Works by Guedj, Emmanuel

Results: 25

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.

Published in:

Journal of Inflammation, 2020, v. 17, n. 1, p. N.PAG, doi. 10.1186/s12950-020-00260-6

By:

Ruiz Castro, Pedro A.;
Kogel, Ulrike;
Lo Sasso, Giuseppe;
Phillips, Blaine W.;
Sewer, Alain;
Titz, Bjorn;
Garcia, Llenalia;
Kondylis, Athanasios;
Guedj, Emmanuel;
Peric, Dariusz;
Bornand, David;
Dulize, Remi;
Merg, Celine;
Corciulo, Maica;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology.

Published in:

Archives of Toxicology, 2019, v. 93, n. 11, p. 3229, doi. 10.1007/s00204-019-02565-9

By:

Iskandar, Anita R.;
Zanetti, Filippo;
Marescotti, Diego;
Titz, Bjorn;
Sewer, Alain;
Kondylis, Athanasios;
Leroy, Patrice;
Belcastro, Vincenzo;
Torres, Laura Ortega;
Acali, Stefano;
Majeed, Shoaib;
Steiner, Sandro;
Trivedi, Keyur;
Guedj, Emmanuel;
Merg, Celine;
Schneider, Thomas;
Frentzel, Stefan;
Martin, Florian;
Ivanov, Nikolai V.;
Peitsch, Manuel C.

Publication type:

Article

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.

Published in:

Inflammation Research, 2015, v. 64, n. 7, p. 471, doi. 10.1007/s00011-015-0820-2

By:

Cabanski, Maciej;
Fields, Brett;
Boue, Stephanie;
Boukharov, Natalia;
DeLeon, Hector;
Dror, Natalie;
Geertz, Marcel;
Guedj, Emmanuel;
Iskandar, Anita;
Kogel, Ulrike;
Merg, Celine;
Peck, Michael;
Poussin, Carine;
Schlage, Walter;
Talikka, Marja;
Ivanov, Nikolai;
Hoeng, Julia;
Peitsch, Manuel

Publication type:

Article

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model.

Published in:

Journal of Applied Toxicology, 2021, v. 41, n. 10, p. 1598, doi. 10.1002/jat.4149

By:

Kogel, Ulrike;
Wong, Ee Tsin;
Szostak, Justyna;
Tan, Wei Teck;
Lucci, Francesco;
Leroy, Patrice;
Titz, Bjoern;
Xiang, Yang;
Low, Tiffany;
Wong, Sin Kei;
Guedj, Emmanuel;
Ivanov, Nikolai V.;
Schlage, Walter K.;
Peitsch, Manuel C.;
Kuczaj, Arkadiusz;
Vanscheeuwijck, Patrick;
Hoeng, Julia

Publication type:

Article

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

Published in:

Romanian Medical Journal, 2019, v. 66, n. 1, p. 70, doi. 10.1016/j.yrtph.2016.10.015

By:

Ee Tsin Wong;
Kogel, Ulrike;
Veljkovic, Emilija;
Martin, Florian;
Yang Xiang;
Boue, Stephanie;
Vuillaume, Gregory;
Leroy, Patrice;
Guedj, Emmanuel;
Rodrigo, Gregory;
Ivanov, Nikolai V.;
Hoeng, Julia;
Peitsch, Manuel C.;
PatrickVanscheeuwijck

Publication type:

Article

Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro.

Published in:

Archives of Toxicology, 2021, v. 95, n. 10, p. 3341, doi. 10.1007/s00204-021-03123-y

By:

Poussin, Carine;
van der Toorn, Marco;
Scheuner, Sophie;
Piault, Romain;
Kondylis, Athanasios;
Savioz, Rebecca;
Dulize, Rémi;
Peric, Dariusz;
Guedj, Emmanuel;
Maranzano, Fabio;
Merg, Celine;
Morelli, Moran;
Egesipe, Anne-Laure;
Johne, Stéphanie;
Majeed, Shoaib;
Pak, Claudius;
Schneider, Thomas;
Schlage, Walter K.;
Ivanov, Nikolai V.;
Peitsch, Manuel C.

Publication type:

Article

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.

Published in:

Archives of Toxicology, 2021, v. 95, n. 5, p. 1805, doi. 10.1007/s00204-021-03020-4

By:

Wong, Ee Tsin;
Szostak, Justyna;
Titz, Bjoern;
Lee, Tom;
Wong, Sin Kei;
Lavrynenko, Oksana;
Merg, Celine;
Corciulo, Maica;
Simicevic, Jovan;
Auberson, Mehdi;
Peric, Dariusz;
Dulize, Remi;
Bornand, David;
Loh, Guo Jie;
Lee, Kyeonghee Monica;
Zhang, Jingjie;
Miller IV, John H.;
Schlage, Walter K.;
Guedj, Emmanuel;
Schneider, Thomas

Publication type:

Article

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.

Published in:

Archives of Toxicology, 2020, v. 94, n. 6, p. 2179, doi. 10.1007/s00204-020-02759-6

By:

Ho, Jenny;
Sciuscio, Davide;
Kogel, Ulrike;
Titz, Bjoern;
Leroy, Patrice;
Vuillaume, Gregory;
Talikka, Marja;
Martin, Elyette;
Pospisil, Pavel;
Lebrun, Stefan;
Xia, Wenhao;
Lee, Tom;
Chng, Yun Xuan;
Phillips, Blaine W.;
Veljkovic, Emilija;
Guedj, Emmanuel;
Xiang, Yang;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Systems biology reveals anatabine to be an NRF2 activator.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1011184

By:

Messinis, Dimitris E.;
Poussin, Carine;
Latino, Diogo A. R. S.;
Eb-Levadoux, Yvan;
Dulize, Remi;
Peric, Dariusz;
Guedj, Emmanuel;
Titz, Bjoern;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy.

Published in:

Frontiers in Neuroscience, 2023, p. 1, doi. 10.3389/fnins.2023.1239009

By:

Fares, Mohamed Bilal;
Alijevic, Omar;
Johne, Stephanie;
Overk, Cassia;
Hashimoto, Makoto;
Kondylis, Athanasios;
Adame, Anthony;
Dulize, Remi;
Peric, Dariusz;
Nury, Catherine;
Battey, James;
Guedj, Emmanuel;
Sierro, Nicolas;
Mc Hugh, Damian;
Rockenstein, Edward;
Kim, Changyoun;
Rissman, Robert A.;
Hoeng, Julia;
Peitsch, Manuel C.;
Masliah, Eliezer

Publication type:

Article

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-60175-3

By:

Lo Sasso, Giuseppe;
Phillips, Blaine W.;
Sewer, Alain;
Battey, James N. D.;
Kondylis, Athanasios;
Talikka, Marja;
Titz, Bjoern;
Guedj, Emmanuel;
Peric, Dariusz;
Bornand, David;
Dulize, Remi;
Merg, Celine;
Corciulo, Maica;
Ouadi, Sonia;
Yanuar, Rendy;
Tung, Ching Keong;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

A framework for in vitro systems toxicology assessment of e-liquids.

Published in:

Toxicology Mechanisms & Methods, 2016, v. 26, n. 6, p. 392, doi. 10.3109/15376516.2016.1170251

By:

Iskandar, Anita R.;
Gonzalez-Suarez, Ignacio;
Majeed, Shoaib;
Marescotti, Diego;
Sewer, Alain;
Xiang, Yang;
Leroy, Patrice;
Guedj, Emmanuel;
Mathis, Carole;
Schaller, Jean-Pierre;
Vanscheeuwijck, Patrick;
Frentzel, Stefan;
Martin, Florian;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6419, doi. 10.3390/ijms24076419

By:

Verhaeghe, Catherine;
Talikka, Marja;
Sewer, Alain;
Sierro, Nicolas;
Auberson, Mehdi;
Peric, Dariusz;
Bornand, David;
Dulize, Remi;
Guedj, Emmanuel;
Nef, Patrick;
Tabruyn, Sebastien P.;
Hoeng, Julia;
Peitsch, Manuel C.;
Lo Sasso, Giuseppe

Publication type:

Article

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach.

Published in:

Toxicology Research, 2017, v. 6, n. 6, p. 930, doi. 10.1039/c7tx00152e

By:

Iskandar, Anita R.;
Martinez, Yannick;
Martin, Florian;
Schlage, Walter K.;
Leroy, Patrice;
Sewer, Alain;
Torres, Laura Ortega;
Majeed, Shoaib;
Merg, Celine;
Trivedi, Keyur;
Guedj, Emmanuel;
Frentzel, Stefan;
Mathis, Carole;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment.

Published in:

2019

By:

Iskandar, Anita R.;
Zanetti, Filippo;
Kondylis, Athanasios;
Martin, Florian;
Leroy, Patrice;
Majeed, Shoaib;
Steiner, Sandro;
Xiang, Yang;
Ortega Torres, Laura;
Trivedi, Keyur;
Guedj, Emmanuel;
Merg, Celine;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Doshi, Utkarsh;
Lee, Kyeonghee Monica;
McKinney, Willie J.;
Peitsch, Manuel C.;
Hoeng, Julia;
McKinney, Willie J Jr

Publication type:

journal article

3D Human Microvessel-on-a-Chip Model for Studying Monocyte-to-Endothelium Adhesion under Flow - Application in Systems Toxicology.

Published in:

Altex, 2020, v. 37, n. 1, p. 47, doi. 10.14573/altex.1811301

By:

Poussin, Carine;
Kramer, Bart;
Lanz, Henriette L.;
van den Heuvel, Angelique;
Laurent, Alexandra;
Olivier, Thomas;
Vermeer, Marjolein;
Peric, Dariusz;
Baumer, Karine;
Dulize, Rémi;
Guedj, Emmanuel;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia;
Joore, Jos

Publication type:

Article

How Complex Should an In Vitro Model Be? Evaluation of a Complex 3D Alveolar Model with Transcriptomic Data and Computational Biological Network Models.

Published in:

Altex, 2019, v. 36, n. 3, p. 388, doi. 10.14573/altex.1811221

By:

Marescotti, Diego;
Serchi, Tommaso;
Luettich, Karsta;
Yang Xiang;
Moschini, Elisa;
Talikka, Marja;
Martin, Florian;
Baumer, Karine;
Dulize, Remi;
Peric, Dariusz;
Bornand, David;
Guedj, Emmanuel;
Sewer, Alain;
Cambier, Sebastien;
Contal, Servane;
Chary, Aline;
Gutleb, Arno C.;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Peitsch, Manuel C.

Publication type:

Article

3-D Nasal Cultures: Systems Toxicological Assessment of a Candidate Modified-Risk Tobacco Product.

Published in:

Altex, 2017, v. 34, n. 1, p. 23, doi. 10.14573/altex.1605041

By:

Iskandar, Anita R.;
Mathis, Carole;
Martin, Florian;
Leroy, Patrice;
Sewer, Alain;
Majeed, Shoaib;
Kuehn, Diana;
Trivedi, Keyur;
Grandolfo, Davide;
Cabanski, Maciej;
Guedj, Emmanuel;
Merg, Céline;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Published in:

Romanian Journal of Stomatology / Revista Romana de Stomatologie, 2019, v. 65, n. 2, p. 15, doi. 10.1016/j.fct.2016.12.027

By:

Zanetti, Filippo;
Titz, Bjoern;
Sewer, Alain;
Lo Sasso, Giuseppe;
Scotti, Elena;
Schlage, Walter K.;
Mathis, Carole;
Leroy, Patrice;
Majeed, Shoaib;
Torres, Laura Ortega;
Keppler, Brian R.;
Elamin, Ashraf;
Trivedi, Keyur;
Guedj, Emmanuel;
Martin, Florian;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis.

Published in:

Toxicological Sciences, 2016, v. 149, n. 2, p. 441, doi. 10.1093/toxsci/kfv244

By:

Titz, Bjoern;
Boué, Stéphanie;
Phillips, Blaine;
Talikka, Marja;
Vihervaara, Terhi;
Schneider, Thomas;
Nury, Catherine;
Elamin, Ashraf;
Guedj, Emmanuel;
Peck, Michael J.;
Schlage, Walter K.;
Cabanski, Maciej;
Leroy, Patrice;
Vuillaume, Gregory;
Martin, Florian;
Martin, Nikolai V.;
Veljkovic, Emilija;
Kim Ekroos;
Laaksonen, Reijo;
Vanscheeuwijck, Patrick

Publication type:

Article

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

Published in:

Toxicological Sciences, 2016, v. 149, n. 2, p. 411, doi. 10.1093/toxsci/kfv243

By:

Phillips, Blaine;
Veljkovic, Emilija;
Boué, Stéphanie;
Schlage, Walter K.;
Vuillaume, Gregory;
Martin, Florian;
Titz, Bjoern;
Leroy, Patrice;
Buettner, Ansgar;
Elamin, Ashraf;
Oviedo, Alberto;
Cabanski, Maciej;
León, Héctor De;
Guedj, Emmanuel;
Schneider, Thomas;
Talikka, Marja;
Ivanov, Nikolai V.;
Vanscheeuwijck, Patrick;
Peitsch, Manuel C.;
Julia Hoeng

Publication type:

Article

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts.

Published in:

Toxicological Sciences, 2015, v. 147, n. 1, p. 207, doi. 10.1093/toxsci/kfv122

By:

Iskandar, Anita R.;
Yang Xiang;
Frentzel, Stefan;
Talikka, Marja;
Leroy, Patrice;
Kuehn, Diana;
Guedj, Emmanuel;
Martin, Florian;
Mathis, Carole;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Julia Hoeng

Publication type:

Article

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols.

Published in:

Inhalation Toxicology, 2018, v. 30, n. 13/14, p. 553, doi. 10.1080/08958378.2019.1576807

By:

Lee, K. Monica;
Hoeng, Julia;
Harbo, Sam;
Kogel, Ulrike;
Gardner, William;
Oldham, Michael;
Benson, Eric;
Talikka, Marja;
Kondylis, Athanasios;
Martin, Florian;
Titz, Bjoern;
Ansari, Sam;
Trivedi, Keyur;
Guedj, Emmanuel;
Elamin, Ashraf;
Ivanov, Nikolai V.;
Vanscheeuwijck, Patrick;
Peitsch, Manuel C.;
McKinney, Willie J.

Publication type:

Article

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe mice – a systems toxicology analysis.

Published in:

Inhalation Toxicology, 2016, v. 28, n. 5, p. 226, doi. 10.3109/08958378.2016.1150368

By:

Lo Sasso, Giuseppe;
Titz, Bjoern;
Nury, Catherine;
Boué, Stéphanie;
Phillips, Blaine;
Belcastro, Vincenzo;
Schneider, Thomas;
Dijon, Sophie;
Baumer, Karine;
Peric, Daruisz;
Dulize, Remi;
Elamin, Ashraf;
Guedj, Emmanuel;
Buettner, Ansgar;
Leroy, Patrice;
Kleinhans, Samuel;
Vuillaume, Gregory;
Veljkovic, Emilija;
Ivanov, Nikolai V.;
Martin, Florian

Publication type:

Article

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice.

Published in:

Toxicological Sciences, 2020, v. 178, n. 1, p. 138, doi. 10.1093/toxsci/kfaa132

By:

Titz, Bjoern;
Sewer, Alain;
Luettich, Karsta;
Wong, Ee Tsin;
Guedj, Emmanuel;
Nury, Catherine;
Schneider, Thomas;
Xiang, Yang;
Trivedi, Keyur;
Vuillaume, Grégory;
Leroy, Patrice;
Büttner, Ansgar;
Martin, Florian;
Ivanov, Nikolai V;
Vanscheeuwijck, Patrick;
Hoeng, Julia;
Peitsch, Manuel C

Publication type:

Article

Works by Guedj, Emmanuel

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology.

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE<sup>−/−</sup> mouse model.

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro.

A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract.

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.

Systems biology reveals anatabine to be an NRF2 activator.

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy.

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts.

A framework for in vitro systems toxicology assessment of e-liquids.

Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System.

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach.

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment.

3D Human Microvessel-on-a-Chip Model for Studying Monocyte-to-Endothelium Adhesion under Flow - Application in Systems Toxicology.

How Complex Should an In Vitro Model Be? Evaluation of a Complex 3D Alveolar Model with Transcriptomic Data and Computational Biological Network Models.

3-D Nasal Cultures: Systems Toxicological Assessment of a Candidate Modified-Risk Tobacco Product.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe<sup>-/-</sup> Mice-An Integrative Systems Toxicology Analysis.

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe<sup>-/-</sup> Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts.

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols.

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe mice – a systems toxicology analysis.

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice.