Works matching AU Guarente, Leonard

Results: 66

The Many Faces of Sirtuins: Sirtuins and the Warburg effect.

Published in:

Nature Medicine, 2014, v. 20, n. 1, p. 24, doi. 10.1038/nm.3438

By:

Guarente, Leonard

Publication type:

Article

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.

Published in:

Nature Medicine, 2013, v. 19, n. 11, p. 1496, doi. 10.1038/nm.3363

By:

Hasegawa, Kazuhiro;
Wakino, Shu;
Simic, Petra;
Sakamaki, Yusuke;
Minakuchi, Hitoshi;
Fujimura, Keiko;
Hosoya, Kozi;
Komatsu, Motoaki;
Kaneko, Yuka;
Kanda, Takeshi;
Kubota, Eiji;
Tokuyama, Hirobumi;
Hayashi, Koichi;
Guarente, Leonard;
Itoh, Hiroshi

Publication type:

Article

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

Published in:

Nature Medicine, 2012, v. 18, n. 1, p. 159, doi. 10.1038/nm.2559

By:

Jeong, Hyunkyung;
Cohen, Dena E;
Cui, Libin;
Supinski, Andrea;
Savas, Jeffrey N;
Mazzulli, Joseph R;
Yates, John R;
Bordone, Laura;
Guarente, Leonard;
Krainc, Dimitri

Publication type:

Article

Essential role of limiting telomeres in the pathogenesis of Werner syndrome.

Published in:

Nature Genetics, 2004, v. 36, n. 8, p. 877, doi. 10.1038/ng1389

By:

Sandy Chang;
Multani, Asha S.;
Cabrera, Noelia G.;
Naylor, Maria L.;
Laud, Purnima;
Lombard, David;
Pathak, Sen;
Guarente, Leonard;
DePinho, Ronald A.

Publication type:

Article

Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment.

Published in:

Aging Cell, 2024, v. 23, n. 10, p. 1, doi. 10.1111/acel.14255

By:

Holmes, Holly E.;
Valentin, Rafael E.;
Jernerén, Fredrik;
de Jager Loots, Celeste A.;
Refsum, Helga;
Smith, A. David;
Guarente, Leonard;
Dellinger, Ryan W.;
Sampson, Dayle

Publication type:

Article

Myeloid Cell Sirtuin-1 Expression Does Not Alter Host Immune Responses to Gram-Negative Endotoxemia or Gram-Positive Bacterial Infection.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0084481

By:

Crotty Alexander, Laura E.;
Marsh, Brenda J.;
Timmer, Anjuli M.;
Lin, Ann E.;
Zainabadi, Kayvan;
Czopik, Agnieszka;
Guarente, Leonard;
Nizet, Victor

Publication type:

Article

SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034805

By:

Bobrowska, Anna;
Donmez, Gizem;
Weiss, Andreas;
Guarente, Leonard;
Bates, Gillian

Publication type:

Article

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth.

Published in:

PLoS ONE, 2008, v. 3, n. 4, p. 1, doi. 10.1371/journal.pone.0002020

By:

Firestein, Ron;
Blander, Gil;
Michan, Shaday;
Oberdoerffer, Philipp;
Ogino, Shuji;
Campbell, Jennifer;
Bhimavarapu, Anupama;
Luikenhuis, Sandra;
de Cabo, Rafael;
Fuchs, Charles;
Hahn, William C.;
Guarente, Leonard P.;
Sinclair, David A.

Publication type:

Article

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.

Published in:

FASEB Journal, 2011, v. 25, n. 5, p. 1664, doi. 10.1096/fj.10-173492

By:

Yu Li;
Shanqin Xu;
Giles, Amber;
Nakamura, Kazuto;
Jong Woo Lee;
Xiuyun Hou;
Gizem Donmez;
Ji Li;
Zhijun Luo;
Walsh, Kenneth;
Guarente, Leonard;
Mengwei Zang

Publication type:

Article

Nicotinamide riboside with pterostilbene (NRPT) increases NAD<sup>+</sup> in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI.

Published in:

2020

By:

Simic, Petra;
Vela Parada, Xavier Fernando;
Parikh, Samir M.;
Dellinger, Ryan;
Guarente, Leonard P.;
Rhee, Eugene P.

Publication type:

journal article

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 6, p. 2032, doi. 10.1172/JCI60132

By:

Yao, Hongwei;
Chung, Sangwoon;
Hwang, Jae-woong;
Rajendrasozhan, Saravanan;
Sundar, Isaac K.;
Dean, David A.;
McBurney, Michael W.;
Guarente, Leonard;
Gu, Wei;
Rönty, Mikko;
Kinnula, Vuokko L.;
Rahman, Irfan

Publication type:

Article

Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

Published in:

2015

By:

Bordone, Laura;
Motta, Maria Carla;
Picard, Frederic;
Robinson, Ashley;
Jhala, Ulupi S.;
Apfeld, Javier;
McDonagh, Thomas;
Lemieux, Madeleine;
McBurney, Michael;
Szilvasi, Akos;
Easlon, Erin J.;
Lin, Su-Ju;
Guarente, Leonard

Publication type:

Correction Notice

Function of a yeast TATA element-binding protein in a mammalian transcription system.

Published in:

Nature, 1988, v. 334, n. 6177, p. 37, doi. 10.1038/334037a0

By:

Buratowski, Stephen;
Hahn, Steven;
Sharp, Phillip A.;
Guarente, Leonard

Publication type:

Article

The multifaceted functions of sirtuins in cancer.

Published in:

2015

By:

Chalkiadaki, Angeliki;
Guarente, Leonard

Publication type:

journal article

Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity.

Published in:

Genetics, 2002, v. 160, n. 1, p. 83, doi. 10.1093/genetics/160.1.83

By:

Kaeberlein, Matt;
Guarente, Leonard

Publication type:

Article

Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.

Published in:

PLoS ONE, 2017, v. 12, n. 12, p. 1, doi. 10.1371/journal.pone.0188341

By:

Hayashi, Hideki;
Cherpokova, Deya;
Martinod, Kimberly;
Witsch, Thilo;
Wong, Siu Ling;
Gallant, Maureen;
Cifuni, Stephen M.;
Guarente, Leonard P.;
Wagner, Denisa D.

Publication type:

Article

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0185236

By:

Zainabadi, Kayvan;
Liu, Cassie J.;
Caldwell, Alison L. M.;
Guarente, Leonard

Publication type:

Article

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.

Published in:

PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0178520

By:

Zainabadi, Kayvan;
Liu, Cassie J.;
Guarente, Leonard

Publication type:

Article

Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 24, p. 33, doi. 10.1128/MCB.01636-07

By:

Lombard, David B.;
Alt, Frederick W.;
Hwei-Ling Cheng;
Bunkenborg, Jakob;
Streeper, Ryan S.;
Mostoslavsky, Raul;
Kim, Jennifer;
Yancopoulos, George;
Valenzuela, David;
Murphy, Andrew;
Yinhua Yang;
Yaohui Chen;
Hirschey, Matthew D.;
Bronson, Roderick T.;
Haigis, Marcia;
Guarente, Leonard P.;
Farese Jr, Robert V.;
Weissman, Sherman;
Verdin, Eric;
Schwer, Bjoern

Publication type:

Article

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

Published in:

PLoS Biology, 2006, v. 4, n. 2, p. e31, doi. 10.1371/journal.pbio.0040031

By:

Bordone, Laura;
Motta, Maria Carla;
Picard, Frederic;
Robinson, Ashley;
Jhala, Ulupi S.;
Apfeld, Javier;
McDonagh, Thomas;
Lemieux, Madeleine;
McBurney, Michael;
Szilvasi, Akos;
Easlon, Erin J.;
Su-Ju Lin;
Guarente, Leonard

Publication type:

Article

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

Published in:

PLoS Biology, 2005, v. 3, n. 12, p. 1, doi. 10.1371/journal.pbio.0040031

By:

Bordone, Laura;
Motta, Maria Carla;
Picard, Frederic;
Robinson, Ashley;
Jhala, Ulupi S;
Apfeld, Javier;
McDonagh, Thomas;
Lemieux, Madeleine;
McBurney, Michael;
Szilvasi, Akos;
Easlon, Erin J;
Lin, Su-Ju;
Guarente, Leonard

Publication type:

Article

Sirtuins and ageing-new findings.

Published in:

EMBO Reports, 2013, v. 14, n. 9, p. 750, doi. 10.1038/embor.2013.121

By:

Guarente, Leonard

Publication type:

Article

Metabolic signals regulate SIRT1 expression.

Published in:

EMBO Reports, 2011, v. 12, n. 10, p. 985, doi. 10.1038/embor.2011.179

By:

Chalkiadaki, Angeliki;
Guarente, Leonard

Publication type:

Article

The place of genetics in ageing research.

Published in:

Nature Reviews Genetics, 2012, v. 13, n. 8, p. 589, doi. 10.1038/nrg3290

By:

Barzilai, Nir;
Guarente, Leonard;
Kirkwood, Thomas B. L.;
Partridge, Linda;
Rando, Thomas A.;
Slagboom, P. Eline

Publication type:

Article

Genetic links between diet and lifespan: shared mechanisms from yeast to humans.

Published in:

Nature Reviews Genetics, 2007, v. 8, n. 11, p. 835, doi. 10.1038/nrg2188

By:

Bishop, Nicholas A.;
Guarente, Leonard

Publication type:

Article

Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth.

Published in:

2024

By:

Firestein, Ron;
Blander, Gil;
Michan, Shaday;
Oberdoerffer, Philipp;
Ogino, Shuji;
Campbell, Jennifer;
Bhimavarapu, Anupama;
Luikenhuis, Sandra;
de Cabo, Rafael;
Fuchs, Charles;
Hahn, William C.;
Guarente, Leonard P.;
Sinclair, David A.

Publication type:

Correction Notice

The unexpected role of mTORC1 in intestinal stem cells during calorie restriction.

Published in:

Cell Cycle, 2017, v. 16, n. 1, p. 1, doi. 10.1080/15384101.2016.1221210

By:

Igarashi, Masaki;
Guarente, Leonard

Publication type:

Article

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.

Published in:

EMBO Journal, 2001, v. 20, n. 4, p. 905, doi. 10.1093/emboj/20.4.905

By:

Johnson, F.Brad;
Marciniak, Robert A.;
McVey, Mitch;
Stewart, Sheila A.;
Hahn, William C.;
Guarente, Leonard

Publication type:

Article

Structure of HAP1-18?DNA implicates direct allosteric effect of protein?DNA interactions on transcriptional activation.

Published in:

Nature Structural Biology, 1999, v. 6, n. 1, p. 22

By:

King, Daniel A.;
Zhang, Li;
Guarente, Leonard;
Marmorstein, Ronen

Publication type:

Article

Structure of a HAP1?DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein.

Published in:

Nature Structural Biology, 1999, v. 6, n. 1, p. 64

By:

King, Daniel A.;
Zhang, Li;
Guarente, Leonard;
Marmorstein, Ronen

Publication type:

Article

Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes.

Published in:

Molecular & Cellular Biology, 2004, v. 24, n. 19, p. 8437, doi. 10.1128/MCB.24.19.8437-8446.2004

By:

Du, Xiaobing;
Shen, Johnny;
Kugan, Nishan;
Furth, Emma E.;
Lombard, David B.;
Cheung, Catherine;
Pak, Sally;
Luo, Guangbin;
Pignolo, Robert J.;
Depinho, Ronald A.;
Guarente, Leonard;
Johnson, F. Brad

Publication type:

Article

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

Published in:

EMBO Molecular Medicine, 2013, v. 5, n. 3, p. 482, doi. 10.1002/emmm.201390004

By:

Simic, Petra;
Zainabadi, Kayvan;
Bell, Eric;
Sykes, David B.;
Saez, Borja;
Lotinun, Sutada;
Baron, Roland;
Scadden, David;
Schipani, Ernestina;
Guarente, Leonard

Publication type:

Article

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

Published in:

EMBO Molecular Medicine, 2013, v. 5, n. 3, p. 430, doi. 10.1002/emmm.201201606

By:

Simic, Petra;
Zainabadi, Kayvan;
Bell, Eric;
Sykes, David B.;
Saez, Borja;
Lotinun, Sutada;
Baron, Roland;
Scadden, David;
Schipani, Ernestina;
Guarente, Leonard

Publication type:

Article

SIRT1 Promotes Differentiation of Normal Human Keratinocytes.

Published in:

Journal of Investigative Dermatology, 2009, v. 129, n. 1, p. 41, doi. 10.1038/jid.2008.179

By:

Blander, Gil;
Bhimavarapu, Anupama;
Mammone, Thomas;
Maes, Daniel;
Elliston, Keith;
Reich, Christian;
Matsui, Mary Steidl;
Guarente, Leonard;
Loureiro, Joseph Jorge

Publication type:

Article

corrigendum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-?

Published in:

2004

By:

Picard, Frédéric;
Kurtev, Martin;
Chung, Namjin;
Topark-Ngarm, Acharawan;
Senawong, Thanaset;
de Oliveira, Rita Machado;
Leid, Mark;
McBurney, Michael W.;
Guarente, Leonard

Publication type:

Correction Notice

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-?

Published in:

2004

By:

Picard, Frédéric;
Kurtev, Martin;
Chung, Namjin;
Topark-Ngarm, Acharawan;
Senawong, Thanaset;
Machado de Oliveira, Rita;
Leid, Mark;
McBurney, Michael E.;
Guarente, Leonard

Publication type:

Letter

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

Published in:

Nature, 2002, v. 418, n. 6895, p. 344, doi. 10.1038/nature00829

By:

Su-Ju Lin;
Kaeberlein, Matt;
Andalis, Alex A.;
Sturtz, Lori A.;
Defossez, Pierre-Antoine;
Culotta, Valeria C.;
Fink, Gerald R.;
Guarente, Leonard

Publication type:

Article

Testing telomerase.

Published in:

Nature, 2001, v. 413, n. 6854, p. 370, doi. 10.1038/35096663

By:

Marciniak, Robert;
Guarente, Leonard

Publication type:

Article

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Published in:

Nature, 2001, v. 410, n. 6825, p. 227, doi. 10.1038/35065638

By:

Tissenbaum, Heidi A.;
Guarente, Leonard

Publication type:

Article

Genetic pathways that regulate ageing in model organisms.

Published in:

Nature, 2000, v. 408, n. 6809, p. 255, doi. 10.1038/35041700

By:

Guarente, Leonard;
Kenyon, Cynthia

Publication type:

Article

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

Published in:

Nature Communications, 2016, v. 7, n. 5, p. 11445, doi. 10.1038/ncomms11445

By:

Cunha-Santos, Janete;
Duarte-Neves, Joana;
Carmona, Vitor;
Guarente, Leonard;
Pereira de Almeida, Luís;
Cavadas, Cláudia

Publication type:

Article

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

Published in:

Nature Communications, 2013, v. 4, n. 7, p. 2236, doi. 10.1038/ncomms3236

By:

Fendt, Sarah-Maria;
Bell, Eric L.;
Keibler, Mark A.;
Olenchock, Benjamin A.;
Mayers, Jared R.;
Wasylenko, Thomas M.;
Vokes, Natalie I.;
Guarente, Leonard;
Heiden, Matthew G. Vander;
Stephanopoulos, Gregory

Publication type:

Article

Sirtuins, aging and diseases.

Published in:

2012

By:

Guarente, Leonard

Publication type:

Abstract

NO link between calorie restriction and mitochondria.

Published in:

Nature Chemical Biology, 2005, v. 1, n. 7, p. 355, doi. 10.1038/nchembio1205-355

By:

Guarente, Leonard

Publication type:

Article

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Published in:

2008

By:

Liu, Yi;
Dentin, Renaud;
Chen, Danica;
Hedrick, Susan;
Ravnskjaer, Kim;
Schenk, Simon;
Milne, Jill;
Meyers, David J.;
Cole, Phil;
III, John Yates;
Olefsky, Jerrold;
Guarente, Leonard;
Montminy, Marc

Publication type:

Letter

Two neurons mediate diet-restriction-induced longevity in C. elegans.

Published in:

Nature, 2007, v. 447, n. 7144, p. 545, doi. 10.1038/nature05904

By:

Bishop, Nicholas A.;
Guarente, Leonard

Publication type:

Article

Sirtuins as potential targets for metabolic syndrome.

Published in:

Nature, 2006, v. 444, n. 7121, p. 868, doi. 10.1038/nature05486

By:

Guarente, Leonard

Publication type:

Article

Science fact and the SENS agenda.

Published in:

EMBO Reports, 2005, v. 6, n. 11, p. 1006, doi. 10.1038/sj.embor.7400555

By:

Warner, Huber;
Anderson, Julie;
Austad, Steven;
Bergamini, Ettore;
Bredesen, Dale;
Butler, Robert;
Carnes, Bruce A.;
Clark, Brian F. C.;
Cristofalo, Vincent;
Faulkner, John;
Guarente, Leonard;
Harrison, David E.;
Kirkwood, Tom;
Lithgow, Gordon;
Martin, George;
Masoro, Ed;
Melov, Simon;
Miller, Richard A.;
Olshansky, S. Jay;
Partridge, Linda

Publication type:

Article

Sirtuins and calorie restriction.

Published in:

Nature Reviews Molecular Cell Biology, 2012, v. 13, n. 4, p. 207, doi. 10.1038/nrm3308

By:

Guarente, Leonard

Publication type:

Article

Calorie restriction, SIRT1 and metabolism: understanding longevity.

Published in:

Nature Reviews Molecular Cell Biology, 2005, v. 6, n. 4, p. 298, doi. 10.1038/nrm1616

By:

Bordone, Laura;
Guarente, Leonard

Publication type:

Article