Works by Guchelaar, Henk-Jan

Results: 164
    1

    Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account.

    Published in:
    Clinical Pharmacology & Therapeutics, 2025, v. 118, n. 1, p. 218, doi. 10.1002/cpt.3680
    By:
    • Johansson, Inger;
    • Xanthopoulou, Emmanouella M.;
    • Zhou, Yitian;
    • Sanchez‐Spitman, Anabel;
    • van der Lee, Maaike;
    • Wollmann, Birgit M.;
    • Størset, Elisabet;
    • Swen, Jesse J.;
    • Guchelaar, Henk‐Jan;
    • Molden, Espen;
    • Jukic, Marin M.;
    • Ingelman‐Sundberg, Magnus
    Publication type:
    Article
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    Logical Imputation to Optimize Prognostic Risk Classification in Metastatic Renal Cell Cancer.

    Published in:
    Kidney Cancer (2468-4562), 2022, v. 6, n. 3, p. 169, doi. 10.3233/KCA-220007
    By:
    • Maurits, Jake S.F.;
    • van der Zanden, Loes F.M.;
    • Diekstra, Meta H.M.;
    • Ambert, Valentin;
    • Castellano, Daniel;
    • Garcia-Donas, Jesus;
    • Troyas, Rosa Guarch;
    • Guchelaar, Henk-Jan;
    • Jaehde, Ulrich;
    • Junker, Kerstin;
    • Martinez-Cardus, Anna;
    • Radu, Marius T.;
    • Rodriguez-Antona, Cristina;
    • Roessler, Max;
    • Warren, Anne;
    • Eisen, Tim;
    • Oosterwijk, Egbert;
    • Kiemeney, Lambertus A.L.M.;
    • Vermeulen, Sita H.
    Publication type:
    Article
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    Clinical Benefits and Utility of Pretherapeutic DPYD and UGT1A1 Testing in Gastrointestinal Cancer: A Secondary Analysis of the PREPARE Randomized Clinical Trial.

    Published in:
    JAMA Network Open, 2024, v. 7, n. 12, p. e2449441, doi. 10.1001/jamanetworkopen.2024.49441
    By:
    • Roncato, Rossana;
    • Bignucolo, Alessia;
    • Peruzzi, Elena;
    • Montico, Marcella;
    • De Mattia, Elena;
    • Foltran, Luisa;
    • Guardascione, Michela;
    • D'Andrea, Mario;
    • Favaretto, Adolfo;
    • Puglisi, Fabio;
    • Swen, Jesse Joachim;
    • Guchelaar, Henk-Jan;
    • Toffoli, Giuseppe;
    • Cecchin, Erika
    Publication type:
    Article
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    Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities.

    Published in:
    Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.01241
    By:
    • Hurkmans, Evelien G. E.;
    • Klumpers, Marije J.;
    • Vermeulen, Sita H.;
    • Hagleitner, Melanie M.;
    • Flucke, Uta;
    • Schreuder, H. W. Bart;
    • Gelderblom, Hans;
    • Bras, Johannes;
    • Guchelaar, Henk-Jan;
    • Coenen, Marieke J. H.;
    • te Loo, D. Maroeska W. M.
    Publication type:
    Article
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    Model-Informed Development of a Cost-Saving Dosing Regimen for Sacituzumab Govitecan.

    Published in:
    Targeted Oncology, 2024, v. 19, n. 5, p. 789, doi. 10.1007/s11523-024-01075-8
    By:
    • Moes, Dirk J. A. R.;
    • Hendrikx, Jeroen J. M. A.;
    • Guchelaar, Henk-Jan;
    • Mathijssen, Ron H. J.;
    • Bakker, J. L.;
    • Dezentjé, Vincent O.;
    • de Rouw, Nikki;
    • van Erp, Nielka P.;
    • Smit, Egbert F.;
    • van den Heuvel, Michel M.;
    • Munnink, Thijs H. Oude;
    • van Kats, Maartje;
    • Croes, Sander;
    • Kroep, Judith R.;
    • Zwaveling, Juliette;
    • ter Heine, Rob
    Publication type:
    Article
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    Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.

    Published in:
    Nature Genetics, 2013, v. 45, n. 5, p. 468, doi. 10.1038/ng.2623
    By:
    • Plenge, Robert M;
    • Greenberg, Jeffrey D;
    • Mangravite, Lara M;
    • Derry, Jonathan M J;
    • Stahl, Eli A;
    • Coenen, Marieke J H;
    • Barton, Anne;
    • Padyukov, Leonid;
    • Klareskog, Lars;
    • Gregersen, Peter K;
    • Mariette, Xavier;
    • Moreland, Larry W;
    • Bridges, S Louis;
    • de Vries, Niek;
    • Huizinga, Tom W J;
    • Guchelaar, Henk-Jan;
    • Friend, Stephen H;
    • Stolovitzky, Gustavo
    Publication type:
    Article
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    Influence of Genetic Variants in TPMT and COMT Associated with Cisplatin Induced Hearing Loss in Patients with Cancer: Two New Cohorts and a Meta-Analysis Reveal Significant Heterogeneity between Cohorts.

    Published in:
    PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115869
    By:
    • Hagleitner, Melanie M.;
    • Coenen, Marieke J. H.;
    • Patino-Garcia, Ana;
    • de Bont, Eveline S. J. M.;
    • Gonzalez-Neira, Anna;
    • Vos, Hanneke I.;
    • van Leeuwen, Frank N.;
    • Gelderblom, Hans;
    • Hoogerbrugge, Peter M.;
    • Guchelaar, Henk-Jan;
    • te Loo, Maroeska W. M.
    Publication type:
    Article
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    Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data.

    Published in:
    Science Translational Medicine, 2021, v. 13, n. 603, p. 1, doi. 10.1126/scitranslmed.abf3637
    By:
    • van der Lee, Maaike;
    • Allard, William G.;
    • Vossen, Rolf H. A. M.;
    • Baak-Pablo, Renée F.;
    • Menafra, Roberta;
    • Deiman, Birgit A. L. M.;
    • Deenen, Maarten J.;
    • Neven, Patrick;
    • Johansson, Inger;
    • Gastaldello, Stefano;
    • Ingelman-Sundberg, Magnus;
    • Guchelaar, Henk-Jan;
    • Swen, Jesse J.;
    • Anvar, Seyed Yahya
    Publication type:
    Article
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    Population pharmacokinetics of lenalidomide in multiple myeloma patients.

    Published in:
    2017
    By:
    • Guglieri-López, Beatriz;
    • Pérez-Pitarch, Alejandro;
    • Moes, Dirk;
    • Porta-Oltra, Begoña;
    • Climente-Martí, Mónica;
    • Guchelaar, Henk;
    • Merino-Sanjuán, Matilde;
    • Guglieri-López, Beatriz;
    • Pérez-Pitarch, Alejandro;
    • Moes, Dirk Jan A R;
    • Porta-Oltra, Begoña;
    • Climente-Martí, Mónica;
    • Guchelaar, Henk Jan;
    • Merino-Sanjuán, Matilde
    Publication type:
    journal article