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In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques.
Published in:
Stem Cells, 2006, v. 24, n. 6, p. 1539, doi. 10.1634/stemcells.2005-0455
By:
- Loré, Karin;
- Seggewiss, Ruth;
- Guenaga, F. Javier;
- Pittaluga, Stefania;
- Donahue, Robert E.;
- Krouse, Allen;
- Metzger, Mark E.;
- Koup, Richard A.;
- Reilly, Cavan;
- Douek, Daniel C.;
- Dunbar, Cynthia E.
Publication type:
Article
HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation.
Published in:
Scientific Reports, 2016, p. 20987, doi. 10.1038/srep20987
By:
- Dai, Kaifan;
- Khan, Salar N;
- Wang, Yimeng;
- He, Linling;
- Guenaga, Javier;
- Ingale, Jidnyasa;
- Sundling, Christopher;
- O'Dell, Sijy;
- McKee, Krisha;
- Phad, Ganesh;
- Corcoran, Martin;
- Wilson, Richard;
- Mascola, John R;
- Zhu, Jiang;
- Li, Yuxing;
- Hedestam, Gunilla B Karlsson;
- Wyatt, Richard T
Publication type:
Article
Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage.
Published in:
Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.01631
By:
- Yang, Lifei;
- Sharma, Shailendra Kumar;
- Cottrell, Christopher;
- Guenaga, Javier;
- Tran, Karen;
- Wilson, Richard;
- Behrens, Anna-Janina;
- Crispin, Max;
- de Val, Natalia;
- Wyatt, Richard T.
Publication type:
Article
Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice.
Published in:
Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01654
By:
- Soldemo, Martina;
- Àdori, Monika;
- Stark, Julian M.;
- Yu Feng;
- Tran, Karen;
- Wilson, Richard;
- Lifei Yang;
- Guenaga, Javier;
- Wyatt, Richard T.;
- Karlsson Hedestam, Gunilla B.
Publication type:
Article
Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41.
Published in:
PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044241
By:
- Mei-Yun Zhang;
- Tingting Yuan;
- Jingjing Li;
- Borges, Andrew Rosa;
- Watkins, Jennifer D.;
- Guenaga, Javier;
- Zheng Yang;
- Yanping Wang;
- Wilson, Richard;
- Yuxing Li;
- Polonis, Victoria R.;
- Pincus, Seth H.;
- Ruprecht, Ruth M.;
- Dimitrov, Dimiter S.;
- Shibo Jiang
Publication type:
Article
Heterologous Epitope-Scaffold Prime:Boosting Immuno- Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant.
Published in:
PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016074
By:
- Guenaga, Javier;
- Dosenovic, Pia;
- Ofek, Gilad;
- Baker, David;
- Schief, William R.;
- Kwong, Peter D.;
- Hedestam, Gunilla B. Karlsson;
- Wyatt, Richard T.
Publication type:
Article
Evaluation of the Pathogenesis of Decreasing CD4<sup>+</sup> T Cell Counts in Human Immunodeficiency Virus Type 1-Infected Patients Receiving Successfully Suppressive Antiretroviral Therapy.
Published in:
Journal of Infectious Diseases, 2009, v. 199, n. 11, p. 1648, doi. 10.1086/598980
By:
- Nies-Kraske, Elizabeth;
- Schacker, Timothy W.;
- Condoluci, David;
- Orenstein, Jan;
- Brenchley, Jason;
- Fox, Cecil;
- Daucher, Marybeth;
- Dewar, Robin;
- Urban, Elizabeth;
- Hill, Brenna;
- Guenaga, Javier;
- Hoover, Shelley;
- Maldarelli, Frank;
- Hallahan, Claire W.;
- Horn, Judith;
- Kottilil, Shyamasundaran;
- Tae-Wook Chun;
- Folino, Marlene;
- Palmer, Sara;
- Wiegand, Ann
Publication type:
Article
Evolution of B cell analysis and Env trimer redesign.
Published in:
Immunological Reviews, 2017, v. 275, n. 1, p. 183, doi. 10.1111/imr.12515
By:
- Karlsson Hedestam, Gunilla B.;
- Guenaga, Javier;
- Corcoran, Martin;
- Wyatt, Richard T.
Publication type:
Article
Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1180959
By:
- Bale, Shridhar;
- Lifei Yang;
- Alirezaei, Mehrdad;
- Wilson, Richard;
- Takayuki Ota;
- Doyle, Esmeralda D.;
- Cottrell, Christopher A.;
- Guenaga, Javier;
- Tran, Karen;
- Wenjuan Li;
- Stamatatos, Leonidas;
- Nemazee, David;
- Ward, Andrew B.;
- Wyatt, Richard T.
Publication type:
Article
Global site-specific N-glycosylation analysis of HIV envelope glycoprotein.
Published in:
Nature Communications, 2017, v. 8, n. 3, p. 14954, doi. 10.1038/ncomms14954
By:
- Cao, Liwei;
- Diedrich, Jolene K.;
- Kulp, Daniel W.;
- Pauthner, Matthias;
- He, Lin;
- Park, Sung-Kyu Robin;
- Sok, Devin;
- Su, Ching Yao;
- Delahunty, Claire M.;
- Menis, Sergey;
- Andrabi, Raiees;
- Guenaga, Javier;
- Georgeson, Erik;
- Kubitz, Michael;
- Adachi, Yumiko;
- Burton, Dennis R.;
- Schief, William R.;
- Yates III, John R.;
- Paulson, James C.
Publication type:
Article
Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies.
Published in:
PLoS Pathogens, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.ppat.1005767
By:
- Feng, Yu;
- Tran, Karen;
- Bale, Shridhar;
- Kumar, Shailendra;
- Guenaga, Javier;
- Wilson, Richard;
- de Val, Natalia;
- Arendt, Heather;
- DeStefano, Joanne;
- Ward, Andrew B.;
- Wyatt, Richard T.
Publication type:
Article
Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties.
Published in:
PLoS Pathogens, 2015, v. 11, n. 1, p. 1, doi. 10.1371/journal.ppat.1004570
By:
- Guenaga, Javier;
- de Val, Natalia;
- Tran, Karen;
- Feng, Yu;
- Satchwell, Karen;
- Ward, Andrew B.;
- Wyatt, Richard T.
Publication type:
Article
HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization.
Published in:
PLoS Pathogens, 2014, v. 10, n. 8, p. 1, doi. 10.1371/journal.ppat.1004337
By:
- Navis, Marjon;
- Tran, Karen;
- Bale, Shridhar;
- Phad, Ganesh E.;
- Guenaga, Javier;
- Wilson, Richard;
- Soldemo, Martina;
- McKee, Krisha;
- Sundling, Christopher;
- Mascola, John;
- Li, Yuxing;
- Wyatt, Richard T.;
- Karlsson Hedestam, Gunilla B.
Publication type:
Article
Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function.
Published in:
PLoS Pathogens, 2012, v. 8, n. 7, p. 1, doi. 10.1371/journal.ppat.1002806
By:
- Guenaga, Javier;
- Wyatt, Richard T.
Publication type:
Article
Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.
Published in:
PLoS Pathogens, 2017, v. 13, n. 9, p. 1, doi. 10.1371/journal.ppat.1006614
By:
- Dubrovskaya, Viktoriya;
- Guenaga, Javier;
- de Val, Natalia;
- Wilson, Richard;
- Feng, Yu;
- Movsesyan, Arlette;
- Karlsson Hedestam, Gunilla B.;
- Ward, Andrew B.;
- Wyatt, Richard T.
Publication type:
Article
Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06121-4
By:
- Cao, Liwei;
- Pauthner, Matthias;
- Andrabi, Raiees;
- Rantalainen, Kimmo;
- Berndsen, Zachary;
- Diedrich, Jolene K.;
- Menis, Sergey;
- Sok, Devin;
- Bastidas, Raiza;
- Park, Sung-Kyu Robin;
- Delahunty, Claire M.;
- He, Lin;
- Guenaga, Javier;
- Wyatt, Richard T.;
- Schief, William R.;
- Ward, Andrew B.;
- Yates, John R.;
- Burton, Dennis R.;
- Paulson, James C.
Publication type:
Article
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03335-4
By:
- Steinhardt, James J.;
- Guenaga, Javier;
- Turner, Hannah L.;
- McKee, Krisha;
- Louder, Mark K.;
- O’Dell, Sijy;
- Chi-I Chiang;
- Lin Lei;
- Galkin, Andrey;
- Andrianov, Alexander K.;
- Doria-Rose, Nicole A.;
- Bailer, Robert T.;
- Ward, Andrew B.;
- Mascola, John R.;
- Yuxing Li
Publication type:
Article
mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1426232
By:
- Guenaga, Javier;
- Alirezaei, Mehrdad;
- Yu Feng;
- Alameh, Mohamad-Gabriel;
- Wen-Hsin Lee;
- Baboo, Sabyasachi;
- Cluff, Jocelyn;
- Wilson, Richard;
- Bale, Shridhar;
- Ozorowski, Gabriel;
- Lin, Paulo;
- Ying Tam;
- Diedrich, Jolene K.;
- Yates III, John R.;
- Paulson, James C.;
- Ward, Andrew B.;
- Weissman, Drew;
- Wyatt, Richard T.
Publication type:
Article

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