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Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1018273
By:
- Xiaoyi Zhang;
- Kexin Wang;
- Hui Dai;
- Jieqi Cai;
- Yujie Liu;
- Chuanhui Yin;
- Jie Wu;
- Xiaowei Li;
- Guiyong Wu;
- Aiping Lu;
- Qinwen Liu;
- Daogang Guan
Publication type:
Article
An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.801350
By:
- Wu, Jie;
- Wang, Kexin;
- Liu, Qinwen;
- Li, Yi;
- Huang, Yingying;
- Liu, Yujie;
- Cai, Jieqi;
- Yin, Chuanhui;
- Li, Xiaowei;
- Yu, Hailang;
- Meng, Wei;
- Wang, Handuo;
- Lu, Aiping;
- Li, Yazi;
- Guan, Daogang
Publication type:
Article
PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs.
Published in:
International Journal of Molecular Sciences, 2017, v. 18, n. 10, p. 2111, doi. 10.3390/ijms18102111
By:
- Luyao Wang;
- Chao Liang;
- Fangfei Li;
- Daogang Guan;
- Xiaoqiu Wu;
- Xuekun Fu;
- Aiping Lu;
- Ge Zhang
Publication type:
Article
Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer.
Published in:
International Journal of Molecular Sciences, 2016, v. 17, n. 12, p. 2095, doi. 10.3390/ijms17122095
By:
- Quanxia Lv;
- Ziyuan Meng;
- Yuanyuan Yu;
- Feng Jiang;
- Daogang Guan;
- Chao Liang;
- Junwei Zhou;
- Aiping Lu;
- Ge Zhang
Publication type:
Article
Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research.
Published in:
International Journal of Molecular Sciences, 2016, v. 17, n. 12, p. 2018, doi. 10.3390/ijms17122018
By:
- Huanhuan Lv;
- Feng Jiang;
- Daogang Guan;
- Cheng Lu;
- Baosheng Guo;
- Chileung Chan;
- Songlin Peng;
- Baoqin Liu;
- Wenwei Guo;
- Hailong Zhu;
- Xuegong Xu;
- Aiping Lu;
- Ge Zhang
Publication type:
Article
PlaMoM: a comprehensive database compiles plant mobile macromolecules.
Published in:
Nucleic Acids Research, 2017, v. 45, n. D1, p. D1021, doi. 10.1093/nar/gkw988
By:
- Daogang Guan;
- Bin Yan;
- Thieme, Christoph;
- Jingmin Hua;
- Hailong Zhu;
- Boheler, Kenneth R.;
- Zhongying Zhao;
- Kragler, Friedrich;
- Yiji Xia;
- Shoudong Zhang
Publication type:
Article
PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data.
Published in:
Nucleic Acids Research, 2014, v. 42, n. W1, p. W130, doi. 10.1093/nar/gku471
By:
- Guan, Daogang;
- Shao, Jiaofang;
- Zhao, Zhongying;
- Wang, Panwen;
- Qin, Jing;
- Deng, Youping;
- Boheler, Kenneth R.;
- Wang, Junwen;
- Yan, Bin
Publication type:
Article
Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model.
Published in:
Oxidative Medicine & Cellular Longevity, 2021, p. 1, doi. 10.1155/2021/6641838
By:
- Yang, Lang;
- Fan, Liuyi;
- Wang, Kexin;
- Chen, Yupeng;
- Liang, Lan;
- Qin, Xuemei;
- Lu, Aiping;
- Cao, Peng;
- Yu, Bin;
- Guan, Daogang;
- Peng, Junxiang
Publication type:
Article
A System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.723147
By:
- Li, Yi;
- Wang, Kexin;
- Chen, Yupeng;
- Cai, Jieqi;
- Qin, Xuemei;
- Lu, Aiping;
- Guan, Daogang;
- Qin, Genggeng;
- Chen, Weiguo
Publication type:
Article
Computational Network Pharmacology–Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.782060
By:
- Wang, Kexin;
- Li, Kai;
- Chen, Yupeng;
- Wei, Genxia;
- Yu, Hailang;
- Li, Yi;
- Meng, Wei;
- Wang, Handuo;
- Gao, Li;
- Lu, Aiping;
- Peng, Junxiang;
- Guan, Daogang
Publication type:
Article
Unraveling Regulatory Programs for NF-kappaB, p53 and MicroRNAs in Head and Neck Squamous Cell Carcinoma.
Published in:
PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0073656
By:
- Yan, Bin;
- Li, Huai;
- Yang, Xinping;
- Shao, Jiaofang;
- Jang, Minyoung;
- Guan, Daogang;
- Zou, Sige;
- Van Waes, Carter;
- Chen, Zhong;
- Zhan, Ming
Publication type:
Article
HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12163-z
By:
- Liang, Chao;
- Li, Jie;
- Lu, Cheng;
- Xie, Duoli;
- Liu, Jin;
- Zhong, Chuanxin;
- Wu, Xiaohao;
- Dai, Rongchen;
- Zhang, Huarui;
- Guan, Daogang;
- Guo, Baosheng;
- He, Bing;
- Li, Fangfei;
- He, Xiaojuan;
- Zhang, Wandong;
- Zhang, Bao-Ting;
- Zhang, Ge;
- Lu, Aiping
Publication type:
Article
Injectable Ozone‐Rich Nanocomposite Hydrogel Loaded with D‐Mannose for Anti‐Inflammatory and Cartilage Protection in Osteoarthritis Treatment.
Published in:
Small, 2024, v. 20, n. 25, p. 1, doi. 10.1002/smll.202309597
By:
- Wu, Hangtian;
- Wang, Jun;
- Lin, Yanpeng;
- He, Wanling;
- Hou, Jiahui;
- Deng, Mingye;
- Chen, Yupeng;
- Liu, Qinwen;
- Lu, Aiping;
- Cui, Zhuang;
- Guan, Daogang;
- Yu, Bin
Publication type:
Article
Integrated transcriptomic and regulatory network analyses identify microRNA-200c as a novel repressor of human pluripotent stem cell-derived cardiomyocyte differentiation and maturation.
Published in:
Cardiovascular Research, 2018, v. 114, n. 6, p. 894, doi. 10.1093/cvr/cvy019
By:
- Poon, Ellen Ngar-yun;
- Baixia Hao;
- Daogang Guan;
- Mulin Jun Li;
- Jun Lu;
- Yong Yang;
- Binbin Wu;
- Wu, Stanley Chun-ming;
- Webb, Sarah E.;
- Yan Liang;
- Miller, Andrew L.;
- Xiaoqiang Yao;
- Junwen Wang;
- Bin Yan;
- Boheler, Kenneth R.
Publication type:
Article
Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets.
Published in:
Functional & Integrative Genomics, 2019, v. 19, n. 4, p. 645, doi. 10.1007/s10142-019-00670-7
By:
- He, Kan;
- Li, Wen-Xing;
- Guan, Daogang;
- Gong, Mengting;
- Ye, Shoudong;
- Fang, Zekun;
- Huang, Jing-Fei;
- Lu, Aiping
Publication type:
Article
Zwitterion‐Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age‐Associated Osteoarthritis.
Published in:
Advanced Science, 2024, v. 11, n. 30, p. 1, doi. 10.1002/advs.202402477
By:
- Hou, Jiahui;
- Lin, Yanpeng;
- Zhu, Chencheng;
- Chen, Yupeng;
- Lin, Rongmin;
- Lin, Hancheng;
- Liu, Dahai;
- Guan, Daogang;
- Yu, Bin;
- Wang, Jun;
- Wu, Hangtian;
- Cui, Zhuang
Publication type:
Article
A Loop‐Based and AGO‐Incorporated Virtual Screening Model Targeting AGO‐Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice.
Published in:
Advanced Science, 2020, v. 7, n. 13, p. 1, doi. 10.1002/advs.201903451
By:
- Zhuo, Zhenjian;
- Wan, Youyang;
- Guan, Daogang;
- Ni, Shuaijian;
- Wang, Luyao;
- Zhang, Zongkang;
- Liu, Jin;
- Liang, Chao;
- Yu, Yuanyuan;
- Lu, Aiping;
- Zhang, Ge;
- Zhang, Bao‐Ting
Publication type:
Article
A Metabolic Driven Bio‐Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis.
Published in:
Small, 2023, v. 19, n. 21, p. 1, doi. 10.1002/smll.202207319
By:
- Wang, Kexin;
- Yin, Chuanhui;
- Ye, Xiangmin;
- Chen, Quanlin;
- Wu, Jie;
- Chen, Yupeng;
- Li, Yi;
- Wang, Jun;
- Duan, Chuanzhi;
- Lu, Aiping;
- Guan, Daogang
Publication type:
Article
Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry.
Published in:
Molecular Systems Biology, 2015, v. 11, n. 6, p. n/a, doi. 10.15252/msb.20145857
By:
- Ho, Vincy Wing Sze;
- Wong, Ming‐Kin;
- An, Xiaomeng;
- Guan, Daogang;
- Shao, Jiaofang;
- Ng, Hon Chun Kaoru;
- Ren, Xiaoliang;
- He, Kan;
- Liao, Jinyue;
- Ang, Yingjin;
- Chen, Long;
- Huang, Xiaotai;
- Yan, Bin;
- Xia, Yiji;
- Chan, Leanne Lai Hang;
- Chow, King Lau;
- Yan, Hong;
- Zhao, Zhongying
Publication type:
Article
A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis.
Published in:
Chinese Medicine, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13020-024-00896-z
By:
- Liu, Qinwen;
- Li, Xiaowei;
- Li, Yi;
- Luo, Qian;
- Fan, Qiling;
- Lu, Aiping;
- Guan, Daogang;
- Li, Jiahui
Publication type:
Article
Imperatorin and β‐sitosterol have synergistic activities in alleviating collagen‐induced arthritis.
Published in:
Journal of Leukocyte Biology, 2020, v. 108, n. 2, p. 509, doi. 10.1002/JLB.3MA0320-440RR
By:
- Guo, Qingqing;
- Li, Li;
- Zheng, Kang;
- Zheng, Guang;
- Shu, Haiyang;
- Shi, Yingjie;
- Lu, Cheng;
- Shu, Jun;
- Guan, Daogang;
- Lu, Aiping;
- He, Xiaojuan
Publication type:
Article
Screening of the key response component groups and mechanism verification of Huangqi-Guizhi-Wuwu-Decoction in treating rheumatoid arthritis based on a novel computational pharmacological model.
Published in:
BMC Complementary Medicine & Therapies, 2024, v. 24, n. 1, p. 1, doi. 10.1186/s12906-023-04315-y
By:
- Liu, Qinwen;
- Luo, Qian;
- Fan, Qiling;
- Li, Yi;
- Lu, Aiping;
- Guan, Daogang
Publication type:
Article
Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation.
Published in:
BMC Complementary Medicine & Therapies, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12906-023-03990-1
By:
- Xu, Anqi;
- Li, Wenxing;
- Cai, Jieqi;
- Wen, Zhuohua;
- Wang, Kexin;
- Chen, Yupeng;
- Li, Xifeng;
- Guan, Daogang;
- Duan, Chuanzhi
Publication type:
Article
Corrigendum: An integrative pharmacology model for decoding the underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid arthritis.
Published in:
Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1302388
By:
- Jie Wu;
- Kexin Wang;
- Qinwen Liu;
- Yi Li;
- Yingying Huang;
- Yujie Liu;
- Jieqi Cai;
- Chuanhui Yin;
- Xiaowei Li;
- Hailang Yu;
- Wei Meng;
- Handuo Wang;
- Aiping Lu;
- Yazi Li;
- Daogang Guan
Publication type:
Article
PlaMoM: a comprehensive database compiles plant mobile macromolecules.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 13, p. 7607, doi. 10.1093/nar/gkaa538
By:
- Guan, Daogang;
- Yan, Bin;
- Thieme, Christoph;
- Hua, Jingmin;
- Zhu, Hailong;
- Boheler, Kenneth R;
- Zhao, Zhongying;
- Kragler, Friedrich;
- Xia, Yiji;
- Zhang, Shoudong
Publication type:
Article
Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05974-z
By:
- Liang, Chao;
- Peng, Songlin;
- Li, Jie;
- Lu, Jun;
- Guan, Daogang;
- Jiang, Feng;
- Lu, Cheng;
- Li, Fangfei;
- He, Xiaojuan;
- Zhu, Hailong;
- Au, D. W. T.;
- Yang, Dazhi;
- Zhang, Bao-Ting;
- Lu, Aiping;
- Zhang, Ge
Publication type:
Article
A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01565-6
By:
- Fangfei Li;
- Jun Lu;
- Jin Liu;
- Chao Liang;
- Maolin Wang;
- Luyao Wang;
- Defang Li;
- Houzong Yao;
- Qiulong Zhang;
- Jia Wen;
- Zong-Kang Zhang;
- Jie Li;
- Quanxia Lv;
- Xiaojuan He;
- Baosheng Guo;
- Daogang Guan;
- Yuanyuan Yu;
- Lei Dang;
- Xiaohao Wu;
- Yongshu Li
Publication type:
Article
An integrative method to decode regulatory logics in gene transcription.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01193-0
By:
- Bin Yan;
- Daogang Guan;
- Chao Wang;
- Junwen Wang;
- Bing He;
- Jing Qin;
- Boheler, Kenneth R.;
- Aiping Lu;
- Ge Zhang;
- Hailong Zhu
Publication type:
Article
Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-38335-3
By:
- Zheng, Yuxin;
- Wang, Xuezong;
- Zhang, Zong-Kang;
- Guo, Baosheng;
- Dang, Lei;
- He, Bing;
- Zhang, Chi;
- Zhou, Jiwei;
- Shi, Wanzhong;
- Zhao, Yongfang;
- Zhan, Hongsheng;
- Xu, Yu;
- Liang, Chao;
- Liu, Jin;
- Guan, Daogang;
- Wang, Luyao;
- Wu, Xiaohao;
- Li, Jie;
- Zhuo, Zhenjian;
- Lin, Zhixiu
Publication type:
Article
A newly identified lncRNA MAR1 acts as a miR‐487b sponge to promote skeletal muscle differentiation and regeneration.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2018, v. 9, n. 3, p. 613, doi. 10.1002/jcsm.12281
By:
- Zhang, Zong‐Kang;
- Li, Jie;
- Guan, Daogang;
- Liang, Chao;
- Zhuo, Zhenjian;
- Liu, Jin;
- Lu, Aiping;
- Zhang, Ge;
- Zhang, Bao‐Ting
Publication type:
Article
Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer.
Published in:
Cell & Bioscience, 2015, v. 5, n. 1, p. 1, doi. 10.1186/s13578-015-0043-9
By:
- Yongyi Bi;
- Jialing Zhang;
- Xiulan Su;
- Cornelius, Shaleeka;
- Van Waes, Carter;
- Zhong Chen;
- Bin Yan;
- Späth, Stephan Stanislaw;
- Hu Qun;
- Guan, Daogang;
- Jiaofang Shao;
- Koichi Hagiwara
Publication type:
Article
Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial.
Published in:
Chinese Medicine, 2019, v. 14, n. 1, p. N.PAG, doi. 10.1186/s13020-019-0247-8
By:
- Zhang, Chi;
- Guan, Daogang;
- Jiang, Miao;
- Liang, Chao;
- Li, Li;
- Zhao, Ning;
- Zha, Qinglin;
- Zhang, Wandong;
- Lu, Cheng;
- Zhang, Ge;
- Liu, Jian;
- Lu, Aiping
Publication type:
Article
CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data.
Published in:
Bioinformatics, 2014, v. 30, n. 8, p. 1190, doi. 10.1093/bioinformatics/btt761
By:
- Guan, Daogang;
- Shao, Jiaofang;
- Deng, Youping;
- Wang, Panwen;
- Zhao, Zhongying;
- Liang, Yan;
- Wang, Junwen;
- Yan, Bin
Publication type:
Article
Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer.
Published in:
BMC Complementary Medicine & Therapies, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12906-023-03985-y
By:
- Cai, Jieqi;
- Chen, Yupeng;
- Wang, Kexin;
- Li, Yi;
- Wu, Jie;
- Yu, Hailang;
- Li, Qingping;
- Wu, Qi;
- Meng, Wei;
- Wang, Handuo;
- Lu, Aiping;
- Huang, Mianbo;
- Wei, Genxia;
- Guan, Daogang
Publication type:
Article
Author Correction: HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis.
Published in:
2020
By:
- Liang, Chao;
- Li, Jie;
- Lu, Cheng;
- Xie, Duoli;
- Liu, Jin;
- Zhong, Chuanxin;
- Wu, Xiaohao;
- Dai, Rongchen;
- Zhang, Huarui;
- Guan, Daogang;
- Guo, Baosheng;
- He, Bing;
- Li, Fangfei;
- He, Xiaojuan;
- Zhang, Wandong;
- Zhang, Bao-Ting;
- Zhang, Ge;
- Lu, Aiping
Publication type:
Correction Notice
2235-PUB: Detection and Validation of Hidden Driven Networks in Diabetic Microangiopathy.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-2235-PUB
By:
- CHEN, YANMING;
- LI, HAICHENG;
- GUAN, DAOGANG
Publication type:
Article

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