Works matching AU Gumbo, Tawanda

Results: 94

Bacterial load slopes represent biomarkers of tuberculosis therapy success, failure, and relapse.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02184-0

By:

Magombedze, Gesham;
Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

Article

Tedizolid, Faropenem, and Moxifloxacin Combination With Potential Activity Against Nonreplicating Mycobacterium tuberculosis.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.616294

By:

Srivastava, Shashikant;
Cirrincione, Kayle N.;
Deshpande, Devyani;
Gumbo, Tawanda

Publication type:

Article

Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.01103

By:

Zentner, Isaac;
Back, Hyun-moon;
Kagan, Leonid;
Subbian, Selvakumar;
Nagajyothi, Jyothi;
Srivastava, Shashikant;
Pasipanodya, Jotam;
Gumbo, Tawanda;
Bisson, Gregory P.;
Vinnard, Christopher

Publication type:

Article

Case Report. Nattrassia mangiferae endophthalmitis.

Published in:

Mycoses, 2002, v. 45, n. 3/4, p. 118, doi. 10.1046/j.1439-0507.2002.00723.x

By:

Gumbo, Tawanda;
Mkanganwi, Ndodini;
Robertson, Valerie J;
Masvaire, Praise

Publication type:

Article

Biological variability and the emergence of multidrug-resistant tuberculosis.

Published in:

Nature Genetics, 2013, v. 45, n. 7, p. 720, doi. 10.1038/ng.2675

By:

Gumbo, Tawanda

Publication type:

Article

Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study.

Published in:

2019

By:

Mehta, Krina;
Ravimohan, Shruthi;
Pasipanodya, Jotam G;
Srivastava, Shashikant;
Modongo, Chawangwa;
Zetola, Nicola M;
Weissman, Drew;
Ivaturi, Vijay;
Gumbo, Tawanda;
Bisson, Gregory P;
Vinnard, Christopher

Publication type:

journal article

Minocycline treatment for pulmonary Mycobacterium avium complex disease based on pharmacokinetics/pharmacodynamics and Bayesian framework mathematical models.

Published in:

2019

By:

Ruth, Mike M;
Magombedze, Gesham;
Gumbo, Tawanda;
Bendet, Paula;
Sangen, Jasper J N;
Zweijpfenning, Sanne;
Hoefsloot, Wouter;
Pennings, Lian;
Koeken, Valerie A C M;
Wertheim, Heiman F L;
Lee, Pooi S;
Ingen, Jakko van;
Deshpande, Devyani;
van Ingen, Jakko

Publication type:

journal article

Once-a-week tigecycline for the treatment of drug-resistant TB.

Published in:

2019

By:

Deshpande, Devyani;
Magombedze, Gesham;
Srivastava, Shashikant;
Bendet, Paula;
Lee, Pooi S;
Cirrincione, Kayle N;
Martin, Katherine R;
Dheda, Keertan;
Gumbo, Tawanda

Publication type:

journal article

Failure of the azithromycin and ethambutol combination regimen in the hollow-fibre system model of pulmonary Mycobacterium avium infection is due to acquired resistance.

Published in:

2017

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Gumbo, Tawanda

Publication type:

journal article

Linezolid as treatment for pulmonary Mycobacterium avium disease.

Published in:

2017

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

journal article

A novel ceftazidime/avibactam, rifabutin, tedizolid and moxifloxacin (CARTM) regimen for pulmonary Mycobacterium avium disease.

Published in:

2017

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Lee, Pooi S.;
Gumbo, Tawanda

Publication type:

journal article

A 'shock and awe' thioridazine and moxifloxacin combination-based regimen for pulmonary Mycobacterium avium-intracellulare complex disease.

Published in:

2017

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Sherman, Carleton M.;
Gumbo, Tawanda

Publication type:

journal article

The discovery of ceftazidime/avibactam as an anti-Mycobacterium avium agent.

Published in:

2017

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Chapagain, Moti. L.;
Lee, Pooi S.;
Cirrincione, Kayle N.;
Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

journal article

Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease.

Published in:

2017

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Lee, Pooi S.;
Gumbo, Tawanda

Publication type:

journal article

A programme to create short-course chemotherapy for pulmonary Mycobacterium avium disease based on pharmacokinetics/pharmacodynamics and mathematical forecasting.

Published in:

2017

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

journal article

Meta-analyses and the evidence base for microbial outcomes in the treatment of pulmonary Mycobacterium avium-intracellulare complex disease.

Published in:

2017

By:

Pasipanodya, Jotam G.;
Ogbonna, Deborah;
Deshpande, Devyani;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

journal article

Markers of gut dysfunction do not explain low rifampicin bioavailability in HIV-associated TB.

Published in:

2017

By:

Vinnard, Christopher;
Ravimohan, Shruthi;
Tamuhla, Neo;
Pasipanodya, Jotam;
Srivastava, Shashikant;
Modongo, Chawangwa;
Zetola, Nicola M.;
Weissman, Drew;
Gumbo, Tawanda;
Bisson, Gregory P.

Publication type:

journal article

Subtherapeutic concentrations of first-line anti-TB drugs in South African children treated according to current guidelines: the PHATISA study.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 4, p. 1115, doi. 10.1093/jac/dku478

By:

Hiruy, Hiwot;
Rogers, Zoe;
Mbowane, Chris;
Adamson, John;
Ngotho, Lihle;
Karim, Farina;
Gumbo, Tawanda;
Bishai, William;
Jeena, Prakash

Publication type:

Article

Comment on: Clinical significance of 2 h plasma concentrations of first-line anti-tuberculosis drugs: a prospective observational study.

Published in:

2015

By:

Pasipanodya, Jotam G;
Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Journal Article

The pyrazinamide susceptibility breakpoint above which combination therapy fails.

Published in:

2014

By:

Gumbo, Tawanda;
Chigutsa, Emmanuel;
Pasipanodya, Jotam;
Visser, Marianne;
van Helden, Paul D;
Sirgel, Frederick A;
McIlleron, Helen

Publication type:

journal article

The pyrazinamide susceptibility breakpoint above which combination therapy fails.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 9, p. 2420, doi. 10.1093/jac/dku136

By:

Gumbo, Tawanda;
Chigutsa, Emmanuel;
Pasipanodya, Jotam;
Visser, Marianne;
van Helden, Paul D.;
Sirgel, Frederick A;
McIlleron, Helen

Publication type:

Article

Comment on "Long-term Safety and Tolerability of Omadacycline for the Treatment of Mycobacterium abscessus Infections".

Published in:

Open Forum Infectious Diseases, 2023, v. 10, n. 8, p. 1, doi. 10.1093/ofid/ofad423

By:

Srivastava, Shashikant;
Gumbo, Tawanda

Publication type:

Article

Urine colorimetry to detect Low rifampin exposure during tuberculosis therapy: a proof-of-concept study.

Published in:

2016

By:

Zentner, Isaac;
Schlecht, Hans P.;
Khensouvann, Lorna;
Tamuhla, Neo;
Kutzler, Michele;
Ivaturi, Vijay;
Pasipanodya, Jotam G.;
Gumbo, Tawanda;
Peloquin, Charles A.;
Bisson, Gregory P.;
Vinnard, Christopher

Publication type:

journal article

Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.

Published in:

BMC Infectious Diseases, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2334-14-115

By:

Pusch, Tobias;
Pasipanodya, Jotam G.;
Hall II, Ronald G.;
Gumbo, Tawanda

Publication type:

Article

Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.

Published in:

2014

By:

Pusch, Tobias;
Pasipanodya, Jotam G;
Hall 2nd, Ronald G;
Gumbo, Tawanda;
Hall, Ronald G 2nd

Publication type:

journal article

Transformation Morphisms and Time-to-Extinction Analysis That Map Therapy Duration From Preclinical Models to Patients With Tuberculosis: Translating From Apples to Oranges.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S349, doi. 10.1093/cid/ciy623

By:

Magombedze, Gesham;
Pasipanodya, Jotam G;
Srivastava, Shashikant;
Deshpande, Devyani;
Visser, Marianne E;
Chigutsa, Emmanuel;
McIlleron, Helen;
Gumbo, Tawanda

Publication type:

Article

The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S336, doi. 10.1093/cid/ciy626

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Nuermberger, Eric;
Lee, Pooi S;
Cirrincione, Kayle;
Dheda, Keertan;
Gumbo, Tawanda

Publication type:

Article

Pharmacokinetic/Pharmacodynamic Background and Methods and Scientific Evidence Base for Dosing of Second-line Tuberculosis Drugs.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S267, doi. 10.1093/cid/ciy608

By:

Gumbo, Tawanda;
Alffenaar, Jan-Willem C

Publication type:

Article

Multiparameter Responses to Tedizolid Monotherapy and Moxifloxacin Combination Therapy Models of Children With Intracellular Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S342, doi. 10.1093/cid/ciy612

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Nuermberger, Eric;
Koeuth, Thearith;
Martin, Katherine R;
Cirrincione, Kayle N;
Lee, Pooi S;
Gumbo, Tawanda

Publication type:

Article

Linezolid-based Regimens for Multidrug-resistant Tuberculosis (TB): A Systematic Review to Establish or Revise the Current Recommended Dose for TB Treatment.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S327, doi. 10.1093/cid/ciy625

By:

Bolhuis, Mathieu S;
Akkerman, Onno W;
Sturkenboom, Marieke G G;
Ghimire, Samiksha;
Srivastava, Shashikant;
Gumbo, Tawanda;
Alffenaar, Jan-Willem C

Publication type:

Article

Ethionamide Pharmacokinetics/Pharmacodynamics-derived Dose, the Role of MICs in Clinical Outcome, and the Resistance Arrow of Time in Multidrug-resistant Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S317, doi. 10.1093/cid/ciy609

By:

Deshpande, Devyani;
Pasipanodya, Jotam G;
Mpagama, Stellah G;
Srivastava, Shashikant;
Bendet, Paula;
Koeuth, Thearith;
Lee, Pooi S;
Heysell, Scott K;
Gumbo, Tawanda

Publication type:

Article

Efficacy Versus Hepatotoxicity of High-dose Rifampin, Pyrazinamide, and Moxifloxacin to Shorten Tuberculosis Therapy Duration: There Is Still Fight in the Old Warriors Yet!

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S359, doi. 10.1093/cid/ciy627

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Magombedze, Gesham;
Gumbo, Tawanda

Publication type:

Article

Artificial intelligence–derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis.

Published in:

Clinical Infectious Diseases, 2018, v. 67, p. S284, doi. 10.1093/cid/ciy610

By:

Pasipanodya, Jotam G;
Smythe, Wynand;
Merle, Corinne S;
Olliaro, Piero L;
Deshpande, Devyani;
Magombedze, Gesham;
McIlleron, Helen;
Gumbo, Tawanda

Publication type:

Article

Intermediate Susceptibility Dose-Dependent Breakpoints For High-Dose Rifampin, Isoniazid, and Pyrazinamide Treatment in Multidrug-Resistant Tuberculosis Programs.

Published in:

Clinical Infectious Diseases, 2018, v. 67, n. 11, p. 1743, doi. 10.1093/cid/ciy346

By:

Zuur, Marlanka A;
Pasipanodya, Jotam G;
Soolingen, Dick van;
Werf, Tjip S van der;
Gumbo, Tawanda;
Alffenaar, Jan-Willem C

Publication type:

Article

Individualizing Tuberculosis (TB) Treatment: Are TB Programs in High Burden Settings Ready for Prime Time Therapeutic Drug Monitoring?

Published in:

2018

By:

Pasipanodya, Jotam G;
Gumbo, Tawanda

Publication type:

Letter to the Editor

Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis.

Published in:

Clinical Infectious Diseases, 2017, v. 64, n. 10, p. 1350, doi. 10.1093/cid/cix158

By:

Rockwood, Neesha;
Pasipanodya, Jotam G.;
Denti, Paolo;
Sirgel, Frederick;
Lesosky, Maia;
Gumbo, Tawanda;
Meintjes, Graeme;
McIlleron, Helen;
Wilkinson, Robert J.

Publication type:

Article

Reply to Raoult.

Published in:

2017

By:

Seddon, James A.;
Makhene, Mamodikoe K.;
Gumbo, Tawanda

Publication type:

Letter to the Editor

Optimal Clinical Doses of Faropenem, Linezolid, and Moxifloxacin in Children With Disseminated Tuberculosis: Goldilocks.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S102, doi. 10.1093/cid/ciw483

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Pasipanodya, Jotam;
Nuermberger, Eric;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

Partnerships to Design Novel Regimens to Treat Childhood Tuberculosis, Sui Generis: The Road Ahead.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S110, doi. 10.1093/cid/ciw484

By:

Gumbo, Tawanda;
Makhene, Mamodikoe K.;
Seddon, James A.

Publication type:

Article

A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S95, doi. 10.1093/cid/ciw474

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Nuermberger, Eric;
Pasipanodya, Jotam G.;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S88, doi. 10.1093/cid/ciw473

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Nuermberger, Eric;
Pasipanodya, Jotam G.;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S80, doi. 10.1093/cid/ciw482

By:

Deshpande, Devyani;
Srivastava, Shashikant;
Pasipanodya, Jotam G.;
Bush, Stephen J.;
Nuermberger, Eric;
Swaminathan, Soumya;
Gumbo, Tawanda

Publication type:

Article

A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S75, doi. 10.1093/cid/ciw472

By:

Srivastava, Shashikant;
Deshpande, Devyani;
Pasipanodya, Jotam G.;
Thomas, Tania;
Swaminathan, Soumya;
Nuermberger, Eric;
Gumbo, Tawanda

Publication type:

Article

Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests.

Published in:

Clinical Infectious Diseases, 2016, v. 63, p. S63, doi. 10.1093/cid/ciw471

By:

Swaminathan, Soumya;
Pasipanodya, Jotam G.;
Ramachandran, Geetha;
Kumar, A. K. Hemanth;
Srivastava, Shashikant;
Deshpande, Devyani;
Nuermberger, Eric;
Gumbo, Tawanda

Publication type:

Article

Single or 2-Dose Micafungin Regimen for Treatment of Invasive Candidiasis: Therapia Sterilisans Magna!

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S635, doi. 10.1093/cid/civ715

By:

Gumbo, Tawanda

Publication type:

Article

Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments.

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S10, doi. 10.1093/cid/civ425

By:

Pasipanodya, Jotam G.;
Nuermberger, Eric;
Romero, Klaus;
Gumbo, Tawanda

Publication type:

Article

Forecasting Accuracy of the Hollow Fiber Model of Tuberculosis for Clinical Therapeutic Outcomes.

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S25, doi. 10.1093/cid/civ427

By:

Gumbo, Tawanda;
Pasipanodya, Jotam G.;
Romero, Klaus;
Hanna, Debra;
Nuermberger, Eric

Publication type:

Article

Correlations Between the Hollow Fiber Model of Tuberculosis and Therapeutic Events in Tuberculosis Patients: Learn and Confirm.

Published in:

Clinical Infectious Diseases, 2015, v. 61, p. S18, doi. 10.1093/cid/civ426

By:

Gumbo, Tawanda;
Pasipanodya, Jotam G.;
Nuermberger, Eric;
Romero, Klaus;
Hanna, Debra

Publication type:

Article

Acquired Drug Resistance: We Can Do More Than We Think!

Published in:

Clinical Infectious Diseases, 2015, v. 60, n. 6, p. 969, doi. 10.1093/cid/ciu1146

By:

Alffenaar, Jan-Willem C.;
Gumbo, Tawanda;
Aarnoutse, Rob E.

Publication type:

Article

Reply to Moonan and Weis, Seaworth et al, and Nunn and Phillips.

Published in:

2013

By:

Pasipanodya, Jotam G.;
Gumbo, Tawanda

Publication type:

Letter