Works by Gujar, Shashi A.

Results: 38

Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 4, p. 654, doi. 10.3390/v13040654

By:

Kumar, Vishnupriyan;
Giacomantonio, Michael A.;
Gujar, Shashi;
Danthi, Pranav;
Shmulevitz, Maya

Publication type:

Article

Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response.

Published in:

Cell Cycle, 2015, v. 14, n. 14, p. 2301, doi. 10.1080/15384101.2015.1044187

By:

Ahn, Dae-Gyun;
Sharif, Tanveer;
Chisholm, Kenneth;
Pinto, Devanand M;
Gujar, Shashi A;
Lee, Patrick WK

Publication type:

Article

The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target.

Published in:

Cell Cycle, 2014, v. 13, n. 6, p. 1041, doi. 10.4161/cc.28128

By:

Lu-Zhe Pan;
Dae-Gyun Ahn;
Sharif, Tanveer;
Clements, Derek;
Gujar, Shashi A.;
Lee, Patrick W. K.

Publication type:

Article

Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.

Published in:

Molecular Oncology, 2015, v. 9, n. 1, p. 17, doi. 10.1016/j.molonc.2014.07.010

By:

Marcato, Paola;
Dean, Cheryl A.;
Liu, Rong-Zong;
Coyle, Krysta M.;
Bydoun, Moamen;
Wallace, Melissa;
Clements, Derek;
Turner, Colin;
Mathenge, Edward G.;
Gujar, Shashi A.;
Giacomantonio, Carman A.;
Mackey, John R.;
Godbout, Roseline;
Lee, Patrick W.K.

Publication type:

Article

A Qualitative Evaluation of Program Budgeting and Marginal Analysis in a Canadian Pediatric Tertiary Care Institution.

Published in:

Applied Health Economics & Health Policy, 2016, v. 14, n. 5, p. 559, doi. 10.1007/s40258-016-0250-5

By:

Smith, Neale;
Mitton, Craig;
Hiltz, Mary-Ann;
Campbell, Matthew;
Dowling, Laura;
Magee, J.;
Gujar, Shashi

Publication type:

Article

TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 52, n. 4, p. 742, doi. 10.33594/000000052

By:

Almasi, Shekoufeh;
Yu Long, Clara;
Sterea, Andra;
Clements, Derek Richard;
Gujar, Shashi;
El Hiani, Yassine

Publication type:

Article

Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00654

By:

Cruickshank, Brianne;
Giacomantonio, Michael;
Marcato, Paola;
McFarland, Sherri;
Pol, Jonathan;
Gujar, Shashi

Publication type:

Article

Improving MHC‐I Ligand Identifications from LC‐MS/MS Data by Incorporating Allelic Peptide Motifs.

Published in:

Proteomics, 2019, v. 19, n. 5, p. N.PAG, doi. 10.1002/pmic.201800458

By:

Konda, Prathyusha;
Murphy, J. Patrick;
Gujar, Shashi

Publication type:

Article

Flow Cytometric Quantification of T Cell Proliferation and Division Kinetics in Woodchuck Model of Hepatitis B.

Published in:

Immunological Investigations, 2005, v. 34, n. 2, p. 215, doi. 10.1081/IMM-200055834

By:

Gujar, Shashi A.;
Michalak, Tomasz I.

Publication type:

Article

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.

Published in:

Acta Neuropathologica Communications, 2018, v. 6, p. 1, doi. 10.1186/s40478-017-0506-9

By:

Warford, Jordan R.;
Lamport, Anna-Claire;
Clements, Derek R.;
Malone, Alicia;
Kennedy, Barry E.;
Kim, Youra;
Gujar, Shashi A.;
Hoskin, David W.;
Easton, Alexander S.

Publication type:

Article

Multiprong CD38 targeting to enhance anti-PD1 immune checkpoint blockade efficacy.

Published in:

2024

By:

Vijayan, Vishnu Vijay;
Nair, Preethi Gopalakrishnan;
Gujar, Shashi

Publication type:

Editorial

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy.

Published in:

OncoImmunology, 2021, v. 10, n. 1, p. 1, doi. 10.1080/2162402X.2020.1863626

By:

Konda, Prathyusha;
Lifshits, Liubov M.;
Roque III, John A.;
Cole, Houston D.;
Cameron, Colin G.;
McFarland, Sherri A.;
Gujar, Shashi

Publication type:

Article

Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?

Published in:

OncoImmunology, 2020, v. 9, n. 1, p. 1, doi. 10.1080/2162402X.2020.1794424

By:

Gujar, Shashi;
Pol, Jonathan G.;
Kim, Youra;
Kroemer, Guido

Publication type:

Article

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.

Published in:

OncoImmunology, 2018, v. 7, n. 12, p. 1, doi. 10.1080/2162402X.2018.1503032

By:

G. Pol, Jonathan;
Lévesque, Sarah;
Workenhe, Samuel T.;
Gujar, Shashi;
Le Boeuf, Fabrice;
R. Clements, Derek;
Fahrner, Jean-Eudes;
Fend, Laetitia;
C. Bell, John;
L. Mossman, Karen;
Fucikova, Jitka;
Spisek, Radek;
Zitvogel, Laurence;
Kroemer, Guido;
Galluzzi, Lorenzo

Publication type:

Article

Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies.

Published in:

OncoImmunology, 2018, v. 7, n. 8, p. 1, doi. 10.1080/2162402X.2018.1442169

By:

Gujar, Shashi;
Pol, Jonathan G.;
Kroemer, Guido

Publication type:

Article

All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy.

Published in:

OncoImmunology, 2016, v. 5, n. 1, p. 1, doi. 10.1080/2162402X.2015.1057674

By:

Clements, Derek R;
Kim, Youra;
Lee, Patrick WK;
Gujar, Shashi A

Publication type:

Article

Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses.

Published in:

OncoImmunology, 2014, v. 3, n. 2, p. N.PAG, doi. 10.4161/onci.27622

By:

Gujar, Shashi;
Clements, Derek;
Lee, Patrick W.K.

Publication type:

Article

Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy.

Published in:

Nature Protocols, 2024, v. 19, n. 9, p. 2540, doi. 10.1038/s41596-024-00985-1

By:

Gujar, Shashi;
Pol, Jonathan G.;
Kumar, Vishnupriyan;
Lizarralde-Guerrero, Manuela;
Konda, Prathyusha;
Kroemer, Guido;
Bell, John C.

Publication type:

Article

Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis.

Published in:

Metabolomics, 2022, v. 18, n. 1, p. 1, doi. 10.1007/s11306-021-01864-6

By:

Dahn, Margaret L.;
Walsh, Hayley R.;
Dean, Cheryl A.;
Giacomantonio, Michael A.;
Fernando, Wasundara;
Murphy, J Patrick;
Walker, Olivia L.;
Wasson, Marie-Claire D.;
Gujar, Shashi;
Pinto, Devanand M.;
Marcato, Paola

Publication type:

Article

Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells.

Published in:

Autophagy, 2019, v. 15, n. 5, p. 934, doi. 10.1080/15548627.2019.1586321

By:

Sharif, Tanveer;
Martell, Emma;
Dai, Cathleen;
Singh, Sheila K.;
Gujar, Shashi

Publication type:

Article

TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-40330-1

By:

Almasi, Shekoufeh;
Sterea, Andra M.;
Fernando, Wasundara;
Clements, Derek R.;
Marcato, Paola;
Hoskin, David W.;
Gujar, Shashi;
El Hiani, Yassine

Publication type:

Article

Multifaceted Therapeutic Targeting of Ovarian Peritoneal Carcinomatosis Through Virus-induced Immunomodulation.

Published in:

Molecular Therapy, 2013, v. 21, n. 2, p. 338, doi. 10.1038/mt.2012.228

By:

Gujar, Shashi;
Dielschneider, Rebecca;
Clements, Derek;
Helson, Erin;
Shmulevitz, Maya;
Marcato, Paola;
Pan, Da;
Pan, Lu-zhe;
Ahn, Dae-Gyun;
Alawadhi, Abdulaziz;
Lee, Patrick WK

Publication type:

Article

Oncolytic Virus-initiated Protective Immunity Against Prostate Cancer.

Published in:

Molecular Therapy, 2011, v. 19, n. 4, p. 797, doi. 10.1038/mt.2010.297

By:

Gujar, Shashi A.;
Pan, Da;
Marcato, Paola;
Garant, Katy A.;
Lee, Patrick W. K.

Publication type:

Article

HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells.

Published in:

Autophagy, 2019, v. 15, n. 4, p. 686, doi. 10.1080/15548627.2018.1548547

By:

Sharif, Tanveer;
Martell, Emma;
Dai, Cathleen;
Ghassemi-Rad, Mohammad Saleh;
Hanes, Mark Robert;
Murphy, Patrick J.;
Margam, Nandini N.;
Parmar, Hirendrasinh B.;
Giacomantonio, Carman A.;
Duncan, Roy;
Lee, Patrick W.K.;
Gujar, Shashi

Publication type:

Article

Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.

Published in:

Autophagy, 2018, v. 14, n. 1, p. 134, doi. 10.1080/15548627.2017.1370171

By:

Yoo, Byong Hoon;
Khan, Iman Aftab;
Koomson, Ananda;
Gowda, Pramod;
Sasazuki, Takehiko;
Shirasawa, Senji;
Gujar, Shashi;
V. Rosen, Kirill

Publication type:

Article

Autophagic homeostasis is required for the pluripotency of cancer stem cells.

Published in:

Autophagy, 2017, v. 13, n. 2, p. 264, doi. 10.1080/15548627.2016.1260808

By:

Sharif, Tanveer;
Martell, Emma;
Dai, Cathleen;
Kennedy, Barry E.;
Murphy, Patrick;
Clements, Derek R.;
Kim, Youra;
Lee, Patrick W. K.;
Gujar, Shashi A.

Publication type:

Article

Oncolytic virus-mediated reversal of impaired tumor antigen presentation.

Published in:

Frontiers in Oncology, 2014, v. 4, p. 1, doi. 10.3389/fonc.2014.00077

By:

Gujar, Shashi A.;
Lee, Patrick W. K.

Publication type:

Article

Reovirus in cancer therapy: an evidence-based review.

Published in:

Oncolytic Virotherapy, 2014, v. 3, p. 69, doi. 10.2147/OV.S51321

By:

Clements, Derek;
Helson, Erin;
Gujar, Shashi A.;
Lee, Patrick W. K.

Publication type:

Article

The lysosomal ion channel TRPML1 in breast cancer.

Published in:

Journal of Cellular Neuroscience & Oxidative Stress, 2018, v. 10, n. 2, p. 683

By:

ALMASI, Shekoufeh;
STEREA, Andra M.;
KENNEDY, Barry E.;
CLEMENTS, Derek R.;
GUJAR, Shashi;
HIANI, Yassine EL

Publication type:

Article

Introducing New Priority Setting and Resource Allocation Processes in a Canadian Healthcare Organization: A Case Study Analysis Informed by Multiple Streams Theory.

Published in:

2016

By:

Smith, Neale;
Mitton, Craig;
Dowling, Laura;
Hiltz, Mary-Ann;
Campbell, Matthew;
Gujar, Shashi Ashok

Publication type:

Case Study

Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00800

By:

Holay, Namit;
Kim, Youra;
Lee, Patrick;
Gujar, Shashi

Publication type:

Article

Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054006

By:

Da Pan;
Marcato, Paola;
Ahn, Dae-Gyun;
Gujar, Shashi;
Lu-Zhe Pan;
Shmulevitz, Maya;
Lee, Partrick W. K.

Publication type:

Article

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis.

Published in:

Stem Cells, 2011, v. 29, n. 1, p. 32, doi. 10.1002/stem.563

By:

Marcato, Paola;
Dean, Cheryl A.;
Pan, Da;
Araslanova, Rakhna;
Gillis, Megan;
Joshi, Madalsa;
Helyer, Lucy;
Pan, Luzhe;
Leidal, Andrew;
Gujar, Shashi;
Giacomantonio, Carman A.;
Lee, Patrick W. K.

Publication type:

Article

Hide-and-seek: the interplay between cancer stem cells and the immune system.

Published in:

Carcinogenesis, 2017, v. 38, n. 2, p. 107, doi. 10.1093/carcin/bgw115

By:

Sultan, Mohammad;
Coyle, Krysta Mila;
Vidovic, Dejan;
Thomas, Margaret Lois;
Gujar, Shashi;
Marcato, Paola

Publication type:

Article

Dendritic Cells in Oncolytic Virus-Based Anti-Cancer Therapy.

Published in:

Viruses (1999-4915), 2015, v. 7, n. 12, p. 6506, doi. 10.3390/v7122953

By:

Youra Kim;
Clements, Derek R.;
Sterea, Andra M.;
Hyun Woo Jang;
Gujar, Shashi A.;
Lee, Patrick W. K.

Publication type:

Article

Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively.

Published in:

PLoS Pathogens, 2020, v. 16, n. 9, p. 1, doi. 10.1371/journal.ppat.1008803

By:

Mohamed, Adil;
Konda, Prathyusha;
Eaton, Heather E.;
Gujar, Shashi;
Smiley, James R.;
Shmulevitz, Maya

Publication type:

Article

After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 1, doi. 10.3389/fimmu.2022.1047661

By:

Holay, Namit;
Kennedy, Barry E.;
Murphy, J. Patrick;
Konda, Prathyusha;
Giacomantonio, Michael;
Brauer-Chapin, Tatjana;
Paulo, Joao A.;
Kumar, Vishnupriyan;
Youra Kim;
Elaghil, Mariam;
Sisson, Gary;
Clements, Derek;
Richardson, Christopher;
Gygi, Steven P.;
Gujar, Shashi

Publication type:

Article

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.

Published in:

Cell Death & Disease, 2018, v. 9, n. 10, p. 1, doi. 10.1038/s41419-018-0997-8

By:

Sharif, Tanveer;
Martell, Emma;
Dai, Cathleen;
Ghassemi-Rad, Mohammad Saleh;
Lee, Kristen;
Singh, Sheila K.;
Weaver, Ian C. G.;
Gujar, Shashi

Publication type:

Article

Works by Gujar, Shashi A.

Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy.

Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response.

The NAD<sup>+</sup> synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target.

Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.

A Qualitative Evaluation of Program Budgeting and Marginal Analysis in a Canadian Pediatric Tertiary Care Institution.

TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.

Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy.

Improving MHC‐I Ligand Identifications from LC‐MS/MS Data by Incorporating Allelic Peptide Motifs.

Flow Cytometric Quantification of T Cell Proliferation and Division Kinetics in Woodchuck Model of Hepatitis B.

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.

Multiprong CD38 targeting to enhance anti-PD1 immune checkpoint blockade efficacy.

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy.

Repurposing CD8<sup>+</sup> T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.

Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies.

All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy.

Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses.

Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy.

Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis.

Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells.

TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway.

Multifaceted Therapeutic Targeting of Ovarian Peritoneal Carcinomatosis Through Virus-induced Immunomodulation.

Oncolytic Virus-initiated Protective Immunity Against Prostate Cancer.

HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells.

Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.

Autophagic homeostasis is required for the pluripotency of cancer stem cells.

Oncolytic virus-mediated reversal of impaired tumor antigen presentation.

Reovirus in cancer therapy: an evidence-based review.

The lysosomal ion channel TRPML1 in breast cancer.

Introducing New Priority Setting and Resource Allocation Processes in a Canadian Healthcare Organization: A Case Study Analysis Informed by Multiple Streams Theory.

Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines.

Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis.

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis.

Hide-and-seek: the interplay between cancer stem cells and the immune system.

Dendritic Cells in Oncolytic Virus-Based Anti-Cancer Therapy.

Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively.

After virus exposure, early bystander naïve CD8 T cell activation relies on NAD<sup>+</sup> salvage metabolism.

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.