Works by Gumbo, Tawanda

Results: 94

Minocycline Immunomodulates via Sonic Hedgehog Signaling and Apoptosis and Has Direct Potency Against Drug-Resistant Tuberculosis.

Published in:

2019

By:

Deshpande, Devyani;
Pasipanodya, Jotam G;
Srivastava, Shashikant;
Martin, Katherine R;
Athale, Shruti;
Zyl, Johanna van;
Antiabong, John;
Koeuth, Thearith;
Lee, Pooi S;
Dheda, Keertan;
Gumbo, Tawanda;
van Zyl, Johanna

Publication type:

journal article

Fatal Lure of Look-Back Studies in Explaining Pharmacological Events Such as Acquired Drug Resistance in Patients With Multidrug-Resistant Tuberculosis.

Published in:

2015

By:

Pasipanodya, Jotam;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Journal Article

Fatal Lure of Look-Back Studies in Explaining Pharmacological Events Such as Acquired Drug Resistance in Patients With Multidrug- Resistant Tuberculosis.

Published in:

2015

By:

Pasipanodya, Jotam;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Letter to the Editor

Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia.

Published in:

2015

By:

Gumbo, Tawanda;
Angulo-Barturen, Iñigo;
Ferrer-Bazaga, Santiago

Publication type:

Journal Article

Nonclinical models for antituberculosis drug development: a landscape analysis.

Published in:

2015

By:

Gumbo, Tawanda;
Lenaerts, Anne J;
Hanna, Debra;
Romero, Klaus;
Nuermberger, Eric

Publication type:

Journal Article

Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes.

Published in:

Journal of Infectious Diseases, 2013, v. 208, n. 9, p. 1464, doi. 10.1093/infdis/jit352

By:

Pasipanodya, Jotam G.;
McIlleron, Helen;
Burger, André;
Wash, Peter A.;
Smith, Peter;
Gumbo, Tawanda

Publication type:

Article

Reply to Alffenaar.

Published in:

2012

By:

Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

Letter

Multidrug-Resistant Tuberculosis Not Due to Noncompliance but to Between-Patient Pharmacokinetic Variability.

Published in:

Journal of Infectious Diseases, 2011, v. 204, n. 12, p. 1951, doi. 10.1093/infdis/jir658

By:

Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Meek, Claudia;
Leff, Richard;
Gumbo, Tawanda

Publication type:

Article

Case Report. Nattrassia mangiferae endophthalmitis.

Published in:

Mycoses, 2002, v. 45, n. 3/4, p. 118, doi. 10.1046/j.1439-0507.2002.00723.x

By:

Gumbo, Tawanda;
Mkanganwi, Ndodini;
Robertson, Valerie J;
Masvaire, Praise

Publication type:

Article

A Human Lung Challenge Model to Evaluate the Safety and Immunogenicity of PPD and Live Bacillus Calmette-Guérin.

Published in:

2020

By:

Davids, Malika;
Pooran, Anil;
Hermann, Clemens;
Mottay, Lynelle;
Thompson, Fawziyah;
Cardenas, Jacob;
Thearith, Jinghua Gu;
Meldau, Richard;
Limberis, Jason;
Gina, Phindile;
Srivastava, Shashikant;
Calder, Bridget;
Esmail, Aliasgar;
Tomasicchio, Michele;
Blackburn, Jonathan;
Gumbo, Tawanda;
Dheda, Keertan;
Gu, Jinghua;
Koeuth, Thearith

Publication type:

journal article

A human lung challenge model to evaluate the safety and immunogenicity of PPD and live BCG.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2020, v. 201, n. 10, p. E1

By:

Pooran, Anil;
Hermann, Clemens;
Mottay, Lynelle;
Thompson, Fawziyah;
Cardenas, Jacob;
Jinghua Gu;
Koeuth, Thearith;
Meldau, Richard;
Limberis, Jason;
Gina, Phindile;
Srivastava, Shashikant;
Calder, Bridget;
Esmail, Aliasgar;
Tomasicchio, Michele;
Blackburn, Jonathan;
Gumbo, Tawanda;
Dheda, Keertan

Publication type:

Article

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Published in:

2018

By:

Dheda, Keertan;
Lenders, Laura;
Magombedze, Gesham;
Srivastava, Shashikant;
Raj, Prithvi;
Arning, Erland;
Ashcraft, Paula;
Bottiglieri, Teodoro;
Wainwright, Helen;
Pennel, Timothy;
Linegar, Anthony;
Moodley, Loven;
Pooran, Anil;
Pasipanodya, Jotam G;
Sirgel, Frederick A;
van Helden, Paul D;
Wakeland, Edward;
Warren, Robin M;
Gumbo, Tawanda

Publication type:

journal article

Drug Concentration Monitoring in Mycobacterium avium Lung Disease: Problems with Methods and Conclusions.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2013, v. 187, n. 5, p. 554, doi. 10.1164/ajrccm.187.5.554

By:

PASIPANODYA, JOTAM G.;
GUMBO, TAWANDA;
WON-JUNG Koh;
BYEONG-HO JEONG;
KYEONGMAN JEON;
SOO-YOUN LEE;
SUNG JAE SHIN

Publication type:

Article

Treatment of Active Pulmonary Tuberculosis in Adults: Current Standards and Recent Advances.

Published in:

Pharmacotherapy, 2009, v. 29, n. 12, p. 1468, doi. 10.1592/phco.29.12.1468

By:

Hall, Ronald G.;
Left, Richard D.;
Gumbo, Tawanda

Publication type:

Article

Transformation Morphisms and Time-to-Extinction Analysis That Map Therapy Duration From Preclinical Models to Patients With Tuberculosis: Translating From Apples to Oranges.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S349, doi. 10.1093/cid/ciy623

By:

Magombedze, Gesham;
Pasipanodya, Jotam G;
Srivastava, Shashikant;
Deshpande, Devyani;
Visser, Marianne E;
Chigutsa, Emmanuel;
McIlleron, Helen;
Gumbo, Tawanda

Publication type:

Article

The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S336, doi. 10.1093/cid/ciy626

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Nuermberger, Eric;
Lee, Pooi S;
Cirrincione, Kayle;
Dheda, Keertan;
Gumbo, Tawanda

Publication type:

Article

Pharmacokinetic/Pharmacodynamic Background and Methods and Scientific Evidence Base for Dosing of Second-line Tuberculosis Drugs.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S267, doi. 10.1093/cid/ciy608

By:

Gumbo, Tawanda;
Alffenaar, Jan-Willem C

Publication type:

Article

Multiparameter Responses to Tedizolid Monotherapy and Moxifloxacin Combination Therapy Models of Children With Intracellular Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S342, doi. 10.1093/cid/ciy612

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Nuermberger, Eric;
Koeuth, Thearith;
Martin, Katherine R;
Cirrincione, Kayle N;
Lee, Pooi S;
Gumbo, Tawanda

Publication type:

Article

Linezolid-based Regimens for Multidrug-resistant Tuberculosis (TB): A Systematic Review to Establish or Revise the Current Recommended Dose for TB Treatment.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S327, doi. 10.1093/cid/ciy625

By:

Bolhuis, Mathieu S;
Akkerman, Onno W;
Sturkenboom, Marieke G G;
Ghimire, Samiksha;
Srivastava, Shashikant;
Gumbo, Tawanda;
Alffenaar, Jan-Willem C

Publication type:

Article

Ethionamide Pharmacokinetics/Pharmacodynamics-derived Dose, the Role of MICs in Clinical Outcome, and the Resistance Arrow of Time in Multidrug-resistant Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S317, doi. 10.1093/cid/ciy609

By:

Deshpande, Devyani;
Pasipanodya, Jotam G;
Mpagama, Stellah G;
Srivastava, Shashikant;
Bendet, Paula;
Koeuth, Thearith;
Lee, Pooi S;
Heysell, Scott K;
Gumbo, Tawanda

Publication type:

Article

Efficacy Versus Hepatotoxicity of High-dose Rifampin, Pyrazinamide, and Moxifloxacin to Shorten Tuberculosis Therapy Duration: There Is Still Fight in the Old Warriors Yet!

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S359, doi. 10.1093/cid/ciy627

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Magombedze, Gesham;
Gumbo, Tawanda

Publication type:

Article

Artificial intelligence–derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S284, doi. 10.1093/cid/ciy610

By:

Pasipanodya, Jotam G;
Smythe, Wynand;
Merle, Corinne S;
Olliaro, Piero L;
Deshpande, Devyani;
Magombedze, Gesham;
McIlleron, Helen;
Gumbo, Tawanda

Publication type:

Article

Intermediate Susceptibility Dose-Dependent Breakpoints For High-Dose Rifampin, Isoniazid, and Pyrazinamide Treatment in Multidrug-Resistant Tuberculosis Programs.

Published in:

Clinical Infectious Diseases, 2018, v. 67, n. 11, p. 1743, doi. 10.1093/cid/ciy346

By:

Zuur, Marlanka A;
Pasipanodya, Jotam G;
Soolingen, Dick van;
Werf, Tjip S van der;
Gumbo, Tawanda;
Alffenaar, Jan-Willem C

Publication type:

Article

Individualizing Tuberculosis (TB) Treatment: Are TB Programs in High Burden Settings Ready for Prime Time Therapeutic Drug Monitoring?

Published in:

2018

By:

Pasipanodya, Jotam G;
Gumbo, Tawanda

Publication type:

Letter to the Editor

Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis.

Published in:

Clinical Infectious Diseases, 2017, v. 64, n. 10, p. 1350, doi. 10.1093/cid/cix158

By:

Rockwood, Neesha;
Pasipanodya, Jotam G.;
Denti, Paolo;
Sirgel, Frederick;
Lesosky, Maia;
Gumbo, Tawanda;
Meintjes, Graeme;
McIlleron, Helen;
Wilkinson, Robert J.

Publication type:

Article

Reply to Raoult.

Published in:

2017

By:

Seddon, James A.;
Makhene, Mamodikoe K.;
Gumbo, Tawanda

Publication type:

Letter to the Editor

Partnerships to Design Novel Regimens to Treat Childhood Tuberculosis, Sui Generis: The Road Ahead.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S110, doi. 10.1093/cid/ciw484

By:

Gumbo, Tawanda;
Makhene, Mamodikoe K.;
Seddon, James A.

Publication type:

Article

Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S63, doi. 10.1093/cid/ciw471

By:

Swaminathan, Soumya;
Pasipanodya, Jotam G.;
Ramachandran, Geetha;
Kumar, A. K. Hemanth;
Srivastava, Shashikant;
Deshpande, Devyani;
Nuermberger, Eric;
Gumbo, Tawanda

Publication type:

Article

A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S95, doi. 10.1093/cid/ciw474

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Nuermberger, Eric;
Pasipanodya, Jotam G.;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S88, doi. 10.1093/cid/ciw473

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Nuermberger, Eric;
Pasipanodya, Jotam G.;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S80, doi. 10.1093/cid/ciw482

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Bush, Stephen J.;
Nuermberger, Eric;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S75, doi. 10.1093/cid/ciw472

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Pasipanodya, Jotam G.;
Thomas, Tania;
Swaminathan, Soumya;
Nuermberger, Eric;
Gumbo, Tawanda

Publication type:

Article

Optimal Clinical Doses of Faropenem, Linezolid, and Moxifloxacin in Children With Disseminated Tuberculosis: Goldilocks.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S102, doi. 10.1093/cid/ciw483

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Pasipanodya, Jotam;
Nuermberger, Eric;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

Single or 2-Dose Micafungin Regimen for Treatment of Invasive Candidiasis: Therapia Sterilisans Magna!

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S635, doi. 10.1093/cid/civ715

By:

Gumbo, Tawanda

Publication type:

Article

Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments.

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S10, doi. 10.1093/cid/civ425

By:

Pasipanodya, Jotam G.;
Nuermberger, Eric;
Romero, Klaus;
Gumbo, Tawanda

Publication type:

Article

Forecasting Accuracy of the Hollow Fiber Model of Tuberculosis for Clinical Therapeutic Outcomes.

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S25, doi. 10.1093/cid/civ427

By:

Gumbo, Tawanda;
Pasipanodya, Jotam G.;
Romero, Klaus;
Hanna, Debra;
Nuermberger, Eric

Publication type:

Article

Correlations Between the Hollow Fiber Model of Tuberculosis and Therapeutic Events in Tuberculosis Patients: Learn and Confirm.

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S18, doi. 10.1093/cid/civ426

By:

Gumbo, Tawanda;
Pasipanodya, Jotam G.;
Nuermberger, Eric;
Romero, Klaus;
Hanna, Debra

Publication type:

Article

Acquired Drug Resistance: We Can Do More Than We Think!

Published in:

Clinical Infectious Diseases, 2015, v. 60, n. 6, p. 969, doi. 10.1093/cid/ciu1146

By:

Alffenaar, Jan-Willem C.;
Gumbo, Tawanda;
Aarnoutse, Rob E.

Publication type:

Article

Reply to Moonan and Weis, Seaworth et al, and Nunn and Phillips.

Published in:

2013

By:

Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

Letter

A Meta-Analysis of Self-Administered vs Directly Observed Therapy Effect on Microbiologic Failure, Relapse, and Acquired Drug Resistance in Tuberculosis Patients.

Published in:

Clinical Infectious Diseases, 2013, v. 57, n. 1, p. 21, doi. 10.1093/cid/cit167

By:

Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

Article

Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy.

Published in:

Clinical Infectious Diseases, 2012, v. 55, n. 2, p. 169, doi. 10.1093/cid/cis353

By:

Pasipanodya, Jotam G.;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Article

Ceftriaxone Efficacy for Mycobacterium avium Complex Lung Disease in the Hollow Fiber and Translation to Sustained Sputum Culture Conversion in Patients.

Published in:

Journal of Infectious Diseases, 2024, v. 230, n. 2, p. e230, doi. 10.1093/infdis/jiad545

By:

Deshpande, Devyani;
Magombedze, Gesham;
Boorgula, Gunavanthi D;
Chapagain, Moti;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Article

Urine colorimetry to detect Low rifampin exposure during tuberculosis therapy: a proof-of-concept study.

Published in:

2016

By:

Zentner, Isaac;
Schlecht, Hans P.;
Khensouvann, Lorna;
Tamuhla, Neo;
Kutzler, Michele;
Ivaturi, Vijay;
Pasipanodya, Jotam G.;
Gumbo, Tawanda;
Peloquin, Charles A.;
Bisson, Gregory P.;
Vinnard, Christopher

Publication type:

journal article

Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.

Published in:

BMC Infectious Diseases, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2334-14-115

By:

Pusch, Tobias;
Pasipanodya, Jotam G.;
Hall II, Ronald G.;
Gumbo, Tawanda

Publication type:

Article

Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.

Published in:

2014

By:

Pusch, Tobias;
Pasipanodya, Jotam G;
Hall 2nd, Ronald G;
Gumbo, Tawanda;
Hall, Ronald G 2nd

Publication type:

journal article

Comment on "Long-term Safety and Tolerability of Omadacycline for the Treatment of Mycobacterium abscessus Infections".

Published in:

Open Forum Infectious Diseases, 2023, v. 10, n. 8, p. 1, doi. 10.1093/ofid/ofad423

By:

Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Article

Minocycline intra-bacterial pharmacokinetic hysteresis as a basis for pharmacologic memory and a backbone for once-a-week pan-tuberculosis therapy.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1024608

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Pasipanodya, Jotam Garaimunashe;
Gumbo, Tawanda

Publication type:

Article

Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore.

Published in:

Clinical Infectious Diseases, 2007, v. 44, n. 1, p. 79, doi. 10.1086/510079

By:

Ambrose, Paul G.;
Bhavnani, Sujata M.;
Rubino, Christopher M.;
Louie, Arnold;
Gumbo, Tawanda;
Forrest, Alan;
Drusano, George L.

Publication type:

Article

The Crisis of Resistance: Identifying Drug Exposures to Suppress Amplification of Resistant Mutant Subpopulations.

Published in:

Clinical Infectious Diseases, 2006, v. 42, n. 4, p. 525, doi. 10.1086/499046

By:

Drusano, G. L.;
Louie, Arnold;
Deziel, Mark;
Gumbo, Tawanda

Publication type:

Article

Cryptococcus myelitis: Atypical Presentation of a Common Infection.

Published in:

Clinical Infectious Diseases, 2001, v. 32, n. 8, p. 1235, doi. 10.1086/319749

By:

Gumbo, Tawanda;
Hakim, James G.;
Mielke, Jens;
Siwji, Safdarali;
Just-Nubling, Gudrun;
Ismail, Ayaaz

Publication type:

Article