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A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-48929-0
By:
- Beetham, Henry;
- Chen, Augustine;
- Telford, Bryony J.;
- Single, Andrew;
- Jarman, Kate E.;
- Lackovic, Kurt;
- Luxenburger, Andreas;
- Guilford, Parry
Publication type:
Article
Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.
Published in:
Oncogene, 2002, v. 21, n. 53, p. 8192, doi. 10.1038/sj.onc.1205921
By:
- Humar, Bostjan;
- Graziano, Francesco;
- Cascinu, Stefano;
- Catalano, Vincenzo;
- Ruzzo, Anna M;
- Magnani, Mauro;
- Toro, Tumi;
- Burchill, Tudor;
- Futschik, Matthias E;
- Merriman, Tony;
- Guilford, Parry
Publication type:
Article
Germline E-cadherin gene mutations.
Published in:
Cancer (0008543X), 2001, v. 92, n. 1, p. 181, doi. 10.1002/1097-0142(20010701)92:1<181::AID-CNCR1307>3.0.CO;2-J
By:
- Chun, Yun Shin;
- Lindor, Noralane M.;
- Smyrk, Thomas C.;
- Petersen, Bret T.;
- Burgart, Lawrence J.;
- Guilford, Parry J.;
- Donohue, John H.
Publication type:
Article
Blending space and time to talk about cancer in extended reality.
Published in:
NPJ Digital Medicine, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s41746-024-01262-x
By:
- Robb, Tamsin J.;
- Liu, Yinan;
- Woodhouse, Braden;
- Windahl, Charlotta;
- Hurley, Daniel;
- McArthur, Grant;
- Fox, Stephen B.;
- Brown, Lisa;
- Guilford, Parry;
- Minhinnick, Alice;
- Jackson, Christopher;
- Blenkiron, Cherie;
- Parker, Kate;
- Henare, Kimiora;
- McColl, Rose;
- Haux, Bianca;
- Young, Nick;
- Boyle, Veronica;
- Cameron, Laird;
- Deva, Sanjeev
Publication type:
Article
Analytical Validation of Cxbladder ® Detect, Triage, and Monitor: Assays for Detection and Management of Urothelial Carcinoma.
Published in:
Diagnostics (2075-4418), 2024, v. 14, n. 18, p. 2061, doi. 10.3390/diagnostics14182061
By:
- Harvey, Justin C.;
- Cambridge, Lisa M.;
- Ellen, Charles W.;
- Colonval, Megan;
- Hazlett, Jody A.;
- Newell, Jordan;
- Zhou, Xin;
- Guilford, Parry J.
Publication type:
Article
Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations.
Published in:
Carcinogenesis, 1999, v. 20, n. 6, p. 1127, doi. 10.1093/carcin/20.6.1127
By:
- Shinmura, Kazuya;
- Kohno, Takashi;
- Takahashi, Mina;
- Sasaki, Atsushi;
- Ochiai, Atsushi;
- Guilford, Parry;
- Hunter, Airlie;
- Reeve, Anthony E.;
- Sugimura, Haruhiko;
- Yamaguchi, Naohito;
- Yokota, Jun
Publication type:
Article
Dynamic ctDNA Mutational Complexity in Patients with Melanoma Receiving Immunotherapy.
Published in:
Molecular Diagnosis & Therapy, 2023, v. 27, n. 4, p. 537, doi. 10.1007/s40291-023-00651-4
By:
- Fitzgerald, Sandra;
- Blenkiron, Cherie;
- Stephens, Rosalie;
- Mathy, Jon A.;
- Somers-Edgar, Tiffany;
- Rolfe, Gill;
- Martin, Richard;
- Jackson, Christopher;
- Eccles, Michael;
- Robb, Tamsin;
- Rodger, Euan;
- Lawrence, Ben;
- Guilford, Parry;
- Lasham, Annette;
- Print, Cristin G.
Publication type:
Article
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin ( CDH1) as a target for chemoprevention of lobular neoplasia.
Published in:
Journal of Pathology, 2009, v. 218, n. 2, p. 265, doi. 10.1002/path.2541
By:
- Zou, Donghui;
- Yoon, Han-Seung;
- Perez, David;
- Weeks, Robert J;
- Guilford, Parry;
- Humar, Bostjan
Publication type:
Article
E-Cadherin-Deficient Cells Are Sensitive to the Multikinase Inhibitor Dasatinib.
Published in:
Cancers, 2022, v. 14, n. 7, p. 1609, doi. 10.3390/cancers14071609
By:
- Bougen-Zhukov, Nicola;
- Decourtye-Espiard, Lyvianne;
- Mitchell, Wilson;
- Redpath, Kieran;
- Perkinson, Jacqui;
- Godwin, Tanis;
- Black, Michael A.;
- Guilford, Parry
Publication type:
Article
E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors.
Published in:
Cancers, 2022, v. 14, n. 1, p. 175, doi. 10.3390/cancers14010175
By:
- Decourtye-Espiard, Lyvianne;
- Bougen-Zhukov, Nicola;
- Godwin, Tanis;
- Brew, Tom;
- Schulpen, Emily;
- Black, Michael A.;
- Guilford, Parry
Publication type:
Article
Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking.
Published in:
Cancers, 2022, v. 14, n. 1, p. 102, doi. 10.3390/cancers14010102
By:
- Brew, Tom;
- Bougen-Zhukov, Nicola;
- Mitchell, Wilson;
- Decourtye, Lyvianne;
- Schulpen, Emily;
- Nouri, Yasmin;
- Godwin, Tanis;
- Guilford, Parry
Publication type:
Article
Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells.
Published in:
Cancers, 2019, v. 11, n. 9, p. 1359, doi. 10.3390/cancers11091359
By:
- Bougen-Zhukov, Nicola;
- Nouri, Yasmin;
- Godwin, Tanis;
- Taylor, Megan;
- Hakkaart, Christopher;
- Single, Andrew;
- Brew, Tom;
- Permina, Elizabeth;
- Chen, Augustine;
- Black, Michael A.;
- Guilford, Parry
Publication type:
Article
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing.
Published in:
Journal of Pathology, 2021, v. 254, n. 3, p. 254, doi. 10.1002/path.5675
By:
- Dixon, Katherine;
- Brew, Tom;
- Farnell, David;
- Godwin, Tanis D;
- Cheung, Simon;
- Chow, Christine;
- Ta, Monica;
- Ho, Germain;
- Bui, Minh;
- Douglas, J Maxwell;
- Campbell, Kieran R;
- El‐Naggar, Amal;
- Kaurah, Pardeep;
- Kalloger, Steve E;
- Lim, Howard J;
- Schaeffer, David F;
- Cochrane, Dawn;
- Guilford, Parry;
- Huntsman, David G
Publication type:
Article
E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.
Published in:
2014
By:
- Chen, Augustine;
- Beetham, Henry;
- Black, Michael A;
- Priya, Rashmi;
- Telford, Bryony J;
- Guest, Joanne;
- Wiggins, George A R;
- Godwin, Tanis D;
- Yap, Alpha S;
- Guilford, Parry J
Publication type:
journal article
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population.
Published in:
2008
By:
- Nasri S;
- More H;
- Graziano F;
- Ruzzo A;
- Wilson E;
- Dunbier A;
- McKinney C;
- Merriman T;
- Guilford P;
- Magnani M;
- Humar B;
- Nasri, Soroush;
- More, Helen;
- Graziano, Francesco;
- Ruzzo, Annamaria;
- Wilson, Emily;
- Dunbier, Anita;
- McKinney, Cushla;
- Merriman, Tony;
- Guilford, Parry
Publication type:
journal article
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population.
Published in:
BMC Cancer, 2008, v. 8, p. 1, doi. 10.1186/1471-2407-8-138
By:
- Nasri, Soroush;
- More, Helen;
- Graziano, Francesco;
- Ruzzo, Annamaria;
- Wilson, Emily;
- Dunbier, Anita;
- McKinney, Cushla;
- Merriman, Tony;
- Guilford, Parry;
- Magnani, Mauro;
- Humar, Bostjan
Publication type:
Article
Hereditary diffuse gastric cancer: A manifestation of lost cell polarity.
Published in:
Cancer Science, 2009, v. 100, n. 7, p. 1151, doi. 10.1111/j.1349-7006.2009.01163.x
By:
- Humar, Bostjan;
- Guilford, Parry
Publication type:
Article
Novel germline CDH1 mutations in hereditary diffuse gastric cancer families.
Published in:
Human Mutation, 2002, v. 19, n. 5, p. 518, doi. 10.1002/humu.10067
By:
- Humar, Bostjan;
- Toro, Tumi;
- Graziano, Francesco;
- Müller, Hansjakob;
- Dobbie, Zuzana;
- Kwang-Yang, Han;
- Eng, Charis;
- Hampel, Heather;
- Gilbert, Dale;
- Winship, Ingrid;
- Parry, Susan;
- Ward, Robyn;
- Findlay, Mike;
- Christian, Alice;
- Tucker, Monica;
- Tucker, Kathy;
- Merriman, Tony;
- Guilford, Parry
Publication type:
Article
E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer.
Published in:
Human Mutation, 1999, v. 14, n. 3, p. 249, doi. 10.1002/(SICI)1098-1004(1999)14:3<249::AID-HUMU8>3.0.CO;2-9
By:
- Guilford, Parry J.;
- Hopkins, Justin B.W.;
- Grady, William M.;
- Markowitz, Sanford D.;
- Willis, Joseph;
- Lynch, Henry;
- Rajput, Ashwani;
- Wiesner, Georgia L.;
- Lindor, Noralane M.;
- Burgart, Lawrence J.;
- Toro, Tumi T.;
- Lee, Don;
- Limacher, Jean-Marc;
- Shaw, David W.;
- Findlay, Michael P.N.;
- Reeve, Anthony E.
Publication type:
Article
Expression of Krüppel-like factor 5 in human gastric carcinomas.
Published in:
Journal of Cancer Research & Clinical Oncology, 2008, v. 134, n. 2, p. 163, doi. 10.1007/s00432-007-0265-2
By:
- Mi Kyung Kwak;
- Hyuk-Joon Lee;
- Keun Hur;
- Do Joong Park;
- Hye Seung Lee;
- Woo Ho Kim;
- Kuhn Uk Lee;
- Kuk Jin Choe;
- Guilford, Parry;
- Han-Kwang Yang
Publication type:
Article
Circulating tumor DNA is a sensitive marker for routine monitoring of treatment response in advanced colorectal cancer.
Published in:
Carcinogenesis, 2020, v. 41, n. 11, p. 1507, doi. 10.1093/carcin/bgaa102
By:
- Zou, Donghui;
- Day, Robert;
- Cocadiz, Judy A;
- Parackal, Sarah;
- Mitchell, Wilson;
- Black, Michael A;
- Lawrence, Ben;
- Fitzgerald, Sandra;
- Print, Cristin;
- Jackson, Christopher;
- Guilford, Parry
Publication type:
Article
E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.
Published in:
BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-552
By:
- Chen, Augustine;
- Beetham, Henry;
- Black, Michael A.;
- Priya, Rashmi;
- Telford, Bryony J.;
- Guest, Joanne;
- Wiggins, George A. R.;
- Godwin, Tanis D.;
- Yap, Alpha S.;
- Guilford, Parry J.
Publication type:
Article
E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.
Published in:
BMC Cancer, 2014, v. 14, n. 1, p. 552, doi. 10.1186/1471-2407-14-552
By:
- Chen, Augustine;
- Beetham, Henry;
- Black, Michael A;
- Priya, Rashmi;
- Telford, Bryony J;
- Guest, Joanne;
- Wiggins, George A R;
- Godwin, Tanis D;
- Yap, Alpha S;
- Guilford, Parry J
Publication type:
Article
E-cadherin germline mutations in familial gastric cancer.
Published in:
Nature, 1998, v. 392, n. 6674, p. 402, doi. 10.1038/32918
By:
- Guilford, Parry;
- Hopkins, Justin;
- Harraway, James;
- McLeod, Maybelle;
- McLeod, Ngahiraka;
- Harawira, Pauline;
- Taite, Huriana;
- Scoular, Robin;
- Miller, Andrew;
- Reeve, Anthony E.
Publication type:
Article
An estimate of limited duration cancer prevalence in New Zealand using 'big' data.
Published in:
2020
By:
- Brewer, Naomi;
- Atkinson, June;
- Guilford, Parry;
- Print, Cristin;
- Blakely, Tony;
- Teng, Andrea
Publication type:
journal article
Where to from here? Posthumous healthcare data, digital e(lectronic)-mortality and New Zealand's healthcare future.
Published in:
2017
By:
- Hoeksema, Katie;
- Wee, Richman;
- Macdonald, Alastair;
- Guilford, Parry;
- Wall, Jesse;
- Cornwall, Jon
Publication type:
journal article
Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.
Published in:
Nature Genetics, 2000, v. 26, n. 1, p. 16, doi. 10.1038/79120
By:
- Grady, William M.;
- Willis, Joseph;
- Guilford, Parry J.;
- Dunbier, Anita K.;
- Toro, Tumi T.;
- Lynch, Henry;
- Wiesner, Georgia;
- Ferguson, Kelly;
- Eng, Charis;
- Park, Jae-Gahb;
- Kim, Seong-Jin;
- Markowitz, Sanford
Publication type:
Article
E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.
Published in:
Gastric Cancer, 2019, v. 22, n. 2, p. 273, doi. 10.1007/s10120-018-0859-1
By:
- Godwin, Tanis D.;
- Kelly, S. Thomas;
- Brew, Tom P.;
- Bougen-Zhukov, Nicola M.;
- Single, Andrew B.;
- Chen, Augustine;
- Stylianou, Cassie E.;
- Harris, Lawrence D.;
- Currie, Sophie K.;
- Telford, Bryony J.;
- Beetham, Henry G.;
- Evans, Gary B.;
- Black, Michael A.;
- Guilford, Parry J.
Publication type:
Article
Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice.
Published in:
Gastric Cancer, 2010, v. 13, n. 1, p. 1, doi. 10.1007/s10120-009-0531-x
By:
- Guilford, Parry;
- Humar, Bostjan;
- Blair, Vanessa
Publication type:
Article
Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models.
Published in:
Bioinformatics, 2007, v. 23, n. 6, p. 732, doi. 10.1093/bioinformatics/btl663
By:
- Shigeyuki Matsui;
- Masaaki Ito;
- Hiroyuki Nishiyama;
- Hajime Uno;
- Hirokazu Kotani;
- Jun Watanabe;
- Parry Guilford;
- Anthony Reeve;
- Masanori Fukushima;
- Osamu Ogawa
Publication type:
Article
Hereditary gastric cancer: what's new? Update 2013–2018.
Published in:
Familial Cancer, 2019, v. 18, n. 3, p. 363, doi. 10.1007/s10689-019-00127-7
By:
- van der Post, Rachel S.;
- Oliveira, Carla;
- Guilford, Parry;
- Carneiro, Fátima
Publication type:
Article
Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori.
Published in:
Familial Cancer, 2019, v. 18, n. 1, p. 83, doi. 10.1007/s10689-018-0080-8
By:
- Hakkaart, Christopher;
- Ellison-Loschmann, Lis;
- Day, Robert;
- Sporle, Andrew;
- Koea, Jonathan;
- Harawira, Pauline;
- Cheng, Soo;
- Gray, Michelle;
- Whaanga, Tracey;
- Pearce, Neil;
- Guilford, Parry
Publication type:
Article
ASO Visual Abstract: Disappearing Signet Ring Cell Adenocarcinoma in Gastric Cancer Patients.
Published in:
2024
By:
- Sreeram, Aravind;
- Stroobant, Emily E.;
- Laszkowska, Monika;
- Guilford, Parry;
- Shimada, Shoji;
- Nishimura, Makoto;
- Shah, Sohrab;
- Vardhana, Santosha;
- Tang, Laura H.;
- Strong, Vivian E.
Publication type:
Abstract
Disappearing Signet Ring Cell Adenocarcinoma in Gastric Cancer Patients.
Published in:
Annals of Surgical Oncology: An Oncology Journal for Surgeons, 2024, v. 31, n. 13, p. 9030, doi. 10.1245/s10434-024-16117-8
By:
- Sreeram, Aravind;
- Stroobant, Emily E.;
- Laszkowska, Monika;
- Guilford, Parry;
- Shimada, Shoji;
- Nishimura, Makoto;
- Shah, Sohrab;
- Vardhana, Santosha;
- Tang, Laura H.;
- Strong, Vivian E.
Publication type:
Article
Risk of stomach cancer in Aotearoa/New Zealand: A Māori population based case-control study.
Published in:
PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0181581
By:
- Ellison-Loschmann, Lis;
- Sporle, Andrew;
- Corbin, Marine;
- Cheng, Soo;
- Harawira, Pauline;
- Gray, Michelle;
- Whaanga, Tracey;
- Guilford, Parry;
- Koea, Jonathan;
- Pearce, Neil
Publication type:
Article
E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer.
Published in:
Molecular Cancer, 2018, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12943-018-0859-0
By:
- Figueiredo, Joana;
- Melo, Soraia;
- Gamet, Kimberley;
- Godwin, Tanis;
- Seixas, Susana;
- Sanches, João M.;
- Guilford, Parry;
- Seruca, Raquel
Publication type:
Article
Identification of c.1531C>T Pathogenic Variant in the CDH1 Gene as a Novel Germline Mutation of Hereditary Diffuse Gastric Cancer.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 4980, doi. 10.3390/ijms20204980
By:
- Norero, Enrique;
- Alarcon, M. Alejandra;
- Hakkaart, Christopher;
- de Mayo, Tomas;
- Mellado, Cecilia;
- Garrido, Marcelo;
- Aguayo, Gloria;
- Lagos, Marcela;
- Torres, Javiera;
- Calvo, Alfonso;
- Guilford, Parry;
- Corvalan, Alejandro H.
Publication type:
Article
Cohesin mutations are synthetic lethal with stimulation of WNT signaling.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.61405
By:
- Chue Vin Chin;
- Antony, Jisha;
- Ketharnathan, Sarada;
- Labudina, Anastasia;
- Gimenez, Gregory;
- Parsons, Kate M.;
- Jinshu He;
- George, Amee J.;
- Pallotta, Maria Michela;
- Musio, Antonio;
- Braithwaite, Antony;
- Guilford, Parry;
- Hannan, Ross D.;
- Horsfield, Julia A.
Publication type:
Article
A gene responsible for a dominant form of neurosensory non-syndromic deafness maps to the NSRD1 recessive deafness gene interval.
Published in:
Human Molecular Genetics, 1994, v. 3, n. 12, p. 2219
By:
- Chaib, Hassan;
- Lina-Granade, Geneviéve;
- Guilford, Parry;
- Plauchu, Henri;
- Levilliers, Jacqueline;
- Morgon, Alain;
- Petit, Christine
Publication type:
Article
A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene.
Published in:
Human Molecular Genetics, 1994, v. 3, n. 6, p. 989
By:
- Guilford, Parry;
- Ayadi, Hamadi;
- Blanchard, Stéphane;
- Chaib, Hassan;
- Paslier, Denis Le;
- Weissenbach, Jean;
- Drira, Mohamed;
- Petit, Christine
Publication type:
Article
Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer.
Published in:
2017
By:
- McInnes, Tyler;
- Donghui Zou;
- Rao, Dasari S.;
- Munro, Francesca M.;
- Phillips, Vicky L.;
- McCall, John L.;
- Black, Michael A.;
- Reeve, Anthony E.;
- Guilford, Parry J.;
- Zou, Donghui
Publication type:
journal article

Found: 41