, Sumedha;
Davis, John S.;
Chotigeat, Wilaiwan;
Christenson, Lane K.

Publication type:

Article

Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer.

Published in:

Cell Death & Disease, 2024, v. 15, n. 5, p. 1, doi. 10.1038/s41419-024-06717-3

By:

Standing, David;
Dandawate, Prasad;
Gunewardena, Sumedha;
Covarrubias-Zambrano, Obdulia;
Roby, Katherine F.;
Khabele, Dineo;
Jewell, Andrea;
Tawfik, Ossama;
Bossmann, Stefan H.;
Godwin, Andrew K.;
Weir, Scott J.;
Jensen, Roy A.;
Anant, Shrikant

Publication type:

Article

Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing.

Published in:

Epigenetics, 2012, v. 7, n. 8, p. 914, doi. 10.4161/epi.21113

By:

Hong Lu;
Cui, Julia Yue;
Gunewardena, Sumedha;
Byunggil Yoo;
Xiao-Bo Zhong;
Klaassen, Curtis D.

Publication type:

Article